Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed

Regulator ID	Locus tag (Gene)	Related T6SS	Regulator type	Regulatory pathway	Organism	Replicon (Accession)	Coordinates (Strand)	NCBI ID	Target (Regulation)
REG0001	vfu_A02134 (ihfA)	T6SS00529 ; T6SS00530	protein	Transcription regulator	Vibrio furnissii NCTC 11218	chromosome (NC_016602)	2226951..2227244 (-)	490864172	tssD2_a promoter (↓); VflT6SS2 major cluster promoter (↓)
REG0002	vfu_A02422 (ihfB)	T6SS00529 ; T6SS00530	protein	Transcription regulator	Vibrio furnissii NCTC 11218	chromosome (NC_016602)	2516092..2516376 (-)	490864456	tssD2_a promoter (↓); VflT6SS2 major cluster promoter (↓)
REG0003	RT90_01105 (rcsC)	T6SS01264	protein	TCS-HK	Serratia marcescens strain RM66262	chromosome (JWLO01000001)	232638..235499 (+)	735006326	RT90_01115 (rcsB) (↑)
REG0004	RT90_01115 (rcsB)	T6SS01264	protein	TCS-RR	Serratia marcescens strain RM66262	chromosome (JWLO01000001)	235561..236211 (-)	735006328	vgrG promoter (↓)
REG0005	RT90_16255 (wecG)	T6SS01264	protein	TCS regulatory pathway	Serratia marcescens strain RM66262	chromosome (JWLO01000003)	92056..92796 (-)	735005313	RT90_01105 (rcsC) (↑)
REG0006	L085_RS13655 (ppka)	T6SS01033	protein	Tpp	Serratia sp. FS14	chromosome (NZ_CP005927)	3028273..3029718 (-)	763151328	Unknown (↓)
REG0007	Y880_04683 (pnp)	T6SS01211 ; T6SS01212 ; T6SS01213	protein	RsmA regulatory pathway	Pseudomonas aeruginosa PAK	chromosome (NZ_CP020659)	4637120..4639225 (-)	489185761	PA0527.1 (RsmY) (↑); PA3621.1 (RsmZ) (↑)
REG0010	Y880_06257 (rsmA)	T6SS01211 ; T6SS01212 ; T6SS01213	protein	RsmA regulatory pathway	Pseudomonas aeruginosa PAK	chromosome (NZ_CP020659)	6213838..6214644 (-)	510932573	PA4492 mRNA (↑)
REG0011	Y880_05180 (rmsF)	T6SS01211 ; T6SS01212 ; T6SS01213	protein	RsmA regulatory pathway	Pseudomonas aeruginosa PAK	chromosome (NZ_CP020659)	5147809..5148024 (-)	489186811	tssA1 expression (↑)
REG0012	Y880_02189 (gacA/uvrY)	T6SS01211 ; T6SS01212 ; T6SS01213	protein	TCS-RR	Pseudomonas aeruginosa PAK	chromosome (NZ_CP020659)	2199690..2200334 (-)	510933056	hcp expression (↓)
REG0013	Y880_03649 (suhB)	T6SS01211 ; T6SS01212 ; T6SS01213	protein	TCS regulatory pathway	Pseudomonas aeruginosa PAK	chromosome (NZ_CP020659)	3616623..3617438 (+)	489183406	Y880_02189 (gacA/uvrY) (↓)
REG0014	SMDB11_2275 (PpKA)	T6SS00929	protein	Tpp	Serratia marcescens subsp. marcescens Db11	chromosome (HG326223)	2399154..2400599 (+)	560174118	SMDB11_2267 (FHA) (↓)
REG0015	SMDB11_2268 (PppA)	T6SS00929	protein	Tpp	Serratia marcescens subsp. marcescens Db11	chromosome (HG326223)	2390232..2391005 (+)	560174111	SMDB11_2267 (FHA) (↑)
REG0016	SMDB11_2269 (RtkS)	T6SS00929	protein	Tpp	Serratia marcescens subsp. marcescens Db11	chromosome (HG326223)	2391034..2392020 (+)	560174112	SMDB11_2275 (PpKA) (↓)
REG0017	SMDB11_2256 (TagF)	T6SS00929	protein	Tpp	Serratia marcescens subsp. marcescens Db11	chromosome (HG326223)	2380702..2381421 (+)	560174099	Unknown (↑)
REG0018	PA4462 (RpoN)	T6SS00003 ; T6SS00004 ; T6SS00005	protein	Global regulator	Pseudomonas aeruginosa PAO1	chromosome (NC_002516)	4992870..4994363 (+)	15599658	PA1512 (hcpA) promotor (↓); PA5267 (hcpB) promotor (↓)
REG0019	PC1_3721 (Hfq)	T6SS01001	protein	QS regulatory pathway	Pectobacterium carotovorum subsp. carotovorum PC1	chromosome (CP001657)	4199890..4200189 (-)	251756660	hcp expression (↓)
REG0021	GPY04_RS11195 (CytR)	T6SS01168	protein	Unknown	Vibrio cholerae C6706	chromosome (NZ_CP046844)	2449479..2450486 (-)	446146597	Unknown (↓)
REG0022	GPY04_RS03590 (TfoX)	T6SS01168	protein	QS regulatory pathway	Vibrio cholerae C6706	chromosome (NZ_CP046844)	777344..777952 (+)	487807468	Unknown (↓)
REG0023	GPY04_RS00870 (HapR)	T6SS01168	protein	QS regulatory pathway	Vibrio cholerae C6706	chromosome (NZ_CP046844)	164935..165546 (-)	446262243	Unknown (↓)
REG0024	GPY04_RS13335/VC0070 (tsrA)	T6SS01168	protein	Global regulator	Vibrio cholerae C6706	chromosome (NZ_CP046844)	2888303..2888587 (+)	445982516	T6SS transcripts (↑)
REG0029	GPY04_RS15835 (luxO)	T6SS01168	protein	QS regulatory pathway	Vibrio cholerae C6706	chromosome (NZ_CP046845)	273631..274983 (-)	446367907	VC0070 (tsrA) (↑); GPY04_RS00870 (hapR) (↑)
REG0030	GPY04_RS13825 (QstR)	T6SS01168	protein	Global regulator	Vibrio cholerae C6706	chromosome (NZ_CP046844)	2994333..2994977 (-)	447111060	Unknown (↓)
REG0033	GPY04_RS01040 (ChiS)	T6SS01168	protein	ChiS-induced regulatory pathway	Vibrio cholerae C6706	chromosome (NZ_CP046844)	210606..213995 (-)	446410424	Necessory for TfoX/TfoR (↓)
REG0034	GPY04_RS03200 (chiA2)	T6SS01168	protein	ChiS-induced regulatory pathway	Vibrio cholerae C6706	chromosome (NZ_CP046844)	692014..695280 (+)	487807405	GPY04_RS01040 (ChiS) (↓)
REG0035	GPY04_RS07700 (chiA1)	T6SS01168	protein	ChiS-induced regulatory pathway	Vibrio cholerae C6706	chromosome (NZ_CP046844)	1709613..1712153 (-)	446755770	GPY04_RS01040 (ChiS) (↓)
REG0036	VC1920/VCA1552_01695 (LonA)	T6SS01112	protein	Unknown	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	1845472..1847832 (-)	446970355	Unknown (↑)
REG0037	Y880_05519 (dgcP)	T6SS01211 ; T6SS01212 ; T6SS01213	protein	c-di-GMP regulatory pathway	Pseudomonas aeruginosa PAK	chromosome (NZ_CP020659)	5487251..5489266 (-)	489205065	the levels of c-di-GMP (↓)
REG0038	PSA3335_06200 (dgcP)	T6SS01041	protein	c-di-GMP regulatory pathway	Pseudomonas savastanoi pv. savastanoi NCPPB 3335	chromosome (NZ_CP008742)	1344347..1346692 (+)	488618048	the levels of c-di-GMP (↓)
REG0039	VC_RS13930 (VasH)	T6SS00002	protein	Global regulator	Vibrio cholerae O1 biovar El Tor str. N16961	chromosome (NC_002506)	128790..130382 (+)	446006938	VCA0017 (hcp-2) transcript (↓)
REG0040	PA0592 (RsmA)	T6SS00003	protein	RsmA regulatory pathway	Pseudomonas aeruginosa PAO1	chromosome (NC_002516)	650575..651381 (-)	15595789	FHA (PA0081) (↑)
REG0041	PA5183a (RsmN)	T6SS00003	protein	RsmA regulatory pathway	Pseudomonas aeruginosa PAO1	chromosome (NC_002516)	5836470..5836685 (-)	554753081	FHA (PA0081) (↑); PA3487 (pldA) expression (↑)
REG0042	PA0075 (PppA)	T6SS00003	protein	Tpp	Pseudomonas aeruginosa PAO1	chromosome (NC_002516)	90106..90834 (-)	15595273	PA0081 (Fha-1/TagH) (↑)
REG0043	PA0074 (PpkA)	T6SS00003	protein	Tpp	Pseudomonas aeruginosa PAO1	chromosome (NC_002516)	87000..90098 (-)	15595272	PA0081 (Fha-1/TagH) (↓)
REG0044	PA2586 (gacA)	T6SS00003	protein	TCS-RR	Pseudomonas aeruginosa PAO1	chromosome (NC_002516)	2925788..2926432 (-)	15597782	hcp1 (PA0085) expression and secretion (↓)
REG0045	PA0610 (prtN)	T6SS00003	protein	TCS-HK	Pseudomonas aeruginosa PAO1	chromosome (NC_002516)	672777..673091 (-)	15595807	PA0611 (prtR) (↑)
REG0046	PA0611 (prtR)	T6SS00003	protein	TCS-RR	Pseudomonas aeruginosa PAO1	chromosome (NC_002516)	673191..673961 (-)	15595808	hcp1 (PA0085) expression and secretion (↑); PA2586 (gacA) (↑)
REG0047	PA0072 (TagS)	T6SS00003	protein	Tpp	Pseudomonas aeruginosa PAO1	chromosome (NC_002516)	85085..86284 (-)	15595270	PA0073 (TagT) (↓)
REG0048	PA0070 (TagQ)	T6SS00003	protein	Tpp	Pseudomonas aeruginosa PAO1	chromosome (NC_002516)	82404..83318 (-)	15595268	PA0071 (tagR) (↓)
REG0049	PA0073 (TagT)	T6SS00003	protein	Tpp	Pseudomonas aeruginosa PAO1	chromosome (NC_002516)	86284..87003 (-)	15595271	PA0072 (TagS) (↓)
REG0050	PA2492 (MexT)	T6SS00003	protein	Unknown	Pseudomonas aeruginosa PAO1	chromosome (NC_002516)	2807469..2808512 (+)	15597688	T6SS transcripts (↑)
REG0051	PA1006	T6SS00003	protein	Unknown	Pseudomonas aeruginosa PAO1	chromosome (NC_002516)	1090606..1090857 (+)	15596203	T6SS transcripts (↓)
REG0052	PA0071 (tagR)	T6SS00003	protein	Tpp	Pseudomonas aeruginosa PAO1	chromosome (NC_002516)	83380..85092 (-)	15595269	PA0074 (PpkA) (↓)
REG0053	PA4856 (RetS)	T6SS00003	protein	Global regulator	Pseudomonas aeruginosa PAO1	chromosome (NC_002516)	5452150..5454978 (+)	15600049	hcp1 (PA0085) expression and secretion (↑)
REG0054	PA3974 (LadS)	T6SS00003	protein	Global regulator	Pseudomonas aeruginosa PAO1	chromosome (NC_002516)	4453289..4455676 (-)	15599169	hcp1 (PA0085) expression and secretion (↓)
