Regulators of regulatory pathway: Cysteine and methionine metabolism

All displayed regulators are experimentally validated.


Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negative regulation.
experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed
Regulator ID Locus tag (Gene) Related T6SS Regulator type Regulatory pathway Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Target (Regulation)
REG0224 experimental ETAE_2773 (mtnN) T6SS00372 experimental protein TCS regulatory pathway Edwardsiella tarda EIB202 chromosome (NC_013508) 2910743..2911441 (+) 502612632 ETAE_0886 (esrB) promoter (↑)
REG0298 experimental VCA1552_RS01665 (LuxS) T6SS01112 experimental protein QS regulatory pathway Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 319588..320106 (+) 447052971 Hcp expression and secretion (↓)
REG0066 experimental PA3476 (rhlI) T6SS00004 experimental protein QS regulatory pathway Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 3889139..3889744 (-) 15598672 PA3477 (RhlR) (↓)
REG0327 experimental WQ49_05060 (cepI) T6SS01276 experimental protein QS regulatory pathway Burkholderia cenocepacia strain K56-2 chromosome (LAUA01000002) 547435..548043 (+) 815852485 T6SS expression (↓)
REG0093 experimental ECA_RS00520 (expI) T6SS00040 experimental protein QS regulatory pathway Pectobacterium atrosepticum SCRI1043 chromosome (NC_004547) 125689..126339 (+) 499404281 T6SS transcripts (ECA4275[hcp1], ECA3428[hcp2] and ECA2866[hcp3]) (↓)
REG0197 experimental YPK_RS08350 (ypsI) T6SS00256 insolico protein QS regulatory pathway Yersinia pseudotuberculosis YPIII chromosome (NC_010465) 1838406..1839050 (-) 501053391 T6SS transcripts (↓)
REG0198 experimental YPK_RS03970 (ytbI) T6SS00256 insolico; T6SS00260 experimental protein QS regulatory pathway Yersinia pseudotuberculosis YPIII chromosome (NC_010465) 901200..901850 (-) 488144695 T6SS transcripts (↓); T6SS4 transcripts and hcp secretion (↓)
REG0322 experimental GT391_RS06405 (expI) T6SS01170 experimental protein QS regulatory pathway Pectobacterium brasiliense strain 1692 chromosome (NZ_CP047495) 1436931..1437581 (-) 497970044 GT391_RS06470 (expR1) (↓)
REG0121 experimental CV_RS23145 (CviI) T6SS00049 insolico protein QS regulatory pathway Chromobacterium violaceum ATCC 12472 chromosome (NC_005085) 4426967..4427620 (-) 499450174 CV_RS20220 (CviR) (↓)
REG0370 experimental ACX60_RS11355 (racK) T6SS01046 experimental protein Environmental signal Acinetobacter baumannii strain ATCC 17978 chromosome (NZ_CP012004) 2382673..2383965 (+) WP_000769882.1 ACX60_RS00605 (Tse4) (↓)

Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negative regulation.
experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed
Regulator ID Locus tag (Gene) Related T6SS Regulator type Regulatory pathway Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Target (Regulation)
REG0224 experimental ETAE_2773 (mtnN) T6SS00372 experimental protein TCS regulatory pathway Edwardsiella tarda EIB202 chromosome (NC_013508) 2910743..2911441 (+) 502612632 ETAE_0886 (esrB) promoter (↑)
REG0298 experimental VCA1552_RS01665 (LuxS) T6SS01112 experimental protein QS regulatory pathway Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 319588..320106 (+) 447052971 Hcp expression and secretion (↓)
REG0066 experimental PA3476 (rhlI) T6SS00004 experimental protein QS regulatory pathway Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 3889139..3889744 (-) 15598672 PA3477 (RhlR) (↓)
REG0327 experimental WQ49_05060 (cepI) T6SS01276 experimental protein QS regulatory pathway Burkholderia cenocepacia strain K56-2 chromosome (LAUA01000002) 547435..548043 (+) 815852485 T6SS expression (↓)
REG0093 experimental ECA_RS00520 (expI) T6SS00040 experimental protein QS regulatory pathway Pectobacterium atrosepticum SCRI1043 chromosome (NC_004547) 125689..126339 (+) 499404281 T6SS transcripts (ECA4275[hcp1], ECA3428[hcp2] and ECA2866[hcp3]) (↓)
REG0197 experimental YPK_RS08350 (ypsI) T6SS00256 insolico protein QS regulatory pathway Yersinia pseudotuberculosis YPIII chromosome (NC_010465) 1838406..1839050 (-) 501053391 T6SS transcripts (↓)
REG0198 experimental YPK_RS03970 (ytbI) T6SS00256 insolico; T6SS00260 experimental protein QS regulatory pathway Yersinia pseudotuberculosis YPIII chromosome (NC_010465) 901200..901850 (-) 488144695 T6SS transcripts (↓); T6SS4 transcripts and hcp secretion (↓)
REG0322 experimental GT391_RS06405 (expI) T6SS01170 experimental protein QS regulatory pathway Pectobacterium brasiliense strain 1692 chromosome (NZ_CP047495) 1436931..1437581 (-) 497970044 GT391_RS06470 (expR1) (↓)
REG0121 experimental CV_RS23145 (CviI) T6SS00049 insolico protein QS regulatory pathway Chromobacterium violaceum ATCC 12472 chromosome (NC_005085) 4426967..4427620 (-) 499450174 CV_RS20220 (CviR) (↓)
REG0370 experimental ACX60_RS11355 (racK) T6SS01046 experimental protein Environmental signal Acinetobacter baumannii strain ATCC 17978 chromosome (NZ_CP012004) 2382673..2383965 (+) WP_000769882.1 ACX60_RS00605 (Tse4) (↓)

Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negative regulation.
experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed
Regulator ID Locus tag (Gene) Related T6SS Regulator type Regulatory pathway Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Target (Regulation)