Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negative regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed

Regulator ID	Locus tag (Gene)	Related T6SS	Regulator type	Regulatory pathway	Organism	Replicon (Accession)	Coordinates (Strand)	NCBI ID	Target (Regulation)
REG0220	ETAE_2787 (guaB)	T6SS00372	protein	TCS regulatory pathway	Edwardsiella tarda EIB202	chromosome (NC_013508)	2925310..2926776 (-)	502612646	ETAE_0886 (esrB) promoter (↑)
REG0223	ETAE_0659 (aceE)	T6SS00372	protein	TCS regulatory pathway	Edwardsiella tarda EIB202	chromosome (NC_013508)	731608..734271 (+)	502610523	ETAE_0886 (esrB) promoter (↑)
REG0209	ETAE_0743 (cdsA)	T6SS00372	protein	TCS regulatory pathway	Edwardsiella tarda EIB202	chromosome (NC_013508)	820052..820909 (+)	502610607	ETAE_0886 (esrB) promoter (↑)
REG0013	Y880_03649 (suhB)	T6SS01211 ; T6SS01212 ; T6SS01213	protein	TCS regulatory pathway	Pseudomonas aeruginosa PAK	chromosome (NZ_CP020659)	3616623..3617438 (+)	489183406	Y880_02189 (gacA/uvrY) (↓)
REG0208	ETAE_0154 (hemB)	T6SS00372	protein	TCS regulatory pathway	Edwardsiella tarda EIB202	chromosome (NC_013508)	159867..160889 (+)	502610017	ETAE_0886 (esrB) promoter (↑)
REG0211	ETAE_1096 (dapA)	T6SS00372	protein	TCS regulatory pathway	Edwardsiella tarda EIB202	chromosome (NC_013508)	1194778..1195659 (+)	502610962	ETAE_0886 (esrB) promoter (↑)
REG0229	ETAE_3449 (tpiA)	T6SS00372	protein	TCS regulatory pathway	Edwardsiella tarda EIB202	chromosome (NC_013508)	3637381..3638145 (+)	502613286	ETAE_0886 (esrB) promoter (↓)
REG0281	V12G01_02325 (HP)	T6SS00939	protein	QS regulatory pathway	Vibrio alginolyticus 12G01	chromosome (AAPS01000004)	115263..116411 (+)	91190993	V12G01-21538 (luxR) promoter; V12G01-14830 (aphA) promoter
REG0168	PA14_51380 (pqsE)	T6SS00150 ; T6SS00152	protein	QS regulatory pathway	Pseudomonas aeruginosa UCBPP-PA14	chromosome (NC_008463)	4566077..4566982 (-)	489176725	T6SS Transciption (↓)