Regulators of regulatory pathway: QS regulatory pathway

All displayed regulators are experimentally validated.


Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negative regulation.
experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed
Regulator ID Locus tag (Gene) Related T6SS Regulator type Regulatory pathway Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Target (Regulation)
REG0019 experimental PC1_3721 (Hfq) T6SS01001 insolico protein QS regulatory pathway Pectobacterium carotovorum subsp. carotovorum PC1 chromosome (CP001657) 4199890..4200189 (-) 251756660 hcp expression (↓)
REG0022 experimental GPY04_RS03590 (TfoX) T6SS01168 experimental protein QS regulatory pathway Vibrio cholerae C6706 chromosome (NZ_CP046844) 777344..777952 (+) 487807468 Unknown (↓)
REG0023 experimental GPY04_RS00870 (HapR) T6SS01168 experimental protein QS regulatory pathway Vibrio cholerae C6706 chromosome (NZ_CP046844) 164935..165546 (-) 446262243 Unknown (↓)
REG0025 experimental Qrr1 quorum regulatory RNA T6SS01168 experimental ncRNA QS regulatory pathway Vibrio cholerae C6706 chromosome (NZ_CP046844) - - VCA0107 mRNA (↑)
REG0026 experimental Qrr2 quorum regulatory RNA T6SS01168 experimental ncRNA QS regulatory pathway Vibrio cholerae C6706 chromosome (NZ_CP046844) - - VCA0107 mRNA (↑)
REG0027 experimental Qrr3 quorum regulatory RNA T6SS01168 experimental ncRNA QS regulatory pathway Vibrio cholerae C6706 chromosome (NZ_CP046844) - - VCA0107 mRNA (↑)
REG0028 experimental Qrr4 quorum regulatory RNA T6SS01168 experimental ncRNA QS regulatory pathway Vibrio cholerae C6706 chromosome (NZ_CP046844) - - VCA0107 mRNA (↑)
REG0029 experimental GPY04_RS15835 (luxO) T6SS01168 experimental protein QS regulatory pathway Vibrio cholerae C6706 chromosome (NZ_CP046845) 273631..274983 (-) 446367907 VC0070 (tsrA) (↑); GPY04_RS00870 (hapR) (↑)
REG0059 experimental PA4704.1 (prrF1) T6SS00003 experimental; T6SS00004 experimental ncRNA QS regulatory pathway Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 5283960..5284110 (+) 4179187 T6SS transcripts (↓)
REG0060 experimental PA4704.2 (prrF2) T6SS00003 experimental; T6SS00004 experimental ncRNA QS regulatory pathway Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 5284172..5284319 (+) 4179185 T6SS transcripts (↓)
REG0062 experimental PA1244 (QslA) T6SS00004 experimental protein QS regulatory pathway Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 1348060..1348401 (-) 15596441 H2-T6SS (PA1656) promotor (↑)
REG0065 experimental PA1430 (LasR) T6SS00004 experimental protein Global regulator; QS regulatory pathway Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 1558171..1558890 (+) 15596627 H2-T6SS promotor P (hsiA2) (↓)
REG0066 experimental PA3476 (rhlI) T6SS00004 experimental protein QS regulatory pathway Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 3889139..3889744 (-) 15598672 PA3477 (RhlR) (↓)
REG0067 experimental PA3477 (RhlR) T6SS00004 experimental protein QS regulatory pathway Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 3889925..3890650 (-) 15598673 T6SS transcript (↓)
REG0070 experimental pa1663 (sfa2) T6SS00004 experimental; T6SS00005 experimental protein Global regulator; QS regulatory pathway Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 1813395..1814906 (+) 15596860 PA4462 (rpoN) (↑); T6SS transcript (↑); T6SS transcript (↓)
REG0093 experimental ECA_RS00520 (expI) T6SS00040 experimental protein QS regulatory pathway Pectobacterium atrosepticum SCRI1043 chromosome (NC_004547) 125689..126339 (+) 499404281 T6SS transcripts (ECA4275[hcp1], ECA3428[hcp2] and ECA2866[hcp3]) (↓)
REG0111 experimental VP2762 (AphA) T6SS00043 experimental; T6SS00044 experimental protein QS regulatory pathway Vibrio parahaemolyticus RIMD 2210633 chromosome (NC_004603) 2929909..2930448 (+) 28899536 T6SS1 transcript (↑); T6SS2 (VPA1027-1024, VPA1043-1028,VPA1044-1046) transcripts (↑)
