Detailed information of TA system TA100385

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicA
• Location: 1608589..1608995
• Replicon: chromosome
• Accession: NZ_CP027860
• Organism: Ahniella affigens strain D13

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: C7S18_RS06180
• Protein ID: WP_106890738.1
• Coordinates: 1608589..1608777 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: C7S18_RS06185
• Protein ID: WP_106890739.1
• Coordinates: 1608783..1608995 (+)
• Length: 71 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C7S18_RS06140	1603867..1604241	+	375	WP_146151784.1	hypothetical protein	-
C7S18_RS06145	1604339..1604659	+	321	WP_106890731.1	hypothetical protein	-
C7S18_RS06150	1604740..1605129	+	390	WP_106890732.1	DUF5071 domain-containing protein	-
C7S18_RS06155	1605200..1605580	+	381	WP_146151785.1	hypothetical protein	-
C7S18_RS06165	1606487..1606813	+	327	WP_106890735.1	hypothetical protein	-
C7S18_RS06170	1606918..1607382	+	465	WP_106890736.1	hypothetical protein	-
C7S18_RS24165	1607777..1608064	+	288	WP_146151786.1	hypothetical protein	-
C7S18_RS06180	1608589..1608777	+	189	WP_106890738.1	type II toxin-antitoxin system HicA family toxin	Toxin
C7S18_RS06185	1608783..1608995	+	213	WP_106890739.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
C7S18_RS06190	1609088..1609438	+	351	WP_106890740.1	DUF3024 domain-containing protein	-
C7S18_RS06195	1609545..1609979	+	435	WP_146151787.1	hypothetical protein	-
C7S18_RS06205	1610977..1611348	+	372	WP_106890743.1	hypothetical protein	-
C7S18_RS06210	1611752..1612324	+	573	WP_146151788.1	hypothetical protein	-
C7S18_RS06215	1612451..1613029	+	579	WP_206207983.1	methyltransferase domain-containing protein	-
C7S18_RS06220	1613166..1613453	+	288	WP_106890746.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	1584535..1618806	34271

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-65)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 6775.91 Da
• Isoelectric Point: 11.1475

>T100385 WP_106890738.1 NZ_CP027860:1608589-1608777 [Ahniella affigens]
VKVSEVLKLLHDDGWFLVATRGSHRQFKHPSKPGRVTIAGKPSDDLATGTLLSILKQAGLKR

Nucleotide

• Length: 189 bp

>T100385 NZ_CP027860:1608589-1608777 [Ahniella affigens]
GTGAAGGTCAGTGAAGTCTTGAAGCTGCTGCATGATGATGGCTGGTTCTTAGTCGCCACTCGCGGCAGCCATCGCCAGTT
CAAGCACCCTAGCAAGCCTGGGCGGGTCACGATTGCAGGCAAACCCAGCGATGATTTGGCAACTGGTACACTTTTGAGCA
TACTCAAGCAAGCGGGACTGAAGAGGTAA

Antitoxin

Protein

• Length: 71 a.a.
• Molecular weight: 7560.49 Da
• Isoelectric Point: 3.9098

>AT100385 WP_106890739.1 NZ_CP027860:1608783-1608995 [Ahniella affigens]
MRYAIVIEQAESNFSAYVPDLPGCVATGGSLEEVEREIREAISFHLEGLREDGLPPPPAASVVEYVEIAA

Nucleotide

• Length: 213 bp

>AT100385 NZ_CP027860:1608783-1608995 [Ahniella affigens]
ATGCGCTACGCCATCGTCATTGAACAAGCGGAATCGAACTTCTCGGCGTATGTTCCCGATCTCCCGGGCTGCGTCGCCAC
TGGCGGTTCGCTGGAGGAAGTAGAGCGCGAGATTCGAGAAGCCATTTCATTCCATCTTGAAGGGCTTCGTGAAGATGGGC
TACCACCGCCGCCGGCAGCGAGCGTAGTCGAGTACGTCGAGATTGCAGCCTAA