LOCUS NC_002483 99159 bp DNA circular BCT 10-MAR-2011 DEFINITION Plasmid F, complete sequence. ACCESSION NC_002483 VERSION NC_002483.1 GI:9507713 DBLINK Project:15844 KEYWORDS . SOURCE Plasmid F ORGANISM Plasmid F other sequences; plasmids. REFERENCE 1 AUTHORS Manwaring,N.P., Skurray,R.A. and Firth,N. TITLE Nucleotide sequence of the F plasmid leading region JOURNAL Plasmid 41 (3), 219-225 (1999) PUBMED 10366527 REFERENCE 2 AUTHORS Broom,J.E., Hill,D.F., Hughes,G., Jones,W.A., McNaughton,J.C., Stockwell,P.A. and Petersen,G.B. TITLE Sequence of a transposon identified as Tn1000 (gamma delta) JOURNAL DNA Seq. 5 (3), 185-189 (1995) PUBMED 7612932 REFERENCE 3 AUTHORS Frost,L.S., Ippen-Ihler,K. and Skurray,R.A. TITLE Analysis of the sequence and gene products of the transfer region of the F sex factor JOURNAL Microbiol. Rev. 58 (2), 162-210 (1994) PUBMED 7915817 REFERENCE 4 AUTHORS Yoshioka,Y., Fujita,Y. and Ohtsubo,E. TITLE Nucleotide sequence of the promoter-distal region of the tra operon of plasmid R100, including traI (DNA helicase I) and traD genes JOURNAL J. Mol. Biol. 214 (1), 39-53 (1990) PUBMED 2164585 REFERENCE 5 AUTHORS Saadi,S., Maas,W.K., Hill,D.F. and Bergquist,P.L. TITLE Nucleotide sequence analysis of RepFIC, a basic replicon present in IncFI plasmids P307 and F, and its relation to the RepA replicon of IncFII plasmids JOURNAL J. Bacteriol. 169 (5), 1836-1846 (1987) PUBMED 3032897 REFERENCE 6 AUTHORS Helsberg,M. and Eichenlaub,R. TITLE Twelve 43-base-pair repeats map in a cis-acting region essential for partition of plasmid mini-F JOURNAL J. Bacteriol. 165 (3), 1043-1045 (1986) PUBMED 3949712 REFERENCE 7 AUTHORS Eichenlaub,R. TITLE F Plasmid DNA complete mini-F region (F coordinates 40.301F to 49.869F) JOURNAL Unpublished REFERENCE 8 AUTHORS Shimizu,H., Saitoh,Y., Suda,Y., Uehara,K., Sampei,G. and Mizobuchi,K. TITLE Complete nucleotide sequence of the F plasmid: Its implications for organization and diversification of plasmid genomes JOURNAL Unpublished REFERENCE 9 (bases 1 to 99159) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (27-JUL-2000) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 10 (bases 1 to 99159) CONSRTM NCBI Genome Project NCBI Microbial Genomes Annotation Project TITLE Direct Submission JOURNAL Submitted (27-APR-2000) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AP001918. COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..99159 /mol_type="genomic DNA" /db_xref="taxon:2465" /lab_host="Escherichia coli K-12 strain CR63" /plasmid="F" /organism="Plasmid F" gene join(98764..99159,1259..1426) /locus_tag="Fpla003" /db_xref="GeneID:1498117" /gene="finO" /note="interrupted gene" misc_feature join(98764..99159,1259..1426) /locus_tag="Fpla003" /gene="finO" /note="RNA-binding protein FinO; interrupted by IS3 insertion; FinO promotes finP traJ mRNA leader sequence duplex formation, resulting in repression of the transfer operon; IS3 insertion results in constitutive expression of transfer operon" mobile_element 1..1258 /mobile_element_type="insertion sequence:IS3a" repeat_region join(1..39,1220..1258) /rpt_type=inverted /note="IS3a terminal repeats" gene 66..365 /locus_tag="Fpla001" /db_xref="GeneID:1263552" /gene="yaaA" CDS 66..365 /locus_tag="Fpla001" /protein_id="NP_061380.1" /gene="yaaA" /transl_table=11 /db_xref="GI:9507714" /db_xref="GeneID:1263552" /codon_start=1 /translation="MTKTVSTSKKPRKQHSPEFRSEALKLAERIGVTAAARELSLYES QLYNWRSKQQNQQTSSERELEMSTEIARLKRQLAERDEELAILQKAATYFAKRLK" /product="hypothetical protein" gene 362..1228 /locus_tag="Fpla002" /db_xref="GeneID:1263587" /gene="yaaB" CDS 362..1228 /locus_tag="Fpla002" /protein_id="NP_061381.1" /gene="yaaB" /transl_table=11 /db_xref="GI:9507715" /db_xref="GeneID:1263587" /codon_start=1 /translation="MKYVFIEKHQAEFSIKAMCRVLRVARSGWYTWCQRRTRISTRQQ FRQHCDSVVLAAFTRSKQRYGAPRLTDELRAQGYPFNVKTVAASLRRQGLRAKASRKF SPVSYRAHGLPVSENLLEQDFYASGPNQKWAGDITYLRTDEGWLYLAVVIDLWSRAVI GWSMSPRMTAQLACDALQMALWRRKRPRNVIVHTDRGGQYCSADYQAQLKRHNLRGSM SAKGCCYDNACVESFFHSLKVECIHGEHFISREIMRATVFNYIECDYNRWRRHSWCGG LSPEQFENKNLA" /product="transposase" misc_difference 2059 /note="A is changed to G in EMBL Accession Numbers X57429 and X57429" gene 2110..2550 /locus_tag="Fpla004" /db_xref="GeneID:1263579" /gene="yacA" CDS 2110..2550 /locus_tag="Fpla004" /protein_id="NP_061382.1" /gene="yacA" /transl_table=11 /db_xref="GI:9507716" /db_xref="GeneID:1263579" /codon_start=1 /translation="MAHRYLREKCFALNLNWKCKLFLTPPKSFWGTTHAYNFCPIHFL QALPSLPLSRNVEVAYGMPLIFVDVNGPSDVEVVRSFDVSTYLPLMPFSARALDFMIT KSAHFSAATYCGSFSTFPAHAVIVKTVAAANNLPGFIFIPYWVY" /product="hypothetical protein" gene complement(2821..2882) /locus_tag="Fplas001" /db_xref="GeneID:1263526" /gene="srnC" misc_RNA complement(2821..2882) /locus_tag="Fplas001" /db_xref="GeneID:1263526" /gene="srnC" /product="antisense regulator of srnB" /note="similar to flmB; stable RNA degradation gene C; antisense RNA of srnB mRNA; prevents translation of the toxin srnB' indirectly by inhibiting translation of srnB; unstable RNA" gene 2869..3075 /locus_tag="Fpla005" /db_xref="GeneID:1263515" /gene="srnB" CDS 2869..3075 /locus_tag="Fpla005" /experiment="experimental evidence, no additional details recorded" /protein_id="NP_061383.1" /gene="srnB" /transl_table=11 /note="similar to FlmC; stable RNA degradation protein B; modulates translation of host killing protein SrnB'; translation of srnB results in translation of srnB'" /db_xref="GI:9507717" /db_xref="GeneID:1263515" /codon_start=1 /translation="MKYLNTTDCSLFLAERSKFMTKYALIGLLAVCATVLCFSLIFRE RLCELNIHRGNTVVQVTLAYEARK" /product="modulator of post-segregation killing protein" gene 2926..3075 /locus_tag="Fpla006" /db_xref="GeneID:1263549" /gene="srnB'" CDS 2926..3075 /locus_tag="Fpla006" /experiment="experimental evidence, no additional details recorded" /protein_id="NP_061384.1" /gene="srnB'" /transl_table=11 /note="similar to FlmA; stable RNA degradation B'; stable RNA negative protein; kills the host cell by destabilizing polar membranes unless the antidote antisense regulator srnC is produced to turn off expression of srnB; srnB mRNA is stable and persists in cells that have lost the F plasmid resulting in death of plasmid-free bacterial cells; may also inhibit competitor plasmids" /db_xref="GI:9507718" /db_xref="GeneID:1263549" /codon_start=1 /translation="MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLA YEARK" /product="post-segregation killing protein" misc_difference 3085 /note="G is omitted from gb:M16168; gb:M16168" misc_difference 3089 /note="G is changed to C in gb:M16168; gb:M16168" -35_signal 3292..3297 gene 3315..3616 /locus_tag="Fpla007" /db_xref="GeneID:1263536" /gene="repA2" -10_signal 3315..3321 /locus_tag="Fpla007" /gene="repA2" RBS 3349..3354 /locus_tag="Fpla007" /gene="repA2" CDS 3359..3616 /locus_tag="Fpla007" /protein_id="NP_061385.1" /gene="repA2" /transl_table=11 /note="copy number control protein" /db_xref="GI:9507719" /db_xref="GeneID:1263536" /codon_start=1 /translation="MSQTENAVTSSSGNKRAYRKGNPVPARERQRASLARRSNTHKAF HAVIQARLKDRLSELADEEGITQAQMLEKLIESELKRRATL" /product="replication protein" -35_signal 3629..3634 -10_signal 3653..3658 gene complement(3741..3832) /locus_tag="Fplas002" /db_xref="GeneID:1263582" /gene="inc" misc_RNA complement(3741..3832) /locus_tag="Fplas002" /db_xref="GeneID:1263582" /gene="inc" /product="antisense inhibitor of RepFIC replication initiation protein" /note="inhibits RepFIC replication intiation protein synthesis; overlaps leader RNA of replication protein; determines incompatibility of plasmid replication" RBS 3829..3834 gene 3850..3924 /locus_tag="Fpla008" /db_xref="GeneID:1263553" /gene="repL" CDS 3850..3924 /locus_tag="Fpla008" /protein_id="NP_061386.1" /gene="repL" /transl_table=11 /note="RepA6" /db_xref="GI:9507720" /db_xref="GeneID:1263553" /codon_start=1 /translation="MPGKVQDFFLCSLLLCIVSAGWCG" /product="leader peptide RepL" gene 3917..4190 /locus_tag="Fpla009" /db_xref="GeneID:1263525" /gene="repA1" misc_feature 3917..4190 /locus_tag="Fpla009" /gene="repA1" /note="RepFIC replication initiation protein; inactivated by insertion sequence gamma delta(Tn1000) and therefore partial" mobile_element 4191..10171 /mobile_element_type="transposon:gamma delta(Tn1000)" repeat_region join(4191..4225,10137..10171) /rpt_type=inverted /note="gamma delta(Tn1000) terminal repeats" gene complement(4303..6399) /locus_tag="Fpla010" /db_xref="GeneID:1263581" /gene="tnpX" CDS complement(4303..6399) /locus_tag="Fpla010" /protein_id="NP_061387.1" /gene="tnpX" /transl_table=11 /db_xref="GI:9507721" /db_xref="GeneID:1263581" /codon_start=1 /translation="MELNITSKSNPFGDTTAENDKKMLSNAFIETADFRTLIETDDRT IVVGRRGTGKSALFIQLNEHWKKDKKILILSFSPDDSQIIGFRSMLKPFTGSFNLARA ATRLLWRYAMLMEIASYISSHYKLSSQISSETLLNEHLKKWNSAQGDILRKCRLVAKE YLDENNPEESIGDLQFNLNISEIENNIVSLLERSDRKVVILMDKLDEAYEPDNIGIGI IAGLAYASIELNQKAKCIRPIIFLRDNIFRSLSKEDPDYSRNIEGQVIRLHWDWAQLL MLSAKRMKVAFKLDIEKDQRVWDRCTADDLKGRNGFKRCLQFTLYRPRDLLSLLNEAF FSAFRENRETIINTDLEYAAKSISMARLEDLWKEYQKIFPSIQVITSAFRSIEPELTV YTCLKKIEASFELIEENGDPKITSEIQLLKASGILQSLYSVGFVGIRDKNTSSYSFCH DGRTPDKGFESNEKLLIHPCYWLGLNLNRNALAPEEAEEINDEYDINIISDNSAIRNK TIGQITTHLDQIPIGNEGATEFEQWCLDALRIVFASHLTDIKSHPNGNAVQRRDIIGT NGGKSDFWKRVLEDYKTRQVVFDAKNFEELGPSEYRQLQSYLTGPYGKLGFIINRDES EVLKSGKDLDWTKEMYQSHNSLIIKLPAKYISKLLQKLRNPEKHDAIDRQMGKLLTLY ETSYMAIKSTQKKRRK" /product="hypothetical protein" gene complement(6415..6966) /locus_tag="Fpla011" /db_xref="GeneID:1263577" /gene="tnpR" CDS complement(6415..6966) /locus_tag="Fpla011" /protein_id="NP_061388.1" /gene="tnpR" /transl_table=11 /db_xref="GI:9507722" /db_xref="GeneID:1263577" /codon_start=1 /translation="MRLFGYARVSTSQQSLDIQVRALKDAGVKANRIFTDKASGSSSD RKGLDLLRMKVEEGDVILVKKLDRLGRDTADMIQLIKEFDAQGVSIRFIDDGISTDGE MGKMVVTILSAVAQAERQRILERTNEGRQEAMAKGVVFGRKRKIDRDAVLNMWQQGLG ASHISKTMNIARSTVYKVINESN" /product="resolvase" gene 7130..10138 /locus_tag="Fpla012" /db_xref="GeneID:1263527" /gene="tnpA" CDS 7130..10138 /locus_tag="Fpla012" /protein_id="NP_061389.1" /gene="tnpA" /transl_table=11 /db_xref="GI:9507723" /db_xref="GeneID:1263527" /codon_start=1 /translation="MPVDFLTSDQKQNYGCYAAEPNDVQLARYFHLDERDLAFINQRR GKHNRLGIALQLTTARFLGTFLTDLTQVLPGVQHFVAVQLNIHRPEVLSRYAERDTTL REHTALIKEYYGYHEFGDFPWSFRLKRLLYTRAWLSNERPGLMFDFATAWLLQNKVLL PGATTLVRLISEIRERANQRLWKKLAALPNKWQAAQVMELLVIPEGQRVSALEQLKKG PVTVSGPAFNEALERYIRLRSLEFSRLNFSGLPAIQLRNLARYAGMASVKYIARMPQQ RKLAVLTAFVKAQEITALDDAVDVLDMLILDIIREAKKTGQKKRLRTLKDLDQAALLL ARACALLLDDNTDVPDLRQVIFKCVPKNRLAESVSKVNELARPQNNNFHDEMVEQYGR VKRFLPAVLRDLHFRAAPAGEHVLAAIHYLAELNGSKKRILDDAPEHIITGPWKRLVY DAEGRIQRAGYSLCLLERLQDALRRRDIWLENSDRWGDPREKLLQGEEWQTQRIPVCR ALGHPVDGRKGVQQLAIQLDETWKAVASRFEKNAEVHICNEGKYPSLTISCLEKQEEP PSLLRLNNRIKQLLPPVDLTELLLEIDAQTGFTHEFAHVSESGARAQDLHISLCAVLM AEACNIGLEPLIKHNIPALTRHRLSWVKQNYLRAETLVSANARLVDFQSTLELAGRWG GGEVASADGMRFVTPVKTINSGSNRKYFGSGRGITWYNFVSDQYSGFHGIVVPGTLRD SIFVLEGLLEQQTGLNPVEIMTDTAGSSDIIFGLFWLLGYQFSPRLADAGEAVFWRVN KSANYGVLDKLARGYADLSKAESQWDEMMRTAGSLKLGTIHASELIRSLLKSSRPSGL AQAIMEVGRVNKTLYLLNYIDDEDYRRRILTQLNRGEGRHAVARAICYGQRGEIRKRY REGQEDQLGALGLVTNAVVLWNTLYMEEALSWMRRNGEEIIDEDIARLSPLMHGHINM LGHYTFTLPEDILKGELRALNLNINNELSP" /product="transposase" gene complement(10729..11790) /locus_tag="Fpla013" /db_xref="GeneID:1263551" /gene="ybaA" CDS complement(10729..11790) /locus_tag="Fpla013" /protein_id="NP_061390.1" /gene="ybaA" /transl_table=11 /db_xref="GI:9507724" /db_xref="GeneID:1263551" /codon_start=1 /translation="MNTIKIKLNLIDYDSIVNIEFPCLLSEIEIELLSQLLKGYSVNE ISKRRNRSIKTVSCQKMKLYKKLNVKSDLTLWRDVFLRFKAYLQPKNIICDNFNSSVL PVVSSKGESMAHYNIYYQPIYNAKNGNIAGCDVTIALKNSDGSAFALDSDRINYNPND NKVSYLFGHINKLFSPIKNNLPHGFFITININPEDILTCDIERECLHFIKVFGTERIR LVLQFSTKEELYIIRRYQSSLRRIRNNNVYLSLNDFGMGYAELSHLQNIPFSYVNLHK TMFHDIESNSLTDIIATTIIDLSKQLHIDVIADGIETKKQAGYMIERGVKYLKGIALS SPLPADAFVRKLLASLKQV" /product="hypothetical protein" gene complement(11900..12313) /locus_tag="Fpla014" /db_xref="GeneID:1263533" /gene="ybbA" CDS complement(11900..12313) /locus_tag="Fpla014" /protein_id="NP_061391.1" /gene="ybbA" /transl_table=11 /db_xref="GI:9507725" /db_xref="GeneID:1263533" /codon_start=1 /translation="MMIIFRYLIIIILSVYMTGCTNNNLKKEDIPEDMFAIIYGSDSI KKYEHGQMELTKNINSGCIEALVFLSEEDPEKYSDYINDYHKIAEGYRFLDDNRTFMN KDSIELLVRGLNVKKDVLCSRVKFESFQHLKNKFQ" /product="hypothetical protein" gene complement(12477..13040) /locus_tag="Fpla015" /db_xref="GeneID:1263503" /gene="ybcA" CDS complement(12477..13040) /locus_tag="Fpla015" /protein_id="NP_061392.1" /gene="ybcA" /transl_table=11 /note="mutations in this gene affect swarming motility and cell shape in Proteus mirabilis; swarming motility requires close cell-to-cell contact; another truncated protein may be produced from a downstream start codon" /db_xref="GI:9507726" /db_xref="GeneID:1263503" /codon_start=1 /translation="MRAYCPHYQFMLFWIASLCWFSLIVLWGTGFYSLLFYIISVLLI IILYTLYFIGENMFSKGKIKESDSTTTIISKNTSFVGDISSGEKIIIHGKINGNINTN NGVVFIDKGGVVNGRVLCEKMILNGELYGECCCSTLDVYENGFLQGEVSYRFLEIRNG GCITGIVNKVTDEVQNNVSELVKARES" /product="hypothetical protein" gene complement(13047..13460) /locus_tag="Fpla016" /db_xref="GeneID:1263519" /gene="ybdA" CDS complement(13047..13460) /locus_tag="Fpla016" /protein_id="NP_061393.1" /gene="ybdA" /transl_table=11 /db_xref="GI:9507727" /db_xref="GeneID:1263519" /codon_start=1 /translation="MFNRRVLFLSVFSCAVFMLSGCSSNRFASRDANATYVNTQLKII PRSQEKIQAQSQCSRSFSLLQKLNTDKFSMYRNQFDEINDAYFFYKRNVDLMNKDSKE LMASVLDSKLDMVCVRVDNASFVGIYGKMKKVMDL" /product="hypothetical protein" gene complement(13453..14055) /locus_tag="Fpla017" /db_xref="GeneID:1263524" /gene="ybdB" CDS complement(13453..14055) /locus_tag="Fpla017" /protein_id="NP_061394.1" /gene="ybdB" /transl_table=11 /db_xref="GI:9507728" /db_xref="GeneID:1263524" /codon_start=1 /translation="MYCINTDCTYTKIAIEQLLHEKYFDDRRYCHSIKIYDLRFFKIE DVAYKLIQLFKERRKENIIFLCSDRFIHSKEKPRNIFFLDTKDSIRNWSRHLKKLRYC NSNLLICFLFLCGLYHISVFTGKKQVIIACIKKGFSFAEIVNFLNINARTLVNYLGGL TTYFILPYSDSLYKYIIDNIIASSTEEYHILLTNQRRYYV" /product="hypothetical protein" mobile_element 15093..16350 /mobile_element_type="insertion sequence:IS3b" repeat_region join(15093..15131,16312..16350) /rpt_type=inverted /note="IS3b terminal repeats" gene 15158..15457 /locus_tag="Fpla018" /db_xref="GeneID:1263530" /gene="ybfA" CDS 15158..15457 /locus_tag="Fpla018" /protein_id="NP_061395.1" /gene="ybfA" /transl_table=11 /db_xref="GI:9507729" /db_xref="GeneID:1263530" /codon_start=1 /translation="MTKTVSTSKKPRKQHSPEFRSEALKLAERIGVTAAARELSLYES QLYNWRSKQQNQQTSSERELEMSTEIARLKRQLAERDEELAILQKAATYFAKRLK" /product="transposase" gene 15454..16320 /locus_tag="Fpla019" /db_xref="GeneID:1263538" /gene="ybfB" CDS 15454..16320 /locus_tag="Fpla019" /protein_id="NP_061396.1" /gene="ybfB" /transl_table=11 /db_xref="GI:9507730" /db_xref="GeneID:1263538" /codon_start=1 /translation="MKYVFIEKHQAEFSIKAMCRVLRVARSGWYTWCQRRTRISTRQQ FRQHCDSVVLAAFTRSKQRYCAPRLTDELRAQGYPFNVKTVAASLRCQGLRAKASRKF SPVSYRAHGLPVSENLLEQDFYASGPNQKWAGDITYLRTDEGWLYLAVVIDLWSRAVI GWSMSPRMTAQLACDALQMALWRRKRPWNVIVHTDRGGQYCSADYQAQLKRHNLRGSM SAKGCCYDNACVESFFHSLKVECIHGEHFISREIMRATVFNYIECDYNRWRRHSWCGG LSPEQFENQNLA" /product="transposase" gene complement(16317..16571) /locus_tag="Fpla020" /db_xref="GeneID:1263529" /gene="ybgA" CDS complement(16317..16571) /locus_tag="Fpla020" /protein_id="NP_061397.1" /gene="ybgA" /transl_table=11 /db_xref="GI:9507731" /db_xref="GeneID:1263529" /codon_start=1 /translation="MLPVFTVRFLREVFLSFYRTACAAVLQPAPSAGWFRKHKSPPAM RAGGCIHPSGRWCPVASSTVPATGLHQHHSDPTHVIWTQA" /product="hypothetical protein" gene 16415..16558 /locus_tag="Fpla109" /db_xref="GeneID:2845545" CDS 16415..16558 /locus_tag="Fpla109" /protein_id="YP_024413.1" /transl_table=11 /db_xref="GI:48527945" /db_xref="GeneID:2845545" /codon_start=1 /product="hypothetical protein" /translation="MDEYNRLLSSQVATYASETNRLKALVAKLQRMQFGKSSEKLRAK IER" gene 16771..16917 /locus_tag="Fpla110" /db_xref="GeneID:2845546" CDS 16771..16917 /locus_tag="Fpla110" /protein_id="YP_024414.1" /transl_table=11 /db_xref="GI:48527946" /db_xref="GeneID:2845546" /codon_start=1 /product="hypothetical protein" /translation="MSELLELISCTFKVIETQRPKQACCRCNYIVQTPEPSAVIPDRG FRPM" gene 17061..17273 /locus_tag="Fpla111" /db_xref="GeneID:2845547" CDS 17061..17273 /locus_tag="Fpla111" /protein_id="YP_024415.1" /transl_table=11 /db_xref="GI:48527947" /db_xref="GeneID:2845547" /codon_start=1 /product="hypothetical protein" /translation="MLMAGKTRTVRQWCYVRDDRDAGSEMPPAVWFAYSPAGKVSIHK ITWPVTAVCFKPMLTVATGRYTNQAE" gene 17216..17548 /locus_tag="Fpla021" /db_xref="GeneID:1263520" /gene="ybhA" CDS 17216..17548 /locus_tag="Fpla021" /protein_id="NP_061398.1" /gene="ybhA" /transl_table=11 /db_xref="GI:9507732" /db_xref="GeneID:1263520" /codon_start=1 /translation="MFQADAYGGYRALYESGRITEAACMAHARRKIHDVHARAPTDVT TEALQRISELYAIEVAVRGCSAEQRLAARKARPAPLMQSLYDWIQTQMKTLARHSDTA KAFAYLLQ" /product="hypothetical protein" mobile_element 17662..18992 /mobile_element_type="insertion sequence:IS2" repeat_region join(17662..17702,18951..18992) /rpt_type=inverted /note="IS2 terminal repeats" gene complement(17673..18578) /locus_tag="Fpla022" /db_xref="GeneID:1263540" /gene="ybhB" CDS complement(17673..18578) /locus_tag="Fpla022" /protein_id="NP_061399.1" /gene="ybhB" /transl_table=11 /note="IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats" /db_xref="GI:9507733" /db_xref="GeneID:1263540" /codon_start=1 /translation="MDSARALIARGWGVSLVSRCLRVSRAQLHVILRRTDDWMDGRRS RHTDDTDVLLRIHHVIGELPTYGYRRVWALLRRQAELDGMPAINAKRVYRIMRQNALL LERKPAVPPSKRAHTGRVAVKESNQRWCSDGFEFCCDNGERLRVTFALDCCDREALHW AVTTGGFNSETVQDVMLGAVERRFGNDLPSSPVEWLTDNGSCYRANETRQFARMLGLE PKNTAVRSPESNGIAESFVKTIKRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSAL GYRSPREYLRQRACNGLSDNRCLEI" /product="insertion element IS2 transposase InsD" gene complement(18536..18901) /locus_tag="Fpla023" /db_xref="GeneID:1263543" /gene="ybiA" CDS complement(18536..18901) /locus_tag="Fpla023" /protein_id="NP_061400.2" /gene="ybiA" /transl_table=11 /note="IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats" /db_xref="GI:161347171" /db_xref="GeneID:1263543" /codon_start=1 /translation="MIDVLGPEKRRRRTTQEKIAIVQQSFEPGMTVSLVARQHGVAAS QLFLWRKQYQEGSLTAVAAGEQVVPASELAAAMKQIKELQRLLGKKTMENELLKEAVE YGRAKKWIAHAPLLPGDGE" /product="insertion sequence 2 OrfA protein" gene 18858..19142 /locus_tag="Fpla024" /db_xref="GeneID:1263518" /gene="ybiB" CDS 18858..19142 /locus_tag="Fpla024" /protein_id="NP_061401.1" /gene="ybiB" /transl_table=11 /db_xref="GI:9507735" /db_xref="GeneID:1263518" /codon_start=1 /translation="MVRRLRFSGPKTSIICSPMTSLKTSIKTITYLSDIGCLEIQGAS LAGSGSGGEHAAVLYSLIGTCRLNNVELEKWLCYGIEHIQDWSANLVRDL" /product="hypothetical protein" gene 19245..19454 /locus_tag="Fpla025" /db_xref="GeneID:1263539" /gene="ybjA" misc_feature 19245..19454 /locus_tag="Fpla025" /gene="ybjA" /note="similar to transposase; fragment" gene complement(20096..20791) /locus_tag="Fpla026" /db_xref="GeneID:1263542" /gene="ycaA" CDS complement(20096..20791) /locus_tag="Fpla026" /protein_id="NP_061403.1" /gene="ycaA" /transl_table=11 /db_xref="GI:9507737" /db_xref="GeneID:1263542" /codon_start=1 /translation="MMYRVNHIMRTINEMSSYTPHMKVNRIAERLSKVQKISFCISVI SFFLLAIITLTYGPFNTKSNLSFISALSLYFINVIMGVTYLSVPVINTIKYIYNFKGE VVNELIYDIDSDEQHIEALLPYSLEELTYVSNCIQVRIPKIKSKCFLWGGGKTAIISI LCLSYSAICIVNGGSIDGIFVGETGDKIIVAIMFFILYTSLMNMFFKQKLLYLQNLKM IIDMTIKIKRNFT" /product="hypothetical protein" gene complement(21222..21455) /locus_tag="Fpla027" /db_xref="GeneID:1263501" /gene="ycbA" CDS complement(21222..21455) /locus_tag="Fpla027" /protein_id="NP_061404.1" /gene="ycbA" /transl_table=11 /db_xref="GI:9507738" /db_xref="GeneID:1263501" /codon_start=1 /translation="MVRYHGEFTYYVYQQSGRYFFCKKLTKKRDTSNCNHLHIIRELS FNEDELELIDFSTDGLDANDKEIIRGMIDELKK" /product="hypothetical protein" gene complement(21541..26817) /locus_tag="Fpla028" /db_xref="GeneID:1263513" /gene="ycbB" CDS complement(21541..26817) /locus_tag="Fpla028" /protein_id="NP_061405.1" /gene="ycbB" /transl_table=11 /note="similar to Adhesin AidA-I precursors, ice nucleaation proteins, surface proteins, and outer membrane proteins; similar to ychA" /db_xref="GI:9507739" /db_xref="GeneID:1263513" /codon_start=1 /translation="MCFFLGSRLAYAENIDGSSTISNRDISGSLNIGINKDANIDING TVNIKDYFSVATCNGQSSTCPEGGLNASAKIDKSASVGASVTIVGDSSKGELNIDGGS TLYTQQLWVSGNDNDKTSNVSDDSNGSLSINNGSNVFVVSSQDDTPFKTNSVKWNQNI ISQGNNITDGTVSSGDLVLGKTGNGIIDIDNNSKLDVKNDVVVSTGVDGIPNEKPSEI NIKNESNFSVHGDMKGGISAAGKLNLNMDNSSNLHVDKNIAVGIGRESNITVSASRES SIFSDGNFTVATGNNSNANLKLDASNLSVNGVSTIGSGDGSITKFDIKNGSVVTSSSD MTLAKGKGTQANINISSSELNTGSLSVGEGDNADVKMTGSGASVSSKKTFTVAKGNNA SATLNYTGSKIDIGSGYIGEGESAKTQLELNNSALTASGKVFIGQGNTTQTNLTLNDK SSVNVSGEMSVAQGSSASVDVTATNAVLSADSLSLGGGEAAKVTMTGSGATVSSKNTF TVAKGNNASATLDYTDSKIDIGSGYIGEGEAAKTQLELNNSALTASGKVFIGQGNTTQ TNLTLNDKSSVNVSDEMSVAQGSSASVDVTITNAVLSADSLSLGGGEAAKVTMTGNRA TISSGNTFTVAKGNNASATLDYSDSKINIGNGYIGGGEKAQTVLTLKDSALAATGDVI MGQGQETQTDLTLSPQSSIKVSGNMSIAQGNAASAKVIVDNADLSANSMSIGEGDTAA VTMTGNGATISSGNTFTVARGNNASATLDYSDSKINIGNGYIGGGEKAQTVLTLKDSA LAATGDVIMGQGQETQTDLTLSPQSSIKVSGNMSIAQGNAASAKVIVDNADLSANSMS IGEGDTAAVTMTGNGATISSGNTFTVARGNNASATLDYSDSKINIGNGYIGVGEKSHT LLKLDNSTFHAAGNIDIGKGSSTIANVSVGAGSNMSIKGNASIGVGDQAKAKFSVKDS VLNIGSSLVLGQGNSTEAEMSVEHSQLYSGGLLLGTANNAVVSMSANNSEISVVGDYT VAKGDGSEATLIYKNSDINLGNGILGAGSGVKTDLSLDNSKFVASDGIIIGKGDNAIT NLSISDHSVFKGERINIGNGSYSKNSISITGNSIFDFGSSQESTIGEGDYSQSLVTIN DASVYGDGSLTLAKGNNSFAVLNLQDNAVTNANNISLATGLGSKAIVNVSNMNSGQFN PVSMGAGDGYAEVNFDGVNGYTLSTNFICMDSGSCADTVINVNRGTVSLSGTNDWKGQ INVYDGTRLDARGNDAVDGILNVSKEAQVDFNGYSQHMTGIDNKGMIYLSDGSASSDV YLDKDYVAHDGSGVQFGIFGQKEADVMHVKGDTSGSSGIVVTTNSKNKIKKGGDILLV EVNGDSSGSFYLNSLIKNGKEYKVTGDYIDVGAWEYALNKKRKNWYLSVDMRPEPGAF INNSKSMLDMFALQRYDIPGQHRYPTLFENLYNNGMWIQFNNNSGSNSEVYDNLKTSY SLNTMMIGGDIYNWTDGYNYSHIGIMGGMGSAANKTTSTNNKRATGNVDGYTLGLYHV FQQNISDGLNESERQGLWTYSSIQYMDYDNSVSSTNNFKANYGVNGFRLTGEVGYLKN IGGIQPSDFYVEPKLYLSHTELSGGVVEDLQGGKITYPNSLTIIEPGVFFSYRKTHES TSNDEAMFKDYIKQSVVDAWFGGGYSFKTGNYSRTNFDSDMVEYNTSDNFALKSGVEF EFLKDARLLLTSSYSINNDRNLSFILGGNYYF" /product="hypothetical protein" repeat_region 24085..24456 /note="repeat H" repeat_region 24457..24828 /note="repeat H" repeat_region 24829..25200 /note="repeat H" repeat_region 25201..25572 /note="repeat H" repeat_region 25573..25818 /note="repeat H" gene 26990..27259 /locus_tag="Fpla029" /db_xref="GeneID:1263528" /gene="ycgA" CDS 26990..27259 /locus_tag="Fpla029" /protein_id="NP_061406.1" /gene="ycgA" /transl_table=11 /db_xref="GI:9507740" /db_xref="GeneID:1263528" /codon_start=1 /translation="MYFMTKKMLTFVQTPKEGLSFAMTTYLNLFVKLLIFLYIQNTKA CLSINNVNNNSKNKLRSGVSYYIINLKMSMLFTEQIVTIYNKLIF" /product="hypothetical protein" gene complement(27486..31601) /locus_tag="Fpla030" /db_xref="GeneID:1263499" /gene="ychA" CDS complement(27486..31601) /locus_tag="Fpla030" /protein_id="NP_061407.1" /gene="ychA" /transl_table=11 /note="similar to Adhesin AidA-I precursors, ice nucleaation proteins, surface proteins, and outer membrane proteins; similar to ychB" /db_xref="GI:9507741" /db_xref="GeneID:1263499" /codon_start=1 /translation="MNCQRYFCFVNGIVEIRTAPEEYQNKPVLVGSQSDGLLIIDNHA DIEDGIFSTLHIGNGYNGAVDVINGAALHMDNRSGSAPLIVGAFGNDIAGKLNISGRN SIVSYRDTPSSSGHNESIYVGFGPGATGWINIFNGGVFEVLNSTNIYVGSDTPGGGDG SIVIDGSNSKMTADFSEAYVGLYGNGDISLKNGGQLSASNLYIGGNGRAIVNISGTDS RLIANMITISGSSGAPGIYIADQGILNVDNYINITTANDTKGKLFINSDMPGTIESKG ILFGVGKAELIFKHNSDNYAFSSPLISKNTGNGIINAESGETHLTGDNTDYSGLLNIL PTASIDISSQKNIGKSVIVNNGVLQITSQDDWTFNNNMTGNGYLNVHTGGHNFAFQNS TNTQEFTGTLALSDTLFDLSDDNTTALTSALVLAGVGSVITAGTGTQVINGFSFDGGA VNFGAVTQGAQQTESQIQVTDNLYINGNGAVRVSTPTDVNGIPQVINSSLSLLEQDDS NATIKLVDASSAVVKGNGGNLQLQDASGQVISSGKQRNIVQQGKNVAKGVYDYRLTSG PHNDGLYIGYALTQLDLLASGVDALVLDAAGTTGNAADMSARITGAGDLAFNSQKGET VSLSNQDNDYTGVTAIRGGNVLMNSNSVLGQTSEIRLATDTRLDMNGHSQTVGKLNGA AGSVLNINGGNLTLTDDGVSAGTLTGGGFLNISGGVLDITGGNHTFAVSTIIAKDATV RMNDVSGLGTGNISNAGTLSLTHASGLLSNNLSGSGTVSLINSDTQISGNNSNYSGLF VVDTSSQLTATGAQNLGIASVSNRGILQLNNTTDWQLINNVTGTGNVRKTGSGSLTVR SNAAWSGQTDIDDGSLILGQSDAPVMLASSLVNIAKNGKLTGFGGVVGNVTNSGSLDL RSAAPGNILTIGGNYTGNNGTLLINTVLDDSSSATDKLVIKGDASGKTRVAVTNVGGS GANTLNSIEVIHVDGNAANAEFIQAGRIAAGAYDYTLGRGPGSNYGNWYLSSSKNTPE PRPDPEPTPEGHDNNLRPEASSYTANIAAANTMFVTRLHERLGQTQYVDAITGEPKAT SMWMRHEGGHNRWRDGSGQLKTQSNRYVIQLGGDIAQWDWGGTNRWHLGVMAGYGNNH SSTGAVRTGYHSKGSVNGYSTGLYATWYADDETHNGAYLDTWAQYGWFDNHVKGDGLP GESWKSKGLTASLETGYAWKIGEFSSNYGNLNEWYVQPQAQLVWMGVKADELYESNGT LIESTGDGNVHTRLGVKTWIKRLNKMDDGKSREFSPFVEVNWLHNTRDFGVRMNGEPV YQDGTRNIGEVKTGVEGQINPHLNLWGNVRVQVGDKGYNDTSAMLGVKYTF" /product="hypothetical protein" gene 32322..33269 /locus_tag="Fpla031" /db_xref="GeneID:1263511" /gene="ompP" CDS 32322..33269 /locus_tag="Fpla031" /protein_id="NP_061408.1" /gene="ompP" /transl_table=11 /note="outer membrane protease; involved in virulence in many organisms; OmpT; IcsP; SopA; Pla; PgtE; omptin; in Escherichia coli OmpT can degrade antimicrobial peptides; in Yersinia Pla activates plasminogen during infection; in Shigella flexneria SopA cleaves the autotransporter IcsA" /db_xref="GI:9507742" /db_xref="GeneID:1263511" /codon_start=1 /translation="MQTKLLAIMLAAPVVFSSQEASASDFFGPEKISTEINLGTLSGK TKERVYEPEEGGRKVSQLDWKYSNAAILKGAVNWELNPWLSVGAAGWTTLNSRGGNMV DQDWMDSGTPGTWTDESRHPDTRLNYANEFDLNVKGWFLKESDYRLAIMAGYQESRYS FNATGGTYIYSENGGFRNETGALPDKIKVIGYKQHFKIPYVGLTGNYRYDNFEFGGAF KYSGWVRGSDNDEHYVRQTTFRSKVINQNYYSVAVNAGYYITPEAKVYIEGVWSRLTN KKGDTSLYDRSDNTSEHNNNGAGIENYNFITTAGLKYTF" /product="outer membrane protease" /EC_number="3.4.23.49" gene 33362..34861 /locus_tag="Fpla032" /db_xref="GeneID:1263517" /gene="yddA" CDS 33362..34861 /locus_tag="Fpla032" /protein_id="NP_061409.1" /gene="yddA" /transl_table=11 /db_xref="GI:9507743" /db_xref="GeneID:1263517" /codon_start=1 /translation="MRVIMKPLRRTLVFFIFSVFLCGTVSARQIEWQSCMTSPYSDWF GKESSSPELLCGYLSVPLKYTDTGKDVSDENIPLVRLAMTKLPAKSKRKGSVIIISGG PGLPGINPYINFDWPVTNLRESWDIIGFDPRGVGQSFPAINCQQSNQERLVNVSEKQL ILQKINACIHNTGAEVIRHIGSHEAVYDIERIRQALGDKQLTAVAYSYGTQIAALYAE RFPSSIRSIVFDGVVDIDDLNDNFSWKLRQAHSYQETFDRFAAWCARTKSCPLSSDRN QAIHQFHQLLLKLHNSPLTDSRGESISSDDLISLTTELLLWRSSWPTLATAVRQFSQG IVSNEIETALNSSIASEKVSDALGVILCVDQSDEQLSQEQRKSRKKALADAFPAVNFE REQSDLPEFCELWPIHRDLQQTRLKNTVLPSGLLFVAHKYDPTTPWINARKMADKFSA PLLTINGDGHTLALAGTNLCVDEAVVRHLLFPGKSEDITCQGSGTGDTN" /product="hypothetical protein" gene 35217..35504 /locus_tag="Fpla033" /db_xref="GeneID:1263502" /gene="ydfA" CDS 35217..35504 /locus_tag="Fpla033" /protein_id="NP_061410.1" /gene="ydfA" /transl_table=11 /db_xref="GI:9507744" /db_xref="GeneID:1263502" /codon_start=1 /translation="MGRIAYKSVIMLSLQPSCVKSNCQGDGDVPGQNTRGAPSPFLFP FSVFSDPIHPGITPILPKTANQPSARATTGLIRDPCCKTYLYVFGFTRNNA" /product="hypothetical protein" gene 35618..36358 /locus_tag="Fpla034" /db_xref="GeneID:1263535" /gene="int" CDS 35618..36358 /locus_tag="Fpla034" /protein_id="NP_061411.1" /gene="int" /transl_table=11 /note="integrase/resolvase" /db_xref="GI:9507745" /db_xref="GeneID:1263535" /codon_start=1 /translation="MNNVIPLQNSPERVSLLPIAPGVDFATALSLRRMATSTGATPAY LLAPEVSALLFYMPDQRHHMLFATLWNTGMRIGEARMLTPESFDLDGVRPFVRILSEK VRARRGRPPKDEVRLVPLTDISYVRQMESWMITTRPRRREPLWAVTDETMRNWLKQAV RRAEADGVHFSIPVTPHTFRHSYIMHMLYHRQPRKVIQALAGHRDPRSMEVYTRVFAL DMAATLAVPFTGDGRDAAEILRTLPPLK" /product="site-specific recombinase" repeat_region complement(35982..36002) /note="RepFIB repeat sequence" rep_origin 36002..38238 /note="replication origin RepFIB; this origin functions in the absence of RepFIA; replication initiates through binding of the RepB protein to the repeated iterons in the origin; replication initiates in upstream iterons while downstream iterons control plasmid copy number" repeat_region complement(36377..36397) /note="RepFIB repeat sequence" repeat_region complement(36407..36427) /note="RepFIB repeat sequence" repeat_region complement(36425..36445) /note="RepFIB repeat sequence" repeat_region complement(36552..36572) /note="RepFIB repeat sequence" repeat_region complement(36592..36612) /note="RepFIB repeat sequence" repeat_region 36622..36642 /note="RepFIB repeat sequence" gene complement(36643..37620) /locus_tag="Fpla035" /db_xref="GeneID:1263561" /gene="repB" CDS complement(36643..37620) /locus_tag="Fpla035" /protein_id="NP_061412.1" /gene="repB" /transl_table=11 /note="binds to repeated iterons in RepFIB" /db_xref="GI:9507746" /db_xref="GeneID:1263561" /codon_start=1 /translation="MDKSSGELVTLTPNNNNTVQPVALMRLGVFVPTLKSLKNSKKNT LSRTDATEELTRLSLARAEGFDKVEITGPRLDMDNDFKTWVGIIHSFARHNVIGDKVE LPFVEFAKLCGIPSSQSSRRLRERISPSLKRIAGTVISFSRTDEKHTREYITHLVQSA YYDTERDIVQLQADPRLFELYQFDRKVLLQLKAINALKRRESAQALYTFIESLPRDPA PISLARLRARLNLKSPVFSQNQTVRRAMEQLREIGYLDYTEIQRGRTKFFCIHYRRPR LKAPNDESKENPLPPSPAEKVSPEMAEKLALLEKLGITLDDLEKLFKSR" /product="replication initiator protein" repeat_region 37816..37836 /note="RepFIB repeat sequence" repeat_region 37837..37857 /note="RepFIB repeat sequence" repeat_region 37858..37878 /note="RepFIB repeat sequence" gene complement(37942..38403) /locus_tag="Fpla036" /db_xref="GeneID:1263505" /gene="ydhA" CDS complement(37942..38403) /locus_tag="Fpla036" /protein_id="NP_061413.1" /gene="ydhA" /transl_table=11 /db_xref="GI:9507747" /db_xref="GeneID:1263505" /codon_start=1 /translation="MFEDPEIRIHKLQPCTQCPRLEDLWFSWYFRYIHDRCLRSSACH QDIHGASLYAPLALKQTYEVYFGYDCTLRKYGRFRQKLPVKTDFRKNGARRRPVTGRS PRTGEEAQWICNHSEQVRPEAFIIGSVCCFSGMIYPHIQRPDPVNRSMNDQ" /product="hypothetical protein" repeat_region complement(38218..38238) /note="RepFIB repeat sequence" gene complement(38460..39101) /locus_tag="Fpla037" /db_xref="GeneID:1263508" /gene="ydiA" CDS complement(38460..39101) /locus_tag="Fpla037" /protein_id="NP_061414.1" /gene="ydiA" /transl_table=11 /db_xref="GI:9507748" /db_xref="GeneID:1263508" /codon_start=1 /translation="MNADTWTRLQAFRHALELTSCEASLTAGYDHLKDFPAGCSELAS QTLTDYLTEDGSNLYSCIVGMQWDNGPGRYGHVIAAPARDYIDLTLDQFPGYHNRIVA EPVESGGQLAADLNREPAISTADGIVASASDKVNYITEQKNRQPMVIITECYKLIRMT ARFIPMCQSSQLFQHQIFPRLFIISDVGSCSLSRNTLDRLATDWKVTLSVLSL" /product="hypothetical protein" gene 39088..39318 /locus_tag="Fpla038" /db_xref="GeneID:1263500" /gene="ydjA" CDS 39088..39318 /locus_tag="Fpla038" /protein_id="NP_061415.1" /gene="ydjA" /transl_table=11 /db_xref="GI:9507749" /db_xref="GeneID:1263500" /codon_start=1 /translation="MSAFTFSPSRHDGPGTEVYGRPPGILSAQLSYPAAAPPAVFFPG ADFPGTYSFRSYPQNLWITVAPLLREKALLTA" /product="hypothetical protein" gene complement(40634..40870) /locus_tag="Fpla039" /db_xref="GeneID:1263506" /gene="yeaA" CDS complement(40634..40870) /locus_tag="Fpla039" /protein_id="NP_061416.1" /gene="yeaA" /transl_table=11 /db_xref="GI:9507750" /db_xref="GeneID:1263506" /codon_start=1 /translation="MADLNLIPENCQRCEDEESITAKAVIPPHPASSYVETYVGRAVP TGQYRIDRPSGPLTSLYDKGGRLDIANYCTVSLF" /product="hypothetical protein" gene 41216..41506 /locus_tag="Fpla040" /db_xref="GeneID:1263504" /gene="yebA" CDS 41216..41506 /locus_tag="Fpla040" /protein_id="NP_061417.1" /gene="yebA" /transl_table=11 /db_xref="GI:9507751" /db_xref="GeneID:1263504" /codon_start=1 /translation="MGVKITGLDKMQKQLKEVERATEALNGSYDVRFDANDPSSIENA IQEAYSMVDERASGYATNPMVSPLIEHMKENLRQQILDSAEQQRQESGQDGD" /product="hypothetical protein" gene 41496..42395 /locus_tag="Fpla041" /db_xref="GeneID:1263545" /gene="yebB" CDS 41496..42395 /locus_tag="Fpla041" /protein_id="NP_061418.1" /gene="yebB" /transl_table=11 /db_xref="GI:9507752" /db_xref="GeneID:1263545" /codon_start=1 /translation="MAIDIFQSLKNCVFDLQRADVQNYQQPLKQLARLLNSENLQSVN AHLTRNVELDTFLARSEDTESSMAGSAVLQWPDEPADILGLKLLLIEKMADDNNFSFN FCHTFFYDRNIIESIRKFTSSLVAPFVRDYQLYVENQHDPEPAVFRPVSRKIFIVHGH DNDALQSVARFISRIGLEEIILSERPDGSRTIIEKFEAESGDVSFAIVLMTPDDSGSA LASESTRLRARQNVLYELGYFAGKLGRGKVLVLRKGDIEIPSDLAGVLYTELDEHGGW KRKLLSELAYAGVPFDKDKALSA" /product="hypothetical protein" gene complement(42445..44670) /locus_tag="Fpla042" /db_xref="GeneID:1263512" /gene="pifA" CDS complement(42445..44670) /locus_tag="Fpla042" /experiment="experimental evidence, no additional details recorded" /protein_id="NP_061419.1" /gene="pifA" /transl_table=11 /note="phage inhibition by F protein A; this protein inhibits phage T7 development resulting in abortive infection" /db_xref="GI:9507753" /db_xref="GeneID:1263512" /codon_start=1 /translation="MKILRQLWNQKGLDAAVEDVPEDRYGFGNIAENISRSILTLPLE ASNVVGIEGAWGSGKTSLLNLILRNLALKKDAHTHVLHISPWLSGGSPVEALFLPVAT VIQQEMEIRYPPKGFKKLWRKYLLSPEAQKVIEYAQDTSSRVLPLVQYIGQFSSIINW IAGGIKVFSDSRLAVDQKTTTKLRAEIAGQLVSLDLKFIVVMDDLDRLEPSQVAEVFR LVRAVADLPRFTHILCYDRQIITHAVEHALNIEDGSRYLQKIIQLSFKLPRPEAFDLR NEFRQRAEALYQQINNQPPDSGMVRDLIAVTDTYGAALSTPREIHQAINSLIFLYPGM RDFVYFPDLCLLQLIRVTNPALYDWTEHYLTERSVIETGQGMLSDGEKADFREGLIRC MKTFRASNADSFLTLADWIPGISGHNDEYLNLFEPVSEDFRHIQTTGKRLSSLTHWRY YFAFSSPQNVLPPEFFRQLFEQAGVSEKQQQLSELLLSKINSVGSLSGTWFEHILSRL TPGLIRERNFEECAGLVHFFFDHTDEVSTRFSIRNPWFSLREMAINEVVRHLLKHMQD IDETRTITLMEKLIVTGASPFWIADFMRDLIWEHGLAQNAVPSPSDALFSRDITERLR DRFAERMNQPELQQQLLLRKSLLGYLYAWRDMSSGETVKQWVREVTTTDEGLVNLLIR LQTSVFSSHRGAYRRIARDQVSPFFDDWPAVEEKLKVMLSGNELTPEQEALKTALEND D" /product="phage inhibition protein" misc_difference 43446 /note="C is changed to A in gb:M12987; gb:M12987" gene complement(44672..45852) /locus_tag="Fpla043" /db_xref="GeneID:1263560" /gene_synonym="pifC" /gene="repC" CDS complement(44672..45763) /locus_tag="Fpla043" /gene_synonym="pifC" /experiment="experimental evidence, no additional details recorded" /protein_id="NP_061420.1" /gene="repC" /transl_table=11 /note="PifC; phage inhibition by F protein C; this regulatory protein affects pif expression, initiation of DNA replication and RP4 conjugation" /db_xref="GI:9507754" /db_xref="GeneID:1263560" /codon_start=1 /translation="MMLSQLNLRFHKKLIEALKTRAGRENTSVNALAERFLDDGLKTV APGDGYFQLIADPEATVRQLYRHIILGQTFGTSALSRDELRFVLVHVREAFLRGHNRL ATLPALDTLLDITGNLLAWQVEHDRPVDGHYLKGIFRLAGKNWTEEFEAFRAALRPVV DQMYAEHLLRPLESDCFGLAEVPDAVLAEIFTLPRLKAVFPLMLRGLDWNTEQARTLA QELRPVISAVTETIEAGTLRLEIRVDGQHPGERPGAWYTTPRLHLLITGQDFVVPYGW EALSELLGLFTLYARHPEALTHGHQGERVMFSPPGNVTPEGFFGIDGLRIFMPAEAFE TLVRELATRCQEGPLAEALTGLRCLYGDL" /product="replication protein" misc_difference 44709 /note="G is added to gb:M12987; gb:M12987" misc_difference 44736 /note="C is added to gb:M12987; gb:M12987" misc_difference 44747 /note="C is changed to G in gb:M12987; gb:M12987" misc_difference 44769 /note="G is added to gb:M12987; gb:M12987" misc_difference 44816 /note="C is added to gb:M12987; gb:M12987" RBS complement(45770..45774) /locus_tag="Fpla043" /gene_synonym="pifC" /gene="repC" -10_signal complement(45782..45787) /locus_tag="Fpla043" /gene_synonym="pifC" /gene="repC" repeat_region complement(45797..45807) /rpt_type=inverted /note="repeat A" -35_signal complement(45819..45852) /locus_tag="Fpla043" /gene_synonym="pifC" /gene="repC" misc_feature 45922..45949 /note="rfsF site" rep_origin 45934..46135 /note="oriV(ori-1) region; preferred replication initiation site" gene 46340..46558 /locus_tag="Fpla044" /db_xref="GeneID:1263592" /gene_synonym="letA" /gene="ccdA" CDS 46340..46558 /locus_tag="Fpla044" /gene_synonym="letA" /experiment="experimental evidence, no additional details recorded" /protein_id="NP_061421.1" /gene="ccdA" /transl_table=11 /note="antidote protein; reversibly inactivates CcdB; is less stable than CcdB; upon loss of the F plasmid CcdA is degraded by lon protease allowing CcdB toxin to work" /db_xref="GI:9507755" /db_xref="GeneID:1263592" /codon_start=1 /translation="MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERW KAENQEGMAEVARFIEMNGSFADENRDW" /product="plasmid maintenance protein CcdA" gene 46560..46865 /locus_tag="Fpla045" /db_xref="GeneID:1263593" /gene_synonym="letD" /gene="ccdB" CDS 46560..46865 /locus_tag="Fpla045" /gene_synonym="letD" /experiment="experimental evidence, no additional details recorded" /protein_id="NP_061422.1" /gene="ccdB" /transl_table=11 /note="controlled cell death protein; post-segregation toxin; toxin addiction system" /db_xref="GI:9507756" /db_xref="GeneID:1263593" /codon_start=1 /translation="MQFKVYTYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSD KVSRELYPVVHIGDESWRMMTTDMASVPVSVIGEEVADLSHRENDIKNAINLMFWGI" /product="plasmid maintenance protein CcdB" gene 46866..47672 /locus_tag="Fpla046" /db_xref="GeneID:1263556" /gene="resD" CDS 46866..47672 /locus_tag="Fpla046" /experiment="experimental evidence, no additional details recorded" /protein_id="NP_061423.1" /gene="resD" /transl_table=11 /note="resolvase/integrase" /db_xref="GI:9507757" /db_xref="GeneID:1263556" /codon_start=1 /translation="MSGSVIHSQSAVMVPAVYSAGQPASLPVAIDYPAALALRQMSMV HDELPKYLLAPEVSALLHYVPDLHRKMLLATLWNTGARINEALALTRGDFSLAPPYPF VQLATLKQRTEKAARTAGRMPAGQQTHRLVPLSDSWYVSQLQTMVATLKIPMERRNRR TGRTEKARIWEVTDRTVRTWIGEAVAAAAADGVTFSVPVTPHTFRHSYAMHMLYAGIP LKVLQSLMGHKSISSTEVYTKVFALDVAARHRVQFAMPESDAVAMLKQLS" /product="site-specific recombinase" misc_difference 47310..47311 /locus_tag="Fpla046" /gene="resD" /note="AC is changed to CA in gb:M12987; gb:M12987" misc_difference 48030 /note="T is added to gb: M12987; gb:M12987" misc_difference 48051..48052 /note="AG is added to gb: M12987; gb:M12987" rep_origin 48136..48352 /note="oriS(ori-2) region; can function if oriV is deleted" gene 48254..49201 /locus_tag="Fpla047" /db_xref="GeneID:1263547" /gene="repE" repeat_region 48254..48273 /note="IncB direct repeat" repeat_region 48275..48294 /note="IncB direct repeat" repeat_region 48308..48327 /note="IncB direct repeat" repeat_region 48330..48349 /note="IncB direct repeat" -35_signal 48382..48387 /locus_tag="Fpla047" /gene="repE" repeat_region join(48399..48408,48418..48427) /rpt_type=inverted /note="repeat A" -10_signal 48404..48409 /locus_tag="Fpla047" /gene="repE" RBS 48432..48436 /locus_tag="Fpla047" /gene="repE" CDS 48446..49201 /locus_tag="Fpla047" /experiment="experimental evidence, no additional details recorded" /protein_id="NP_061424.1" /gene="repE" /transl_table=11 /note="RepE; RepFIB" /db_xref="GI:9507758" /db_xref="GeneID:1263547" /codon_start=1 /translation="MAETAVINHKKRKNSPRIVQSNDLTEAAYSLSRDQKRMLYLFVD QIRKSDGTLQEHDGICEIHVAKYAEIFGLTSAEASKDIRQALKSFAGKEVVFYRPEED AGDEKGYESFPWFIKRAHSPSRGLYSVHINPYLIPFFIGLQNRFTQFRLSETKEITNP YAMRLYESLCQYRKPDGSGIVSLKIDWIIERYQLPQSYQRMPDFRRRFLQVCVNEINS RTPMRLSYIEKKKGRQTTHIVFSFRDITSMTTG" /product="replication protein" operon 49204..52004 /operon="sopAB operon" /note="regulated by SopA/SopB protein" repeat_region 49204..49222 /note="IncC direct repeat" misc_feature 49205..49455 /note="incompatibility region" repeat_region 49226..49244 /note="IncC direct repeat" repeat_region 