Regulators of regulatory pathway: Global regulator

All displayed regulators are experimentally validated.


Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negative regulation.
experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed
Regulator ID Locus tag (Gene) Related T6SS Regulator type Regulatory pathway Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Target (Regulation)
REG0018 experimental PA4462 (RpoN) T6SS00003 experimental; T6SS00004 experimental; T6SS00005 experimental protein Global regulator Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 4992870..4994363 (+) 15599658 PA1512 (hcpA) promotor (↓); PA5267 (hcpB) promotor (↓)
REG0024 experimental GPY04_RS13335/VC0070 (tsrA) T6SS01168 experimental protein Global regulator Vibrio cholerae C6706 chromosome (NZ_CP046844) 2888303..2888587 (+) 445982516 T6SS transcripts (↑)
REG0030 experimental GPY04_RS13825 (QstR) T6SS01168 experimental protein Global regulator Vibrio cholerae C6706 chromosome (NZ_CP046844) 2994333..2994977 (-) 447111060 Unknown (↓)
REG0039 experimental VC_RS13930 (VasH) T6SS00002 experimental protein Global regulator Vibrio cholerae O1 biovar El Tor str. N16961 chromosome (NC_002506) 128790..130382 (+) 446006938 VCA0017 (hcp-2) transcript (↓)
REG0053 experimental PA4856 (RetS) T6SS00003 experimental protein Global regulator Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 5452150..5454978 (+) 15600049 hcp1 (PA0085) expression and secretion (↑)
REG0054 experimental PA3974 (LadS) T6SS00003 experimental protein Global regulator Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 4453289..4455676 (-) 15599169 hcp1 (PA0085) expression and secretion (↓)
REG0065 experimental PA1430 (LasR) T6SS00004 experimental protein Global regulator; QS regulatory pathway Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 1558171..1558890 (+) 15596627 H2-T6SS promotor P (hsiA2) (↓)
REG0068 experimental PA4764 (Fur) T6SS00004 experimental protein Global regulator Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 5351675..5352079 (-) 15599958 H2-T6SS Transcription (↑)
REG0069 experimental PA4462 (rpoN) T6SS00004 experimental protein Global regulator Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 4992870..4994363 (+) 15599658 T6SS transcript (↑)
REG0070 experimental pa1663 (sfa2) T6SS00004 experimental; T6SS00005 experimental protein Global regulator; QS regulatory pathway Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 1813395..1814906 (+) 15596860 PA4462 (rpoN) (↑); T6SS transcript (↑); T6SS transcript (↓)
REG0071 experimental Z4049 (RpoS) T6SS00006 insolico protein Global regulator Escherichia coli O157:H7 str. EDL933 chromosome (NC_002655) 3654380..3655372 (-) 446003635 Z1921 (KatN) (↓)
REG0072 experimental Z5519 (OxyR) T6SS00006 insolico protein Global regulator Escherichia coli O157:H7 str. EDL933 chromosome (NC_002655) 5033893..5034810 (+) 446948683 Z1921 (KatN) (↓)
REG0073 experimental Z2013 (hns) T6SS00006 insolico protein Global regulator Escherichia coli O157:H7 str. EDL933 chromosome (NC_002655) 1829490..1829903 (-) 447210122 Z0264 (hcp-2) (↑)
REG0087 experimental STM1751 (H-NS) T6SS00023 experimental protein Global regulator Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 chromosome (NC_003197) 1847277..1847690 (+) 16765095 STM0272 (ClpV) promotor (↑); STM0279 (hcp) promotor (↑); STM0285 promotor (↑); STM0289 (VgrG) promotor (↑); STM0268 promotor (↑)
REG0088 experimental STM0693 (Fur) T6SS00023 experimental protein Global regulator Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 chromosome (NC_003197) 756397..756849 (-) 16764063 STM0272 (ClpV) promoter (↑)
REG0094 experimental ECA3435 (bEBP/VasH) T6SS00040 experimental protein Global regulator Pectobacterium atrosepticum SCRI1043 chromosome (NC_004547) 3850745..3852298 (-) 499407476 T6SS gene cluster promoter (PECA3445) (↓); Hcp gene cluster promoter (PECA4275) (↓); Hcp gene cluster promoter (PECA2866) (↓)