REG0055	PA4109 (AmpR)	T6SS00003	protein	Unknown	Pseudomonas aeruginosa PAO1	chromosome (NC_002516)	4592990..4593880 (-)	15599304	T6SS transcripts (↑)
REG0056	PA0076 (TagF)	T6SS00003	protein	Tpp	Pseudomonas aeruginosa PAO1	chromosome (NC_002516)	90844..91524 (-)	15595274	hcp1 (PA0086) secretion (↑)
REG0057	PA0081 (Fha-1/TagH)	T6SS00003	protein	Tpp	Pseudomonas aeruginosa PAO1	chromosome (NC_002516)	98263..99756 (-)	15595279	Unknown (↓); clpV (↓)
REG0058	PA2976 (RNase E)	T6SS00003	protein	Unknown	Pseudomonas aeruginosa PAO1	chromosome (NC_002516)	3332881..3336054 (+)	15598172	PA0077 (icmF1) expression (↑)
REG0061	PA0996 (pqsA)	T6SS00004	protein	Unknown	Pseudomonas aeruginosa PAO1	chromosome (NC_002516)	1078462..1080015 (+)	15596193	T6SS transcripts
REG0062	PA1244 (QslA)	T6SS00004	protein	QS regulatory pathway	Pseudomonas aeruginosa PAO1	chromosome (NC_002516)	1348060..1348401 (-)	15596441	H2-T6SS (PA1656) promotor (↑)
REG0063	PA4778 (CueR)	T6SS00004	protein	Transcription regulator	Pseudomonas aeruginosa PAO1	chromosome (NC_002516)	5366257..5366655 (+)	15599972	tssA2 (-173 to -140 relative to the ATG start codon) (↓); hcp2 (-208 to -159 relative to the ATG start codon) (↓)
REG0065	PA1430 (LasR)	T6SS00004	protein	Global regulator; QS regulatory pathway	Pseudomonas aeruginosa PAO1	chromosome (NC_002516)	1558171..1558890 (+)	15596627	H2-T6SS promotor P (hsiA2) (↓)
REG0066	PA3476 (rhlI)	T6SS00004	protein	QS regulatory pathway	Pseudomonas aeruginosa PAO1	chromosome (NC_002516)	3889139..3889744 (-)	15598672	PA3477 (RhlR) (↓)
REG0067	PA3477 (RhlR)	T6SS00004	protein	QS regulatory pathway	Pseudomonas aeruginosa PAO1	chromosome (NC_002516)	3889925..3890650 (-)	15598673	T6SS transcript (↓)
REG0068	PA4764 (Fur)	T6SS00004	protein	Global regulator	Pseudomonas aeruginosa PAO1	chromosome (NC_002516)	5351675..5352079 (-)	15599958	H2-T6SS Transcription (↑)
REG0069	PA4462 (rpoN)	T6SS00004	protein	Global regulator	Pseudomonas aeruginosa PAO1	chromosome (NC_002516)	4992870..4994363 (+)	15599658	T6SS transcript (↑)
REG0070	pa1663 (sfa2)	T6SS00004 ; T6SS00005	protein	Global regulator; QS regulatory pathway	Pseudomonas aeruginosa PAO1	chromosome (NC_002516)	1813395..1814906 (+)	15596860	PA4462 (rpoN) (↑); T6SS transcript (↑); T6SS transcript (↓)
REG0071	Z4049 (RpoS)	T6SS00006	protein	Global regulator	Escherichia coli O157:H7 str. EDL933	chromosome (NC_002655)	3654380..3655372 (-)	446003635	Z1921 (KatN) (↓)
REG0072	Z5519 (OxyR)	T6SS00006	protein	Global regulator	Escherichia coli O157:H7 str. EDL933	chromosome (NC_002655)	5033893..5034810 (+)	446948683	Z1921 (KatN) (↓)
REG0073	Z2013 (hns)	T6SS00006	protein	Global regulator	Escherichia coli O157:H7 str. EDL933	chromosome (NC_002655)	1829490..1829903 (-)	447210122	Z0264 (hcp-2) (↑)
REG0074	PP_4373 (FleQ)	T6SS00014	protein	c-di-GMP regulatory pathway	Pseudomonas putida KT2440	chromosome (NC_002947)	4963882..4965357 (-)	26991062	K1-T6SS (hcp1) expression (↑)
REG0075	PP_0952 (RopN)	T6SS00014	protein	c-di-GMP regulatory pathway	Pseudomonas putida KT2440	chromosome (NC_002947)	1094567..1096060 (-)	26987688	PP_4373 (FleQ) (↑)
REG0076	PP_0914 (BifA)	T6SS00014	protein	c-di-GMP regulatory pathway	Pseudomonas putida KT2440	chromosome (NC_002947)	1055990..1058071 (-)	26987650	the levels of c-di-GMP (↓)
REG0077	Atu4335 (Fha/TagH)	T6SS00016	protein	Tpp	Agrobacterium fabrum str. C58	chromosome (NC_003063)	1467064..1468263 (-)	499280697	Unknown (↓)
REG0078	Atu4330 (PpkA)	T6SS00016	protein	Tpp	Agrobacterium fabrum str. C58	chromosome (NC_003063)	1458366..1459271 (-)	737274050	Unknown (↓)
REG0079	Atu4331 (TagF-PppA)	T6SS00016	protein	Tpp	Agrobacterium fabrum str. C58	chromosome (NC_003063)	1459258..1460673 (-)	159186120	Fha (Atu4335) (↑)
REG0080	Atu2091	T6SS00016	protein	c-di-GMP regulatory pathway	Agrobacterium fabrum str. C58	chromosome (NC_003063)	2054055..2054864 (-)	159185045	the levels of c-di-GMP (↑)
REG0081	Atu5372	T6SS00016	protein	c-di-GMP regulatory pathway	Agrobacterium fabrum str. C58	chromosome (NC_003064)	363293..364387 (+)	1805892863	the levels of c-di-GMP (↑)
REG0082	Atu1257 (DgcA)	T6SS00016	protein	c-di-GMP regulatory pathway	Agrobacterium fabrum str. C58	chromosome (NC_003062)	1244567..1245814 (-)	159184686	the levels of c-di-GMP (↑)
REG0083	Atu2179 (DgcC)	T6SS00016	protein	c-di-GMP regulatory pathway	Agrobacterium fabrum str. C58	chromosome (NC_003062)	2154605..2155744 (-)	159185090	the levels of c-di-GMP (↑)
REG0084	chvG	T6SS00016	protein	TCS-HK	Agrobacterium fabrum str. C58	chromosome (NC_003062)	34679..36469 (-)		chvI (↓)
REG0085	chvI	T6SS00016	protein	TCS-RR	Agrobacterium fabrum str. C58	chromosome (NC_003062)	36525..37250 (-)		The intergenic region of the imp and hcp operons (↓)
REG0086	exoR	T6SS00016	protein	TCS regulatory pathway	Agrobacterium fabrum str. C58	chromosome (NC_003062)	1702398..1703192 (-)		chvG (↑)
REG0087	STM1751 (H-NS)	T6SS00023	protein	Global regulator	Salmonella enterica subsp. enterica serovar Typhimurium str. LT2	chromosome (NC_003197)	1847277..1847690 (+)	16765095	STM0272 (ClpV) promotor (↑); STM0279 (hcp) promotor (↑); STM0285 promotor (↑); STM0289 (VgrG) promotor (↑); STM0268 promotor (↑)
REG0088	STM0693 (Fur)	T6SS00023	protein	Global regulator	Salmonella enterica subsp. enterica serovar Typhimurium str. LT2	chromosome (NC_003197)	756397..756849 (-)	16764063	STM0272 (ClpV) promoter (↑)
REG0089	xac4129 (ecfK/RpoE,ECF σ factor)	T6SS00028	protein	Unknown	Xanthomonas citri pv. citri str. 306	chromosome (NC_003919)	4850278..4850805 (+)	489582896	Unknown (↓)
REG0090	xac4127 (PknS)	T6SS00028	protein	Unknown	Xanthomonas citri pv. citri str. 306	chromosome (NC_003919)	4846892..4849411 (-)	505284326	Unknown (↓)
REG0091	PFL_RS17995 (gacA/uvrY/SirA)	T6SS00035	protein	TCS-RR	Pseudomonas protegens Pf-5	chromosome (NC_004129)	4110513..4111154 (-)	499374263	T6SS transcripts (↓)
REG0092	PFL_RS30815 (pppA)	T6SS00035	protein	Tpp	Pseudomonas protegens Pf-5	chromosome (NC_004129)	6902924..6903658 (-)	499376669	Hcp secretion (↑)
REG0093	ECA_RS00520 (expI)	T6SS00040	protein	QS regulatory pathway	Pectobacterium atrosepticum SCRI1043	chromosome (NC_004547)	125689..126339 (+)	499404281	T6SS transcripts (ECA4275[hcp1], ECA3428[hcp2] and ECA2866[hcp3]) (↓)
REG0094	ECA3435 (bEBP/VasH)	T6SS00040	protein	Global regulator	Pectobacterium atrosepticum SCRI1043	chromosome (NC_004547)	3850745..3852298 (-)	499407476	T6SS gene cluster promoter (PECA3445) (↓); Hcp gene cluster promoter (PECA4275) (↓); Hcp gene cluster promoter (PECA2866) (↓)
REG0095	ECA0288 (rpoN)	T6SS00040	protein	Global regulator	Pectobacterium atrosepticum SCRI1043	chromosome (NC_004547)	336007..337440 (-)	499404454	T6SS gene cluster promoter (PECA3445) (↓); Hcp gene cluster promoter (PECA4275) (↓); Hcp gene cluster promoter (PECA2866) (↓)
REG0096	PSPTO_RS08845 (relA)	T6SS00041 ; T6SS00042	protein	(p)ppGpp regulatory pathway	Pseudomonas syringae pv. tomato str. DC3000	chromosome (NC_004578)	1863879..1866122 (+)	494457621	T6SS transcripts (↓)
REG0097	PSPTO_RS00410 (spoT)	T6SS00041 ; T6SS00042	protein	(p)ppGpp regulatory pathway	Pseudomonas syringae pv. tomato str. DC3000	chromosome (NC_004578)	94805..96910 (-)	492171753	T6SS transcripts (↓)
REG0098	PSPTO_RS04545 (fpRel)	T6SS00041 ; T6SS00042	protein	(p)ppGpp regulatory pathway	Pseudomonas syringae pv. tomato str. DC3000	chromosome (NC_004578)	927082..927900 (+)	499415849	T6SS transcripts (↓)
REG0099	PSPTO_RS28060 (Sfa)	T6SS00041 ; T6SS00042	protein	Global regulator	Pseudomonas syringae pv. tomato str. DC3000	chromosome (NC_004578)	6165047..6166564 (-)	499418021	T6SS transcripts (↓)
REG0100	VP_RS12495 (barA)	T6SS00043 ; T6SS00044	protein	TCS-HK	Vibrio parahaemolyticus RIMD 2210633	chromosome (NC_004603)	2712492..2715290 (+)	491625032	Hcp expression and secretion (↓)
REG0101	VP_RS09470 (UvrY)	T6SS00043 ; T6SS00044	protein	TCS-RR	Vibrio parahaemolyticus RIMD 2210633	chromosome (NC_004603)	2037468..2038112 (-)	491529158	CsrB (↓)