REG0112 experimental VP2516 (opaR) T6SS00043 experimental; T6SS00044 experimental protein QS regulatory pathway Vibrio parahaemolyticus RIMD 2210633 chromosome (NC_004603) 2653215..2653829 (+) 28899290 vp1407 (↑); VP1388 promotor (↑); VP1400 promotor (↑); VP1409 promotor (↑); T6SS2 (Hcp2) expression and secretion (↓); VPA1027-1024 transcript (↓); VPA1027-1024 transcript (↓); VPA1027-1024 transcript (↓); VPA1043-1028 transcript (↓); VPA1044-1046 transcript (↓)
REG0119 experimental VP1241 (TfoX) T6SS00044 experimental; T6SS00043 experimental protein QS regulatory pathway; c-di-GMP regulatory pathway Vibrio parahaemolyticus RIMD 2210633 chromosome (NC_004603) 1309223..1309810 (+) 28898016 T6SS2 (↓); T6SS1 (↓)
REG0120 experimental CV_RS20220 (CviR) T6SS00049 insolico protein QS regulatory pathway Chromobacterium violaceum ATCC 12472 chromosome (NC_005085) 4426186..4427046 (+) 1169634970 CV_RS06990 (VgrG) promotor (↓)
REG0121 experimental CV_RS23145 (CviI) T6SS00049 insolico protein QS regulatory pathway Chromobacterium violaceum ATCC 12472 chromosome (NC_005085) 4426967..4427620 (-) 499450174 CV_RS20220 (CviR) (↓)
REG0122 experimental VF2177 (LitR) T6SS00084 experimental protein QS regulatory pathway Aliivibrio fischeri ES114 chromosome (NC_006840) 2446537..2447142 (+) 59712784 Unknown (↓)
REG0151 experimental Psyr_4339 (ladS) T6SS00086 experimental protein QS regulatory pathway Pseudomonas syringae pv. syringae B728a chromosome (NC_007005) 5191591..5193585 (-) 639463044 T6SS transcription (↓)
REG0152 experimental Psyr_4408 (retS) T6SS00086 experimental protein QS regulatory pathway Pseudomonas syringae pv. syringae B728a chromosome (NC_007005) 5270882..5273671 (+) 489494774 T6SS transcription (↑)
REG0155 experimental BTH_II1510 (BtaR1) T6SS00115 experimental protein QS regulatory pathway Burkholderia thailandensis E264 chromosome (NC_007650) 1779070..1779789 (-) 497583165 BTH_I2691/BTH_I2693-99/BTH_I2701-702 (↓)
REG0164 experimental PA14_RS05020 (LadS) T6SS00150 experimental protein QS regulatory pathway Pseudomonas aeruginosa UCBPP-PA14 chromosome (NC_008463) 1069280..1071716 (+) 15599169 Unknown
REG0165 experimental PA14_64230 (RetS) T6SS00150 experimental protein QS regulatory pathway Pseudomonas aeruginosa UCBPP-PA14 chromosome (NC_008463) 5722815..5725643 (+) 489202068 Unknown
REG0166 experimental PA14_45960 (lasR) T6SS00152 experimental; T6SS00151 experimental; T6SS00150 experimental protein QS regulatory pathway Pseudomonas aeruginosa UCBPP-PA14 chromosome (NC_008463) 4085339..4086058 (-) 489173455 TssA2 (PA14_43050) promotor (↓); HSI-III transcripts (↓); HSI-I transcripts (↑)
REG0167 experimental PA14_51340 (MvfR) T6SS00152 experimental; T6SS00151 experimental; T6SS00150 experimental protein QS regulatory pathway Pseudomonas aeruginosa UCBPP-PA14 chromosome (NC_008463) 4562837..4563835 (+) 489176730 Upstream of pqs operon (↓); HSI-III transcripts (↓); HSI-I transcripts (↑)
REG0168 experimental PA14_51380 (pqsE) T6SS00150 experimental; T6SS00152 experimental protein QS regulatory pathway Pseudomonas aeruginosa UCBPP-PA14 chromosome (NC_008463) 4566077..4566982 (-) 489176725 T6SS Transciption (↓)
REG0172 experimental PA14_48150 (QslA) T6SS00152 experimental protein QS regulatory pathway Pseudomonas aeruginosa UCBPP-PA14 chromosome (NC_008463) 4286222..4286536 (+) 489177206 H2-T6SS (PA14_43050) promotor (↑)
REG0195 experimental YPK_RS08345 (YpsR) T6SS00256 insolico protein QS regulatory pathway Yersinia pseudotuberculosis YPIII chromosome (NC_010465) 1837676..1838413 (+) 488140651 T6SS transcripts (↓)
REG0196 experimental YPK_RS03965 (YtbR) T6SS00256 insolico protein QS regulatory pathway Yersinia pseudotuberculosis YPIII chromosome (NC_010465) 900476..901219 (+) 488140447 T6SS transcripts (↓)
REG0197 experimental YPK_RS08350 (ypsI) T6SS00256 insolico protein QS regulatory pathway Yersinia pseudotuberculosis YPIII chromosome (NC_010465) 1838406..1839050 (-) 501053391 T6SS transcripts (↓)
REG0198 experimental YPK_RS03970 (ytbI) T6SS00256 insolico; T6SS00260 experimental protein QS regulatory pathway Yersinia pseudotuberculosis YPIII chromosome (NC_010465) 901200..901850 (-) 488144695 T6SS transcripts (↓); T6SS4 transcripts and hcp secretion (↓)