REG0095 experimental ECA0288 (rpoN) T6SS00040 experimental protein Global regulator Pectobacterium atrosepticum SCRI1043 chromosome (NC_004547) 336007..337440 (-) 499404454 T6SS gene cluster promoter (PECA3445) (↓); Hcp gene cluster promoter (PECA4275) (↓); Hcp gene cluster promoter (PECA2866) (↓)
REG0099 experimental PSPTO_RS28060 (Sfa) T6SS00041 insolico; T6SS00042 experimental protein Global regulator Pseudomonas syringae pv. tomato str. DC3000 chromosome (NC_004578) 6165047..6166564 (-) 499418021 T6SS transcripts (↓)
REG0108 experimental vp1391 T6SS00043 experimental protein Global regulator Vibrio parahaemolyticus RIMD 2210633 chromosome (NC_004603) 1491226..1492857 (-) 28898165 T6SS1 (VgrG1) expression and secretion (↓)
REG0110 experimental VP1133 (hns) T6SS00043 experimental protein Global regulator Vibrio parahaemolyticus RIMD 2210633 chromosome (NC_004603) 1189718..1190125 (-) 28897907 VP1028 (TfoY) (↑)
REG0118 experimental VP2516 (OpaR) T6SS00043 experimental protein Global regulator Vibrio parahaemolyticus RIMD 2210633 chromosome (NC_004603) 2653215..2653829 (+) 28899290 T6SS1 (↓)
REG0123 experimental VF0896 (TfoX) T6SS00084 experimental protein Global regulator Aliivibrio fischeri ES114 chromosome (NC_006840) 986000..986629 (+) 59711503 T6SS transcripts (↓)
REG0124 experimental VFFQA001_02105 (rpoN) T6SS01277 experimental protein Global regulator Aliivibrio fischeri strain FQ-A001 chromosome (NZ_SJSX01000002) 62995..64464 (-) 501526930 hcp1/hcp transcript (↓)
REG0125 experimental VFFQA001_15620 (VasH) T6SS01278 experimental protein Global regulator Aliivibrio fischeri strain FQ-A001 chromosome (NZ_SJSX01000004) 359608..360108 (+) 1027725198 Unknown (↓)
REG0153 experimental BTH_I1281 (OxyR) T6SS00113 experimental protein Global regulator Burkholderia thailandensis E264 chromosome (NC_007651) 1432632..1433591 (+) 497575020 BTH_RS09735 (T6SS-4) Promotor,−536 to −186 relative to the ATG start codon (↑)
REG0154 experimental bth_I0691 (Zur) T6SS00113 experimental protein Global regulator Burkholderia thailandensis E264 chromosome (NC_007651) 796074..796538 (-) 497578547 BTH_RS09735 (T6SS-4) Promotor,−541 to −1 relative to the ATG start codon (↑)
REG0156 experimental pvfC T6SS00125 insolico protein Global regulator Pseudomonas entomophila L48 chromosome (NC_008027) - - T6SS secreted proteome (↓)
REG0169 experimental PA14_22470 (PA3225) T6SS00150 experimental; T6SS00152 experimental; T6SS00151 experimental protein Global regulator Pseudomonas aeruginosa UCBPP-PA14 chromosome (NC_008463) 1955624..1956553 (-) 489182081 PA14_00990 (TssA) promotor (↓); TssA1 (PA14_00990) transcript (↑); TssA2 (PA14_43050) transcript (↑); TssB3 (PA14_34070) transcript (↑)
REG0170 experimental PA14_20290 (AmrZ) T6SS00150 experimental; T6SS00152 experimental; T6SS00151 experimental protein Global regulator Pseudomonas aeruginosa UCBPP-PA14 chromosome (NC_008463) 1747602..1747928 (-) 489182353 TssA1 (PA14_00990) promotor (↓); TssA2 (PA14_43050) promotor (↑); TssB3 (PA14_34070) promotor (↓)
REG0171 experimental APECO1_487 (FNR) T6SS00155 insolico protein Global regulator Escherichia coli APEC O1 chromosome (NC_008563) 1455411..1456163 (-) 446534565 APECO1_1756 (VgrG1) (↓)
REG0177 experimental FTN_RS06615 (mglB) T6SS00158 experimental protein Global regulator; TCS regulatory pathway Francisella tularensis subsp. novicida U112 chromosome (NC_008601) 1362901..1363308 (+) 489112095 IglA expression (↓); T6SS Transciption (↓)
REG0180 experimental VC0395_RS17530 (TsrA) T6SS00208 insolico; T6SS00487 insolico protein Global regulator Vibrio cholerae O395 chromosome (NC_009457) 2598392..2598676 (-) 445982516 T6SS Transciption (↑)