REG0102	VP_RS12395 (CsrA)	T6SS00043 ; T6SS00044	protein	carbon storage regulatory pathway	Vibrio parahaemolyticus RIMD 2210633	chromosome (NC_004603)	2688313..2688510 (-)	490550575	Hcp and vgrG expression and secretion (↓)
REG0106	vp2049 (Thymidylate kinase, Tmk)	T6SS00043	protein	Unknown	Vibrio parahaemolyticus RIMD 2210633	chromosome (NC_004603)	2150113..2150745 (-)	28898823	T6SS1 (VgrG1) expression and secretion (↓)
REG0107	VP1028 (TfoY)	T6SS00043	protein	c-di-GMP regulatory pathway	Vibrio parahaemolyticus RIMD 2210633	chromosome (NC_004603)	1077946..1078536 (-)	28897802	T6SS1 (VgrG1) expression and secretion (↓)
REG0108	vp1391	T6SS00043	protein	Global regulator	Vibrio parahaemolyticus RIMD 2210633	chromosome (NC_004603)	1491226..1492857 (-)	28898165	T6SS1 (VgrG1) expression and secretion (↓)
REG0109	vp1407	T6SS00043	protein	Unknown	Vibrio parahaemolyticus RIMD 2210633	chromosome (NC_004603)	1511565..1512017 (-)	28898181	T6SS1 (VgrG1) expression and secretion (↓)
REG0110	VP1133 (hns)	T6SS00043	protein	Global regulator	Vibrio parahaemolyticus RIMD 2210633	chromosome (NC_004603)	1189718..1190125 (-)	28897907	VP1028 (TfoY) (↑)
REG0111	VP2762 (AphA)	T6SS00043 ; T6SS00044	protein	QS regulatory pathway	Vibrio parahaemolyticus RIMD 2210633	chromosome (NC_004603)	2929909..2930448 (+)	28899536	T6SS1 transcript (↑); T6SS2 (VPA1027-1024, VPA1043-1028,VPA1044-1046) transcripts (↑)
REG0112	VP2516 (opaR)	T6SS00043 ; T6SS00044	protein	QS regulatory pathway	Vibrio parahaemolyticus RIMD 2210633	chromosome (NC_004603)	2653215..2653829 (+)	28899290	vp1407 (↑); VP1388 promotor (↑); VP1400 promotor (↑); VP1409 promotor (↑); T6SS2 (Hcp2) expression and secretion (↓); VPA1027-1024 transcript (↓); VPA1027-1024 transcript (↓); VPA1027-1024 transcript (↓); VPA1043-1028 transcript (↓); VPA1044-1046 transcript (↓)
REG0114	VP0820 (ToxR)	T6SS00043	protein	Transcription regulator	Vibrio parahaemolyticus RIMD 2210633	chromosome (NC_004603)	847892..848770 (-)	28897594	VP1400 promotor (↑); VP1409 promotor (↑)
REG0115	VP0350 (CalR/LeuO)	T6SS00044	protein	Transcription regulator	Vibrio parahaemolyticus RIMD 2210633	chromosome (NC_004603)	344763..345722 (+)	28897124	VPA1027 (hcp2) promotor (↓); VPA1043 (Fha) promotor (↓); VP1133 (H-NS) (↓)
REG0116	VPA1088 (cdpA)	T6SS00043	protein	c-di-GMP regulatory pathway	Vibrio parahaemolyticus RIMD 2210633	chromosome (NC_004605)	1147728..1150091 (+)	28900943	VP1028 (TfoY) (↑)
REG0117	VPA0739 (vdcA)	T6SS00043	protein	c-di-GMP regulatory pathway	Vibrio parahaemolyticus RIMD 2210633	chromosome (NC_004605)	772439..773809 (+)	28900594	VP1028 (TfoY) (↓)
REG0118	VP2516 (OpaR)	T6SS00043	protein	Global regulator	Vibrio parahaemolyticus RIMD 2210633	chromosome (NC_004603)	2653215..2653829 (+)	28899290	T6SS1 (↓)
REG0119	VP1241 (TfoX)	T6SS00044 ; T6SS00043	protein	QS regulatory pathway; c-di-GMP regulatory pathway	Vibrio parahaemolyticus RIMD 2210633	chromosome (NC_004603)	1309223..1309810 (+)	28898016	T6SS2 (↓); T6SS1 (↓)
REG0120	CV_RS20220 (CviR)	T6SS00049	protein	QS regulatory pathway	Chromobacterium violaceum ATCC 12472	chromosome (NC_005085)	4426186..4427046 (+)	1169634970	CV_RS06990 (VgrG) promotor (↓)
REG0121	CV_RS23145 (CviI)	T6SS00049	protein	QS regulatory pathway	Chromobacterium violaceum ATCC 12472	chromosome (NC_005085)	4426967..4427620 (-)	499450174	CV_RS20220 (CviR) (↓)
REG0122	VF2177 (LitR)	T6SS00084	protein	QS regulatory pathway	Aliivibrio fischeri ES114	chromosome (NC_006840)	2446537..2447142 (+)	59712784	Unknown (↓)
REG0123	VF0896 (TfoX)	T6SS00084	protein	Global regulator	Aliivibrio fischeri ES114	chromosome (NC_006840)	986000..986629 (+)	59711503	T6SS transcripts (↓)
REG0124	VFFQA001_02105 (rpoN)	T6SS01277	protein	Global regulator	Aliivibrio fischeri strain FQ-A001	chromosome (NZ_SJSX01000002)	62995..64464 (-)	501526930	hcp1/hcp transcript (↓)
REG0125	VFFQA001_15620 (VasH)	T6SS01278	protein	Global regulator	Aliivibrio fischeri strain FQ-A001	chromosome (NZ_SJSX01000004)	359608..360108 (+)	1027725198	Unknown (↓)
REG0126	BMAA1517	T6SS00070	protein	Transcription regulator	Burkholderia mallei ATCC 23344	chromosome (NC_006349)	1646532..1647593 (-)	499517952	Hcp1 (BMAA0742) expression (↓)
REG0127	BMAA0746 (VirG)	T6SS00070	protein	TCS-RR	Burkholderia mallei ATCC 23344	chromosome (NC_006349)	764773..765510 (+)	490311617	Hcp1 (BMAA0742) expression (↓)
REG0128	BMAA0745 (VirA)	T6SS00070	protein	TCS-HK	Burkholderia mallei ATCC 23344	chromosome (NC_006349)	762932..764776 (+)	490305845	Hcp1 (BMAA0742) expression (↓)
REG0129	BMAA0746 (VirG)	T6SS00070	protein	TCS-RR	Burkholderia mallei ATCC 23344	chromosome (NC_006349)	764773..765510 (+)	53717366	BMAA0742 (Hcp1) expression (↓); BMAA0729.1 (TssM1) expression (↓)
REG0130	BMAA0745 (VirA)	T6SS00070	protein	TCS-HK	Burkholderia mallei ATCC 23344	chromosome (NC_006349)	763148..764776 (+)	53717365	BMAA0746 (VirG) (↓)
REG0131	BPSL3431 (TctR)	T6SS00074	protein	Unknown	Burkholderia pseudomallei K96243	chromosome (NC_006350)	4073388..4074029 (-)	53721038	T6SS-2 (hcp2) transcript (↑)
REG0132	BPSL2246 (PpiB)	T6SS00076 ; T6SS00077	protein	Unknown	Burkholderia pseudomallei K96243	chromosome (NC_006350)	2708622..2709113 (+)	53719855	T6SS-3 (BPSS2099/TssCIII and BPSS2098/HcpIII) expression (↑); T6SS-6 (hcp6) transcript (↓)
REG0133	BPSS1504	T6SS00077	protein	Unknown	Burkholderia pseudomallei K96243	chromosome (NC_006351)	2052905..2055547 (+)	499518990	hcp1 secretion
REG0134	BPSS1546 (BsaN)	T6SS00077	protein	BsaN regulon	Burkholderia pseudomallei K96243	chromosome (NC_006351)	2100565..2101230 (-)	490660320	BPSS1495 (virA) promotor (↓)
REG0135	BPS_RS27070 (bicA)	T6SS00077	protein	BsaN regulon	Burkholderia pseudomallei K96243	chromosome (NC_006351)	2087441..2087956 (-)	490293043	BPSS 1495(virA) (↓)
REG0136	BPS_RS27175 (bprP)	T6SS00077	protein	BsaN regulon	Burkholderia pseudomallei K96243	chromosome (NC_006351)	2105881..2106081 (+)	490293055	BPSS1546 (BsaN) (↓)
REG0137	BPSS1495 (virA)	T6SS00077	protein	TCS-RR; BsaN regulon	Burkholderia pseudomallei K96243	chromosome (NC_006351)	2038711..2040555 (-)	499518988	T6SS-1 transpript (↓)
REG0138	BPSS1494 (virG)	T6SS00077	protein	TCS-HK; BsaN regulon	Burkholderia pseudomallei K96243	chromosome (NC_006351)	2037977..2038714 (-)	490663798	BPSS1495 (virA) (↓)
REG0139	BPSL1105 (bprP)	T6SS00077	protein	bspR-dependent signalling cascade	Burkholderia pseudomallei K96243	chromosome (NC_006350)	1275668..1276300 (+)	490290369	tssA expression (↓)
REG0140	bprp	-	protein	bspR-dependent signalling cascade	Burkholderia pseudomallei strain KHW	chromosome (HM447214)	175..1146 (+)	298239796	tssA expression (↓)
REG0141	bsaN	-	protein	bspR-dependent signalling cascade	Burkholderia pseudomallei strain KHW	chromosome (-)	-	-	tssA expression (↓)
REG0142	bspR	-	protein	bspR-dependent signalling cascade	Burkholderia pseudomallei strain KHW	chromosome (HM358865)	258..890 (+)	298239780	tssA expression (↓)
REG0143	bprc	-	protein	bspR-dependent signalling cascade	Burkholderia pseudomallei strain KHW	chromosome (-)	-	-	tssA expression (↓)
REG0144	BPSS1520 (bprC)	T6SS00077	protein	bspR-dependent signalling cascade	Burkholderia pseudomallei K96243	chromosome (NC_006351)	2072125..2073186 (-)	499518995	tssA expression (↓)
REG0145	BPSS1495 (virA)	T6SS00077	protein	TCS-HK	Burkholderia pseudomallei K96243	chromosome (NC_006351)	2038711..2040555 (-)	53722517	hcp1 expression (↓)
REG0146	BPSS1494 (virG)	T6SS00077	protein	TCS-RR	Burkholderia pseudomallei K96243	chromosome (NC_006351)	2037977..2038714 (-)	53722516	hcp1 expression (↓)
REG0147	FTT1557c/FNU0663.2 (pmrA)	T6SS00081	protein	TCS-RR	Francisella tularensis subsp. tularensis SCHU S4	chromosome (NC_006570)	1618742..1619428 (-)	489108239	T6SS transcription (↓)
REG0148	PSYR_RS19090 (relA)	T6SS00086	protein	(p)ppGpp regulatory pathway	Pseudomonas syringae pv. syringae B728a	chromosome (NC_007005)	4380642..4382885 (-)	499587809	T6SS transcripts (↓)
REG0149	PSYR_RS01070 (spoT)	T6SS00086	protein	(p)ppGpp regulatory pathway	Pseudomonas syringae pv. syringae B728a	chromosome (NC_007005)	223004..225109 (-)	489499092	T6SS transcripts (↓)