REG0246 experimental ETAE_3474 (fabR) T6SS00372 experimental protein QS regulatory pathway Edwardsiella tarda EIB202 chromosome (NC_013508) 3666488..3667159 (-) 502613311 Unknown (↓)
REG0255 experimental HMPREF1171_RS20340 T6SS00788 experimental protein QS regulatory pathway Aeromonas dhakensis strain SSU chromosome (NZ_JH815591) 4528194..4528817 (-) WP_005308454.1 ahyR (↓)
REG0256 experimental HMPREF1171_RS20345 T6SS00788 experimental protein QS regulatory pathway Aeromonas dhakensis strain SSU chromosome (NZ_JH815591) 4528880..4529662 (+) WP_005308457.1 hcp and vgrG2 expression (↓)
REG0260 experimental EPGS_00471 (VtsR) T6SS00794 experimental protein QS regulatory pathway Vibrio alginolyticus strain EPJS chromosome (FJ790777) - - LuxO (↓)
REG0261 experimental EPGS_00471 (VtsR) T6SS00793 experimental protein QS regulatory pathway Vibrio alginolyticus strain EPJS chromosome (FJ790776) - - LuxO (↑)
REG0262 experimental luxR T6SS00794 experimental protein QS regulatory pathway Vibrio alginolyticus strain EPJS chromosome (FJ790777) - - T6SS2 transcript and expression (↓)
REG0263 experimental luxR T6SS00793 experimental protein QS regulatory pathway Vibrio alginolyticus strain EPJS chromosome (FJ790776) - - T6SS1 transcript and expression (↑)
REG0264 experimental VEPGS_0621 (pppA) T6SS00793 experimental protein Tpp; QS regulatory pathway Vibrio alginolyticus strain EPJS chromosome (FJ790777) 23577..24245 (+) 225382187 Unknown (↑); T6SS1 transcript (↑); hcp1 transcript (↓)
REG0265 experimental luxS T6SS00793 experimental protein QS regulatory pathway Vibrio alginolyticus strain EPJS chromosome (FJ790776) - - hcp1 transcript (↓)
REG0266 experimental LuxO T6SS00793 experimental protein QS regulatory pathway Vibrio alginolyticus strain EPJS chromosome (FJ790776) - - hcp1 transcript (↓)
REG0267 experimental LuxO T6SS00794 experimental protein QS regulatory pathway Vibrio alginolyticus strain EPJS chromosome (FJ790777) - - Unknown (↑)
REG0275 experimental V12G01_21538 (LuxR) T6SS00939 experimental protein QS regulatory pathway Vibrio alginolyticus 12G01 chromosome (AAPS01000053) 13551..14165 (-) 91187814 T6SS2 transcripts (↓); V12G01-18672 (vqsA) promotor
REG0279 experimental V12G01_18672 (vqsA) T6SS00939 experimental protein QS regulatory pathway Vibrio alginolyticus 12G01 chromosome (AAPS01000003) 114208..115086 (+) 91191289 V12G01-21538 (luxR) promoter (↓); V12G01-14830 (aphA) promoter (↓); V12G01-18672 (vqsA) promotor (↓)
REG0280 experimental V12G01_10813 (AsnC) T6SS00939 experimental protein QS regulatory pathway Vibrio alginolyticus 12G01 chromosome (AAPS01000004) 181050..181484 (-) 91191052 V12G01-21538 (luxR) promoter; V12G01-14830 (aphA) promoter
REG0281 experimental V12G01_02325 (HP) T6SS00939 experimental protein QS regulatory pathway Vibrio alginolyticus 12G01 chromosome (AAPS01000004) 115263..116411 (+) 91190993 V12G01-21538 (luxR) promoter; V12G01-14830 (aphA) promoter
REG0282 experimental V12G01_01665 (HP) T6SS00939 experimental protein QS regulatory pathway Vibrio alginolyticus 12G01 chromosome (AAPS01000007) 185299..185712 (+) 91190406 V12G01-21538 (luxR) promoter; V12G01-14830 (aphA) promoter
REG0283 experimental V12G01_06711 (HP) T6SS00939 experimental protein QS regulatory pathway Vibrio alginolyticus 12G01 chromosome (AAPS01000024) 47707..48585 (-) 91188835 V12G01-21538 (luxR) promoter; V12G01-14830 (aphA) promoter
REG0284 experimental V12G01_16177 (MetR) T6SS00939 experimental protein QS regulatory pathway Vibrio alginolyticus 12G01 chromosome (AAPS01000023) 58420..59331 (-) 91188901 V12G01-21538 (luxR) promoter; V12G01-14830 (aphA) promoter
REG0285 experimental V12G01_02620 (SoxR) T6SS00939 experimental protein QS regulatory pathway Vibrio alginolyticus 12G01 chromosome (AAPS01000004) 181050..181484 (-) 91191052 V12G01-21538 (luxR) promoter; V12G01-14830 (aphA) promoter
REG0287 experimental V12G01_14830 (aphA) T6SS00939 experimental protein QS regulatory pathway Vibrio alginolyticus 12G01 chromosome (AAPS01000027) 42305..42880 (+) 91188695 V12G01-18672 (vqsA) promotor
REG0296 experimental VCA1552_RS03895 (LuxO) T6SS01112 experimental protein QS regulatory pathway Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 818142..819509 (+) 487814784 Hcp expression and secretion (↑)
