Regulators of regulatory pathway: TCS-RR

All displayed regulators are experimentally validated.


Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negative regulation.
experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed
Regulator ID Locus tag (Gene) Related T6SS Regulator type Regulatory pathway Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Target (Regulation)
REG0004 experimental RT90_01115 (rcsB) T6SS01264 experimental protein TCS-RR Serratia marcescens strain RM66262 chromosome (JWLO01000001) 235561..236211 (-) 735006328 vgrG promoter (↓)
REG0012 experimental Y880_02189 (gacA/uvrY) T6SS01211 experimental; T6SS01212 experimental; T6SS01213 experimental protein TCS-RR Pseudomonas aeruginosa PAK chromosome (NZ_CP020659) 2199690..2200334 (-) 510933056 hcp expression (↓)
REG0044 experimental PA2586 (gacA) T6SS00003 experimental protein TCS-RR Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 2925788..2926432 (-) 15597782 hcp1 (PA0085) expression and secretion (↓)
REG0046 experimental PA0611 (prtR) T6SS00003 experimental protein TCS-RR Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 673191..673961 (-) 15595808 hcp1 (PA0085) expression and secretion (↑); PA2586 (gacA) (↑)
REG0085 experimental chvI T6SS00016 experimental protein TCS-RR Agrobacterium fabrum str. C58 chromosome (NC_003062) 36525..37250 (-) The intergenic region of the imp and hcp operons (↓)
REG0091 experimental PFL_RS17995 (gacA/uvrY/SirA) T6SS00035 experimental protein TCS-RR Pseudomonas protegens Pf-5 chromosome (NC_004129) 4110513..4111154 (-) 499374263 T6SS transcripts (↓)
REG0101 experimental VP_RS09470 (UvrY) T6SS00043 experimental; T6SS00044 experimental protein TCS-RR Vibrio parahaemolyticus RIMD 2210633 chromosome (NC_004603) 2037468..2038112 (-) 491529158 CsrB (↓)
REG0127 experimental BMAA0746 (VirG) T6SS00070 experimental protein TCS-RR Burkholderia mallei ATCC 23344 chromosome (NC_006349) 764773..765510 (+) 490311617 Hcp1 (BMAA0742) expression (↓)
REG0129 experimental BMAA0746 (VirG) T6SS00070 experimental protein TCS-RR Burkholderia mallei ATCC 23344 chromosome (NC_006349) 764773..765510 (+) 53717366 BMAA0742 (Hcp1) expression (↓); BMAA0729.1 (TssM1) expression (↓)
REG0137 experimental BPSS1495 (virA) T6SS00077 insolico protein TCS-RR; BsaN regulon Burkholderia pseudomallei K96243 chromosome (NC_006351) 2038711..2040555 (-) 499518988 T6SS-1 transpript (↓)
REG0146 experimental BPSS1494 (virG) T6SS00077 insolico protein TCS-RR Burkholderia pseudomallei K96243 chromosome (NC_006351) 2037977..2038714 (-) 53722516 hcp1 expression (↓)
REG0147 experimental FTT1557c/FNU0663.2 (pmrA) T6SS00081 experimental protein TCS-RR Francisella tularensis subsp. tularensis SCHU S4 chromosome (NC_006570) 1618742..1619428 (-) 489108239 T6SS transcription (↓)
REG0176 experimental FTN_1465 (pmrA) T6SS00158 experimental protein TCS-RR; TCS regulatory pathway Francisella tularensis subsp. novicida U112 chromosome (NC_008601) 1553358..1554044 (-) 489108239 FTN_1465 (pmrA) promotor (↓); pdpD promotor (↓); IglA expression (↓)
REG0185 experimental YpsIP31758_3980 (ompR) T6SS00225 experimental protein TCS-RR Yersinia pseudotuberculosis IP 31758 chromosome (NC_009708) 4465260..4465979 (-) 490527984 T6SS-4 promoter (↓)
REG0199 experimental YPK_RS00840 (OmpR) T6SS00260 experimental protein TCS-RR Yersinia pseudotuberculosis YPIII chromosome (NC_010465) 223260..223979 (+) 488137706 T6SS4 promoter (↓)