REG0150	Psyr_3698 (gacS)	T6SS00086	protein	TCS-HK	Pseudomonas syringae pv. syringae B728a	chromosome (NC_007005)	4385550..4388303 (+)	499587812	T6SS transcription (↓)
REG0151	Psyr_4339 (ladS)	T6SS00086	protein	QS regulatory pathway	Pseudomonas syringae pv. syringae B728a	chromosome (NC_007005)	5191591..5193585 (-)	639463044	T6SS transcription (↓)
REG0152	Psyr_4408 (retS)	T6SS00086	protein	QS regulatory pathway	Pseudomonas syringae pv. syringae B728a	chromosome (NC_007005)	5270882..5273671 (+)	489494774	T6SS transcription (↑)
REG0153	BTH_I1281 (OxyR)	T6SS00114	protein	Global regulator	Burkholderia thailandensis E264	chromosome (NC_007651)	1432632..1433591 (+)	497575020	BTH_RS09735 (T6SS-4) Promotor,−536 to −186 relative to the ATG start codon (↑)
REG0154	BTH_I0691 (Zur)	T6SS00114	protein	Global regulator	Burkholderia thailandensis E264	chromosome (NC_007651)	796074..796538 (-)	497578547	BTH_RS09735 (T6SS-4) Promotor,−541 to −1 relative to the ATG start codon (↑)
REG0155	BTH_II1510 (BtaR1)	T6SS00115	protein	QS regulatory pathway	Burkholderia thailandensis E264	chromosome (NC_007650)	1779070..1779789 (-)	497583165	BTH_I2691/BTH_I2693-99/BTH_I2701-702 (↓)
REG0156	pvfC	T6SS00125	protein	Global regulator	Pseudomonas entomophila L48	chromosome (NC_008027)	-	-	T6SS secreted proteome (↓)
REG0157	rmsF	T6SS00150	protein	RsmA regulatory pathway	Pseudomonas aeruginosa PA103	chromosome (NZ_JARI00000000)	-	-	tssA1 RNA (↑); RsmY/Z (↑)
REG0158	PA14_52570 (RsmA)	T6SS00150	protein	RsmA regulatory pathway	Pseudomonas aeruginosa UCBPP-PA14	chromosome (NC_008463)	4660393..4660578 (-)	489176459	RSMF (↑); tssA1 RNA (↑); RSMA (↑)
REG0159	PA14_RS20260/PA1120 (YfiN/TpbB)	T6SS00150	protein	c-di-GMP regulatory pathway	Pseudomonas aeruginosa UCBPP-PA14	chromosome (NC_008463)	4435431..4436738 (-)	489207392	Hcp1 production (↓)
REG0160	PA14_RS15060 (PA2133 phosphodiesterase)	T6SS00150	protein	c-di-GMP regulatory pathway	Pseudomonas aeruginosa UCBPP-PA14	chromosome (NC_008463)	3294000..3294857 (-)	489200657	Hcp1 production (↑)
REG0161	PA14_RS06615 (WspR)	T6SS00150	protein	c-di-GMP regulatory pathway	Pseudomonas aeruginosa UCBPP-PA14	chromosome (NC_008463)	1413158..1414201 (+)	489183089	Hcp1 production (↓)
REG0164	PA14_RS05020 (LadS)	T6SS00150	protein	QS regulatory pathway	Pseudomonas aeruginosa UCBPP-PA14	chromosome (NC_008463)	1069280..1071716 (+)	15599169	Unknown
REG0165	PA14_64230 (RetS)	T6SS00150	protein	QS regulatory pathway	Pseudomonas aeruginosa UCBPP-PA14	chromosome (NC_008463)	5722815..5725643 (+)	489202068	Unknown
REG0166	PA14_45960 (lasR)	T6SS00152 ; T6SS00151 ; T6SS00150	protein	QS regulatory pathway	Pseudomonas aeruginosa UCBPP-PA14	chromosome (NC_008463)	4085339..4086058 (-)	489173455	TssA2 (PA14_43050) promotor (↓); HSI-III transcripts (↓); HSI-I transcripts (↑)
REG0167	PA14_51340 (MvfR)	T6SS00152 ; T6SS00151 ; T6SS00150	protein	QS regulatory pathway	Pseudomonas aeruginosa UCBPP-PA14	chromosome (NC_008463)	4562837..4563835 (+)	489176730	Upstream of pqs operon (↓); HSI-III transcripts (↓); HSI-I transcripts (↑)
REG0168	PA14_51380 (pqsE)	T6SS00150 ; T6SS00152	protein	QS regulatory pathway	Pseudomonas aeruginosa UCBPP-PA14	chromosome (NC_008463)	4566077..4566982 (-)	489176725	T6SS Transciption (↓)
REG0169	PA14_22470 (PA3225)	T6SS00150 ; T6SS00152 ; T6SS00151	protein	Global regulator	Pseudomonas aeruginosa UCBPP-PA14	chromosome (NC_008463)	1955624..1956553 (-)	489182081	PA14_00990 (TssA) promotor (↓); TssA1 (PA14_00990) transcript (↑); TssA2 (PA14_43050) transcript (↑); TssB3 (PA14_34070) transcript (↑)
REG0170	PA14_20290 (AmrZ)	T6SS00150 ; T6SS00152 ; T6SS00151	protein	Global regulator	Pseudomonas aeruginosa UCBPP-PA14	chromosome (NC_008463)	1747602..1747928 (-)	489182353	TssA1 (PA14_00990) promotor (↓); TssA2 (PA14_43050) promotor (↑); TssB3 (PA14_34070) promotor (↓)
REG0171	APECO1_487 (FNR)	T6SS00155	protein	Global regulator	Escherichia coli APEC O1	chromosome (NC_008563)	1455411..1456163 (-)	446534565	APECO1_1756 (VgrG1) (↓)
REG0172	PA14_48150 (QslA)	T6SS00152	protein	QS regulatory pathway	Pseudomonas aeruginosa UCBPP-PA14	chromosome (NC_008463)	4286222..4286536 (+)	489177206	H2-T6SS (PA14_43050) promotor (↑)
REG0173	FTN_RS06610 (mglA)	T6SS00158	protein	TCS regulatory pathway	Francisella tularensis subsp. novicida U112	chromosome (NC_008601)	1362282..1362899 (+)	489124662	iglC transcription (↓); Unknown (↓)
REG0174	FTN_RS02845 (SspA)	T6SS00158	protein	TCS regulatory pathway	Francisella tularensis subsp. novicida U112	chromosome (NC_008601)	574840..575472 (+)	500053699	FTN_1465 (pmrA) (↓)
REG0175	FTN_RS08805 (KdpD)	T6SS00158	protein	TCS-HK	Francisella tularensis subsp. novicida U112	chromosome (NC_008601)	1838601..1841282 (-)	489131611	FTN_1465 (pmrA) (↓)
REG0176	FTN_1465 (pmrA)	T6SS00158	protein	TCS-RR; TCS regulatory pathway	Francisella tularensis subsp. novicida U112	chromosome (NC_008601)	1553358..1554044 (-)	489108239	FTN_1465 (pmrA) promotor (↓); pdpD promotor (↓); IglA expression (↓)
REG0177	FTN_RS06615 (mglB)	T6SS00158	protein	Global regulator; TCS regulatory pathway	Francisella tularensis subsp. novicida U112	chromosome (NC_008601)	1362901..1363308 (+)	489112095	IglA expression (↓); T6SS Transciption (↓)
REG0178	FTN_0480 (fevR/PigR)	T6SS00158	protein	TCS regulatory pathway	Francisella tularensis subsp. novicida U112	chromosome (NC_008601)	486541..486876 (+)	489108070	T6SS Transciption (↓)
REG0180	VC0395_RS17530 (TsrA)	T6SS00208 ; T6SS00487	protein	Global regulator	Vibrio cholerae O395	chromosome (NC_009457)	2598392..2598676 (-)	445982516	T6SS Transciption (↑)
REG0181	VC0395_0020/VCA0117 (bEBP/vasH)	T6SS00208	protein	Global regulator	Vibrio cholerae O395	chromosome (NC_009456)	22315..23907 (-)	446006938	T6SS gene cluster promoter (PVCA0107/VC0395_RS00160) (↓)
REG0182	VC0395_A2109 (rpoN)	T6SS00208	protein	Global regulator	Vibrio cholerae O395	chromosome (NC_009457)	2265078..2266541 (+)	446727517	T6SS gene cluster promoter (PVCA0107/VC0395_RS00160) (↓); hcp promoter (PVCA0017/VC0395_0116) (↓)
REG0183	Mmwyl1_1758 (bEBP/vasH)	T6SS00216	protein	Global regulator	Marinomonas sp. MWYL1	chromosome (NC_009654)	1985170..1986666 (+)	501016781	T6SS gene cluster promoter (PMWYL1196/PMWYL1195) (↓)
REG0184	Mmwyl1_2418 (RpoN)	T6SS00216	protein	Global regulator	Marinomonas sp. MWYL1	chromosome (NC_009654)	2725212..2726687 (+)	501017436	T6SS gene cluster promoter (PMWYL1196/PMWYL1195) (↓)
REG0185	YpsIP31758_3980 (ompR)	T6SS00225	protein	TCS-RR	Yersinia pseudotuberculosis IP 31758	chromosome (NC_009708)	4465260..4465979 (-)	490527984	T6SS-4 promoter (↓)
REG0186	YpsIP31758_3441 (lptD)	T6SS00225	protein	Unknown	Yersinia pseudotuberculosis IP 31758	chromosome (NC_009708)	3878499..3880841 (+)	499505072	YpsIP31758_3980 (ompR) (↓)
REG0187	YPK_3449 (RelA)	T6SS00260	protein	(p)ppGpp regulatory pathway	Yersinia pseudotuberculosis YPIII	chromosome (NC_010465)	3783755..3785989 (-)	488138165	YPK_1551 (RovM) (↓); YPK_1876 (RovA) (↓)
REG0188	YPK_1876 (RovA)	T6SS00260	protein	(p)ppGpp regulatory pathway	Yersinia pseudotuberculosis YPIII	chromosome (NC_010465)	2082384..2082815 (+)	488139747	T6SS-4 promoter region (↓); T6SS-4 promoter region (↓)
REG0189	YPK_4079 (OxyR)	T6SS00260	protein	Global regulator	Yersinia pseudotuberculosis YPIII	chromosome (NC_010465)	4502978..4503895 (-)	488138270	T6SS-4 promoter region (↓)
REG0190	ypk_3425 (RpoS)	T6SS00260	protein	Global regulator	Yersinia pseudotuberculosis YPIII	chromosome (NC_010465)	3759239..3760237 (-)	499505140	T6SS-4 promoter region (↓)
REG0191	YPK_1551 (RovM)	T6SS00260	protein	(p)ppGpp regulatory pathway	Yersinia pseudotuberculosis YPIII	chromosome (NC_010465)	1713682..1714884 (-)	499506038	T6SS-4 promoter region (↓)
REG0192	YPK_3567 (RovC)	T6SS00260	protein	carbon storage regulatory pathway	Yersinia pseudotuberculosis YPIII	chromosome (NC_010465)	3929654..3930397 (+)	170025782	YPK_3567 promotor (↓)
REG0193	YPK_3372 (CsrA)	T6SS00260	protein	carbon storage regulatory pathway	Yersinia pseudotuberculosis YPIII	chromosome (NC_010465)	3698608..3698793 (-)	169752121	YPK_3567 (RovC) (↑); YPK_3563 transcript (↑)