REG0297 experimental VCA1552_RS17020 (cqsa) T6SS01112 experimental protein QS regulatory pathway Vibrio cholerae strain A1552 chromosome (NZ_CP024868) 455238..456407 (-) 446962656 Hcp expression and secretion (↓)
REG0298 experimental VCA1552_RS01665 (LuxS) T6SS01112 experimental protein QS regulatory pathway Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 319588..320106 (+) 447052971 Hcp expression and secretion (↓)
REG0299 experimental VCA1552_RS00505 (hfq) T6SS01112 experimental protein QS regulatory pathway Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 92673..92936 (+) 446974616 VCA1552_00351 (HapR) (↑)
REG0301 experimental VCA1552_RS12025 (crp) T6SS01112 experimental protein QS regulatory pathway Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 2558371..2559003 (+) 446164894 Hcp expression and secretion (↓)
REG0302 experimental VCA1552_RS12925 (cya) T6SS01112 experimental protein QS regulatory pathway; cAMP regulatory pathway Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 2747346..2749877 (-) 447072406 VCA1552_RS12025 (crp) (↓)
REG0303 experimental VCA1552_00154 (QstR) T6SS01112 experimental protein c-di-GMP regulatory pathway; QS regulatory pathway; Global regulator Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 149920..150564 (-) 447111060 TssB/TfoY transcripts (↓); VC0396/VCA1552_00154 (QstR) (↓); T6SS transcripts (↓)
REG0321 experimental GT391_RS06470 (expR1) T6SS01170 experimental protein QS regulatory pathway Pectobacterium brasiliense strain 1692 chromosome (NZ_CP047495) 1453704..1455596 (+) 746272689 T6SS transcripts (↓)
REG0322 experimental GT391_RS06405 (expI) T6SS01170 experimental protein QS regulatory pathway Pectobacterium brasiliense strain 1692 chromosome (NZ_CP047495) 1436931..1437581 (-) 497970044 GT391_RS06470 (expR1) (↓)
REG0324 experimental WQ49_05050 (cepR) T6SS01276 experimental protein QS regulatory pathway Burkholderia cenocepacia strain K56-2 chromosome (LAUA01000002) 545988..546707 (-) 815852483 T6SS promotor (P (BCAL0340) ) (↓)
REG0325 experimental WQ49_20245 (cciR) T6SS01276 experimental protein QS regulatory pathway Burkholderia cenocepacia strain K56-2 chromosome (LAUA01000016) 843677..844378 (+) 815850423 Unknown (↑)
REG0327 experimental WQ49_05060 (cepI) T6SS01276 experimental protein QS regulatory pathway Burkholderia cenocepacia strain K56-2 chromosome (LAUA01000002) 547435..548043 (+) 815852485 T6SS expression (↓)
REG0328 experimental WQ49_20250 (cciI) T6SS01276 experimental protein QS regulatory pathway Burkholderia cenocepacia strain K56-2 chromosome (LAUA01000016) 844665..845255 (+) 815850424 T6SS expression (↓)
REG0344 experimental BN49_RS26620 (hfq) T6SS01214 experimental protein QS regulatory pathway Klebsiella pneumoniae strain Kp52.145 chromosome (NZ_FO834906) 5173711..5174019 (-) 488974767 TssB transcription (↓)
REG0353 experimental AHA_1842 (VasH) T6SS00157 experimental protein QS regulatory pathway Aeromonas hydrophila subsp. hydrophila ATCC 7966 chromosome (NC_008570) 2010521..2012059 (+) 117617496 T6SS gene cluster promoter (PAHA1826) (↓)
REG0355 experimental N779_15250 (VtpR) T6SS01280 experimental; T6SS01281 experimental protein QS regulatory pathway Vibrio coralliilyticus OCN008 chromosome (AVOO01000045) 7579..8184 (-) 536747482 Unknown (↓)
REG0367 experimental H78_RS02920 (Hfq) - protein QS regulatory pathway Pseudomonas protegens strain H78 chromosome (NZ_CP013184) 662937..663197 (+) 495196588 T6SS transcription level (↓)
REG0373 experimental hapR T6SS01028 experimental; T6SS01029 experimental protein QS regulatory pathway Vibrio fluvialis strain 85003 chromosome (-) - - vgrG (↓)
REG0374 experimental ihfA T6SS01028 experimental; T6SS01029 experimental protein QS regulatory pathway Vibrio fluvialis strain 85003 chromosome (-) - - vgrG (↓)
REG0375 experimental ihfB T6SS01028 experimental; T6SS01029 experimental protein QS regulatory pathway Vibrio fluvialis strain 85003 chromosome (-) - - vgrG (↓)

Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negative regulation.
experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed
Regulator ID Locus tag (Gene) Related T6SS Regulator type Regulatory pathway Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Target (Regulation)
REG0019 experimental PC1_3721 (Hfq) T6SS01001 insolico protein QS regulatory pathway Pectobacterium carotovorum subsp. carotovorum PC1 chromosome (CP001657) 4199890..4200189 (-) 251756660 hcp expression (↓)
REG0022 experimental GPY04_RS03590 (TfoX) T6SS01168 experimental protein QS regulatory pathway Vibrio cholerae C6706 chromosome (NZ_CP046844) 777344..777952 (+) 487807468 Unknown (↓)
REG0023 experimental GPY04_RS00870 (HapR) T6SS01168 experimental protein QS regulatory pathway Vibrio cholerae C6706 chromosome (NZ_CP046844) 164935..165546 (-) 446262243 Unknown (↓)
REG0029 experimental GPY04_RS15835 (luxO) T6SS01168 experimental protein QS regulatory pathway Vibrio cholerae C6706 chromosome (NZ_CP046845) 273631..274983 (-) 446367907 VC0070 (tsrA) (↑); GPY04_RS00870 (hapR) (↑)
REG0062 experimental PA1244 (QslA) T6SS00004 experimental protein QS regulatory pathway Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 1348060..1348401 (-) 15596441 H2-T6SS (PA1656) promotor (↑)
REG0065 experimental PA1430 (LasR) T6SS00004 experimental protein Global regulator; QS regulatory pathway Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 1558171..1558890 (+) 15596627 H2-T6SS promotor P (hsiA2) (↓)
REG0066 experimental PA3476 (rhlI) T6SS00004 experimental protein QS regulatory pathway Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 3889139..3889744 (-) 15598672 PA3477 (RhlR) (↓)
REG0067 experimental PA3477 (RhlR) T6SS00004 experimental protein QS regulatory pathway Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 3889925..3890650 (-) 15598673 T6SS transcript (↓)
REG0070 experimental pa1663 (sfa2) T6SS00004 experimental; T6SS00005 experimental protein Global regulator; QS regulatory pathway Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 1813395..1814906 (+) 15596860 PA4462 (rpoN) (↑); T6SS transcript (↑); T6SS transcript (↓)
REG0093 experimental ECA_RS00520 (expI) T6SS00040 experimental protein QS regulatory pathway Pectobacterium atrosepticum SCRI1043 chromosome (NC_004547) 125689..126339 (+) 499404281 T6SS transcripts (ECA4275[hcp1], ECA3428[hcp2] and ECA2866[hcp3]) (↓)
REG0111 experimental VP2762 (AphA) T6SS00043 experimental; T6SS00044 experimental protein QS regulatory pathway Vibrio parahaemolyticus RIMD 2210633 chromosome (NC_004603) 2929909..2930448 (+) 28899536 T6SS1 transcript (↑); T6SS2 (VPA1027-1024, VPA1043-1028,VPA1044-1046) transcripts (↑)
REG0112 experimental VP2516 (opaR) T6SS00043 experimental; T6SS00044 experimental protein QS regulatory pathway Vibrio parahaemolyticus RIMD 2210633 chromosome (NC_004603) 2653215..2653829 (+) 28899290 vp1407 (↑); VP1388 promotor (↑); VP1400 promotor (↑); VP1409 promotor (↑); T6SS2 (Hcp2) expression and secretion (↓); VPA1027-1024 transcript (↓); VPA1027-1024 transcript (↓); VPA1027-1024 transcript (↓); VPA1043-1028 transcript (↓); VPA1044-1046 transcript (↓)
REG0119 experimental VP1241 (TfoX) T6SS00044 experimental; T6SS00043 experimental protein QS regulatory pathway; c-di-GMP regulatory pathway Vibrio parahaemolyticus RIMD 2210633 chromosome (NC_004603) 1309223..1309810 (+) 28898016 T6SS2 (↓); T6SS1 (↓)
REG0120 experimental CV_RS20220 (CviR) T6SS00049 insolico protein QS regulatory pathway Chromobacterium violaceum ATCC 12472 chromosome (NC_005085) 4426186..4427046 (+) 1169634970 CV_RS06990 (VgrG) promotor (↓)
REG0121 experimental CV_RS23145 (CviI) T6SS00049 insolico protein QS regulatory pathway Chromobacterium violaceum ATCC 12472 chromosome (NC_005085) 4426967..4427620 (-) 499450174 CV_RS20220 (CviR) (↓)
REG0122 experimental VF2177 (LitR) T6SS00084 experimental protein QS regulatory pathway Aliivibrio fischeri ES114 chromosome (NC_006840) 2446537..2447142 (+) 59712784 Unknown (↓)
REG0151 experimental Psyr_4339 (ladS) T6SS00086 experimental protein QS regulatory pathway Pseudomonas syringae pv. syringae B728a chromosome (NC_007005) 5191591..5193585 (-) 639463044 T6SS transcription (↓)