REG0204 experimental NT01EI_RS04325 (EsrB) T6SS00346 experimental protein TCS-RR Edwardsiella ictaluri 93-146 chromosome (NC_012779) 955101..955745 (-) 506350644 T6SS translocon protein EvpC secretion (↓)
REG0243 experimental ETAE_0886 (EsrB) T6SS00372 experimental protein TCS-RR Edwardsiella tarda EIB202 chromosome (NC_013508) 964658..965302 (-) 502610749 Unknown (↓); Unknown (↓)
REG0253 experimental PAM18_RS12360 (gacA) T6SS00612 insolico; T6SS00613 insolico; T6SS00611 insolico protein TCS-RR Pseudomonas aeruginosa M18 chromosome (NC_017548) 2625815..2626459 (+) 489180874 hsiA1 operon transcript (↓); hsiA2 operon transcript (↓); hsiA3 operon transcript (↓)
REG0273 experimental W817_21870 (CpxR) T6SS00937 experimental protein TCS-RR Escherichia coli RS218 chromosome (NZ_CP007149) 4360812..4361510 (-) 446956464 hcp2B promoter (↓)
REG0288 experimental VCA0566 (VxrB) T6SS00002 experimental protein TCS-RR Vibrio cholerae O1 biovar El Tor str. N16961 chromosome (NC_002506) 504728..505384 (+) 446737785 Unknown (↑)
REG0319 experimental Y113_RS04830 (esrB) T6SS00791 experimental protein TCS-RR Edwardsiella tarda strain PPD130/91 chromosome (NZ_JACQ01000008) 20006..20635 (+) 1940020585 EvpA and EvpC protein concentration (↓)
REG0326 experimental WQ49_19595 (atsR) T6SS01276 experimental protein TCS-RR Burkholderia cenocepacia strain K56-2 chromosome (LAUA01000016) 710895..712715 (+) 815849700 T6SS transcripts (↑); T6SS expression (↑)
REG0330 experimental Pchl3084_4333 (gacS) T6SS01266 insolico; T6SS01267 insolico protein TCS-RR Pseudomonas chlororaphis subsp. aureofaciens 30-84 chromosome (NZ_CM001559) 5113748..5116501 (+) 496335944 Pchl3084_3491 (gacA) (↓)
REG0332 experimental GacS T6SS01269 experimental protein TCS-RR Pseudomonas aeruginosa cystic fibrosis isolate CHA chromosome (-) - - hcp1 expression and secretion (↑)
REG0336 experimental BWP10_01550 (ssrB) T6SS01291 experimental protein TCS-RR Salmonella enterica subsp. enterica serovar Typhimurium strain ATCC 14028 chromosome (MTFW01000001) 296600..299362 (+) 1145677935 sciS/TssM transcription (↑)
REG0338 experimental BN49_RS12735 (phoQ) T6SS01214 experimental protein TCS-RR Klebsiella pneumoniae strain Kp52.145 chromosome (NZ_FO834906) 2324171..2325637 (-) 490249900 TssB transcription (↓)
REG0341 experimental BN49_RS21260 (rcsB) T6SS01214 experimental protein TCS-RR Klebsiella pneumoniae strain Kp52.145 chromosome (NZ_FO834906) 4066268..4066918 (+) 489002368 phoPQ (↑)
REG0351 experimental PSEBR_RS22825 (GacS) T6SS00431 insolico; T6SS00432 insolico protein TCS-RR Pseudomonas brassicacearum subsp. brassicacearum NFM421 chromosome (NC_015379) 5188012..5190762 (+) 503459407 hcp1 transcript (↓); hcp2 transcript (↓)
REG0356 experimental W909_RS11820 (VfmH) T6SS01037 insolico protein TCS-RR Dickeya zeae EC1 chromosome (NZ_CP006929) 2699617..2701098 (+) 515507611 T6SS transcripts (↓)
REG0358 experimental PPECC33_RS11185 (BaeR) T6SS01034 experimental protein TCS-RR Escherichia coli PCN033 chromosome (NZ_CP006632) 2272864..2273586 (+) 446060022 T6SS promotor (↓)
REG0362 experimental PPECC33_RS11945 (rcsB) T6SS01034 experimental protein TCS-RR Escherichia coli PCN033 chromosome (NZ_CP006632) 2429320..2429970 (+) 446984661 T6SS transcription (↓)
REG0369 experimental VCV52_RS14135 (wigR/phoB/vxrB) T6SS00790 experimental protein TCS-RR Vibrio cholerae V52 chromosome (NZ_KQ410503) 201806..202495 (-) 446013262 T6SS transcription level (↓)

Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negative regulation.
experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed
Regulator ID Locus tag (Gene) Related T6SS Regulator type Regulatory pathway Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Target (Regulation)
REG0004 experimental RT90_01115 (rcsB) T6SS01264 experimental protein TCS-RR Serratia marcescens strain RM66262 chromosome (JWLO01000001) 235561..236211 (-) 735006328 vgrG promoter (↓)
REG0012 experimental Y880_02189 (gacA/uvrY) T6SS01211 experimental; T6SS01212 experimental; T6SS01213 experimental protein TCS-RR Pseudomonas aeruginosa PAK chromosome (NZ_CP020659) 2199690..2200334 (-) 510933056 hcp expression (↓)
REG0044 experimental PA2586 (gacA) T6SS00003 experimental protein TCS-RR Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 2925788..2926432 (-) 15597782 hcp1 (PA0085) expression and secretion (↓)
REG0046 experimental PA0611 (prtR) T6SS00003 experimental protein TCS-RR Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 673191..673961 (-) 15595808 hcp1 (PA0085) expression and secretion (↑); PA2586 (gacA) (↑)
REG0085 experimental chvI T6SS00016 experimental protein TCS-RR Agrobacterium fabrum str. C58 chromosome (NC_003062) 36525..37250 (-) The intergenic region of the imp and hcp operons (↓)
REG0091 experimental PFL_RS17995 (gacA/uvrY/SirA) T6SS00035 experimental protein TCS-RR Pseudomonas protegens Pf-5 chromosome (NC_004129) 4110513..4111154 (-) 499374263 T6SS transcripts (↓)
REG0101 experimental VP_RS09470 (UvrY) T6SS00043 experimental; T6SS00044 experimental protein TCS-RR Vibrio parahaemolyticus RIMD 2210633 chromosome (NC_004603) 2037468..2038112 (-) 491529158 CsrB (↓)
REG0127 experimental BMAA0746 (VirG) T6SS00070 experimental protein TCS-RR Burkholderia mallei ATCC 23344 chromosome (NC_006349) 764773..765510 (+) 490311617 Hcp1 (BMAA0742) expression (↓)
REG0129 experimental BMAA0746 (VirG) T6SS00070 experimental protein TCS-RR Burkholderia mallei ATCC 23344 chromosome (NC_006349) 764773..765510 (+) 53717366 BMAA0742 (Hcp1) expression (↓); BMAA0729.1 (TssM1) expression (↓)
REG0137 experimental BPSS1495 (virA) T6SS00077 insolico protein TCS-RR; BsaN regulon Burkholderia pseudomallei K96243 chromosome (NC_006351) 2038711..2040555 (-) 499518988 T6SS-1 transpript (↓)
REG0146 experimental BPSS1494 (virG) T6SS00077 insolico protein TCS-RR Burkholderia pseudomallei K96243 chromosome (NC_006351) 2037977..2038714 (-) 53722516 hcp1 expression (↓)
REG0147 experimental FTT1557c/FNU0663.2 (pmrA) T6SS00081 experimental protein TCS-RR Francisella tularensis subsp. tularensis SCHU S4 chromosome (NC_006570) 1618742..1619428 (-) 489108239 T6SS transcription (↓)
REG0176 experimental FTN_1465 (pmrA) T6SS00158 experimental protein TCS-RR; TCS regulatory pathway Francisella tularensis subsp. novicida U112 chromosome (NC_008601) 1553358..1554044 (-) 489108239 FTN_1465 (pmrA) promotor (↓); pdpD promotor (↓); IglA expression (↓)
REG0185 experimental YpsIP31758_3980 (ompR) T6SS00225 experimental protein TCS-RR Yersinia pseudotuberculosis IP 31758 chromosome (NC_009708) 4465260..4465979 (-) 490527984 T6SS-4 promoter (↓)
REG0199 experimental YPK_RS00840 (OmpR) T6SS00260 experimental protein TCS-RR Yersinia pseudotuberculosis YPIII chromosome (NC_010465) 223260..223979 (+) 488137706 T6SS4 promoter (↓)
REG0204 experimental NT01EI_RS04325 (EsrB) T6SS00346 experimental protein TCS-RR Edwardsiella ictaluri 93-146 chromosome (NC_012779) 955101..955745 (-) 506350644 T6SS translocon protein EvpC secretion (↓)
