Detailed information of TA system TA102590

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3405347..3405572
• Replicon: chromosome
• Accession: NZ_CP028674
• Organism: Escherichia coli strain 115

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: -
• Locus tag: C9E44_RS17730
• Protein ID: WP_000813263.1
• Coordinates: 3405347..3405502 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	3405514..3405572 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C9E44_RS17695	3400801..3401514	-	714	WP_000261909.1	helix-turn-helix domain-containing protein	-
C9E44_RS17700	3401652..3401848	-	197	Protein_3371	TrmB family transcriptional regulator	-
C9E44_RS17705	3402135..3402953	-	819	WP_000265265.1	CPBP family intramembrane metalloprotease	-
C9E44_RS17710	3403105..3403476	-	372	WP_000090264.1	antitermination protein	-
C9E44_RS17715	3403466..3403837	-	372	WP_001217436.1	RusA family crossover junction endodeoxyribonuclease	-
C9E44_RS17720	3403850..3404899	-	1050	WP_001265172.1	DUF968 domain-containing protein	-
C9E44_RS17725	3404901..3405179	-	279	WP_001341388.1	hypothetical protein	-
C9E44_RS17730	3405347..3405502	-	156	WP_000813263.1	type I toxin-antitoxin system toxin HokD	Toxin
-	3405514..3405572	+	59	-	-	Antitoxin
C9E44_RS17750	3406107..3406880	+	774	WP_000160654.1	alpha/beta hydrolase	-
C9E44_RS17755	3407232..3407645	-	414	WP_001151233.1	DUF977 family protein	-
C9E44_RS17760	3407661..3408431	-	771	WP_000450992.1	DUF1627 domain-containing protein	-
C9E44_RS17765	3408453..3409199	-	747	WP_000788751.1	ATP-binding protein	-
C9E44_RS17770	3409206..3410297	-	1092	WP_001205823.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5722.86 Da
• Isoelectric Point: 6.1531

>T102590 WP_000813263.1 NZ_CP028674:c3405502-3405347 [Escherichia coli]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRVRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T102590 NZ_CP028674:c3405502-3405347 [Escherichia coli]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAGTCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT102590 NZ_CP028674:3405514-3405572 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Structures

Antitoxin