REG0152 experimental Psyr_4408 (retS) T6SS00086 experimental protein QS regulatory pathway Pseudomonas syringae pv. syringae B728a chromosome (NC_007005) 5270882..5273671 (+) 489494774 T6SS transcription (↑)
REG0155 experimental BTH_II1510 (BtaR1) T6SS00115 experimental protein QS regulatory pathway Burkholderia thailandensis E264 chromosome (NC_007650) 1779070..1779789 (-) 497583165 BTH_I2691/BTH_I2693-99/BTH_I2701-702 (↓)
REG0164 experimental PA14_RS05020 (LadS) T6SS00150 experimental protein QS regulatory pathway Pseudomonas aeruginosa UCBPP-PA14 chromosome (NC_008463) 1069280..1071716 (+) 15599169 Unknown
REG0165 experimental PA14_64230 (RetS) T6SS00150 experimental protein QS regulatory pathway Pseudomonas aeruginosa UCBPP-PA14 chromosome (NC_008463) 5722815..5725643 (+) 489202068 Unknown
REG0166 experimental PA14_45960 (lasR) T6SS00152 experimental; T6SS00151 experimental; T6SS00150 experimental protein QS regulatory pathway Pseudomonas aeruginosa UCBPP-PA14 chromosome (NC_008463) 4085339..4086058 (-) 489173455 TssA2 (PA14_43050) promotor (↓); HSI-III transcripts (↓); HSI-I transcripts (↑)
REG0167 experimental PA14_51340 (MvfR) T6SS00152 experimental; T6SS00151 experimental; T6SS00150 experimental protein QS regulatory pathway Pseudomonas aeruginosa UCBPP-PA14 chromosome (NC_008463) 4562837..4563835 (+) 489176730 Upstream of pqs operon (↓); HSI-III transcripts (↓); HSI-I transcripts (↑)
REG0168 experimental PA14_51380 (pqsE) T6SS00150 experimental; T6SS00152 experimental protein QS regulatory pathway Pseudomonas aeruginosa UCBPP-PA14 chromosome (NC_008463) 4566077..4566982 (-) 489176725 T6SS Transciption (↓)
REG0172 experimental PA14_48150 (QslA) T6SS00152 experimental protein QS regulatory pathway Pseudomonas aeruginosa UCBPP-PA14 chromosome (NC_008463) 4286222..4286536 (+) 489177206 H2-T6SS (PA14_43050) promotor (↑)
REG0195 experimental YPK_RS08345 (YpsR) T6SS00256 insolico protein QS regulatory pathway Yersinia pseudotuberculosis YPIII chromosome (NC_010465) 1837676..1838413 (+) 488140651 T6SS transcripts (↓)
REG0196 experimental YPK_RS03965 (YtbR) T6SS00256 insolico protein QS regulatory pathway Yersinia pseudotuberculosis YPIII chromosome (NC_010465) 900476..901219 (+) 488140447 T6SS transcripts (↓)
REG0197 experimental YPK_RS08350 (ypsI) T6SS00256 insolico protein QS regulatory pathway Yersinia pseudotuberculosis YPIII chromosome (NC_010465) 1838406..1839050 (-) 501053391 T6SS transcripts (↓)
REG0198 experimental YPK_RS03970 (ytbI) T6SS00256 insolico; T6SS00260 experimental protein QS regulatory pathway Yersinia pseudotuberculosis YPIII chromosome (NC_010465) 901200..901850 (-) 488144695 T6SS transcripts (↓); T6SS4 transcripts and hcp secretion (↓)
REG0246 experimental ETAE_3474 (fabR) T6SS00372 experimental protein QS regulatory pathway Edwardsiella tarda EIB202 chromosome (NC_013508) 3666488..3667159 (-) 502613311 Unknown (↓)
REG0255 experimental HMPREF1171_RS20340 T6SS00788 experimental protein QS regulatory pathway Aeromonas dhakensis strain SSU chromosome (NZ_JH815591) 4528194..4528817 (-) WP_005308454.1 ahyR (↓)
REG0256 experimental HMPREF1171_RS20345 T6SS00788 experimental protein QS regulatory pathway Aeromonas dhakensis strain SSU chromosome (NZ_JH815591) 4528880..4529662 (+) WP_005308457.1 hcp and vgrG2 expression (↓)
REG0260 experimental EPGS_00471 (VtsR) T6SS00794 experimental protein QS regulatory pathway Vibrio alginolyticus strain EPJS chromosome (FJ790777) - - LuxO (↓)
REG0261 experimental EPGS_00471 (VtsR) T6SS00793 experimental protein QS regulatory pathway Vibrio alginolyticus strain EPJS chromosome (FJ790776) - - LuxO (↑)
REG0262 experimental luxR T6SS00794 experimental protein QS regulatory pathway Vibrio alginolyticus strain EPJS chromosome (FJ790777) - - T6SS2 transcript and expression (↓)
REG0263 experimental luxR T6SS00793 experimental protein QS regulatory pathway Vibrio alginolyticus strain EPJS chromosome (FJ790776) - - T6SS1 transcript and expression (↑)
REG0264 experimental VEPGS_0621 (pppA) T6SS00793 experimental protein Tpp; QS regulatory pathway Vibrio alginolyticus strain EPJS chromosome (FJ790777) 23577..24245 (+) 225382187 Unknown (↑); T6SS1 transcript (↑); hcp1 transcript (↓)