REG0181 experimental VC0395_0020/VCA0117 (bEBP/vasH) T6SS00208 insolico protein Global regulator Vibrio cholerae O395 chromosome (NC_009456) 22315..23907 (-) 446006938 T6SS gene cluster promoter (PVCA0107/VC0395_RS00160) (↓)
REG0182 experimental VC0395_A2109 (rpoN) T6SS00208 insolico protein Global regulator Vibrio cholerae O395 chromosome (NC_009457) 2265078..2266541 (+) 446727517 T6SS gene cluster promoter (PVCA0107/VC0395_RS00160) (↓); hcp promoter (PVCA0017/VC0395_0116) (↓)
REG0183 experimental Mmwyl1_1758 (bEBP/vasH) T6SS00216 insolico protein Global regulator Marinomonas sp. MWYL1 chromosome (NC_009654) 1985170..1986666 (+) 501016781 T6SS gene cluster promoter (PMWYL1196/PMWYL1195) (↓)
REG0184 experimental Mmwyl1_2418 (RpoN) T6SS00216 insolico protein Global regulator Marinomonas sp. MWYL1 chromosome (NC_009654) 2725212..2726687 (+) 501017436 T6SS gene cluster promoter (PMWYL1196/PMWYL1195) (↓)
REG0189 experimental YPK_4079 (OxyR) T6SS00260 experimental protein Global regulator Yersinia pseudotuberculosis YPIII chromosome (NC_010465) 4502978..4503895 (-) 488138270 T6SS-4 promoter region (↓)
REG0190 experimental ypk_3425 (RpoS) T6SS00260 experimental protein Global regulator Yersinia pseudotuberculosis YPIII chromosome (NC_010465) 3759239..3760237 (-) 499505140 T6SS-4 promoter region (↓)
REG0194 experimental YPK_2462 (HpaR) T6SS00260 experimental protein Global regulator Yersinia pseudotuberculosis YPIII chromosome (NC_010465) 2695107..2695574 (+) 169751221 T6SS4 promoter (↓)
REG0200 experimental YPK_RS01520 (ZntR) T6SS00260 experimental protein Global regulator Yersinia pseudotuberculosis YPIII chromosome (NC_010465) 333471..333896 (+) 488144494 T6SS4 promoter (↓)
REG0201 experimental PMI0271 (MrpJ) T6SS00272 experimental protein Global regulator Proteus mirabilis HI4320 chromosome (NC_010554) 318458..318781 (+) 490365253 PMI0749 (tssA); PMI2990 (idsA/hcp)
REG0203 experimental KP1_3314 (hns) T6SS00344 experimental protein Global regulator Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044 chromosome (NC_012731) 3140175..3140582 (+) 238895262 KP1_2392 (TssB) promotor (↑); KP1_2392 (hcp) (↑)
REG0250 experimental EC042_RS06800 (Hns) T6SS00464 experimental protein Global regulator Escherichia coli 042 chromosome (NC_017626) 1376831..1377244 (-) 447210122 EC042_RS26480 (aggR) promoter (↑)
REG0251 experimental EC042_RS03685 (Fur) T6SS00464 experimental protein Global regulator Escherichia coli 042 chromosome (NC_017626) 786918..787364 (-) 446053847 EC042_4532 promoter (↑); EC042_4524 (TssB) promotor (↑)
REG0252 experimental EC042_RS19435 (Dam) T6SS00464 experimental protein Global regulator Escherichia coli 042 chromosome (NC_017626) 3861171..3862007 (-) 446664793 EC042_4532 promoter (↑)
REG0271 experimental H1D38_08255 (fur) T6SS00931 experimental protein Global regulator Escherichia coli strain 17-2 chromosome (JACEFV010000001) 1744748..1745194 (-) MBA2233871.1 sciH promotor (↑)
REG0272 experimental H1D38_12840 (Dam) T6SS00931 experimental protein Global regulator Escherichia coli strain 17-2 chromosome (JACEFV010000002) 105877..106713 (+) MBA2234741.1 sciH promotor (↑)
REG0292 experimental VCA1552_02898 (VasH) T6SS01112 experimental protein Global regulator Vibrio cholerae strain A1552 chromosome (NZ_CP024868) 128889..130481 (+) 446006938 VCA1552_00900 (TfoX) (↓)
REG0293 experimental VCA1552_00351 (HapR) T6SS01112 experimental protein Global regulator Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 340447..341058 (-) 446262243 Unknown; Hcp expression and secretion
REG0300 experimental VCA1552_RS11610 (RpoN) T6SS01112 experimental protein Global regulator Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 2488023..2489486 (+) 446727517 Hcp expression and secretion (↓)
REG0303 experimental VCA1552_00154 (QstR) T6SS01112 experimental protein c-di-GMP regulatory pathway; QS regulatory pathway; Global regulator Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 149920..150564 (-) 447111060 TssB/TfoY transcripts (↓); VC0396/VCA1552_00154 (QstR) (↓); T6SS transcripts (↓)
