MGE detailed information
MGE type: Non-Mobilizable plasmid MGE length: 111334 bp
Accession: NZ_CP048916 Location: 1..111334 Organism: Escherichia coli strain E2 Replicon: plasmid pE2-NDM-CTX-M
Accession: NZ_CP048916 Location: 1..111334 Organism: Escherichia coli strain E2 Replicon: plasmid pE2-NDM-CTX-M
Gene structure
The 5 kb flanking regions of this MGE are displayed.
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| G5S48_RS22770 (1) | 1..978 | + | 978 | WP_000361610.1 | RepB family plasmid replication initiator protein | - |
| G5S48_RS22775 (1263) | 1263..2003 | - | 741 | WP_001066942.1 | tyrosine-type recombinase/integrase | - |
| G5S48_RS22780 (2124) | 2124..2306 | - | 183 | WP_042065278.1 | hypothetical protein | - |
| G5S48_RS24465 (2373) | 2373..2662 | - | 290 | Protein_3 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| G5S48_RS22785 (2649) | 2649..2917 | - | 269 | Protein_4 | type II toxin-antitoxin system ParD family antitoxin | - |
| G5S48_RS22790 (3449) | 3449..4618 | + | 1170 | WP_001072355.1 | hypothetical protein | - |
| G5S48_RS22795 (4651) | 4651..4779 | + | 129 | Protein_6 | IS481 family transposase | - |
| G5S48_RS22800 (4814) | 4814..5002 | - | 189 | Protein_7 | hypothetical protein | - |
| G5S48_RS22805 (5050) | 5050..5747 | + | 698 | WP_095033700.1 | IS1-like element IS1B family transposase | - |
| G5S48_RS22810 (5763) | 5763..5882 | + | 120 | Protein_9 | transcriptional regulator | - |
| G5S48_RS22815 (5860) | 5860..6483 | - | 624 | WP_000088605.1 | tetracycline resistance transcriptional repressor TetR(B) | - |
| G5S48_RS22820 (6565) | 6565..7770 | + | 1206 | WP_001089068.1 | tetracycline efflux MFS transporter Tet(B) | - |
| G5S48_RS22825 (7883) | 7883..8476 | - | 594 | WP_000428546.1 | tetracyline resistance-associated transcriptional repressor TetC | - |
| G5S48_RS22830 (8610) | 8610..9314 | + | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| G5S48_RS22835 (9368) | 9368..9733 | - | 366 | Protein_14 | chromate transporter | - |
| G5S48_RS22840 (9889) | 9889..10092 | - | 204 | WP_000376616.1 | hypothetical protein | - |
| G5S48_RS22845 (10220) | 10220..11059 | - | 840 | WP_000259031.1 | sulfonamide-resistant dihydropteroate synthase Sul1 | - |
| G5S48_RS22850 (11053) | 11053..11400 | - | 348 | WP_000679427.1 | quaternary ammonium compound efflux SMR transporter QacE delta 1 | - |
| G5S48_RS22855 (11606) | 11606..12394 | - | 789 | WP_000503573.1 | ANT(3'')-Ia family aminoglycoside nucleotidyltransferase AadA5 | - |
| G5S48_RS22860 (12525) | 12525..12998 | - | 474 | WP_001389366.1 | trimethoprim-resistant dihydrofolate reductase DfrA17 | - |
| G5S48_RS22865 (13156) | 13156..14169 | + | 1014 | WP_000845039.1 | class 1 integron integrase IntI1 | - |
| G5S48_RS24470 (14372) | 14372..14680 | + | 309 | Protein_21 | EAL domain-containing protein | - |
| G5S48_RS22875 (14571) | 14571..15275 | - | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| G5S48_RS22880 (15440) | 15440..15733 | + | 294 | Protein_23 | IS30 family transposase | - |
| G5S48_RS22885 (15834) | 15834..16646 | + | 813 | WP_023408309.1 | subclass B1 metallo-beta-lactamase NDM-5 | - |
| G5S48_RS22890 (16650) | 16650..17015 | + | 366 | WP_004201167.1 | bleomycin binding protein Ble-MBL | - |
| G5S48_RS22895 (17020) | 17020..17658 | + | 639 | WP_004201168.1 | phosphoribosylanthranilate isomerase | - |
| G5S48_RS24475 (17669) | 17669..18226 | - | 558 | Protein_27 | twin-arginine translocation (TAT) pathway signal sequence domain protein | - |
| G5S48_RS24480 (18326) | 18326..18700 | - | 375 | Protein_28 | protein-disulfide reductase DsbD family protein | - |
| G5S48_RS22905 (19013) | 19013..20554 | - | 1542 | WP_000050481.1 | IS91-like element ISCR1 family transposase | - |