REG0265 experimental luxS T6SS00793 experimental protein QS regulatory pathway Vibrio alginolyticus strain EPJS chromosome (FJ790776) - - hcp1 transcript (↓)
REG0266 experimental LuxO T6SS00793 experimental protein QS regulatory pathway Vibrio alginolyticus strain EPJS chromosome (FJ790776) - - hcp1 transcript (↓)
REG0267 experimental LuxO T6SS00794 experimental protein QS regulatory pathway Vibrio alginolyticus strain EPJS chromosome (FJ790777) - - Unknown (↑)
REG0275 experimental V12G01_21538 (LuxR) T6SS00939 experimental protein QS regulatory pathway Vibrio alginolyticus 12G01 chromosome (AAPS01000053) 13551..14165 (-) 91187814 T6SS2 transcripts (↓); V12G01-18672 (vqsA) promotor
REG0279 experimental V12G01_18672 (vqsA) T6SS00939 experimental protein QS regulatory pathway Vibrio alginolyticus 12G01 chromosome (AAPS01000003) 114208..115086 (+) 91191289 V12G01-21538 (luxR) promoter (↓); V12G01-14830 (aphA) promoter (↓); V12G01-18672 (vqsA) promotor (↓)
REG0280 experimental V12G01_10813 (AsnC) T6SS00939 experimental protein QS regulatory pathway Vibrio alginolyticus 12G01 chromosome (AAPS01000004) 181050..181484 (-) 91191052 V12G01-21538 (luxR) promoter; V12G01-14830 (aphA) promoter
REG0281 experimental V12G01_02325 (HP) T6SS00939 experimental protein QS regulatory pathway Vibrio alginolyticus 12G01 chromosome (AAPS01000004) 115263..116411 (+) 91190993 V12G01-21538 (luxR) promoter; V12G01-14830 (aphA) promoter
REG0282 experimental V12G01_01665 (HP) T6SS00939 experimental protein QS regulatory pathway Vibrio alginolyticus 12G01 chromosome (AAPS01000007) 185299..185712 (+) 91190406 V12G01-21538 (luxR) promoter; V12G01-14830 (aphA) promoter
REG0283 experimental V12G01_06711 (HP) T6SS00939 experimental protein QS regulatory pathway Vibrio alginolyticus 12G01 chromosome (AAPS01000024) 47707..48585 (-) 91188835 V12G01-21538 (luxR) promoter; V12G01-14830 (aphA) promoter
REG0284 experimental V12G01_16177 (MetR) T6SS00939 experimental protein QS regulatory pathway Vibrio alginolyticus 12G01 chromosome (AAPS01000023) 58420..59331 (-) 91188901 V12G01-21538 (luxR) promoter; V12G01-14830 (aphA) promoter
REG0285 experimental V12G01_02620 (SoxR) T6SS00939 experimental protein QS regulatory pathway Vibrio alginolyticus 12G01 chromosome (AAPS01000004) 181050..181484 (-) 91191052 V12G01-21538 (luxR) promoter; V12G01-14830 (aphA) promoter
REG0287 experimental V12G01_14830 (aphA) T6SS00939 experimental protein QS regulatory pathway Vibrio alginolyticus 12G01 chromosome (AAPS01000027) 42305..42880 (+) 91188695 V12G01-18672 (vqsA) promotor
REG0296 experimental VCA1552_RS03895 (LuxO) T6SS01112 experimental protein QS regulatory pathway Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 818142..819509 (+) 487814784 Hcp expression and secretion (↑)
REG0297 experimental VCA1552_RS17020 (cqsa) T6SS01112 experimental protein QS regulatory pathway Vibrio cholerae strain A1552 chromosome (NZ_CP024868) 455238..456407 (-) 446962656 Hcp expression and secretion (↓)
REG0298 experimental VCA1552_RS01665 (LuxS) T6SS01112 experimental protein QS regulatory pathway Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 319588..320106 (+) 447052971 Hcp expression and secretion (↓)
REG0299 experimental VCA1552_RS00505 (hfq) T6SS01112 experimental protein QS regulatory pathway Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 92673..92936 (+) 446974616 VCA1552_00351 (HapR) (↑)
REG0301 experimental VCA1552_RS12025 (crp) T6SS01112 experimental protein QS regulatory pathway Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 2558371..2559003 (+) 446164894 Hcp expression and secretion (↓)
REG0302 experimental VCA1552_RS12925 (cya) T6SS01112 experimental protein QS regulatory pathway; cAMP regulatory pathway Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 2747346..2749877 (-) 447072406 VCA1552_RS12025 (crp) (↓)
REG0303 experimental VCA1552_00154 (QstR) T6SS01112 experimental protein c-di-GMP regulatory pathway; QS regulatory pathway; Global regulator Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 149920..150564 (-) 447111060 TssB/TfoY transcripts (↓); VC0396/VCA1552_00154 (QstR) (↓); T6SS transcripts (↓)