REG0304 experimental VCA1552_00900 (TfoX) T6SS01112 experimental protein Global regulator Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 952868..953476 (+) 487807468 VC0396/VCA1552_00154 (QstR) (↓)
REG0314 experimental TfoY T6SS00790 experimental protein Global regulator Vibrio cholerae V52 chromosome (-) - - Unknown (↓)
REG0315 experimental VCV52_RS10780 (TfoX) T6SS00790 experimental protein Global regulator Vibrio cholerae V52 chromosome (NZ_KQ410501) 68827..69435 (-) 487807468 Unknown (↓)
REG0316 experimental VCV52_RS01020 (VasH) T6SS00790 experimental protein Global regulator Vibrio cholerae V52 chromosome (NZ_KQ410497) 212259..213851 (-) 446006947 Unknown (↓)
REG0317 experimental VCV52_RS13040 (rpoN) T6SS00790 experimental protein Global regulator Vibrio cholerae V52 chromosome (NZ_KQ410502) 216932..218395 (-) 446727517 Unknown (↓)
REG0342 experimental BN49_RS18480 (h-ns) T6SS01214 experimental protein Global regulator Klebsiella pneumoniae strain Kp52.145 chromosome (NZ_FO834906) 3427636..3428043 (+) 488999426 TssB transcription (↑)
REG0343 experimental BN49_RS10300 (fur) T6SS01214 experimental protein Global regulator Klebsiella pneumoniae strain Kp52.145 chromosome (NZ_FO834906) 1826878..1827330 (-) 514077307 TssB transcription (↓)
REG0345 experimental BN49_RS03755 (rpoN) T6SS01214 experimental protein Global regulator Klebsiella pneumoniae strain Kp52.145 chromosome (NZ_FO834906) 533564..534997 (-) 489007850 TssB transcription (↓)
REG0346 experimental BN49_RS06445 (rpoS) T6SS01214 experimental protein Global regulator Klebsiella pneumoniae strain Kp52.145 chromosome (NZ_FO834906) 1060243..1061235 (+) 489004494 TssB transcription (↓)
REG0347 experimental sdiA - protein Global regulator Enterobacter cloacae strain JLD400 chromosome (-) - - ENC_07270 transcript (↓)
REG0350 experimental F9K57_RS04510 (VgrGi) T6SS01164 experimental protein Global regulator Acinetobacter baumannii strain AbCAN2 chromosome (NZ_CP045428) 925473..928592 (+) 1797381381 T6SS structure (↑)
REG0354 experimental AHA_3923 (rpoN) T6SS00157 experimental protein Global regulator Aeromonas hydrophila subsp. hydrophila ATCC 7966 chromosome (NC_008570) 4350676..4352115 (-) 117618923 T6SS gene cluster promoter (PAHA1826) (↓)
REG0359 experimental bglu_1g09700 (tepR) T6SS00343 insolico protein Global regulator Burkholderia glumae BGR1 chromosome (NC_012724) 1045102..1046502 (-) - Unknown (↓)
REG0360 experimental ACX61_19655 (tetR2) T6SS01047 insolico protein Global regulator Acinetobacter baumannii strain Ab04-mff plasmid (NZ_CP012007) 144108..144677 (+) 446104352 hcp secretion (↑)
REG0361 experimental ACX61_19615 (tetR1) T6SS01047 insolico protein Global regulator Acinetobacter baumannii strain Ab04-mff plasmid (NZ_CP012007) 139526..140098 (+) 487938137 hcp secretion (↑)
REG0365 experimental Y113_RS02460 (Fur) T6SS00791 experimental protein Global regulator Edwardsiella tarda PPD130/91 chromosome (NZ_JACQ01000003) 461902..462351 (+) 735678383 EvpQ protein level (↑)
REG0366 experimental YPK_RS19410 (Zur) T6SS00260 experimental protein Global regulator Yersinia pseudotuberculosis YPIII chromosome (NC_010465) 4251751..4252260 (+) 488143439 T6SS4 transcription (↓)
REG0368 experimental PA1544 (Anr) T6SS00004 experimental protein Global regulator Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 1681071..1681805 (-) 15596741 H2-T6SS transcriptional level and ModA secretion (↓)
REG0379 experimental REUT_RS14415 (fur) T6SS17507 experimental protein Global regulator Cupriavidus pinatubonensis JMP134 chromosome (NC_007347) 3110053..3110484 (+) WP_011298983.1 reut_A1733 promotor (↑)

Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negative regulation.
experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed
Regulator ID Locus tag (Gene) Related T6SS Regulator type Regulatory pathway Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Target (Regulation)
REG0018 experimental PA4462 (RpoN) T6SS00003 experimental; T6SS00004 experimental; T6SS00005 experimental protein Global regulator Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 4992870..4994363 (+) 15599658 PA1512 (hcpA) promotor (↓); PA5267 (hcpB) promotor (↓)
REG0024 experimental GPY04_RS13335/VC0070 (tsrA) T6SS01168 experimental protein Global regulator Vibrio cholerae C6706 chromosome (NZ_CP046844) 2888303..2888587 (+) 445982516 T6SS transcripts (↑)
REG0030 experimental GPY04_RS13825 (QstR) T6SS01168 experimental protein Global regulator Vibrio cholerae C6706 chromosome (NZ_CP046844) 2994333..2994977 (-) 447111060 Unknown (↓)
REG0039 experimental VC_RS13930 (VasH) T6SS00002 experimental protein Global regulator Vibrio cholerae O1 biovar El Tor str. N16961 chromosome (NC_002506) 128790..130382 (+) 446006938 VCA0017 (hcp-2) transcript (↓)
REG0053 experimental PA4856 (RetS) T6SS00003 experimental protein Global regulator Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 5452150..5454978 (+) 15600049 hcp1 (PA0085) expression and secretion (↑)
REG0054 experimental PA3974 (LadS) T6SS00003 experimental protein Global regulator Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 4453289..4455676 (-) 15599169 hcp1 (PA0085) expression and secretion (↓)
REG0065 experimental PA1430 (LasR) T6SS00004 experimental protein Global regulator; QS regulatory pathway Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 1558171..1558890 (+) 15596627 H2-T6SS promotor P (hsiA2) (↓)
REG0068 experimental PA4764 (Fur) T6SS00004 experimental protein Global regulator Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 5351675..5352079 (-) 15599958 H2-T6SS Transcription (↑)
REG0069 experimental PA4462 (rpoN) T6SS00004 experimental protein Global regulator Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 4992870..4994363 (+) 15599658 T6SS transcript (↑)
REG0070 experimental pa1663 (sfa2) T6SS00004 experimental; T6SS00005 experimental protein Global regulator; QS regulatory pathway Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 1813395..1814906 (+) 15596860 PA4462 (rpoN) (↑); T6SS transcript (↑); T6SS transcript (↓)
REG0071 experimental Z4049 (RpoS) T6SS00006 insolico protein Global regulator Escherichia coli O157:H7 str. EDL933 chromosome (NC_002655) 3654380..3655372 (-) 446003635 Z1921 (KatN) (↓)
REG0072 experimental Z5519 (OxyR) T6SS00006 insolico protein Global regulator Escherichia coli O157:H7 str. EDL933 chromosome (NC_002655) 5033893..5034810 (+) 446948683 Z1921 (KatN) (↓)
REG0073 experimental Z2013 (hns) T6SS00006 insolico protein Global regulator Escherichia coli O157:H7 str. EDL933 chromosome (NC_002655) 1829490..1829903 (-) 447210122 Z0264 (hcp-2) (↑)
REG0087 experimental STM1751 (H-NS) T6SS00023 experimental protein Global regulator Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 chromosome (NC_003197) 1847277..1847690 (+) 16765095 STM0272 (ClpV) promotor (↑); STM0279 (hcp) promotor (↑); STM0285 promotor (↑); STM0289 (VgrG) promotor (↑); STM0268 promotor (↑)
REG0088 experimental STM0693 (Fur) T6SS00023 experimental protein Global regulator Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 chromosome (NC_003197) 756397..756849 (-) 16764063 STM0272 (ClpV) promoter (↑)
REG0094 experimental ECA3435 (bEBP/VasH) T6SS00040 experimental protein Global regulator Pectobacterium atrosepticum SCRI1043 chromosome (NC_004547) 3850745..3852298 (-) 499407476 T6SS gene cluster promoter (PECA3445) (↓); Hcp gene cluster promoter (PECA4275) (↓); Hcp gene cluster promoter (PECA2866) (↓)