REG0194	YPK_2462 (HpaR)	T6SS00260	protein	Global regulator	Yersinia pseudotuberculosis YPIII	chromosome (NC_010465)	2695107..2695574 (+)	169751221	T6SS4 promoter (↓)
REG0195	YPK_RS08345 (YpsR)	T6SS00256	protein	QS regulatory pathway	Yersinia pseudotuberculosis YPIII	chromosome (NC_010465)	1837676..1838413 (+)	488140651	T6SS transcripts (↓)
REG0196	YPK_RS03965 (YtbR)	T6SS00256	protein	QS regulatory pathway	Yersinia pseudotuberculosis YPIII	chromosome (NC_010465)	900476..901219 (+)	488140447	T6SS transcripts (↓)
REG0197	YPK_RS08350 (ypsI)	T6SS00256	protein	QS regulatory pathway	Yersinia pseudotuberculosis YPIII	chromosome (NC_010465)	1838406..1839050 (-)	501053391	T6SS transcripts (↓)
REG0198	YPK_RS03970 (ytbI)	T6SS00256 ; T6SS00260	protein	QS regulatory pathway	Yersinia pseudotuberculosis YPIII	chromosome (NC_010465)	901200..901850 (-)	488144695	T6SS transcripts (↓); T6SS4 transcripts and hcp secretion (↓)
REG0199	YPK_RS00840 (OmpR)	T6SS00260	protein	TCS-RR	Yersinia pseudotuberculosis YPIII	chromosome (NC_010465)	223260..223979 (+)	488137706	T6SS4 promoter (↓)
REG0200	YPK_RS01520 (ZntR)	T6SS00260	protein	Global regulator	Yersinia pseudotuberculosis YPIII	chromosome (NC_010465)	333471..333896 (+)	488144494	T6SS4 promoter (↓)
REG0201	PMI0271 (MrpJ)	T6SS00272	protein	Global regulator	Proteus mirabilis HI4320	chromosome (NC_010554)	318458..318781 (+)	490365253	PMI0749 (tssA); PMI2990 (idsA/hcp)
REG0202	PXO_RS20535	T6SS00287	protein	Unknown	Xanthomonas oryzae pv. oryzae PXO99A	chromosome (NC_010717)	4488457..4488843 (-)	499576999	Unknown (↓)
REG0203	KP1_3314 (hns)	T6SS00344	protein	Global regulator	Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044	chromosome (NC_012731)	3140175..3140582 (+)	238895262	KP1_2392 (TssB) promotor (↑); KP1_2392 (hcp) (↑)
REG0204	NT01EI_RS04325 (EsrB)	T6SS00346	protein	TCS-RR	Edwardsiella ictaluri 93-146	chromosome (NC_012779)	955101..955745 (-)	506350644	T6SS translocon protein EvpC secretion (↓)
REG0205	NT01EI_RS04200 (EsrC)	T6SS00346	protein	TCS regulatory pathway	Edwardsiella ictaluri 93-146	chromosome (NC_012779)	933326..934018 (-)	737638726	T6SS translocon protein EvpC secretion (↓)
REG0206	ETAE_2873 (RpoS)	T6SS00372	protein	TCS regulatory pathway	Edwardsiella tarda EIB202	chromosome (NC_013508)	3025094..3026080 (-)	502612732	ETAE_0886 (esrB) promoter (↑)
REG0207	ETAE_0035	T6SS00372	protein	TCS regulatory pathway	Edwardsiella tarda EIB202	chromosome (NC_013508)	35881..37008 (+)	502609898	ETAE_0886 (esrB) promoter (↑)
REG0208	ETAE_0154 (hemB)	T6SS00372	protein	TCS regulatory pathway	Edwardsiella tarda EIB202	chromosome (NC_013508)	159867..160889 (+)	502610017	ETAE_0886 (esrB) promoter (↑)
REG0209	ETAE_0743 (cdsA)	T6SS00372	protein	TCS regulatory pathway	Edwardsiella tarda EIB202	chromosome (NC_013508)	820052..820909 (+)	502610607	ETAE_0886 (esrB) promoter (↑)
REG0210	ETAE_2082 (pyrF)	T6SS00372	protein	TCS regulatory pathway	Edwardsiella tarda EIB202	chromosome (NC_013508)	2196136..2196858 (-)	502611934	ETAE_0886 (esrB) promoter (↑)
REG0211	ETAE_1096 (dapA)	T6SS00372	protein	TCS regulatory pathway	Edwardsiella tarda EIB202	chromosome (NC_013508)	1194778..1195659 (+)	502610962	ETAE_0886 (esrB) promoter (↑)
REG0212	ETAE_2697 (cysS)	T6SS00372	protein	TCS regulatory pathway	Edwardsiella tarda EIB202	chromosome (NC_013508)	2831230..2832615 (-)	502612557	ETAE_0886 (esrB) promoter (↑)
REG0213	ETAE_1760	T6SS00372	protein	TCS regulatory pathway	Edwardsiella tarda EIB202	chromosome (CP001135)	1870377..1870535 (+)	267984768	ETAE_0886 (esrB) promoter (↑)
REG0214	ETAE_1837	T6SS00372	protein	TCS regulatory pathway	Edwardsiella tarda EIB202	chromosome (CP001135)	1946159..1946284 (-)	267984845	ETAE_0886 (esrB) promoter (↑)
REG0215	ETAE_1202 (ugd)	T6SS00372	protein	TCS regulatory pathway	Edwardsiella tarda EIB202	chromosome (NC_013508)	1306603..1307769 (+)	502611067	ETAE_0886 (esrB) promoter (↑)
REG0216	ETAE_2640 (holA)	T6SS00372	protein	TCS regulatory pathway	Edwardsiella tarda EIB202	chromosome (NC_013508)	2779832..2780866 (+)	502612494	ETAE_0886 (esrB) promoter (↑)
REG0217	ETAE_1439 (ruvA)	T6SS00372	protein	TCS regulatory pathway	Edwardsiella tarda EIB202	chromosome (NC_013508)	1550776..1551384 (+)	502611302	ETAE_0886 (esrB) promoter (↑)
REG0218	ETAE_0358 (purA)	T6SS00372	protein	TCS regulatory pathway	Edwardsiella tarda EIB202	chromosome (NC_013508)	403538..404836 (+)	502610221	ETAE_0886 (esrB) promoter (↑)
REG0219	ETAE_2813 (iscA)	T6SS00372	protein	TCS regulatory pathway	Edwardsiella tarda EIB202	chromosome (NC_013508)	2952011..2952334 (-)	491431780	ETAE_0886 (esrB) promoter (↑)
REG0220	ETAE_2787 (guaB)	T6SS00372	protein	TCS regulatory pathway	Edwardsiella tarda EIB202	chromosome (NC_013508)	2925310..2926776 (-)	502612646	ETAE_0886 (esrB) promoter (↑)
REG0221	ETAE_1412	T6SS00372	protein	TCS regulatory pathway	Edwardsiella tarda EIB202	chromosome (NC_013508)	1522924..1523409 (-)	502611274	ETAE_0886 (esrB) promoter (↑)
REG0222	ETAE_0430	T6SS00372	protein	TCS regulatory pathway	Edwardsiella tarda EIB202	chromosome (NC_013508)	473075..473755 (-)	502610291	ETAE_0886 (esrB) promoter (↑)
REG0223	ETAE_0659 (aceE)	T6SS00372	protein	TCS regulatory pathway	Edwardsiella tarda EIB202	chromosome (NC_013508)	731608..734271 (+)	502610523	ETAE_0886 (esrB) promoter (↑)
REG0224	ETAE_2773 (mtnN)	T6SS00372	protein	TCS regulatory pathway	Edwardsiella tarda EIB202	chromosome (NC_013508)	2910743..2911441 (+)	502612632	ETAE_0886 (esrB) promoter (↑)
REG0225	ETAE_2468	T6SS00372	protein	TCS regulatory pathway	Edwardsiella tarda EIB202	chromosome (NC_013508)	2598484..2599356 (-)	504339400	ETAE_0886 (esrB) promoter (↑)
REG0226	ETAE_1614	T6SS00372	protein	TCS regulatory pathway	Edwardsiella tarda EIB202	chromosome (NC_013508)	1721332..1722024 (-)	754045576	ETAE_0886 (esrB) promoter (↑)
REG0227	ETAE_0994 (Lon)	T6SS00372	protein	TCS regulatory pathway	Edwardsiella tarda EIB202	chromosome (NC_013508)	1085063..1087288 (+)	267984010	ETAE_0886 (esrB) promoter (↓)
REG0228	ETAE_3542 (phoU)	T6SS00372	protein	TCS regulatory pathway	Edwardsiella tarda EIB202	chromosome (NC_013508)	3747537..3748268 (+)	502613380	ETAE_0886 (esrB) promoter (↓)
REG0229	ETAE_3449 (tpiA)	T6SS00372	protein	TCS regulatory pathway	Edwardsiella tarda EIB202	chromosome (NC_013508)	3637381..3638145 (+)	502613286	ETAE_0886 (esrB) promoter (↓)
REG0230	ETAE_1655 (prc)	T6SS00372	protein	TCS regulatory pathway	Edwardsiella tarda EIB202	chromosome (NC_013508)	1757898..1759940 (+)	735677771	ETAE_0886 (esrB) promoter (↓)
REG0231	ETAE_1158	T6SS00372	protein	TCS regulatory pathway	Edwardsiella tarda EIB202	chromosome (NC_013508)	1257412..1258584 (+)	502611022	ETAE_0886 (esrB) promoter (↓)
REG0232	ETAE_0772 (tadA)	T6SS00372	protein	TCS regulatory pathway	Edwardsiella tarda EIB202	chromosome (NC_013508)	850367..850879 (+)	505698653	ETAE_0886 (esrB) promoter (↓)
REG0233	ETAE_0695 (mrcB)	T6SS00372	protein	TCS regulatory pathway	Edwardsiella tarda EIB202	chromosome (NC_013508)	766885..769368 (+)	502610560	ETAE_0886 (esrB) promoter (↓)
REG0234	ETAE_1170	T6SS00372	protein	TCS regulatory pathway	Edwardsiella tarda EIB202	chromosome (CP001135)	1271304..1271447 (-)	267984186	ETAE_0886 (esrB) promoter (↓)
REG0235	ETAE_1562	T6SS00372	protein	TCS regulatory pathway	Edwardsiella tarda EIB202	chromosome (NC_013508)	1668753..1670378 (-)	780104675	ETAE_0886 (esrB) promoter (↓)
REG0236	ETAE_3453 (cpxR)	T6SS00372	protein	TCS regulatory pathway	Edwardsiella tarda EIB202	chromosome (NC_013508)	3641204..3641902 (+)	502613290	ETAE_0886 (esrB) promoter (↓)
REG0237	ETAE_0263 (mltC)	T6SS00372	protein	TCS regulatory pathway	Edwardsiella tarda EIB202	chromosome (NC_013508)	293215..294306 (-)	1392602598	ETAE_0886 (esrB) promoter (↓)
REG0238	ETAE_0542 (slt)	T6SS00372	protein	TCS regulatory pathway	Edwardsiella tarda EIB202	chromosome (NC_013508)	588958..590886 (+)	502610404	ETAE_0886 (esrB) promoter (↓)