REG0321 experimental GT391_RS06470 (expR1) T6SS01170 experimental protein QS regulatory pathway Pectobacterium brasiliense strain 1692 chromosome (NZ_CP047495) 1453704..1455596 (+) 746272689 T6SS transcripts (↓)
REG0322 experimental GT391_RS06405 (expI) T6SS01170 experimental protein QS regulatory pathway Pectobacterium brasiliense strain 1692 chromosome (NZ_CP047495) 1436931..1437581 (-) 497970044 GT391_RS06470 (expR1) (↓)
REG0324 experimental WQ49_05050 (cepR) T6SS01276 experimental protein QS regulatory pathway Burkholderia cenocepacia strain K56-2 chromosome (LAUA01000002) 545988..546707 (-) 815852483 T6SS promotor (P (BCAL0340) ) (↓)
REG0325 experimental WQ49_20245 (cciR) T6SS01276 experimental protein QS regulatory pathway Burkholderia cenocepacia strain K56-2 chromosome (LAUA01000016) 843677..844378 (+) 815850423 Unknown (↑)
REG0327 experimental WQ49_05060 (cepI) T6SS01276 experimental protein QS regulatory pathway Burkholderia cenocepacia strain K56-2 chromosome (LAUA01000002) 547435..548043 (+) 815852485 T6SS expression (↓)
REG0328 experimental WQ49_20250 (cciI) T6SS01276 experimental protein QS regulatory pathway Burkholderia cenocepacia strain K56-2 chromosome (LAUA01000016) 844665..845255 (+) 815850424 T6SS expression (↓)
REG0344 experimental BN49_RS26620 (hfq) T6SS01214 experimental protein QS regulatory pathway Klebsiella pneumoniae strain Kp52.145 chromosome (NZ_FO834906) 5173711..5174019 (-) 488974767 TssB transcription (↓)
REG0353 experimental AHA_1842 (VasH) T6SS00157 experimental protein QS regulatory pathway Aeromonas hydrophila subsp. hydrophila ATCC 7966 chromosome (NC_008570) 2010521..2012059 (+) 117617496 T6SS gene cluster promoter (PAHA1826) (↓)
REG0355 experimental N779_15250 (VtpR) T6SS01280 experimental; T6SS01281 experimental protein QS regulatory pathway Vibrio coralliilyticus OCN008 chromosome (AVOO01000045) 7579..8184 (-) 536747482 Unknown (↓)
REG0367 experimental H78_RS02920 (Hfq) - protein QS regulatory pathway Pseudomonas protegens strain H78 chromosome (NZ_CP013184) 662937..663197 (+) 495196588 T6SS transcription level (↓)
REG0373 experimental hapR T6SS01028 experimental; T6SS01029 experimental protein QS regulatory pathway Vibrio fluvialis strain 85003 chromosome (-) - - vgrG (↓)
REG0374 experimental ihfA T6SS01028 experimental; T6SS01029 experimental protein QS regulatory pathway Vibrio fluvialis strain 85003 chromosome (-) - - vgrG (↓)
REG0375 experimental ihfB T6SS01028 experimental; T6SS01029 experimental protein QS regulatory pathway Vibrio fluvialis strain 85003 chromosome (-) - - vgrG (↓)

Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negative regulation.
experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed
Regulator ID Locus tag (Gene) Related T6SS Regulator type Regulatory pathway Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Target (Regulation)
REG0025 experimental Qrr1 quorum regulatory RNA T6SS01168 experimental ncRNA QS regulatory pathway Vibrio cholerae C6706 chromosome (NZ_CP046844) - - VCA0107 mRNA (↑)
REG0026 experimental Qrr2 quorum regulatory RNA T6SS01168 experimental ncRNA QS regulatory pathway Vibrio cholerae C6706 chromosome (NZ_CP046844) - - VCA0107 mRNA (↑)
REG0027 experimental Qrr3 quorum regulatory RNA T6SS01168 experimental ncRNA QS regulatory pathway Vibrio cholerae C6706 chromosome (NZ_CP046844) - - VCA0107 mRNA (↑)
REG0028 experimental Qrr4 quorum regulatory RNA T6SS01168 experimental ncRNA QS regulatory pathway Vibrio cholerae C6706 chromosome (NZ_CP046844) - - VCA0107 mRNA (↑)
REG0059 experimental PA4704.1 (prrF1) T6SS00003 experimental; T6SS00004 experimental ncRNA QS regulatory pathway Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 5283960..5284110 (+) 4179187 T6SS transcripts (↓)
REG0060 experimental PA4704.2 (prrF2) T6SS00003 experimental; T6SS00004 experimental ncRNA QS regulatory pathway Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 5284172..5284319 (+) 4179185 T6SS transcripts (↓)