Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 4180851..4181544 Replicon chromosome
Accession NZ_CP028741
Organism Escherichia coli strain A34

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag AOY87_RS20580 Protein ID WP_000415584.1
Coordinates 4181248..4181544 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag AOY87_RS20575 Protein ID WP_000650107.1
Coordinates 4180851..4181246 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOY87_RS20565 (4176715) 4176715..4178973 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
AOY87_RS20570 (4179111) 4179111..4180718 - 1608 WP_137503491.1 ABC transporter substrate-binding protein -
AOY87_RS20575 (4180851) 4180851..4181246 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
AOY87_RS20580 (4181248) 4181248..4181544 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
AOY87_RS20585 (4181749) 4181749..4182231 - 483 WP_000183494.1 GyrI-like domain-containing protein -
AOY87_RS20590 (4182284) 4182284..4182676 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
AOY87_RS20595 (4182828) 4182828..4183487 + 660 WP_001221502.1 quorum sensing response regulator transcription factor QseB -
AOY87_RS20600 (4183484) 4183484..4184833 + 1350 WP_053889563.1 quorum sensing histidine kinase QseC -
AOY87_RS20605 (4184943) 4184943..4185524 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
AOY87_RS20610 (4185555) 4185555..4185869 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T103320 WP_000415584.1 NZ_CP028741:c4181544-4181248 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T103320 NZ_CP028741:c4181544-4181248 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT103320 WP_000650107.1 NZ_CP028741:c4181246-4180851 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT103320 NZ_CP028741:c4181246-4180851 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACACAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References