| G5S48_RS22910 (20959) | 20959..21798 | - | 840 | WP_000259031.1 | sulfonamide-resistant dihydropteroate synthase Sul1 | - |
| G5S48_RS22915 (21792) | 21792..22139 | - | 348 | WP_000679427.1 | quaternary ammonium compound efflux SMR transporter QacE delta 1 | - |
| G5S48_RS22920 (22256) | 22256..23094 | - | 839 | Protein_32 | AadA family aminoglycoside 3''-O-nucleotidyltransferase | - |
| G5S48_RS22925 (23100) | 23100..23390 | - | 291 | WP_001336345.1 | DUF1010 domain-containing protein | - |
| G5S48_RS22930 (23502) | 23502..23999 | - | 498 | WP_001083725.1 | trimethoprim-resistant dihydrofolate reductase DfrA12 | - |
| G5S48_RS22935 (24144) | 24144..25010 | + | 867 | Protein_35 | class 1 integron integrase IntI1 | - |
| G5S48_RS22940 (25065) | 25065..25769 | - | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| G5S48_RS22945 (25928) | 25928..26209 | - | 282 | Protein_37 | transposase zinc-binding domain-containing protein | - |
| G5S48_RS22950 (26356) | 26356..27216 | - | 861 | WP_000027057.1 | broad-spectrum class A beta-lactamase TEM-1 | - |
| G5S48_RS22955 (27399) | 27399..27590 | - | 192 | Protein_39 | helix-turn-helix domain-containing protein | - |
| G5S48_RS22960 (27654) | 27654..28358 | + | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| G5S48_RS22965 (28413) | 28413..29258 | - | 846 | Protein_41 | IS4-like element ISVsa5 family transposase | - |
| G5S48_RS22970 (29368) | 29368..30330 | - | 963 | Protein_42 | IS4-like element ISVsa5 family transposase | - |
| G5S48_RS22975 (30473) | 30473..31333 | + | 861 | WP_000557454.1 | aminoglycoside N-acetyltransferase AAC(3)-IId | - |
| G5S48_RS22980 (31346) | 31346..31888 | + | 543 | WP_000587837.1 | AAA family ATPase | - |
| G5S48_RS22985 (32370) | 32370..32561 | - | 192 | WP_000951934.1 | hypothetical protein | - |
| G5S48_RS22990 (32585) | 32585..32812 | + | 228 | WP_000248278.1 | hypothetical protein | - |
| G5S48_RS22995 (32863) | 32863..33990 | + | 1128 | WP_014837927.1 | DUF3883 domain-containing protein | - |
| G5S48_RS23000 (34027) | 34027..34731 | + | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| G5S48_RS23005 (34853) | 34853..35758 | + | 906 | WP_000219391.1 | Mph(A) family macrolide 2'-phosphotransferase | - |
| G5S48_RS23010 (35755) | 35755..36993 | + | 1239 | WP_000004159.1 | macrolide resistance MFS transporter Mrx(A) | - |
| G5S48_RS23015 (36993) | 36993..37577 | + | 585 | WP_001137892.1 | macrolide-binding transcriptional repressor MphR(A) | - |
| G5S48_RS23020 (38070) | 38070..38834 | - | 765 | WP_216263843.1 | IS6-like element IS6100 family transposase | - |
| G5S48_RS23025 (38974) | 38974..39678 | + | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| G5S48_RS23030 (39739) | 39739..40575 | - | 837 | WP_000480968.1 | aminoglycoside O-phosphotransferase APH(6)-Id | - |
| G5S48_RS23035 (40575) | 40575..41378 | - | 804 | WP_001082319.1 | aminoglycoside O-phosphotransferase APH(3'')-Ib | - |
| G5S48_RS23040 (41439) | 41439..42254 | - | 816 | WP_001043265.1 | sulfonamide-resistant dihydropteroate synthase Sul2 | - |
| G5S48_RS23045 (42562) | 42562..43413 | - | 852 | WP_000240536.1 | replication protein C, IncQ-type | - |
| G5S48_RS23050 (43400) | 43400..44119 | - | 720 | Protein_58 | helicase RepA family protein | - |
| G5S48_RS23055 (44169) | 44169..44873 | - | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| G5S48_RS23060 (44937) | 44937..45608 | + | 672 | Protein_60 | Tn3 family transposase | - |
| G5S48_RS23065 (45833) | 45833..46474 | - | 642 | WP_000134999.1 | MBL fold metallo-hydrolase | - |
| G5S48_RS23070 (46714) | 46714..47034 | - | 321 | Protein_62 | IS1380 family transposase | - |
| G5S48_RS23075 (47047) | 47047..47607 | + | 561 | WP_000147567.1 | recombinase family protein | - |
