Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4991757..4992552 Replicon chromosome
Accession NZ_CP028742
Organism Escherichia coli strain A33

Toxin (Protein)


Gene name yeeV Uniprot ID A0A658LKE6
Locus tag AOY86_RS24195 Protein ID WP_001596171.1
Coordinates 4992178..4992552 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag AOY86_RS24190 Protein ID WP_240768470.1
Coordinates 4991757..4992131 (+) Length 125 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOY86_RS24155 (4987599) 4987599..4988279 + 681 WP_240768466.1 WYL domain-containing protein -
AOY86_RS24160 (4988427) 4988427..4989104 + 678 WP_001097301.1 hypothetical protein -
AOY86_RS24165 (4989110) 4989110..4989343 + 234 WP_001278287.1 DUF905 family protein -
AOY86_RS24170 (4989433) 4989433..4990251 + 819 WP_240768468.1 DUF932 domain-containing protein -
AOY86_RS24175 (4990333) 4990333..4990812 + 480 WP_096997664.1 antirestriction protein -
AOY86_RS24180 (4990828) 4990828..4991304 + 477 WP_001186773.1 RadC family protein -
AOY86_RS24185 (4991373) 4991373..4991594 + 222 WP_000692323.1 DUF987 domain-containing protein -
AOY86_RS24190 (4991757) 4991757..4992131 + 375 WP_240768470.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
AOY86_RS24195 (4992178) 4992178..4992552 + 375 WP_001596171.1 TA system toxin CbtA family protein Toxin
AOY86_RS24200 (4992549) 4992549..4993040 + 492 WP_001596172.1 DUF5983 family protein -
AOY86_RS24205 (4993052) 4993052..4993249 + 198 WP_053266182.1 DUF957 domain-containing protein -
AOY86_RS24210 (4993334) 4993334..4994176 + 843 WP_240768649.1 DUF4942 domain-containing protein -
AOY86_RS24215 (4994772) 4994772..4995269 + 498 WP_000509811.1 hypothetical protein -
AOY86_RS24220 (4995436) 4995436..4996359 + 924 WP_000535950.1 carboxylate/amino acid/amine transporter -
AOY86_RS24225 (4996490) 4996490..4997062 - 573 WP_001165549.1 recombinase family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4987325..5033918 46593


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 125 a.a.        Molecular weight: 14161.14 Da        Isoelectric Point: 6.7041

>T103349 WP_001596171.1 NZ_CP028742:4992178-4992552 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLARLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYELVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T103349 NZ_CP028742:4992178-4992552 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGTTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCGC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACTCCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCCGGCATTTCACTGTGCGATGCAGTGAACTTTCTTGTTGAAAAATACGAACTGGTGCGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGTTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13754.55 Da        Isoelectric Point: 6.4757

>AT103349 WP_240768470.1 NZ_CP028742:4991757-4992131 [Escherichia coli]
VSDTLPGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLTVYPTPAPATTS

Download         Length: 375 bp

>AT103349 NZ_CP028742:4991757-4992131 [Escherichia coli]
GTGTCAGACACACTCCCCGGGATAACGCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGACATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGACTGTTTATCCGACACCGGCACCCGCAACCACCTCATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A658LKE6


Antitoxin

Source ID Structure

References