Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negative regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed

Regulator ID	Locus tag (Gene)	Related T6SS	Regulator type	Regulatory pathway	Organism	Replicon (Accession)	Coordinates (Strand)	NCBI ID	Target (Regulation)
REG0037	Y880_05519 (dgcP)	T6SS01211 ; T6SS01212 ; T6SS01213	protein	c-di-GMP regulatory pathway	Pseudomonas aeruginosa PAK	chromosome (NZ_CP020659)	5487251..5489266 (-)	489205065	the levels of c-di-GMP (↓)
REG0038	PSA3335_06200 (dgcP)	T6SS01041	protein	c-di-GMP regulatory pathway	Pseudomonas savastanoi pv. savastanoi NCPPB 3335	chromosome (NZ_CP008742)	1344347..1346692 (+)	488618048	the levels of c-di-GMP (↓)
REG0074	PP_4373 (FleQ)	T6SS00014	protein	c-di-GMP regulatory pathway	Pseudomonas putida KT2440	chromosome (NC_002947)	4963882..4965357 (-)	26991062	K1-T6SS (hcp1) expression (↑)
REG0075	PP_0952 (RopN)	T6SS00014	protein	c-di-GMP regulatory pathway	Pseudomonas putida KT2440	chromosome (NC_002947)	1094567..1096060 (-)	26987688	PP_4373 (FleQ) (↑)
REG0076	PP_0914 (BifA)	T6SS00014	protein	c-di-GMP regulatory pathway	Pseudomonas putida KT2440	chromosome (NC_002947)	1055990..1058071 (-)	26987650	the levels of c-di-GMP (↓)
REG0080	Atu2091	T6SS00016	protein	c-di-GMP regulatory pathway	Agrobacterium fabrum str. C58	chromosome (NC_003063)	2054055..2054864 (-)	159185045	the levels of c-di-GMP (↑)
REG0081	Atu5372	T6SS00016	protein	c-di-GMP regulatory pathway	Agrobacterium fabrum str. C58	chromosome (NC_003064)	363293..364387 (+)	1805892863	the levels of c-di-GMP (↑)
REG0082	Atu1257 (DgcA)	T6SS00016	protein	c-di-GMP regulatory pathway	Agrobacterium fabrum str. C58	chromosome (NC_003062)	1244567..1245814 (-)	159184686	the levels of c-di-GMP (↑)
REG0083	Atu2179 (DgcC)	T6SS00016	protein	c-di-GMP regulatory pathway	Agrobacterium fabrum str. C58	chromosome (NC_003062)	2154605..2155744 (-)	159185090	the levels of c-di-GMP (↑)
REG0107	VP1028 (TfoY)	T6SS00043	protein	c-di-GMP regulatory pathway	Vibrio parahaemolyticus RIMD 2210633	chromosome (NC_004603)	1077946..1078536 (-)	28897802	T6SS1 (VgrG1) expression and secretion (↓)
REG0116	VPA1088 (cdpA)	T6SS00043	protein	c-di-GMP regulatory pathway	Vibrio parahaemolyticus RIMD 2210633	chromosome (NC_004605)	1147728..1150091 (+)	28900943	VP1028 (TfoY) (↑)
REG0117	VPA0739 (vdcA)	T6SS00043	protein	c-di-GMP regulatory pathway	Vibrio parahaemolyticus RIMD 2210633	chromosome (NC_004605)	772439..773809 (+)	28900594	VP1028 (TfoY) (↓)
REG0119	VP1241 (TfoX)	T6SS00044 ; T6SS00043	protein	QS regulatory pathway; c-di-GMP regulatory pathway	Vibrio parahaemolyticus RIMD 2210633	chromosome (NC_004603)	1309223..1309810 (+)	28898016	T6SS2 (↓); T6SS1 (↓)
REG0159	PA14_RS20260/PA1120 (YfiN/TpbB)	T6SS00150	protein	c-di-GMP regulatory pathway	Pseudomonas aeruginosa UCBPP-PA14	chromosome (NC_008463)	4435431..4436738 (-)	489207392	Hcp1 production (↓)
REG0160	PA14_RS15060 (PA2133 phosphodiesterase)	T6SS00150	protein	c-di-GMP regulatory pathway	Pseudomonas aeruginosa UCBPP-PA14	chromosome (NC_008463)	3294000..3294857 (-)	489200657	Hcp1 production (↑)
REG0161	PA14_RS06615 (WspR)	T6SS00150	protein	c-di-GMP regulatory pathway	Pseudomonas aeruginosa UCBPP-PA14	chromosome (NC_008463)	1413158..1414201 (+)	489183089	Hcp1 production (↓)
REG0289	VCA0933 (CspV)	T6SS00002	protein	c-di-GMP regulatory pathway	Vibrio cholerae O1 biovar El Tor str. N16961	chromosome (NC_002506)	886068..886280 (+)	446027150	Unknown (↓)
REG0290	VCA1552_01380 (VdcA/ycdT)	T6SS01112	protein	c-di-GMP regulatory pathway	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	1482426..1483715 (+)	446892247	the levels of c-di-GMP (↑)
REG0291	VCA1552_02536 (CdpA/YfgF)	T6SS01112	protein	c-di-GMP regulatory pathway	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	2739669..2742158 (-)	446417730	the levels of c-di-GMP (↓)
REG0303	VCA1552_00154 (QstR)	T6SS01112	protein	c-di-GMP regulatory pathway; QS regulatory pathway; Global regulator	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	149920..150564 (-)	447111060	TssB/TfoY transcripts (↓); VC0396/VCA1552_00154 (QstR) (↓); T6SS transcripts (↓)
REG0306	VCA1552_01510 (TfoY)	T6SS01112	protein	c-di-GMP regulatory pathway	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	1636980..1637567 (+)	446282733	Unknown (↓)
REG0307	VCA1552_RS06160 (lonA)	T6SS01112	protein	c-di-GMP regulatory pathway	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	1315238..1316887 (+)	446116573	VCA1552_01510 (TfoY) (↑)
REG0308	VCA1552_RS10420 (cdgL)	T6SS01112	protein	c-di-GMP regulatory pathway	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	2215844..2217361 (-)	446975354	the levels of c-di-GMP (↓)
REG0309	VCA1552_RS04310 (cdgK)	T6SS01112	protein	c-di-GMP regulatory pathway	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	901594..903063 (+)	487807420	the levels of c-di-GMP (↓)
REG0310	VCA1552_RS04130 (cdgH)	T6SS01112	protein	c-di-GMP regulatory pathway	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	861187..863208 (+)	446848493	the levels of c-di-GMP (↓)
REG0311	VCA1552_RS02130 (rocS)	T6SS01112	protein	c-di-GMP regulatory pathway	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	425233..427287 (-)	447034155	the levels of c-di-GMP (↑)
REG0312	VCA1552_RS12850 (cdgJ)	T6SS01112	protein	c-di-GMP regulatory pathway	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	2733319..2734545 (-)	446210986	the levels of c-di-GMP (↑)
REG0313	VCA1552_RS17835 (cdgD)	T6SS01112	protein	c-di-GMP regulatory pathway	Vibrio cholerae strain A1552	chromosome (NZ_CP024868)	633312..635195 (+)	446210820	the levels of c-di-GMP (↓)