| G5S48_RS23080 (47610) | 47610..50081 | + | 2472 | Protein_64 | Tn3-like element TnAs3 family transposase | - |
| G5S48_RS23085 (50228) | 50228..51088 | - | 861 | WP_000027057.1 | broad-spectrum class A beta-lactamase TEM-1 | - |
| G5S48_RS23090 (51271) | 51271..51609 | - | 339 | Protein_66 | recombinase family protein | - |
| G5S48_RS23095 (51673) | 51673..52377 | + | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| G5S48_RS24485 (52432) | 52432..52503 | + | 72 | Protein_68 | hypothetical protein | - |
| G5S48_RS23100 (52759) | 52759..53634 | + | 876 | WP_000239590.1 | extended-spectrum class A beta-lactamase CTX-M-15 | - |
| G5S48_RS23105 (53681) | 53681..53974 | - | 294 | WP_116961751.1 | WbuC family cupin fold metalloprotein | - |
| G5S48_RS23110 (54039) | 54039..56258 | + | 2220 | Protein_71 | Tn3-like element Tn3 family transposase | - |
| G5S48_RS23115 (56335) | 56335..57039 | + | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| G5S48_RS23120 (57093) | 57093..57533 | - | 441 | Protein_73 | CatB-related O-acetyltransferase | - |
| G5S48_RS23125 (57671) | 57671..58501 | - | 831 | WP_001334766.1 | oxacillin-hydrolyzing class D beta-lactamase OXA-1 | - |
| G5S48_RS23130 (58632) | 58632..59186 | - | 555 | WP_063840321.1 | fluoroquinolone-acetylating aminoglycoside 6'-N-acetyltransferase AAC(6')-Ib-cr5 | - |
| G5S48_RS23135 (59330) | 59330..60034 | - | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| G5S48_RS23140 (60106) | 60106..62442 | + | 2337 | Protein_77 | Tn3-like element Tn5403 family transposase | - |
| G5S48_RS23145 (62579) | 62579..62980 | - | 402 | WP_001398199.1 | type II toxin-antitoxin system toxin endoribonuclease PemK | - |
| G5S48_RS23150 (62913) | 62913..63170 | - | 258 | WP_000557619.1 | type II toxin-antitoxin system antitoxin PemI | - |
| G5S48_RS23155 (63263) | 63263..63916 | - | 654 | WP_000616807.1 | CPBP family intramembrane metalloprotease | - |
| G5S48_RS23160 (64856) | 64856..65713 | - | 858 | WP_000130640.1 | incFII family plasmid replication initiator RepA | - |
| G5S48_RS23165 (65706) | 65706..65780 | - | 75 | WP_031943482.1 | RepA leader peptide Tap | - |
| G5S48_RS23175 (66142) | 66142..67683 | + | 1542 | WP_001298859.1 | IS21-like element ISEc12 family transposase | - |
| G5S48_RS23180 (67698) | 67698..68444 | + | 747 | WP_053906593.1 | IS21-like element ISEc12 family helper ATPase IstB | - |
| G5S48_RS23185 (68604) | 68604..68858 | - | 255 | WP_000083850.1 | replication regulatory protein RepA | - |
| G5S48_RS23190 (69155) | 69155..69289 | - | 135 | WP_023144756.1 | Hok/Gef family protein | Toxin Detail |
| - (69334) | 69334..69394 | + | 61 | NuclAT_0 | - | Antitoxin Detail |
| - (69334) | 69334..69394 | + | 61 | NuclAT_0 | - | Antitoxin Detail |
| - (69334) | 69334..69394 | + | 61 | NuclAT_0 | - | Antitoxin Detail |
| - (69334) | 69334..69394 | + | 61 | NuclAT_0 | - | Antitoxin Detail |
| G5S48_RS23195 (69361) | 69361..69647 | - | 287 | Protein_87 | DUF2726 domain-containing protein | - |
| G5S48_RS23200 (70160) | 70160..70372 | - | 213 | WP_013023861.1 | hypothetical protein | - |
| G5S48_RS23205 (70503) | 70503..71063 | - | 561 | WP_000139341.1 | fertility inhibition protein FinO | - |
| G5S48_RS23210 (71118) | 71118..71864 | - | 747 | WP_000205718.1 | conjugal transfer pilus acetylase TraX | - |
| G5S48_RS23215 (71884) | 71884..74277 | - | 2394 | Protein_91 | conjugative transfer relaxase/helicase TraI | - |
| G5S48_RS23220 (74271) | 74271..75329 | - | 1059 | Protein_92 | DUF3560 domain-containing protein | - |
| G5S48_RS23225 (75381) | 75381..75611 | - | 231 | WP_000218642.1 | hypothetical protein | - |
| G5S48_RS24490 (76125) | 76125..76279 | + | 155 | Protein_94 | hypothetical protein | - |