REG0095 experimental ECA0288 (rpoN) T6SS00040 experimental protein Global regulator Pectobacterium atrosepticum SCRI1043 chromosome (NC_004547) 336007..337440 (-) 499404454 T6SS gene cluster promoter (PECA3445) (↓); Hcp gene cluster promoter (PECA4275) (↓); Hcp gene cluster promoter (PECA2866) (↓)
REG0099 experimental PSPTO_RS28060 (Sfa) T6SS00041 insolico; T6SS00042 experimental protein Global regulator Pseudomonas syringae pv. tomato str. DC3000 chromosome (NC_004578) 6165047..6166564 (-) 499418021 T6SS transcripts (↓)
REG0108 experimental vp1391 T6SS00043 experimental protein Global regulator Vibrio parahaemolyticus RIMD 2210633 chromosome (NC_004603) 1491226..1492857 (-) 28898165 T6SS1 (VgrG1) expression and secretion (↓)
REG0110 experimental VP1133 (hns) T6SS00043 experimental protein Global regulator Vibrio parahaemolyticus RIMD 2210633 chromosome (NC_004603) 1189718..1190125 (-) 28897907 VP1028 (TfoY) (↑)
REG0118 experimental VP2516 (OpaR) T6SS00043 experimental protein Global regulator Vibrio parahaemolyticus RIMD 2210633 chromosome (NC_004603) 2653215..2653829 (+) 28899290 T6SS1 (↓)
REG0123 experimental VF0896 (TfoX) T6SS00084 experimental protein Global regulator Aliivibrio fischeri ES114 chromosome (NC_006840) 986000..986629 (+) 59711503 T6SS transcripts (↓)
REG0124 experimental VFFQA001_02105 (rpoN) T6SS01277 experimental protein Global regulator Aliivibrio fischeri strain FQ-A001 chromosome (NZ_SJSX01000002) 62995..64464 (-) 501526930 hcp1/hcp transcript (↓)
REG0125 experimental VFFQA001_15620 (VasH) T6SS01278 experimental protein Global regulator Aliivibrio fischeri strain FQ-A001 chromosome (NZ_SJSX01000004) 359608..360108 (+) 1027725198 Unknown (↓)
REG0153 experimental BTH_I1281 (OxyR) T6SS00113 experimental protein Global regulator Burkholderia thailandensis E264 chromosome (NC_007651) 1432632..1433591 (+) 497575020 BTH_RS09735 (T6SS-4) Promotor,−536 to −186 relative to the ATG start codon (↑)
REG0154 experimental bth_I0691 (Zur) T6SS00113 experimental protein Global regulator Burkholderia thailandensis E264 chromosome (NC_007651) 796074..796538 (-) 497578547 BTH_RS09735 (T6SS-4) Promotor,−541 to −1 relative to the ATG start codon (↑)
REG0156 experimental pvfC T6SS00125 insolico protein Global regulator Pseudomonas entomophila L48 chromosome (NC_008027) - - T6SS secreted proteome (↓)
REG0169 experimental PA14_22470 (PA3225) T6SS00150 experimental; T6SS00152 experimental; T6SS00151 experimental protein Global regulator Pseudomonas aeruginosa UCBPP-PA14 chromosome (NC_008463) 1955624..1956553 (-) 489182081 PA14_00990 (TssA) promotor (↓); TssA1 (PA14_00990) transcript (↑); TssA2 (PA14_43050) transcript (↑); TssB3 (PA14_34070) transcript (↑)
REG0170 experimental PA14_20290 (AmrZ) T6SS00150 experimental; T6SS00152 experimental; T6SS00151 experimental protein Global regulator Pseudomonas aeruginosa UCBPP-PA14 chromosome (NC_008463) 1747602..1747928 (-) 489182353 TssA1 (PA14_00990) promotor (↓); TssA2 (PA14_43050) promotor (↑); TssB3 (PA14_34070) promotor (↓)
REG0171 experimental APECO1_487 (FNR) T6SS00155 insolico protein Global regulator Escherichia coli APEC O1 chromosome (NC_008563) 1455411..1456163 (-) 446534565 APECO1_1756 (VgrG1) (↓)
REG0177 experimental FTN_RS06615 (mglB) T6SS00158 experimental protein Global regulator; TCS regulatory pathway Francisella tularensis subsp. novicida U112 chromosome (NC_008601) 1362901..1363308 (+) 489112095 IglA expression (↓); T6SS Transciption (↓)
REG0180 experimental VC0395_RS17530 (TsrA) T6SS00208 insolico; T6SS00487 insolico protein Global regulator Vibrio cholerae O395 chromosome (NC_009457) 2598392..2598676 (-) 445982516 T6SS Transciption (↑)
REG0181 experimental VC0395_0020/VCA0117 (bEBP/vasH) T6SS00208 insolico protein Global regulator Vibrio cholerae O395 chromosome (NC_009456) 22315..23907 (-) 446006938 T6SS gene cluster promoter (PVCA0107/VC0395_RS00160) (↓)
