Detailed information of TA system TA103438

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 4544549..4545347
• Replicon: chromosome
• Accession: NZ_CP028745
• Organism: Escherichia coli strain A30

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: AOY83_RS21525
• Protein ID: WP_000854907.1
• Coordinates: 4544970..4545347 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: AOY83_RS21520
• Protein ID: WP_047659145.1
• Coordinates: 4544549..4544923 (+)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AOY83_RS21500 (4542215)	4542215..4543033	+	819	WP_097308925.1	DUF932 domain-containing protein	-
AOY83_RS21505 (4543125)	4543125..4543610	+	486	WP_097308924.1	antirestriction protein	-
AOY83_RS21510 (4543626)	4543626..4544102	+	477	WP_001186727.1	RadC family protein	-
AOY83_RS21515 (4544165)	4544165..4544386	+	222	WP_000692329.1	DUF987 domain-containing protein	-
AOY83_RS21520 (4544549)	4544549..4544923	+	375	WP_047659145.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
AOY83_RS21525 (4544970)	4544970..4545347	+	378	WP_000854907.1	TA system toxin CbtA family protein	Toxin
AOY83_RS21530 (4545344)	4545344..4545832	+	489	WP_240767523.1	DUF5983 family protein	-
AOY83_RS21535 (4545849)	4545849..4546052	+	204	WP_240767524.1	hypothetical protein	-
AOY83_RS21540 (4546137)	4546137..4547001	+	865	Protein_4233	DUF4942 domain-containing protein	-
AOY83_RS21545 (4547073)	4547073..4547336	+	264	WP_001143297.1	type II toxin-antitoxin system ParD family antitoxin	-
AOY83_RS21550 (4547333)	4547333..4547659	+	327	WP_000779483.1	type II toxin-antitoxin system RelE/ParE family toxin	-
AOY83_RS21555 (4548541)	4548541..4550079	+	1539	WP_001187177.1	lysine decarboxylation/transport transcriptional activator CadC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	clpV/tssH / hcp/tssD / vipB/tssC / vipA/tssB	4511107..4557892	46785

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-116)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14050.02 Da
• Isoelectric Point: 7.9086

>T103438 WP_000854907.1 NZ_CP028745:4544970-4545347 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGTSSQLINSIDILRARRATGLMTRSNYRTVNNITLGKHPEAKQ

Nucleotide

• Length: 378 bp

>T103438 NZ_CP028745:4544970-4545347 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCAGGAACTTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCACGCCGGGCAACAGGTCTGATGACCCGCAG
CAACTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 13736.58 Da
• Isoelectric Point: 6.4757

>AT103438 WP_047659145.1 NZ_CP028745:4544549-4544923 [Escherichia coli]
VSDTLPGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPIPAPATTS

Nucleotide

• Length: 375 bp

>AT103438 NZ_CP028745:4544549-4544923 [Escherichia coli]
GTGTCAGACACACTCCCCGGGATAACGCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGACATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGATACCGGCACCCGCAACCACCTCATAA