REG0239	ETAE_2638 (leuS)	T6SS00372	protein	TCS regulatory pathway	Edwardsiella tarda EIB202	chromosome (NC_013508)	2776570..2779152 (+)	502612492	ETAE_0886 (esrB) promoter (↓)
REG0240	ETAE_3207 (rplQ)	T6SS00372	protein	TCS regulatory pathway	Edwardsiella tarda EIB202	chromosome (NC_013508)	3390207..3390593 (-)	491439763	ETAE_0886 (esrB) promoter (↓)
REG0241	ETAE_1010 (acrB)	T6SS00372	protein	TCS regulatory pathway	Edwardsiella tarda EIB202	chromosome (NC_013508)	1099309..1102461 (-)	502610875	ETAE_0886 (esrB) promoter (↓)
REG0242	ETAE_1425 (mviN)	T6SS00372	protein	TCS regulatory pathway	Edwardsiella tarda EIB202	chromosome (NC_013508)	1535368..1536906 (+)	502611288	ETAE_0886 (esrB) promoter (↓)
REG0243	ETAE_0886 (EsrB)	T6SS00372	protein	TCS-RR	Edwardsiella tarda EIB202	chromosome (NC_013508)	964658..965302 (-)	502610749	Unknown (↓); Unknown (↓)
REG0244	ETAE_2059 (phoP)	T6SS00372	protein	TCS-HK	Edwardsiella tarda EIB202	chromosome (NC_013508)	2172565..2173239 (+)	502611910	ETAE_0886 (EsrB) (↓)
REG0245	ETAE_3098 (PepA)	T6SS00372	protein	Transcription regulator	Edwardsiella tarda EIB202	chromosome (NC_013508)	3260322..3261833 (+)	502612947	ETAE_0886 (esrB) promoter (↑)
REG0246	ETAE_3474 (fabR)	T6SS00372	protein	QS regulatory pathway	Edwardsiella tarda EIB202	chromosome (NC_013508)	3666488..3667159 (-)	502613311	Unknown (↓)
REG0247	ETAE_1505 (H-NS)	T6SS00372	protein	Transcription regulator	Edwardsiella tarda EIB202	chromosome (NC_013508)	1615099..1615506 (-)	505274277	ETAE_2430 (evpB) (↑); evpC promotor (↑)
REG0248	EC042_RS26480 (aggR)	T6SS00464	protein	Transcription regulator	Escherichia coli 042	plasmid (NC_017627)	41080..41877 (-)	446692110	EC042_RS26480 (aggR) promoter (↓); EC042_RS26480 (aggR) promoter (↓)
REG0249	EC042_RS18855 (FIS)	T6SS00464	protein	Transcription regulator	Escherichia coli 042	chromosome (NC_017626)	3772795..3773091 (+)	446385050	EC042_RS26480 (aggR) promoter (↓)
REG0250	EC042_RS06800 (Hns)	T6SS00464	protein	Global regulator	Escherichia coli 042	chromosome (NC_017626)	1376831..1377244 (-)	447210122	EC042_RS26480 (aggR) promoter (↑)
REG0251	EC042_RS03685 (Fur)	T6SS00464	protein	Global regulator	Escherichia coli 042	chromosome (NC_017626)	786918..787364 (-)	446053847	EC042_4532 promoter (↑); EC042_4524 (TssB) promotor (↑)
REG0252	EC042_RS19435 (Dam)	T6SS00464	protein	Global regulator	Escherichia coli 042	chromosome (NC_017626)	3861171..3862007 (-)	446664793	EC042_4532 promoter (↑)
REG0253	PAM18_RS12360 (gacA)	T6SS00612 ; T6SS00613 ; T6SS00611	protein	TCS-RR	Pseudomonas aeruginosa M18	chromosome (NC_017548)	2625815..2626459 (+)	489180874	hsiA1 operon transcript (↓); hsiA2 operon transcript (↓); hsiA3 operon transcript (↓)
REG0254	HMPREF1171_RS04760	T6SS00788	protein	Transcription regulator	Aeromonas dhakensis strain SSU	chromosome (NZ_JH815591)	1041366..1042904 (+)	WP_005299999.1	hcp expression (↓)
REG0255	HMPREF1171_RS20340	T6SS00788	protein	QS regulatory pathway	Aeromonas dhakensis strain SSU	chromosome (NZ_JH815591)	4528194..4528817 (-)	WP_005308454.1	ahyR (↓)
REG0256	HMPREF1171_RS20345	T6SS00788	protein	QS regulatory pathway	Aeromonas dhakensis strain SSU	chromosome (NZ_JH815591)	4528880..4529662 (+)	WP_005308457.1	hcp and vgrG2 expression (↓)
REG0257	VEPGS_0614 (PppA)	T6SS00794	protein	Tpp	Vibrio alginolyticus strain EPJS	chromosome (FJ790777)	15765..16880 (+)	225382180	LuxR (↓)
REG0258	VEPGS_0606 (PpkA2)	T6SS00794	protein	Tpp	Vibrio alginolyticus strain EPJS	chromosome (FJ790777)	3227..5377 (-)	225382172	LuxR (↓); VEPGS_0610 (DotU2) (↓)
REG0259	VEPGS_0607 (Fha2)	T6SS00794	protein	Tpp	Vibrio alginolyticus strain EPJS	chromosome (FJ790777)	5690..6775 (+)	225382173	VEPGS_0610 (DotU2) (↓)
REG0260	EPGS_00471 (VtsR)	T6SS00794	protein	QS regulatory pathway	Vibrio alginolyticus strain EPJS	chromosome (FJ790777)	-	-	LuxO (↓)
REG0261	EPGS_00471 (VtsR)	T6SS00793	protein	QS regulatory pathway	Vibrio alginolyticus strain EPJS	chromosome (FJ790776)	-	-	LuxO (↑)
REG0262	luxR	T6SS00794	protein	QS regulatory pathway	Vibrio alginolyticus strain EPJS	chromosome (FJ790777)	-	-	T6SS2 transcript and expression (↓)
REG0263	luxR	T6SS00793	protein	QS regulatory pathway	Vibrio alginolyticus strain EPJS	chromosome (FJ790776)	-	-	T6SS1 transcript and expression (↑)
REG0264	VEPGS_0621 (pppA)	T6SS00793	protein	Tpp; QS regulatory pathway	Vibrio alginolyticus strain EPJS	chromosome (FJ790777)	23577..24245 (+)	225382187	Unknown (↑); T6SS1 transcript (↑); hcp1 transcript (↓)
REG0265	luxS	T6SS00793	protein	QS regulatory pathway	Vibrio alginolyticus strain EPJS	chromosome (FJ790776)	-	-	hcp1 transcript (↓)
REG0266	LuxO	T6SS00793	protein	QS regulatory pathway	Vibrio alginolyticus strain EPJS	chromosome (FJ790776)	-	-	hcp1 transcript (↓)
REG0267	LuxO	T6SS00794	protein	QS regulatory pathway	Vibrio alginolyticus strain EPJS	chromosome (FJ790777)	-	-	Unknown (↑)
REG0268	rpoN	T6SS00793	protein	Transcription regulator	Vibrio alginolyticus strain EPJS	chromosome (FJ790776)	-	-	T6SS1 transcript (↓)
REG0269	VasH	T6SS00793	protein	Transcription regulator	Vibrio alginolyticus strain EPJS	chromosome (FJ790776)	-	-	T6SS1 transcript (↓)
REG0270	CXG97_03740 (Fur)	T6SS00904	protein	Transcription regulator	Escherichia coli strain ExPEC XM	chromosome (NZ_CP025328)	729474..729920 (-)	446053847	T6SS1 (TssB) promotor (↑)
REG0271	H1D38_08255 (fur)	T6SS00931	protein	Global regulator	Escherichia coli strain 17-2	chromosome (JACEFV010000001)	1744748..1745194 (-)	MBA2233871.1	sciH promotor (↑)
REG0272	H1D38_12840 (Dam)	T6SS00931	protein	Global regulator	Escherichia coli strain 17-2	chromosome (JACEFV010000002)	105877..106713 (+)	MBA2234741.1	sciH promotor (↑)
REG0273	W817_21870 (CpxR)	T6SS00937	protein	TCS-RR	Escherichia coli RS218	chromosome (NZ_CP007149)	4360812..4361510 (-)	446956464	hcp2B promoter (↓)
REG0274	W817_01610 (NplE)	T6SS00937	protein	TCS regulatory pathway	Escherichia coli RS218	chromosome (NZ_CP007149)	214947..215657 (+)	446161331	W817_RS21690 (CpxA) (↓)
REG0275	V12G01_21538 (LuxR)	T6SS00939	protein	QS regulatory pathway	Vibrio alginolyticus 12G01	chromosome (AAPS01000053)	13551..14165 (-)	91187814	T6SS2 transcripts (↓); V12G01-18672 (vqsA) promotor
REG0276	V12G01_19736 (TfoX)	T6SS00939	protein	Transcription regulator	Vibrio alginolyticus 12G01	chromosome (AAPS01000019)	47689..48276 (-)	91189146	T6SS2 transcripts (↓)
REG0277	V12G01_20658 (TfoY)	T6SS00939	protein	Transcription regulator	Vibrio alginolyticus 12G01	chromosome (AAPS01000039)	21665..22255 (+)	91188194	T6SS transcripts (↓)
REG0278	V12G01_20201 (H-NS)	T6SS00939	protein	Transcription regulator	Vibrio alginolyticus 12G01	chromosome (AAPS01000015)	63783..64190 (+)	91189474	VaT6SS1 transcripts (↑)
REG0279	V12G01_18672 (vqsA)	T6SS00939	protein	QS regulatory pathway	Vibrio alginolyticus 12G01	chromosome (AAPS01000003)	114208..115086 (+)	91191289	V12G01-21538 (luxR) promoter (↓); V12G01-14830 (aphA) promoter (↓); V12G01-18672 (vqsA) promotor (↓)
REG0280	V12G01_10813 (AsnC)	T6SS00939	protein	QS regulatory pathway	Vibrio alginolyticus 12G01	chromosome (AAPS01000004)	181050..181484 (-)	91191052	V12G01-21538 (luxR) promoter; V12G01-14830 (aphA) promoter
REG0281	V12G01_02325 (HP)	T6SS00939	protein	QS regulatory pathway	Vibrio alginolyticus 12G01	chromosome (AAPS01000004)	115263..116411 (+)	91190993	V12G01-21538 (luxR) promoter; V12G01-14830 (aphA) promoter
REG0282	V12G01_01665 (HP)	T6SS00939	protein	QS regulatory pathway	Vibrio alginolyticus 12G01	chromosome (AAPS01000007)	185299..185712 (+)	91190406	V12G01-21538 (luxR) promoter; V12G01-14830 (aphA) promoter
REG0283	V12G01_06711 (HP)	T6SS00939	protein	QS regulatory pathway	Vibrio alginolyticus 12G01	chromosome (AAPS01000024)	47707..48585 (-)	91188835	V12G01-21538 (luxR) promoter; V12G01-14830 (aphA) promoter
REG0284	V12G01_16177 (MetR)	T6SS00939	protein	QS regulatory pathway	Vibrio alginolyticus 12G01	chromosome (AAPS01000023)	58420..59331 (-)	91188901	V12G01-21538 (luxR) promoter; V12G01-14830 (aphA) promoter
