Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1913843..1914674 Replicon chromosome
Accession NZ_CP028483
Organism Escherichia coli strain E41-1

Toxin (Protein)


Gene name yeeV Uniprot ID A0A066T988
Locus tag C2U19_RS09580 Protein ID WP_000854815.1
Coordinates 1913843..1914217 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A061Y7A8
Locus tag C2U19_RS09585 Protein ID WP_001280918.1
Coordinates 1914306..1914674 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2U19_RS09540 1909239..1910405 + 1167 WP_001296209.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
C2U19_RS09545 1910524..1910997 + 474 WP_001105368.1 DNA gyrase inhibitor SbmC -
C2U19_RS09550 1911195..1912253 + 1059 WP_001200889.1 FUSC family protein -
C2U19_RS09555 1912425..1912754 + 330 WP_000450409.1 DUF496 family protein -
C2U19_RS09560 1912855..1913037 - 183 WP_001296208.1 hypothetical protein -
C2U19_RS09565 1913091..1913237 + 147 Protein_1760 transposase domain-containing protein -
C2U19_RS09570 1913526..1913639 - 114 WP_001161660.1 DUF957 domain-containing protein -
C2U19_RS09575 1913652..1913846 - 195 WP_000988600.1 hypothetical protein -
C2U19_RS09580 1913843..1914217 - 375 WP_000854815.1 type IV toxin-antitoxin system toxin CbtA Toxin
C2U19_RS09585 1914306..1914674 - 369 WP_001280918.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
C2U19_RS09590 1914690..1915334 - 645 WP_000086752.1 hypothetical protein -
C2U19_RS09595 1915353..1915574 - 222 WP_000692345.1 DUF987 domain-containing protein -
C2U19_RS09600 1915637..1916113 - 477 WP_001186200.1 RadC family protein -
C2U19_RS09605 1916129..1916602 - 474 WP_001542276.1 antirestriction protein -
C2U19_RS09610 1916696..1916941 - 246 WP_001164966.1 hypothetical protein -
C2U19_RS09615 1916941..1917759 - 819 WP_001542275.1 DUF945 domain-containing protein -
C2U19_RS09625 1917980..1918390 - 411 WP_000846703.1 hypothetical protein -
C2U19_RS09630 1918406..1918756 - 351 Protein_1772 hypothetical protein -
C2U19_RS09640 1918839..1919585 - 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13829.83 Da        Isoelectric Point: 7.1326

>T101290 WP_000854815.1 NZ_CP028483:c1914217-1913843 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTSDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T101290 NZ_CP028483:c1914217-1913843 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCAGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13811.70 Da        Isoelectric Point: 6.4767

>AT101290 WP_001280918.1 NZ_CP028483:c1914674-1914306 [Escherichia coli]
VSDKLHETNYPDDHNDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT101290 NZ_CP028483:c1914674-1914306 [Escherichia coli]
GTGTCAGACAAACTCCATGAGACAAATTATCCCGACGACCATAACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A066T988

Antitoxin

Source ID Structure
AlphaFold DB A0A061Y7A8

References