REG0243 experimental ETAE_0886 (EsrB) T6SS00372 experimental protein TCS-RR Edwardsiella tarda EIB202 chromosome (NC_013508) 964658..965302 (-) 502610749 Unknown (↓); Unknown (↓)
REG0253 experimental PAM18_RS12360 (gacA) T6SS00612 insolico; T6SS00613 insolico; T6SS00611 insolico protein TCS-RR Pseudomonas aeruginosa M18 chromosome (NC_017548) 2625815..2626459 (+) 489180874 hsiA1 operon transcript (↓); hsiA2 operon transcript (↓); hsiA3 operon transcript (↓)
REG0273 experimental W817_21870 (CpxR) T6SS00937 experimental protein TCS-RR Escherichia coli RS218 chromosome (NZ_CP007149) 4360812..4361510 (-) 446956464 hcp2B promoter (↓)
REG0288 experimental VCA0566 (VxrB) T6SS00002 experimental protein TCS-RR Vibrio cholerae O1 biovar El Tor str. N16961 chromosome (NC_002506) 504728..505384 (+) 446737785 Unknown (↑)
REG0319 experimental Y113_RS04830 (esrB) T6SS00791 experimental protein TCS-RR Edwardsiella tarda strain PPD130/91 chromosome (NZ_JACQ01000008) 20006..20635 (+) 1940020585 EvpA and EvpC protein concentration (↓)
REG0326 experimental WQ49_19595 (atsR) T6SS01276 experimental protein TCS-RR Burkholderia cenocepacia strain K56-2 chromosome (LAUA01000016) 710895..712715 (+) 815849700 T6SS transcripts (↑); T6SS expression (↑)
REG0330 experimental Pchl3084_4333 (gacS) T6SS01266 insolico; T6SS01267 insolico protein TCS-RR Pseudomonas chlororaphis subsp. aureofaciens 30-84 chromosome (NZ_CM001559) 5113748..5116501 (+) 496335944 Pchl3084_3491 (gacA) (↓)
REG0332 experimental GacS T6SS01269 experimental protein TCS-RR Pseudomonas aeruginosa cystic fibrosis isolate CHA chromosome (-) - - hcp1 expression and secretion (↑)
REG0336 experimental BWP10_01550 (ssrB) T6SS01291 experimental protein TCS-RR Salmonella enterica subsp. enterica serovar Typhimurium strain ATCC 14028 chromosome (MTFW01000001) 296600..299362 (+) 1145677935 sciS/TssM transcription (↑)
REG0338 experimental BN49_RS12735 (phoQ) T6SS01214 experimental protein TCS-RR Klebsiella pneumoniae strain Kp52.145 chromosome (NZ_FO834906) 2324171..2325637 (-) 490249900 TssB transcription (↓)
REG0341 experimental BN49_RS21260 (rcsB) T6SS01214 experimental protein TCS-RR Klebsiella pneumoniae strain Kp52.145 chromosome (NZ_FO834906) 4066268..4066918 (+) 489002368 phoPQ (↑)
REG0351 experimental PSEBR_RS22825 (GacS) T6SS00431 insolico; T6SS00432 insolico protein TCS-RR Pseudomonas brassicacearum subsp. brassicacearum NFM421 chromosome (NC_015379) 5188012..5190762 (+) 503459407 hcp1 transcript (↓); hcp2 transcript (↓)
REG0356 experimental W909_RS11820 (VfmH) T6SS01037 insolico protein TCS-RR Dickeya zeae EC1 chromosome (NZ_CP006929) 2699617..2701098 (+) 515507611 T6SS transcripts (↓)
REG0358 experimental PPECC33_RS11185 (BaeR) T6SS01034 experimental protein TCS-RR Escherichia coli PCN033 chromosome (NZ_CP006632) 2272864..2273586 (+) 446060022 T6SS promotor (↓)
REG0362 experimental PPECC33_RS11945 (rcsB) T6SS01034 experimental protein TCS-RR Escherichia coli PCN033 chromosome (NZ_CP006632) 2429320..2429970 (+) 446984661 T6SS transcription (↓)
REG0369 experimental VCV52_RS14135 (wigR/phoB/vxrB) T6SS00790 experimental protein TCS-RR Vibrio cholerae V52 chromosome (NZ_KQ410503) 201806..202495 (-) 446013262 T6SS transcription level (↓)

Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negative regulation.
experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed
Regulator ID Locus tag (Gene) Related T6SS Regulator type Regulatory pathway Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Target (Regulation)