Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3524029..3524275 Replicon chromosome
Accession NZ_CP028761
Organism Escherichia coli strain A13

Toxin (Protein)


Gene name hokX Uniprot ID S1PD89
Locus tag AOY66_RS16940 Protein ID WP_000956458.1
Coordinates 3524029..3524181 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokX
Locus tag -
Coordinates 3524223..3524275 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOY66_RS16915 3519300..3519623 - 324 WP_001246113.1 DUF3561 family protein -
AOY66_RS16920 3519673..3520278 - 606 WP_001173653.1 adenylyl-sulfate kinase -
AOY66_RS16925 3520278..3521705 - 1428 WP_201475209.1 sulfate adenylyltransferase subunit CysN -
AOY66_RS16930 3521707..3522615 - 909 WP_000372392.1 sulfate adenylyltransferase subunit CysD -
AOY66_RS16935 3522867..3523904 + 1038 WP_000490435.1 alkaline phosphatase isozyme conversion aminopeptidase -
AOY66_RS16940 3524029..3524181 - 153 WP_000956458.1 Hok/Gef family protein Toxin
- 3524223..3524275 + 53 - - Antitoxin
AOY66_RS16945 3524446..3525180 - 735 WP_000039865.1 phosphoadenosine phosphosulfate reductase -
AOY66_RS16950 3525254..3526966 - 1713 WP_001290708.1 assimilatory sulfite reductase (NADPH) hemoprotein subunit -
AOY66_RS16955 3526966..3528765 - 1800 WP_000211918.1 NADPH-dependent assimilatory sulfite reductase flavoprotein subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(5-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5558.77 Da        Isoelectric Point: 7.6757

>T103832 WP_000956458.1 NZ_CP028761:c3524181-3524029 [Escherichia coli]
MLTKYALVAIIVLCCTVLGFTLMVGDSLCELSIRERGMEFKAVLAYESKK

Download         Length: 153 bp

>T103832 NZ_CP028761:c3524181-3524029 [Escherichia coli]
ATGCTGACAAAATATGCCCTTGTGGCAATCATCGTACTGTGTTGTACAGTACTGGGATTCACGTTGATGGTAGGCGACTC
GTTGTGTGAGTTGAGTATCAGAGAACGTGGTATGGAGTTTAAGGCAGTTCTCGCTTACGAATCGAAGAAGTAG

Antitoxin


Download         Length: 53 bp

>AT103832 NZ_CP028761:3524223-3524275 [Escherichia coli]
TTAGGTTCGAACGTAGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TJ83

Antitoxin

Download structure file

References