REG0182 experimental VC0395_A2109 (rpoN) T6SS00208 insolico protein Global regulator Vibrio cholerae O395 chromosome (NC_009457) 2265078..2266541 (+) 446727517 T6SS gene cluster promoter (PVCA0107/VC0395_RS00160) (↓); hcp promoter (PVCA0017/VC0395_0116) (↓)
REG0183 experimental Mmwyl1_1758 (bEBP/vasH) T6SS00216 insolico protein Global regulator Marinomonas sp. MWYL1 chromosome (NC_009654) 1985170..1986666 (+) 501016781 T6SS gene cluster promoter (PMWYL1196/PMWYL1195) (↓)
REG0184 experimental Mmwyl1_2418 (RpoN) T6SS00216 insolico protein Global regulator Marinomonas sp. MWYL1 chromosome (NC_009654) 2725212..2726687 (+) 501017436 T6SS gene cluster promoter (PMWYL1196/PMWYL1195) (↓)
REG0189 experimental YPK_4079 (OxyR) T6SS00260 experimental protein Global regulator Yersinia pseudotuberculosis YPIII chromosome (NC_010465) 4502978..4503895 (-) 488138270 T6SS-4 promoter region (↓)
REG0190 experimental ypk_3425 (RpoS) T6SS00260 experimental protein Global regulator Yersinia pseudotuberculosis YPIII chromosome (NC_010465) 3759239..3760237 (-) 499505140 T6SS-4 promoter region (↓)
REG0194 experimental YPK_2462 (HpaR) T6SS00260 experimental protein Global regulator Yersinia pseudotuberculosis YPIII chromosome (NC_010465) 2695107..2695574 (+) 169751221 T6SS4 promoter (↓)
REG0200 experimental YPK_RS01520 (ZntR) T6SS00260 experimental protein Global regulator Yersinia pseudotuberculosis YPIII chromosome (NC_010465) 333471..333896 (+) 488144494 T6SS4 promoter (↓)
REG0201 experimental PMI0271 (MrpJ) T6SS00272 experimental protein Global regulator Proteus mirabilis HI4320 chromosome (NC_010554) 318458..318781 (+) 490365253 PMI0749 (tssA); PMI2990 (idsA/hcp)
REG0203 experimental KP1_3314 (hns) T6SS00344 experimental protein Global regulator Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044 chromosome (NC_012731) 3140175..3140582 (+) 238895262 KP1_2392 (TssB) promotor (↑); KP1_2392 (hcp) (↑)
REG0250 experimental EC042_RS06800 (Hns) T6SS00464 experimental protein Global regulator Escherichia coli 042 chromosome (NC_017626) 1376831..1377244 (-) 447210122 EC042_RS26480 (aggR) promoter (↑)
REG0251 experimental EC042_RS03685 (Fur) T6SS00464 experimental protein Global regulator Escherichia coli 042 chromosome (NC_017626) 786918..787364 (-) 446053847 EC042_4532 promoter (↑); EC042_4524 (TssB) promotor (↑)
REG0252 experimental EC042_RS19435 (Dam) T6SS00464 experimental protein Global regulator Escherichia coli 042 chromosome (NC_017626) 3861171..3862007 (-) 446664793 EC042_4532 promoter (↑)
REG0271 experimental H1D38_08255 (fur) T6SS00931 experimental protein Global regulator Escherichia coli strain 17-2 chromosome (JACEFV010000001) 1744748..1745194 (-) MBA2233871.1 sciH promotor (↑)
REG0272 experimental H1D38_12840 (Dam) T6SS00931 experimental protein Global regulator Escherichia coli strain 17-2 chromosome (JACEFV010000002) 105877..106713 (+) MBA2234741.1 sciH promotor (↑)
REG0292 experimental VCA1552_02898 (VasH) T6SS01112 experimental protein Global regulator Vibrio cholerae strain A1552 chromosome (NZ_CP024868) 128889..130481 (+) 446006938 VCA1552_00900 (TfoX) (↓)
REG0293 experimental VCA1552_00351 (HapR) T6SS01112 experimental protein Global regulator Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 340447..341058 (-) 446262243 Unknown; Hcp expression and secretion
REG0300 experimental VCA1552_RS11610 (RpoN) T6SS01112 experimental protein Global regulator Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 2488023..2489486 (+) 446727517 Hcp expression and secretion (↓)
REG0303 experimental VCA1552_00154 (QstR) T6SS01112 experimental protein c-di-GMP regulatory pathway; QS regulatory pathway; Global regulator Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 149920..150564 (-) 447111060 TssB/TfoY transcripts (↓); VC0396/VCA1552_00154 (QstR) (↓); T6SS transcripts (↓)
