Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2929432..2930263 Replicon chromosome
Accession NZ_CP028759
Organism Escherichia coli strain A15

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag AOY68_RS14005 Protein ID WP_000854814.1
Coordinates 2929889..2930263 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag AOY68_RS14000 Protein ID WP_001285585.1
Coordinates 2929432..2929800 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOY68_RS13970 (2926336) 2926336..2926791 + 456 WP_000581504.1 IrmA family protein -
AOY68_RS13975 (2926870) 2926870..2927103 + 234 WP_001119729.1 DUF905 family protein -
AOY68_RS13980 (2927203) 2927203..2928021 + 819 WP_001234629.1 DUF932 domain-containing protein -
AOY68_RS13985 (2928103) 2928103..2928582 + 480 WP_000860087.1 antirestriction protein -
AOY68_RS13990 (2928598) 2928598..2929074 + 477 WP_001186726.1 RadC family protein -
AOY68_RS13995 (2929137) 2929137..2929358 + 222 WP_000692323.1 DUF987 domain-containing protein -
AOY68_RS14000 (2929432) 2929432..2929800 + 369 WP_001285585.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
AOY68_RS14005 (2929889) 2929889..2930263 + 375 WP_000854814.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
AOY68_RS14010 (2930260) 2930260..2930454 + 195 WP_000988600.1 DUF5983 family protein -
AOY68_RS14015 (2930500) 2930500..2930580 + 81 Protein_2726 hypothetical protein -
AOY68_RS14020 (2930869) 2930869..2930997 - 129 Protein_2727 transposase domain-containing protein -
AOY68_RS14025 (2931117) 2931117..2931251 + 135 WP_001297944.1 EutP/PduV family microcompartment system protein -
AOY68_RS14030 (2931352) 2931352..2931681 - 330 WP_000450409.1 DUF496 family protein -
AOY68_RS14035 (2931853) 2931853..2932911 - 1059 WP_001200891.1 FUSC family protein -
AOY68_RS14040 (2933108) 2933108..2933581 - 474 WP_001105389.1 DNA gyrase inhibitor SbmC -
AOY68_RS14045 (2933700) 2933700..2934866 - 1167 WP_000830150.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T103772 WP_000854814.1 NZ_CP028759:2929889-2930263 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T103772 NZ_CP028759:2929889-2930263 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT103772 WP_001285585.1 NZ_CP028759:2929432-2929800 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT103772 NZ_CP028759:2929432-2929800 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References