| G5S48_RS23230 (77008) | 77008..78675 | + | 1668 | WP_012372796.1 | group II intron reverse transcriptase/maturase | - |
| G5S48_RS23235 (78989) | 78989..79180 | - | 192 | WP_001027516.1 | hypothetical protein | - |
| G5S48_RS23240 (79177) | 79177..79599 | - | 423 | WP_000271753.1 | DUF1380 family protein | - |
| G5S48_RS23245 (79646) | 79646..80071 | - | 426 | WP_001198928.1 | antirestriction protein | - |
| G5S48_RS23250 (80488) | 80488..81264 | - | 777 | WP_001753849.1 | hypothetical protein | - |
| G5S48_RS23255 (81315) | 81315..81833 | - | 519 | WP_123325260.1 | DUF1380 family protein | - |
| G5S48_RS23260 (81763) | 81763..81984 | - | 222 | WP_001104873.1 | hypothetical protein | - |
| G5S48_RS23265 (81985) | 81985..82668 | - | 684 | WP_000086185.1 | DNA methylase | - |
| G5S48_RS23270 (82745) | 82745..83056 | - | 312 | WP_011254640.1 | hypothetical protein | - |
| G5S48_RS23275 (83053) | 83053..83955 | - | 903 | WP_001348615.1 | DUF1281 domain-containing protein | - |
| G5S48_RS23280 (84822) | 84822..85793 | - | 972 | WP_000817036.1 | ParB/RepB/Spo0J family plasmid partition protein | - |
| G5S48_RS23285 (85793) | 85793..86959 | - | 1167 | WP_000772446.1 | plasmid-partitioning protein SopA | - |
| G5S48_RS23290 (87547) | 87547..88302 | - | 756 | WP_000852146.1 | replication initiation protein RepE | - |
| G5S48_RS23295 (89076) | 89076..89882 | - | 807 | WP_000016982.1 | site-specific integrase | - |
| G5S48_RS23300 (89883) | 89883..90188 | - | 306 | WP_001159868.1 | type II toxin-antitoxin system toxin CcdB | Toxin Detail |
| G5S48_RS23305 (90190) | 90190..90408 | - | 219 | WP_023909027.1 | type II toxin-antitoxin system antitoxin CcdA | - |
| G5S48_RS23310 (91042) | 91042..91239 | + | 198 | WP_000215657.1 | hypothetical protein | - |
| G5S48_RS23315 (91236) | 91236..91520 | - | 285 | WP_000642771.1 | hypothetical protein | - |
| G5S48_RS23320 (91540) | 91540..92673 | - | 1134 | WP_000545983.1 | DUF3800 domain-containing protein | - |
| G5S48_RS23325 (92936) | 92936..96055 | - | 3120 | WP_023909028.1 | hypothetical protein | - |
| G5S48_RS23330 (96362) | 96362..96592 | + | 231 | WP_001261287.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| G5S48_RS23335 (96589) | 96589..97005 | + | 417 | WP_001044768.1 | type II toxin-antitoxin system VapC family toxin | Toxin Detail |
| G5S48_RS23340 (97167) | 97167..99305 | - | 2139 | WP_000350635.1 | AAA family ATPase | - |
| G5S48_RS23345 (99770) | 99770..100765 | + | 996 | WP_000246636.1 | hypothetical protein | - |
| G5S48_RS23350 (100808) | 100808..101701 | + | 894 | WP_001553853.1 | S-4TM family putative pore-forming effector | - |
| G5S48_RS23360 (102749) | 102749..105865 | - | 3117 | WP_031311986.1 | HsdR family type I site-specific deoxyribonuclease | - |
| G5S48_RS23365 (105987) | 105987..107270 | - | 1284 | WP_001617890.1 | restriction endonuclease subunit S | - |
| G5S48_RS23370 (107267) | 107267..108823 | - | 1557 | WP_001553856.1 | type I restriction-modification system subunit M | - |
| G5S48_RS23375 (109006) | 109006..109266 | + | 261 | WP_253207398.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| G5S48_RS23380 (109226) | 109226..109606 | + | 381 | WP_001694510.1 | type II toxin-antitoxin system death-on-curing family toxin | - |
| G5S48_RS23385 (109611) | 109611..109789 | + | 179 | Protein_126 | PdcA protein | - |
| G5S48_RS23390 (109817) | 109817..110095 | + | 279 | Protein_127 | pdcB | - |
| G5S48_RS23395 (110100) | 110100..110539 | + | 440 | Protein_128 | IS3 family transposase | - |
Similar MGE(s)
Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE.
| Detail | Organism | MGE type | Related TA | Genome accession | Coordinates | Mash distance |
|---|