REG0285	V12G01_02620 (SoxR)	T6SS00939	protein	QS regulatory pathway	Vibrio alginolyticus 12G01	chromosome (AAPS01000004)	181050..181484 (-)	91191052	V12G01-21538 (luxR) promoter; V12G01-14830 (aphA) promoter
REG0287	V12G01_14830 (aphA)	T6SS00939	protein	QS regulatory pathway	Vibrio alginolyticus 12G01	chromosome (AAPS01000027)	42305..42880 (+)	91188695	V12G01-18672 (vqsA) promotor
REG0288	VCA0566 (VxrB)	T6SS00002	protein	TCS-RR	Vibrio cholerae O1 biovar El Tor str. N16961	chromosome (NC_002506)	504728..505384 (+)	446737785	Unknown (↑)
REG0289	VCA0933 (CspV)	T6SS00002	protein	c-di-GMP regulatory pathway	Vibrio cholerae O1 biovar El Tor str. N16961	chromosome (NC_002506)	886068..886280 (+)	446027150	Unknown (↓)
REG0290	VCA1552_01380 (VdcA/ycdT)	T6SS01112	protein	c-di-GMP regulatory pathway	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	1482426..1483715 (+)	446892247	the levels of c-di-GMP (↑)
REG0291	VCA1552_02536 (CdpA/YfgF)	T6SS01112	protein	c-di-GMP regulatory pathway	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	2739669..2742158 (-)	446417730	the levels of c-di-GMP (↓)
REG0292	VCA1552_02898 (VasH)	T6SS01112	protein	Global regulator	Vibrio cholerae strain A1552	chromosome (NZ_CP024868)	128889..130481 (+)	446006938	VCA1552_00900 (TfoX) (↓)
REG0293	VCA1552_00351 (HapR)	T6SS01112	protein	Global regulator	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	340447..341058 (-)	446262243	Unknown; Hcp expression and secretion
REG0294	VCA1552_RS04890 (ihfA)	T6SS01112	protein	Transcription regulator	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	1028170..1028466 (+)	447152004	Hcp secretion (↓)
REG0295	VCA1552_RS08565 (ihfB)	T6SS01112	protein	Transcription regulator	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	1839353..1839631 (-)	446089486	Hcp secretion (↓)
REG0296	VCA1552_RS03895 (LuxO)	T6SS01112	protein	QS regulatory pathway	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	818142..819509 (+)	487814784	Hcp expression and secretion (↑)
REG0297	VCA1552_RS17020 (cqsa)	T6SS01112	protein	QS regulatory pathway	Vibrio cholerae strain A1552	chromosome (NZ_CP024868)	455238..456407 (-)	446962656	Hcp expression and secretion (↓)
REG0298	VCA1552_RS01665 (LuxS)	T6SS01112	protein	QS regulatory pathway	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	319588..320106 (+)	447052971	Hcp expression and secretion (↓)
REG0299	VCA1552_RS00505 (hfq)	T6SS01112	protein	QS regulatory pathway	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	92673..92936 (+)	446974616	VCA1552_00351 (HapR) (↑)
REG0300	VCA1552_RS11610 (RpoN)	T6SS01112	protein	Global regulator	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	2488023..2489486 (+)	446727517	Hcp expression and secretion (↓)
REG0301	VCA1552_RS12025 (crp)	T6SS01112	protein	QS regulatory pathway	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	2558371..2559003 (+)	446164894	Hcp expression and secretion (↓)
REG0302	VCA1552_RS12925 (cya)	T6SS01112	protein	QS regulatory pathway; cAMP regulatory pathway	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	2747346..2749877 (-)	447072406	VCA1552_RS12025 (crp) (↓)
REG0303	VCA1552_00154 (QstR)	T6SS01112	protein	c-di-GMP regulatory pathway; QS regulatory pathway; Global regulator	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	149920..150564 (-)	447111060	TssB/TfoY transcripts (↓); VC0396/VCA1552_00154 (QstR) (↓); T6SS transcripts (↓)
REG0304	VCA1552_00900 (TfoX)	T6SS01112	protein	Global regulator	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	952868..953476 (+)	487807468	VC0396/VCA1552_00154 (QstR) (↓)
REG0306	VCA1552_01510 (TfoY)	T6SS01112	protein	c-di-GMP regulatory pathway	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	1636980..1637567 (+)	446282733	Unknown (↓)
REG0307	VCA1552_RS06160 (lonA)	T6SS01112	protein	c-di-GMP regulatory pathway	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	1315238..1316887 (+)	446116573	VCA1552_01510 (TfoY) (↑)
REG0308	VCA1552_RS10420 (cdgL)	T6SS01112	protein	c-di-GMP regulatory pathway	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	2215844..2217361 (-)	446975354	the levels of c-di-GMP (↓)
REG0309	VCA1552_RS04310 (cdgK)	T6SS01112	protein	c-di-GMP regulatory pathway	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	901594..903063 (+)	487807420	the levels of c-di-GMP (↓)
REG0310	VCA1552_RS04130 (cdgH)	T6SS01112	protein	c-di-GMP regulatory pathway	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	861187..863208 (+)	446848493	the levels of c-di-GMP (↓)
REG0311	VCA1552_RS02130 (rocS)	T6SS01112	protein	c-di-GMP regulatory pathway	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	425233..427287 (-)	447034155	the levels of c-di-GMP (↑)
REG0312	VCA1552_RS12850 (cdgJ)	T6SS01112	protein	c-di-GMP regulatory pathway	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	2733319..2734545 (-)	446210986	the levels of c-di-GMP (↑)
REG0313	VCA1552_RS17835 (cdgD)	T6SS01112	protein	c-di-GMP regulatory pathway	Vibrio cholerae strain A1552	chromosome (NZ_CP024868)	633312..635195 (+)	446210820	the levels of c-di-GMP (↓)
REG0314	TfoY	T6SS00790	protein	Global regulator	Vibrio cholerae V52	chromosome (-)	-	-	Unknown (↓)
REG0315	VCV52_RS10780 (TfoX)	T6SS00790	protein	Global regulator	Vibrio cholerae V52	chromosome (NZ_KQ410501)	68827..69435 (-)	487807468	Unknown (↓)
REG0316	VCV52_RS01020 (VasH)	T6SS00790	protein	Global regulator	Vibrio cholerae V52	chromosome (NZ_KQ410497)	212259..213851 (-)	446006947	Unknown (↓)
REG0317	VCV52_RS13040 (rpoN)	T6SS00790	protein	Global regulator	Vibrio cholerae V52	chromosome (NZ_KQ410502)	216932..218395 (-)	446727517	Unknown (↓)
REG0318	Y113_RS04835 (esrC)	T6SS00791	protein	TCS-HK	Edwardsiella tarda strain PPD130/91	chromosome (NZ_JACQ01000008)	20632..23367 (-)	1624663318	EvpQ protein level (↓)
REG0319	Y113_RS04830 (esrB)	T6SS00791	protein	TCS-RR	Edwardsiella tarda strain PPD130/91	chromosome (NZ_JACQ01000008)	20006..20635 (+)	1940020585	EvpA and EvpC protein concentration (↓)
REG0320	VC_A0122	T6SS00002	protein	Transcription regulator	Vibrio cholerae O1 biovar El Tor str. N16961	chromosome (NC_002506)	137379..137621 (+)	9657509	hcp-2 expression (↓)
REG0321	GT391_RS06470 (expR1)	T6SS01170	protein	QS regulatory pathway	Pectobacterium brasiliense strain 1692	chromosome (NZ_CP047495)	1453704..1455596 (+)	746272689	T6SS transcripts (↓)
REG0322	GT391_RS06405 (expI)	T6SS01170	protein	QS regulatory pathway	Pectobacterium brasiliense strain 1692	chromosome (NZ_CP047495)	1436931..1437581 (-)	497970044	GT391_RS06470 (expR1) (↓)
REG0323	GT391_RS16925 (phoP)	T6SS01170	protein	TCS-HK	Pectobacterium brasiliense strain 1692	chromosome (NZ_CP047495)	3795787..3796476 (-)	497961604	GT391_RS06470 (expR1) (↑)
REG0324	WQ49_05050 (cepR)	T6SS01276	protein	QS regulatory pathway	Burkholderia cenocepacia strain K56-2	chromosome (LAUA01000002)	545988..546707 (-)	815852483	T6SS promotor (P (BCAL0340) ) (↓)
REG0325	WQ49_20245 (cciR)	T6SS01276	protein	QS regulatory pathway	Burkholderia cenocepacia strain K56-2	chromosome (LAUA01000016)	843677..844378 (+)	815850423	Unknown (↑)
REG0326	WQ49_19595 (atsR)	T6SS01276	protein	TCS-RR	Burkholderia cenocepacia strain K56-2	chromosome (LAUA01000016)	710895..712715 (+)	815849700	T6SS transcripts (↑); T6SS expression (↑)
REG0327	WQ49_05060 (cepI)	T6SS01276	protein	QS regulatory pathway	Burkholderia cenocepacia strain K56-2	chromosome (LAUA01000002)	547435..548043 (+)	815852485	T6SS expression (↓)
REG0328	WQ49_20250 (cciI)	T6SS01276	protein	QS regulatory pathway	Burkholderia cenocepacia strain K56-2	chromosome (LAUA01000016)	844665..845255 (+)	815850424	T6SS expression (↓)
REG0329	VPBB_RS05425 (H-NS)	T6SS00719	protein	Transcription regulator	Vibrio parahaemolyticus BB22OP	chromosome (NC_019955)	1170475..1170882 (-)	505109423	VgrG1 expression and secretion (↑)
REG0330	Pchl3084_4333 (gacS)	T6SS01266 ; T6SS01267	protein	TCS-RR	Pseudomonas chlororaphis subsp. aureofaciens 30-84	chromosome (NZ_CM001559)	5113748..5116501 (+)	496335944	Pchl3084_3491 (gacA) (↓)
