Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 749578..749836 Replicon chromosome
Accession NZ_CP028750
Organism Escherichia coli strain A25

Toxin (Protein)


Gene name hokC Uniprot ID B7UI62
Locus tag AOY78_RS03585 Protein ID WP_000809165.1
Coordinates 749578..749730 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 749779..749836 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOY78_RS03565 744824..745537 - 714 WP_001102367.1 acidic protein MsyB -
AOY78_RS03570 745563..745967 - 405 WP_000843689.1 DUF2541 family protein -
AOY78_RS03575 746338..748254 + 1917 WP_000516135.1 molecular chaperone DnaK -
AOY78_RS03580 748343..749473 + 1131 WP_001118464.1 molecular chaperone DnaJ -
AOY78_RS03585 749578..749730 - 153 WP_000809165.1 type I toxin-antitoxin system toxin MokC Toxin
- 749779..749836 + 58 - - Antitoxin
AOY78_RS03590 750345..751106 + 762 WP_096891019.1 outer membrane protein OmpK -
AOY78_RS03595 751127..752620 + 1494 WP_024248126.1 sulfatase-like hydrolase/transferase -
AOY78_RS03600 752749..753993 + 1245 WP_201488377.1 IS1 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5513.62 Da        Isoelectric Point: 7.1312

>T103528 WP_000809165.1 NZ_CP028750:c749730-749578 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRIGQTEVAVFTAYESE

Download         Length: 153 bp

>T103528 NZ_CP028750:c749730-749578 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAATTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT103528 NZ_CP028750:749779-749836 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B7UI62

Antitoxin

Download structure file

References