49259..49277 /note="IncC direct repeat" repeat_region join(49337..49353,49364..49372) /rpt_type=inverted /note="imperfect repeat A" repeat_region 49350..49368 /note="IncC direct repeat" repeat_region 49433..49451 /note="IncC direct repeat" -35_signal 49725..49730 /operon="sopAB operon" -10_signal 49728..49753 /operon="sopAB operon" repeat_region 49728..49733 /rpt_type=direct gene 49789..50955 /operon="sopAB operon" /locus_tag="Fpla048" /db_xref="GeneID:1263522" /gene="sopA" CDS 49789..50955 /operon="sopAB operon" /locus_tag="Fpla048" /experiment="experimental evidence, no additional details recorded" /protein_id="NP_061425.2" /gene="sopA" /transl_table=11 /note="ATPase; binds to four repeated sequences in sopAB operator to repress transcription; DNA-binding is enhanced by SopB; membrane-associated; essential for partitioning of the RepFIA replicon" /db_xref="GI:228861763" /db_xref="GeneID:1263522" /codon_start=1 /translation="MKLMETLNQCINAGHEMTKAIAIAQFNDDSPEARKITRRWRIGE AADLVGVSSQAIRDAEKAGRLPHPDMEIRGRVEQRVGYTIEQINHMRDVFGTRLRRAE DVFPPVIGVAAHKGGVYKTSVSVHLAQDLALKGLRVLLVEGNDPQGTASMYHGWVPDL HIHAEDTLLPFYLGEKDDVTYAIKPTCWPGLDIIPSCLALHRIETELMGKFDEGKLPT DPHLMLRLAIETVAHDYDVIVIDSAPNLGIGTINVVCAADVLIVPTPAELFDYTSALQ FFDMLRDLLKNVDLKGFEPDVRILLTKYSNSNGSQSPWMEEQIRDAWGSMVLKNVVRE TDEVGKGQIRMRTVFEQAIDQRSSTGAWRNALSIWEPVCNEIFDRLIKPRWEIR" /product="plasmid-partitioning protein SopA" repeat_region join(49847..49863,49865..49881) /rpt_type=inverted /note="imperfect repeat B" repeat_region join(50483..50497,50500..50513) /rpt_type=inverted /note="imperfect repeat C" -35_signal 50887..50892 /operon="sopAB operon" /locus_tag="Fpla048" /gene="sopA" -10_signal 50912..50917 /operon="sopAB operon" /locus_tag="Fpla048" /gene="sopA" gene 50944..52004 /operon="sopAB operon" /locus_tag="Fpla049" /db_xref="GeneID:1263559" /gene="sopB" RBS 50944..50950 /locus_tag="Fpla049" /gene="sopB" CDS 50955..51926 /operon="sopAB operon" /locus_tag="Fpla049" /experiment="experimental evidence, no additional details recorded" /function="essential for partitioning of the RepFIA replicon" /protein_id="NP_061426.1" /gene="sopB" /transl_table=11 /note="SopB" /db_xref="GI:9507760" /db_xref="GeneID:1263559" /codon_start=1 /translation="MKRAPVIPKHTLNTQPVEDTSLSTPAAPMVDSLIARVGVMARGN AITLPVCGRDVKFTLEVLRGDSVEKTSRVWSGNERDQELLTEDALDDLIPSFLLTGQQ TPAFGRRVSGVIEIADGSRRRKAAALTESDYRVLVGELDDEQMAALSRLGNDYRPTSA YERGQRYASRLQNEFAGNISALADAENISRKIITRCINTAKLPKSVVALFSHPGELSA RSGDALQKAFTDKEELLKQQASNLHEQKKAGVIFEAEEVITLLTSVLKTSSASRTSLS SRHQFAPGATVLYKGDKMVLNLDRSRVPTECIEKIEAILKELEKPAP" /product="plasmid-partitioning protein" terminator 51982..52004 /operon="sopAB operon" /locus_tag="Fpla049" /gene="sopB" /note="putative terminator for sopB; forms potential imperfect stem-loop structure" misc_feature 51999..52472 /note="incD/sopC region; contains 12 43 bp direct repeats that bind SopB protein; required for partitioning of F plasmid to daughter cells after replication as well as repression of sopAB operator; also functions in incompatibility of similar plasmids" repeat_region 51999..52042 /note="IncD(sopC) direct repeat" repeat_region 52043..52085 /note="IncD(sopC) direct repeat" repeat_region 52086..52128 /note="IncD(sopC) direct repeat" repeat_region 52129..52171 /note="IncD(sopC) direct repeat" repeat_region 52172..52214 /note="IncD(sopC) direct repeat" repeat_region 52215..52257 /note="IncD(sopC) direct repeat" repeat_region 52258..52300 /note="IncD(sopC) direct repeat" repeat_region 52301..52343 /note="IncD(sopC) direct repeat" misc_difference 52320 /note="G is changed to A in gb:M12987; gb:M12987" repeat_region 52344..52386 /note="IncD(sopC) direct repeat" repeat_region 52387..52429 /note="IncD(sopC) direct repeat" repeat_region 52430..52472 /note="IncD(sopC) direct repeat" gene 52569..52841 /locus_tag="Fpla050" /db_xref="GeneID:1263598" /gene="yfcA" CDS 52569..52841 /locus_tag="Fpla050" /protein_id="NP_061427.1" /gene="yfcA" /transl_table=11 /db_xref="GI:9507761" /db_xref="GeneID:1263598" /codon_start=1 /translation="MRLYACCGLLLCPAYPQHFAHGYVDKIPGYPGRAGTLTGLHPMQ VCRCRRPPHPVTFRRFSSTRCGFGAAPAFVCGRPVTGAARPDGGRM" /product="hypothetical protein" misc_difference 52762 /locus_tag="Fpla050" /gene="yfcA" /note="G is added to gb:M12987; gb:M12987" gene 52855..53361 /locus_tag="Fpla051" /db_xref="GeneID:1263495" /gene="yfcB" CDS 52855..53361 /locus_tag="Fpla051" /protein_id="NP_061428.1" /gene="yfcB" /transl_table=11 /note="orf168" /db_xref="GI:9507762" /db_xref="GeneID:1263495" /codon_start=1 /translation="MPNWCSNRMYFSGEPAQIAEIKRLASGAVTPLYRRATNEGIQLF LAGSAGLLQTTEDVRFEPCPGLTAAGRGVVSPENIAFTRWLTHLQDGVLLDEQNCLML HELWLQSGTGRRRWEELPDDARESITALFTPKRGDWCDIWSNEDVSVWWNRLCDNVLP EKPCRLTC" /product="hypothetical protein" gene 53343..53780 /locus_tag="Fpla052" /db_xref="GeneID:1263599" /gene="yfdA" CDS 53343..53780 /locus_tag="Fpla052" /protein_id="NP_061429.1" /gene="yfdA" /transl_table=11 /note="orf145" /db_xref="GI:9507763" /db_xref="GeneID:1263599" /codon_start=1 /translation="MPFDLLTVLFTRLDVEVNGFNGGVLNGVPSAYHWYTEQYGVKGP CGYEVNISSQGDNFIQVDFDTPWCQPESDVIAVLSRRFSCTLEHWYAEQGCNFCGWQR YERGELVDVLWGELEWSSPTDDDELPEVTAPEWIVDKVAHYGG" /product="hypothetical protein" misc_difference 53741 /locus_tag="Fpla052" /gene="yfdA" /note="G is changed to C in gb:AF106329; gb:AF106329" gene 53784..54089 /locus_tag="Fpla053" /db_xref="GeneID:1263490" /gene="yfdB" CDS 53784..54089 /locus_tag="Fpla053" /protein_id="NP_061430.1" /gene="yfdB" /transl_table=11 /note="orf101" /db_xref="GI:9507764" /db_xref="GeneID:1263490" /codon_start=1 /translation="MTETGGQPPVSFPVKDVAGLLFLLRRLTRRGRNAACGQCPASGW ARDGRFYRSRLASVTVYASPSPFSDERPSSRFRGIFSPSKRRRLRYSTVGLTRYRTR" /product="hypothetical protein" gene 54166..54849 /locus_tag="Fpla054" /db_xref="GeneID:1263496" /gene="yfeA" CDS 54166..54849 /locus_tag="Fpla054" /protein_id="NP_061431.1" /gene="yfeA" /transl_table=11 /note="orf227; similar to adenine methyltransferase" /db_xref="GI:9507765" /db_xref="GeneID:1263496" /codon_start=1 /translation="MSRFIQGDCVRVMATFPGNAVDFILTDPPYLVGFRDRQGRTIAG DKTDEWLQPACNEMYRVLKKDALMVSFYGWNRVDRFMAAWKNAGFSVVGHLVFTKTYT SKAAYVGYRHECAYILAKGRPALPQKPLPDVLGWKYSGNRHHPTEKPVTSLQPLIESF THPNAIVLDPFAGSGSTCVAALQSGRRYIGIELLEQYHRAGQQRLAAVQRAMQQGAAN DDWFMPEAA" /product="putative methylase" gene 54850..55071 /locus_tag="Fpla055" /db_xref="GeneID:1263491" /gene="yfeB" CDS 54850..55071 /locus_tag="Fpla055" /protein_id="NP_061432.1" /gene="yfeB" /transl_table=11 /note="orf73" /db_xref="GI:9507766" /db_xref="GeneID:1263491" /codon_start=1 /translation="MNYAGHKKLRADVAEVANTMCDLRARLNDMEHRCRFDSDVLVER LARQTLYRANRLFMEAYTEILELDACFKD" /product="hypothetical protein" gene 55085..55519 /locus_tag="Fpla056" /db_xref="GeneID:1263532" /gene="yffA" CDS 55085..55519 /locus_tag="Fpla056" /protein_id="NP_061433.1" /gene="yffA" /transl_table=11 /note="orf144" /db_xref="GI:9507767" /db_xref="GeneID:1263532" /codon_start=1 /translation="MYGTCETLCRELAAKYPGYTPLMLVIWSPEEIQALADGMDISLS DPEIRTVLARLEDIPEDQRIESGISSAAAMEIISNVSENRQVTVPAELLASLIQTAEQ ALWKREWAARDYGLAVPECVTRRQAVVNQARILLKNNTHENG" /product="hypothetical protein" gene 55565..56341 /locus_tag="Fpla057" /db_xref="GeneID:1263492" /gene="yffB" CDS 55565..56341 /locus_tag="Fpla057" /protein_id="NP_061434.1" /gene="yffB" /transl_table=11 /note="orf248" /db_xref="GI:9507768" /db_xref="GeneID:1263492" /codon_start=1 /translation="MNENTTLNALICRHARNLLLAQGWPEETDVDQRNPKYPGWISIY VLLDAPRLATLLVNRHGGVLPPHLASAIQKLTGTGAELVLSGSQWQSLPVLPADGTQV SFPYAGEWLTEDEIRAVLAAVRDAVRSVSCRVAEDMRRIRAALTTTGQTLLTRQTRRF RLVVKESDHPCWLDEDDENLPVVLDAILNRGARFSAVEMYLVSDCIEHILSSGLACDV LRIPDEPPRQWFDRGVLREVVREARAEIRSMADALAKIRG" /product="hypothetical