REG0331	Pchl3084_3491 (gacA)	T6SS01266 ; T6SS01267	protein	TCS-HK	Pseudomonas chlororaphis subsp. aureofaciens 30-84	chromosome (NZ_CM001559)	4134794..4135435 (-)	496335231	Pchl3084_5419 (rsmY)promotor (↓); Pchl3084_1190 (rsmZ)promotor (↓); Pchl3084_1189 (rpoS)transcript (↓)
REG0332	GacS	T6SS01269	protein	TCS-RR	Pseudomonas aeruginosa cystic fibrosis isolate CHA	chromosome (-)	-	-	hcp1 expression and secretion (↑)
REG0333	rsmA	T6SS01269	protein	RsmA regulatory pathway	Pseudomonas aeruginosa cystic fibrosis isolate CHA	chromosome (-)	-	-	hcp1 expression and secretion (↑)
REG0334	PSA3335_RS05390 (iaaM)	T6SS01041	protein	IAA regulatory pathway	Pseudomonas savastanoi pv. savastanoi NCPPB 3335	chromosome (NZ_CP008742)	1090961..1092634 (-)	488619197	The transcript levels of vgrG (↓)
REG0335	PSA3335_RS05385 (iaaH)	T6SS01041	protein	IAA regulatory pathway	Pseudomonas savastanoi pv. savastanoi NCPPB 3335	chromosome (NZ_CP008742)	1089578..1090918 (-)	488619198	The transcript levels of vgrG (↓)
REG0336	BWP10_01550 (ssrB)	T6SS01291	protein	TCS-RR	Salmonella enterica subsp. enterica serovar Typhimurium strain ATCC 14028	chromosome (MTFW01000001)	296600..299362 (+)	1145677935	sciS/TssM transcription (↑)
REG0338	BN49_RS12735 (phoQ)	T6SS01214	protein	TCS-RR	Klebsiella pneumoniae strain Kp52.145	chromosome (NZ_FO834906)	2324171..2325637 (-)	490249900	TssB transcription (↓)
REG0339	BN49_RS12735 (phoP)	T6SS01214	protein	TCS-HK	Klebsiella pneumoniae strain Kp52.145	chromosome (NZ_FO834906)	2325637..2326308 (-)	490252783	BN49_2224 (phoQ) (↓)
REG0340	BN49_RS29275 (mgrB)	T6SS01214	protein	TCS regulatory pathway	Klebsiella pneumoniae strain Kp52.145	chromosome (NZ_FO834906)	3583038..3583181 (-)	489000713	phoPQ (↑)
REG0341	BN49_RS21260 (rcsB)	T6SS01214	protein	TCS-RR	Klebsiella pneumoniae strain Kp52.145	chromosome (NZ_FO834906)	4066268..4066918 (+)	489002368	phoPQ (↑)
REG0342	BN49_RS18480 (h-ns)	T6SS01214	protein	Global regulator	Klebsiella pneumoniae strain Kp52.145	chromosome (NZ_FO834906)	3427636..3428043 (+)	488999426	TssB transcription (↑)
REG0343	BN49_RS10300 (fur)	T6SS01214	protein	Global regulator	Klebsiella pneumoniae strain Kp52.145	chromosome (NZ_FO834906)	1826878..1827330 (-)	514077307	TssB transcription (↓)
REG0344	BN49_RS26620 (hfq)	T6SS01214	protein	QS regulatory pathway	Klebsiella pneumoniae strain Kp52.145	chromosome (NZ_FO834906)	5173711..5174019 (-)	488974767	TssB transcription (↓)
REG0345	BN49_RS03755 (rpoN)	T6SS01214	protein	Global regulator	Klebsiella pneumoniae strain Kp52.145	chromosome (NZ_FO834906)	533564..534997 (-)	489007850	TssB transcription (↓)
REG0346	BN49_RS06445 (rpoS)	T6SS01214	protein	Global regulator	Klebsiella pneumoniae strain Kp52.145	chromosome (NZ_FO834906)	1060243..1061235 (+)	489004494	TssB transcription (↓)
REG0347	sdiA	-	protein	Global regulator	Enterobacter cloacae strain JLD400	chromosome (-)	-	-	ENC_07270 transcript (↓)
REG0348	SMDB11_2275 (PpkA)	T6SS00929	protein	Tpp	Serratia marcescens subsp. marcescens Db11	chromosome (HG326223)	2399154..2400599 (+)	560174118	SMDB11_2267/SMA2267 (Fha) (↓); SMDB11_2267/SMA2267 (Fha) (↑)
REG0349	SMDB11_2267 (Fha)	T6SS00929	protein	Tpp	Serratia marcescens subsp. marcescens Db11	chromosome (HG326223)	2388490..2390232 (+)	560174110	Unknown (↓)
REG0350	F9K57_RS04510 (VgrGi)	T6SS01164	protein	Global regulator	Acinetobacter baumannii strain AbCAN2	chromosome (NZ_CP045428)	925473..928592 (+)	1797381381	T6SS structure (↑)
REG0351	PSEBR_RS22825 (GacS)	T6SS00431 ; T6SS00432	protein	TCS-RR	Pseudomonas brassicacearum subsp. brassicacearum NFM421	chromosome (NC_015379)	5188012..5190762 (+)	503459407	hcp1 transcript (↓); hcp2 transcript (↓)
REG0353	AHA_1842 (VasH)	T6SS00157	protein	QS regulatory pathway	Aeromonas hydrophila subsp. hydrophila ATCC 7966	chromosome (NC_008570)	2010521..2012059 (+)	117617496	T6SS gene cluster promoter (PAHA1826) (↓)
REG0354	AHA_3923 (rpoN)	T6SS00157	protein	Global regulator	Aeromonas hydrophila subsp. hydrophila ATCC 7966	chromosome (NC_008570)	4350676..4352115 (-)	117618923	T6SS gene cluster promoter (PAHA1826) (↓)
REG0355	N779_15250 (VtpR)	T6SS01280 ; T6SS01281	protein	QS regulatory pathway	Vibrio coralliilyticus OCN008	chromosome (AVOO01000045)	7579..8184 (-)	536747482	Unknown (↓)
REG0356	W909_RS11820 (VfmH)	T6SS01037	protein	TCS-RR	Dickeya zeae EC1	chromosome (NZ_CP006929)	2699617..2701098 (+)	515507611	T6SS transcripts (↓)
REG0357	PPECC33_RS11180 (BaeS)	T6SS01034	protein	TCS-HK	Escherichia coli PCN033	chromosome (NZ_CP006632)	2271464..2272867 (+)	446597798	PPECC33_RS11185 (BaeR) (↓)
REG0358	PPECC33_RS11185 (BaeR)	T6SS01034	protein	TCS-RR	Escherichia coli PCN033	chromosome (NZ_CP006632)	2272864..2273586 (+)	446060022	T6SS promotor (↓)
REG0359	bglu_1g09700 (tepR)	T6SS00343	protein	Global regulator	Burkholderia glumae BGR1	chromosome (NC_012724)	1045102..1046502 (-)	-	Unknown (↓)
REG0360	ACX61_19655 (tetR2)	T6SS01047	protein	Global regulator	Acinetobacter baumannii strain Ab04-mff	plasmid (NZ_CP012007)	144108..144677 (+)	446104352	hcp secretion (↑)
REG0361	ACX61_19615 (tetR1)	T6SS01047	protein	Global regulator	Acinetobacter baumannii strain Ab04-mff	plasmid (NZ_CP012007)	139526..140098 (+)	487938137	hcp secretion (↑)
REG0362	PPECC33_RS11945 (rcsB)	T6SS01034	protein	TCS-RR	Escherichia coli PCN033	chromosome (NZ_CP006632)	2429320..2429970 (+)	446984661	T6SS transcription (↓)
REG0364	Y113_RS11250 (RpoS)	T6SS00791	protein	Transcription regulator	Edwardsiella tarda PPD130/91	chromosome (NZ_JACQ01000026)	9122..10108 (-)	502612732	EvpQ transcription and protein level (↑)
REG0365	Y113_RS02460 (Fur)	T6SS00791	protein	Global regulator	Edwardsiella tarda PPD130/91	chromosome (NZ_JACQ01000003)	461902..462351 (+)	735678383	EvpQ protein level (↑)
REG0366	YPK_RS19410 (Zur)	T6SS00260	protein	Global regulator	Yersinia pseudotuberculosis YPIII	chromosome (NC_010465)	4251751..4252260 (+)	488143439	T6SS4 transcription (↓)
REG0367	H78_RS02920 (Hfq)	-	protein	QS regulatory pathway	Pseudomonas protegens strain H78	chromosome (NZ_CP013184)	662937..663197 (+)	495196588	T6SS transcription level (↓)
REG0368	PA1544 (Anr)	T6SS00004	protein	Global regulator	Pseudomonas aeruginosa PAO1	chromosome (NC_002516)	1681071..1681805 (-)	15596741	H2-T6SS transcriptional level and ModA secretion (↓)
REG0369	VCV52_RS14135 (wigR/phoB/vxrB)	T6SS00790	protein	TCS-RR	Vibrio cholerae V52	chromosome (NZ_KQ410503)	201806..202495 (-)	446013262	T6SS transcription level (↓)
REG0370	ACX60_RS11355 (racK)	T6SS01046	protein	Environmental signal	Acinetobacter baumannii strain ATCC 17978	chromosome (NZ_CP012004)	2382673..2383965 (+)	WP_000769882.1	ACX60_RS00605 (Tse4) (↓)
REG0371	VFES401_RS15770 (tasR)	T6SS17506	protein	Unknown	Aliivibrio fischeri strain ES401	chromosome (NZ_SRJG01000005)	373862..374311 (+)	WP_012535053.1	hcp promotor (↓)
REG0372	BMUL_RS00795 (hns)	-	protein	Transcription regulator	Burkholderia multivorans ATCC 17616	chromosome (NC_010084)	179094..179390 (+)	WP_006401402.1	T6SS (↑)
REG0373	hapR	T6SS01028 ; T6SS01029	protein	QS regulatory pathway	Vibrio fluvialis 85003	chromosome (KY319184)	-	-	vgrG (↓)
REG0374	ihfA	T6SS01028 ; T6SS01029	protein	QS regulatory pathway	Vibrio fluvialis 85003	chromosome (KY319184)	-	-	vgrG (↓)
REG0375	ihfB	T6SS01028 ; T6SS01029	protein	QS regulatory pathway	Vibrio fluvialis 85003	chromosome (KY319184)	-	-	vgrG (↓)
REG0376	PA3648 (bamA)	T6SS00003	protein	Tpp	Pseudomonas aeruginosa PAO1	chromosome (NC_002516)	4085062..4087455 (-)	NP_252338.1	ClpV-GFP foci accumulate; H1-T6SS transcript (↑)
REG0377	PA0595 (lptD)	T6SS00003	protein	Tpp	Pseudomonas aeruginosa PAO1	chromosome (NC_002516)	653753..656527 (-)	NP_249286.1	ClpV-GFP foci accumulate; H1-T6SS transcript (↑)
REG0378	PA0972 (tolB)	T6SS00003	protein	Tpp	Pseudomonas aeruginosa PAO1	chromosome (NC_002516)	1056049..1057347 (+)	NP_249663.1	ClpV-GFP foci accumulate; H1-T6SS transcript (↑)
REG0379	REUT_RS14415 (fur)	T6SS17507	protein	Global regulator	Cupriavidus pinatubonensis JMP134	chromosome (NC_007347)	3110053..3110484 (+)	WP_011298983.1	reut_A1733 promotor (↑)