REG0304 experimental VCA1552_00900 (TfoX) T6SS01112 experimental protein Global regulator Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 952868..953476 (+) 487807468 VC0396/VCA1552_00154 (QstR) (↓)
REG0314 experimental TfoY T6SS00790 experimental protein Global regulator Vibrio cholerae V52 chromosome (-) - - Unknown (↓)
REG0315 experimental VCV52_RS10780 (TfoX) T6SS00790 experimental protein Global regulator Vibrio cholerae V52 chromosome (NZ_KQ410501) 68827..69435 (-) 487807468 Unknown (↓)
REG0316 experimental VCV52_RS01020 (VasH) T6SS00790 experimental protein Global regulator Vibrio cholerae V52 chromosome (NZ_KQ410497) 212259..213851 (-) 446006947 Unknown (↓)
REG0317 experimental VCV52_RS13040 (rpoN) T6SS00790 experimental protein Global regulator Vibrio cholerae V52 chromosome (NZ_KQ410502) 216932..218395 (-) 446727517 Unknown (↓)
REG0342 experimental BN49_RS18480 (h-ns) T6SS01214 experimental protein Global regulator Klebsiella pneumoniae strain Kp52.145 chromosome (NZ_FO834906) 3427636..3428043 (+) 488999426 TssB transcription (↑)
REG0343 experimental BN49_RS10300 (fur) T6SS01214 experimental protein Global regulator Klebsiella pneumoniae strain Kp52.145 chromosome (NZ_FO834906) 1826878..1827330 (-) 514077307 TssB transcription (↓)
REG0345 experimental BN49_RS03755 (rpoN) T6SS01214 experimental protein Global regulator Klebsiella pneumoniae strain Kp52.145 chromosome (NZ_FO834906) 533564..534997 (-) 489007850 TssB transcription (↓)
REG0346 experimental BN49_RS06445 (rpoS) T6SS01214 experimental protein Global regulator Klebsiella pneumoniae strain Kp52.145 chromosome (NZ_FO834906) 1060243..1061235 (+) 489004494 TssB transcription (↓)
REG0347 experimental sdiA - protein Global regulator Enterobacter cloacae strain JLD400 chromosome (-) - - ENC_07270 transcript (↓)
REG0350 experimental F9K57_RS04510 (VgrGi) T6SS01164 experimental protein Global regulator Acinetobacter baumannii strain AbCAN2 chromosome (NZ_CP045428) 925473..928592 (+) 1797381381 T6SS structure (↑)
REG0354 experimental AHA_3923 (rpoN) T6SS00157 experimental protein Global regulator Aeromonas hydrophila subsp. hydrophila ATCC 7966 chromosome (NC_008570) 4350676..4352115 (-) 117618923 T6SS gene cluster promoter (PAHA1826) (↓)
REG0359 experimental bglu_1g09700 (tepR) T6SS00343 insolico protein Global regulator Burkholderia glumae BGR1 chromosome (NC_012724) 1045102..1046502 (-) - Unknown (↓)
REG0360 experimental ACX61_19655 (tetR2) T6SS01047 insolico protein Global regulator Acinetobacter baumannii strain Ab04-mff plasmid (NZ_CP012007) 144108..144677 (+) 446104352 hcp secretion (↑)
REG0361 experimental ACX61_19615 (tetR1) T6SS01047 insolico protein Global regulator Acinetobacter baumannii strain Ab04-mff plasmid (NZ_CP012007) 139526..140098 (+) 487938137 hcp secretion (↑)
REG0365 experimental Y113_RS02460 (Fur) T6SS00791 experimental protein Global regulator Edwardsiella tarda PPD130/91 chromosome (NZ_JACQ01000003) 461902..462351 (+) 735678383 EvpQ protein level (↑)
REG0366 experimental YPK_RS19410 (Zur) T6SS00260 experimental protein Global regulator Yersinia pseudotuberculosis YPIII chromosome (NC_010465) 4251751..4252260 (+) 488143439 T6SS4 transcription (↓)
REG0368 experimental PA1544 (Anr) T6SS00004 experimental protein Global regulator Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 1681071..1681805 (-) 15596741 H2-T6SS transcriptional level and ModA secretion (↓)
REG0379 experimental REUT_RS14415 (fur) T6SS17507 experimental protein Global regulator Cupriavidus pinatubonensis JMP134 chromosome (NC_007347) 3110053..3110484 (+) WP_011298983.1 reut_A1733 promotor (↑)

Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negative regulation.
experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed
Regulator ID Locus tag (Gene) Related T6SS Regulator type Regulatory pathway Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Target (Regulation)