Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1934517..1935285 Replicon chromosome
Accession NZ_CP028768
Organism Escherichia coli strain A6

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag AOY57_RS09380 Protein ID WP_201478516.1
Coordinates 1934517..1934891 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag AOY57_RS09385 Protein ID WP_071792336.1
Coordinates 1934980..1935285 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOY57_RS09345 (1929913) 1929913..1931079 + 1167 WP_001297905.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
AOY57_RS09350 (1931198) 1931198..1931671 + 474 WP_001105376.1 DNA gyrase inhibitor SbmC -
AOY57_RS09355 (1931869) 1931869..1932927 + 1059 WP_163420058.1 FUSC family protein -
AOY57_RS09360 (1933099) 1933099..1933428 + 330 WP_000450409.1 DUF496 family protein -
AOY57_RS09365 (1933529) 1933529..1933885 - 357 WP_240726663.1 EutP/PduV family microcompartment system protein -
AOY57_RS09370 (1934200) 1934200..1934280 - 81 Protein_1839 hypothetical protein -
AOY57_RS09375 (1934326) 1934326..1934520 - 195 WP_000988601.1 DUF5983 family protein -
AOY57_RS09380 (1934517) 1934517..1934891 - 375 WP_201478516.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
AOY57_RS09385 (1934980) 1934980..1935285 - 306 WP_071792336.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
AOY57_RS09390 (1935422) 1935422..1935643 - 222 WP_000692323.1 DUF987 domain-containing protein -
AOY57_RS09395 (1935706) 1935706..1936182 - 477 WP_001186773.1 RadC family protein -
AOY57_RS09400 (1936198) 1936198..1936671 - 474 WP_000855075.1 antirestriction protein -
AOY57_RS09405 (1936934) 1936934..1937755 - 822 WP_001234710.1 DUF932 domain-containing protein -
AOY57_RS09410 (1937976) 1937976..1938386 - 411 WP_000846704.1 hypothetical protein -
AOY57_RS09415 (1938402) 1938402..1939079 - 678 WP_001362823.1 hypothetical protein -
AOY57_RS09420 (1939214) 1939214..1940284 - 1071 WP_000102631.1 patatin-like phospholipase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(2-96)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13885.94 Da        Isoelectric Point: 7.8522

>T103989 WP_201478516.1 NZ_CP028768:c1934891-1934517 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNTITLGKYPEAK

Download         Length: 375 bp

>T103989 NZ_CP028768:c1934891-1934517 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATACCATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11097.76 Da        Isoelectric Point: 5.6182

>AT103989 WP_071792336.1 NZ_CP028768:c1935285-1934980 [Escherichia coli]
MPCTVTPCFGARLVQEGNRLHYLADRAGIRGLSSDADAYPLDQAFPLLMKQLELMLTSGELNPRNQHTVTLYAKGLACEA
DTLSSCGYVYLAVYPTPEMKN

Download         Length: 306 bp

>AT103989 NZ_CP028768:c1935285-1934980 [Escherichia coli]
CTGCCCTGCACCGTGACGCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGC
CGGTATCAGAGGCCTGTCCAGCGATGCAGATGCGTACCCCCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAAC
TCATGCTCACCAGCGGTGAACTGAATCCCCGCAATCAGCATACCGTCACGCTGTATGCGAAGGGGCTGGCCTGTGAAGCC
GATACCCTCAGCAGTTGTGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References