protein" misc_difference 56074 /locus_tag="Fpla057" /gene="yffB" /note="C is changed to G in gb:AF106329; gb:AF106329" gene 56429..56740 /locus_tag="Fpla058" /db_xref="GeneID:1263510" /gene="yfgA" CDS 56429..56740 /locus_tag="Fpla058" /protein_id="NP_061435.1" /gene="yfgA" /transl_table=11 /db_xref="GI:9507769" /db_xref="GeneID:1263510" /codon_start=1 /translation="MQAWPCGFSVMWPPCRVRAVPCLHLSRAGGDARVRFAAAVTRSL LPVCRDFPVVHPLRFRGLTLQLPSAVCVRLRLPLRPVHPRLIARLLWRHGTARCRGIC E" /product="hypothetical protein" gene 56755..57180 /locus_tag="Fpla059" /db_xref="GeneID:1263597" /gene="yfgB" CDS 56755..57180 /locus_tag="Fpla059" /protein_id="NP_061436.1" /gene="yfgB" /transl_table=11 /note="orf141; similar to antirestriction protein KlcA" /db_xref="GI:9507770" /db_xref="GeneID:1263597" /codon_start=1 /translation="MQYAKPVTLNVEECDRLSFLPYLFGNDFLYAEAYVYALAQKMMP EYQGGFWHFIRLPDGGGYMMPDGDRFHLVNGENWFDRTVSADAAGIILTSLVINRQLW LYHDSGDVGLTQLYRMRDAQLWRHIEFHPECNAIYAALD" /product="antirestriction protein" gene 57227..57649 /locus_tag="Fpla060" /db_xref="GeneID:1263596" /gene="yfhA" CDS 57227..57649 /locus_tag="Fpla060" /protein_id="NP_061437.1" /gene="yfhA" /transl_table=11 /note="orf140" /db_xref="GI:9507771" /db_xref="GeneID:1263596" /codon_start=1 /translation="MYCTVKEIIRDVLDTDVPDSECVFAVVLTRGDVRHIAQDWNLSD DELETVMQRLDDAFEYGADVSIVHDVVRELMEEKRASRQVTVPAVMLEKVMALAGSEM KRLYAVGSENGGDGDAFVREEREAMDVVLQALDGEHMS" /product="hypothetical protein" gene 57956..58354 /locus_tag="Fpla061" /db_xref="GeneID:1263590" /gene="yfhB" CDS 57956..58354 /locus_tag="Fpla061" /protein_id="NP_061438.1" /gene="yfhB" /transl_table=11 /db_xref="GI:9507772" /db_xref="GeneID:1263590" /codon_start=1 /translation="MCPECFFLMLFFCGYRACYCSSSFSSSSSSSSSSSFRSSPAYGF SGRPPGGAGCRERSQRSCLRPGGLPSLTRNPGLQRPFRSRRLCRAVACAPGIPAKGRR DVRGNAVSQTALHVVAAGPCSLPAGCHTPV" /product="hypothetical protein" gene 58643..59182 /locus_tag="Fpla062" /db_xref="GeneID:1263584" /gene_synonym="ssf" /gene="ssb" CDS 58643..59182 /locus_tag="Fpla062" /gene_synonym="ssf" /experiment="experimental evidence, no additional details recorded" /protein_id="NP_061439.1" /gene="ssb" /transl_table=11 /db_xref="GI:9507773" /db_xref="GeneID:1263584" /codon_start=1 /translation="MAVRGINKVILVGRLGKDPEVRYIPNGGAVANLQVATSESWRDK QTGEMREQTEWHRVVLFGKLAEVAGECLRKGAQVYIEGQLRTRSWEDNGITRYVTEIL VKTTGTMQMLVRAAGAQTQPEEGQQFSGQPQPEPQAEAGTKKGGAKTKGRGRKAAQPE PQPQPPEGDDYGFSDDIPF" /product="single-stranded DNA-binding protein" gene 59233..59472 /locus_tag="Fpla063" /db_xref="GeneID:1263591" /gene="yfjA" CDS 59233..59472 /locus_tag="Fpla063" /protein_id="NP_061440.1" /gene="yfjA" /transl_table=11 /note="orf77" /db_xref="GI:9507774" /db_xref="GeneID:1263591" /codon_start=1 /translation="MRMSEYFRILQGLPDGPFTRKHAEAVAAQYRNVFIEDDHGEQFR LVVRNNGAMVWRTWNFEDGAGYWMNHVIRDFGILK" /product="hypothetical protein" gene 59538..61496 /locus_tag="Fpla064" /db_xref="GeneID:1263594" /gene="yfjB" CDS 59538..61496 /locus_tag="Fpla064" /protein_id="NP_061441.1" /gene="yfjB" /transl_table=11 /note="orf652" /db_xref="GI:9507775" /db_xref="GeneID:1263594" /codon_start=1 /translation="MSVTESKAKTERKSSRKPAKTQETVLSALLAQTEEVSVPLASLI KSPLNVRTVPYSAESVSELADSIKGVGLLQNLVVHALPGDRYGVAAGGRRLAALNMLA ERDIIQVDWPVRVKVIPQELATAASMTENGHRRDMHPAEQIAGFRAMAQEGKTPAQIG DLLGYSPRHVQRMLKLADLAPVILDALAEDRITTEHCQALALENDTARQVQVFEAACQ SGWGGKPDVRVIRNLITESEVAVKDNTKFRFVGADAFSPDELRTDLFSDDEGGYVDCV ALDAALLEKLQAVAEHLREAEGWEWCAGRMEPVGECREDSRAYRNLPEPEAVLTEAEE ERLNELMMRYDALENQCEESDLLAAEMKLIDCMAKVRAWTPEMRAGSGVVVSWRYGNV CVQRGVQLRSEDDVTDDADRTEQVQEKASVEEISLPLLTKMSSERTLAVQAALMQQPD KSLALLTWTLCLNVFGSGAYSKPAQISLECKHYSLTSDAPSGKEGAAFMALMAEKARL VVLLPEGWSRDMTTFLSLSQEVLLSLLSFCTACSIHGVQTRECGHTSRSPLDPLETAI GFHMRDWWQPTKANFFGHLKKPQIIAALNEAGLSGAARDAEKMKKGDAAEHAEFHMKD NRWVPGWMCAPRPQTDATERTDNLADAA" /product="hypothetical protein" gene 61551..61985 /locus_tag="Fpla065" /db_xref="GeneID:1263521" /gene="psiB" CDS 61551..61985 /locus_tag="Fpla065" /experiment="experimental evidence, no additional details recorded" /protein_id="NP_061442.1" /gene="psiB" /transl_table=11 /note="inhibits SOS response; prevents activation of RecA protein; is expressed early when single-stranded F plasmid DNA is injected into host cells to turn off SOS response" /db_xref="GI:9507776" /db_xref="GeneID:1263521" /codon_start=1 /translation="MKTELTLNVLQTMNAQEYEDIRAAGSDERRELTHAVMRELDAPD NWTMNGEYGSEFGGFFPVQVRFTPAHERFHLALCSPGDVSQVWVLVLVNAGGEPFAVV QVQRRFASEAVSHSLALAASLDTQGYSVNDIIHISMAEGGQV" /product="plasmid SOS inhibition protein B" gene 61982..62701 /locus_tag="Fpla066" /db_xref="GeneID:1263537" /gene="psiA" CDS 61982..62701 /locus_tag="Fpla066" /protein_id="NP_061443.1" /gene="psiA" /transl_table=11 /note="PsiA" /db_xref="GI:9507777" /db_xref="GeneID:1263537" /codon_start=1 /translation="MSVRSQALVPLSTEQQAAWRAVAETEKRRHQGNTLAEYPYAGAF FRCLNGSRRISLSDLRFFMPSLTAEELHGNRLQWLYAIDVLIETQGEVCLLPLPGDAA ERLFPSVRFRVRERSRHKSALVMQKYSRQQAREAEQKARAYQALVAQAEIELAFHSPE TVGSWHARWSDRVAEHDLETLFWQWGERFPSLAGMERWQWQDMPFWQVIAEASLAARE AGHAVREMERWMVPNKLREAA" /product="plasmid SOS inhibition protein A" repeat_region join(62057..62066,62107..62116) /rpt_type=inverted /note="inverted repeat A" gene complement(62827..62927) /locus_tag="Fplas003" /db_xref="GeneID:1263558" /gene="flmB" misc_RNA complement(62827..62927) /locus_tag="Fplas003" /db_xref="GeneID:1263558" /gene="flmB" /product="F leading maintenance antisense RNA" /note="antisense RNA of flmC mRNA; similar to srnA; prevents translation of the toxin flmA indirectly by inhibiting translation of flmC; unstable RNA" repeat_region join(62880..62893,62899..62913) /rpt_type=inverted /note="repeat I" gene 62918..63130 /locus_tag="Fpla067" /db_xref="GeneID:1263583" /gene="flmC" CDS 62918..63130 /locus_tag="Fpla067" /experiment="experimental evidence, no additional details recorded" /protein_id="NP_061444.1" /gene="flmC" /transl_table=11 /note="Mok; similar to F leading maintenance protein C" /db_xref="GI:9507778" /db_xref="GeneID:1263583" /codon_start=1 /translation="MLRQHQDSLLLRFAQGEEGHETTTQLSCLVCVDRVSHTVDIHLS DTKIAVRDSLQRRIQGGGGFHGLRIR" /product="modulator of post-segregation killing protein" repeat_region join(62942..62955,62978..63136) /rpt_type=inverted /note="repeat II" gene 62976..63134 /locus_tag="Fpla068" /db_xref="GeneID:1263569" /gene="flmA" CDS 62976..63134 /locus_tag="Fpla068" /experiment="experimental evidence, no additional details recorded" /protein_id="NP_061445.1" /gene="flmA" /transl_table=11 /note="similar to Hok protein and SrnB'; toxin protein; kills the host cell by destabilizing polar membranes unless the antidote antisense regulator flmB is produced to turn off expression of flmC; flmA mRNA is stable and persists in cells that have lost the F plasmid resulting in death of plasmid-free bacterial cells; may also inhibit competitor plasmids" /db_xref="GI:9507779" /db_xref="GeneID:1263569" /codon_start=1 /translation="MKLPRSSLVWCVLIVCLTLLIFTYLTRKSLCEIRYRDGYREVAA FMAYESGK" /product="small toxic polypeptide" repeat_region join(63135..63152,63157..63174) /rpt_type=inverted /note="repeat III" repeat_region join(63208..63221,63226..63239) /rpt_type=inverted /note="repeat IV" gene complement(63372..63689) /locus_tag="Fpla069" /db_xref="GeneID:1263498" /gene="ygdA" CDS complement(63372..63689) /locus_tag="Fpla069" /protein_id="NP_061446.1" /gene="ygdA" /transl_table=11 /db_xref="GI:9507780" /db_xref="GeneID:1263498" /codon_start=1 /translation="MKRGLRNGVAPCIPVAFCRDAGSAGHGATEAARPERSLQARGFA SGMEARQGGDNFAGSVHDSRPARGDARKRHCQENNKTDRNQGSSNQSQNRRKKRIIKG KVM" /product="hypothetical protein" gene 64032..64319 /locus_tag="Fpla070" /db_xref="GeneID:1263534" /gene="ygeA" CDS 64032..64319 /locus_tag="Fpla070" /protein_id="NP_061447.1" /gene="ygeA" /transl_table=11 /db_xref="GI:9507781" /db_xref="GeneID:1263534" /codon_start=1 /translation="MSTRNIHVNTASYTLLVAGKKKNTGEEWDVLEFSSLTELKKYRK SHPEKMAFSYSYALSRGVDTQFRHINIAEADHFKQFLRQIKRAGLDIRAIC" /product="hypothetical protein" gene 64438..65259 /locus_tag="Fpla071" /db_xref="GeneID:1263600" /gene="ygeB" CDS 64438..65259 /locus_tag="Fpla071" /protein_id="NP_061448.1" /gene="ygeB" /transl_table=11 /db_xref="GI:9507782" /db_xref="GeneID:1263600" /codon_start=1 /translation="MRLASRFGRYNSIHRERPLTDDELMQFVPSVFSGDKHESRSERY TYIPTINIINKLRDEGFQPFFACQSRVRDLGRREYSKHMLRLRREGHINGQEVPEIIL LNSHDGSSSYQMIPGIFRFVCTNGLVCGNNFGEIRVPHKGDIVGQVIEGAYEVLGVFD KVTDNMEAMKEIHLNSDEQHLFGRAALMVRYEDENKTPVTPEQIITPRRWEDKQNDLW TTWQRVQENMIKGGLSGRSASGKNTRTRAITGIDGDIRINKALWVIAEQFRKWKS" /product="hypothetical protein" misc_difference 64598 /locus_tag="Fpla071" /gene="ygeB" /note="A is changed to C in gb:AF106329; gb:AF106329" gene complement(65556..66065) /locus_tag="Fpla072" /db_xref="GeneID:1263507" /gene="ygfA" CDS complement(65556..66065) /locus_tag="Fpla072" /protein_id="NP_061449.1" /gene="ygfA" /transl_table=11 /note="may function in locally opening the peptidoglycan layer around the type IV transporter system; p19; orf169" /db_xref="GI:9507783" /db_xref="GeneID:1263507" /codon_start=1 /translation="MKKWMLAICLMFINEICHATDCFDLAGRDYKIDPDLLRAISWKE SRYRVNAIGINPVTGYGSGLMQVDSQHFNELARYGIKPEHLTTDPCMNIYTGAYYLAI AFKKWGVSWEAVGAYNAGFRKTERQNQRRLAYASDVYRIYTGIKSSKGIRIPATKKSL PEINSVQNN" /product="lytic transglycosylase" oriT 66118..66407 repeat_region 66128..66161 /rpt_unit_range="66128..66138" /rpt_type=inverted repeat_region 66130..66148 /rpt_unit_range="66130..66137" /rpt_type=inverted misc_feature 66158 /note="nicking site" repeat_region 66165..66183 /rpt_unit_range="66165..66173" /rpt_type=inverted protein_bind 66184..66210 /bound_moiety="IHF" /note="IHF site A; integration host factor" repeat_region 66196..66240 /rpt_unit_range="66196..66214" /rpt_type=inverted protein_bind 66196..66215 /bound_moiety="TraY" /note="SbyC" protein_bind 66221..66256 /bound_moiety="TraY" /note="SbyA" repeat_region 66250..66294 /rpt_unit_range="66250..66267" /rpt_type=inverted gene 66251..66987 /locus_tag="Fpla073" /db_xref="GeneID:1263565" /gene="traM" mRNA 66251..66987 /locus_tag="Fpla073" /db_xref="GeneID:1263565" /gene="traM" /product="conjugal transfer protein M" /note="traM mRNA III" protein_bind 66251..66294 /locus_tag="Fpla073" /bound_moiety="TraM" /gene="traM" /note="TraM low affinity binding site sbmC; TraM binds the inverted repeats in head-to-head fashion" protein_bind 66306..66335 /locus_tag="Fpla073" /bound_moiety="IHF" /gene="traM" /note="IHF site B; integration host factor" mRNA 66340..66987 /locus_tag="Fpla073" /db_xref="GeneID:1263565" /gene="traM" /product="conjugal transfer protein M" /note="traM mRNA II" repeat_region 66340..66407 /rpt_unit_range="66340..66361" /rpt_type=direct protein_bind 66343..66359 /locus_tag="Fpla073" /bound_moiety="TraM" /gene="traM" /note="TraM high affinity binding site sbmB; TraM binds the direct repeats in head-to-tail fashion" -35_signal 66355..66360 /locus_tag="Fpla073" /gene="traM" -10_signal 66366..66371 /locus_tag="Fpla073" /gene="traM" mRNA 66377..66987 /locus_tag="Fpla073" /db_xref="GeneID:1263565" /gene="traM" /product="conjugal transfer protein M" /note="traM mRNA I" protein_bind 66383..66405 /locus_tag="Fpla073" /bound_moiety="TraM" /gene="traM" /note="TraM high affinity binding site sbmA; TraM binds the direct repeats in head-to-tail fashion" CDS 66479..66862 /locus_tag="Fpla073" /experiment="experimental evidence, no additional details recorded" /protein_id="NP_061450.1" /gene="traM" /transl_table=11 /note="required for F plasmid transfer; forms tetramers; binds with high affinity to sites sbmA and sbmB and with low affinity to sbmC; binding at sbmA/B results in autoregulation while binding at sbmC aids plasmid transfer; binding is cooperative; part of the relaxosome complex that initiates plasmid nicking and initiates plasmid transfer; may interact with the coupling protein TraD; may transmit mating signal that signifies that the cells are juxtaposed and the transferosome is ready to transfer DNA" /db_xref="GI:9507784" /db_xref="GeneID:1263565" /codon_start=1 /translation="MAKVNLYISNDAYEKINAIIEKRRQEGAREKDVSFSATASMLLE LGLRVHEAQMERKESAFNQTEFNKLLLECVVKTQSSVAKILGIESLSPHVSGNSKFEY ANMVEDIREKVSSEMERFFPKNDDE" /product="conjugal transfer protein TraM" gene 66911..67776 /locus_tag="Fpla074" /db_xref="GeneID:1263572" /gene="traJ" -35_signal 66911..66916 /locus_tag="Fpla073" /gene="traM" -10_signal 66931..66936 /locus_tag="Fpla073" /gene="traM" mRNA 66944..67776 /locus_tag="Fpla074" /db_xref="GeneID:1263572" /gene="traJ" /product="positive regulator of conjugal transfer operon" repeat_region 66944..66960 /rpt_unit_range="66944..66949" /rpt_type=inverted /note="possible CRP binding site and start of traJ leader mRNA" gene complement(66977..67089) /locus_tag="Fplas004" /db_xref="GeneID:1263493" /gene="finP" misc_RNA complement(66977..67055) /locus_tag="Fplas004" /db_xref="GeneID:1263493" /gene="finP" /product="antisense RNA FinP" /note="antisense RNA of tra operon; binds traJ mRNA leader and blocks translation; requires the RNA-binding protein FinO to achieve duplex formation; since the finO gene is disrupted by IS3 in the F plasmid the transfer operon is constitutively expressed" repeat_region 66985..67015 /experiment="experimental evidence, no additional details recorded" /rpt_unit_range="66985..66996" /rpt_type=inverted /note="FinP antisense RNA stem-loop 2" terminator 66987 /locus_tag="Fpla073" /gene="traM" repeat_region 67022..67051 /experiment="experimental evidence, no additional details recorded" /rpt_unit_range="67022..67032" /rpt_type=inverted /note="FinP antisense RNA stem-loop 1" CDS 67049..67738 /locus_tag="Fpla074" /experiment="experimental evidence, no additional details recorded" /protein_id="NP_061451.1" /gene="traJ" /transl_table=11 /note="this activator promotes transcription initiation upstream of the traY gene in the transfer operon" /db_xref="GI:9507785" /db_xref="GeneID:1263572" /codon_start=1 /translation="MYPMDRIQQKHARQIDLLENLTAVIQDYPNPACIRDETGKFIFC NTLFHESFLTQDQSAEKWLLSQRDFCELISVTEMEAYRNEHTHLNLVEDVFIQNRFWT ISVQSFLNGHRNIILWQFYDAAHVRHKDSYNQKTIVSDDIRNIIRRMSDDSSVSSYVN DVFYLYSTGISHNAIARILNISISTSKKHASLICDYFSVSNKDELIILLYNKKFIYYL YEKAMCIINTR" /product="conjugal transfer transcriptional regulator TraJ" -10_signal complement(67062..67067) /locus_tag="Fplas004" /gene="finP" -35_signal complement(67084..67089) /locus_tag="Fplas004" /gene="finP" repeat_region 67754..67776 /rpt_unit_range="67754..67761" /rpt_type=inverted /note="terminator of traJ mRNA" terminator 67754..67776 /locus_tag="Fpla074" /gene="traJ" operon 67772..97945 /operon="transfer operon" /note="the transfer operon consists of a polycistronic mRNA transcript; the 5' has been defined while the 3' end has not" promoter 67772..67800 /operon="transfer operon" /note="P(Y) promoter; major promoter for the transfer operon; activated by TraJ protein" -35_signal 67772..67777 /operon="transfer operon" -10_signal 67795..67800 /operon="transfer operon" protein_bind 67810..67836 /operon="transfer operon" /bound_moiety="TraY" /note="TraY binding site sbyB" gene 67837..68232 /operon="transfer operon" /locus_tag="Fpla075" /db_xref="GeneID:1263531" /gene="traY" CDS 67837..68232 /operon="transfer operon" /locus_tag="Fpla075" /experiment="experimental evidence, no additional details recorded" /protein_id="NP_061452.1" /gene="traY" /transl_table=11 /note="ribon-helix-helix protein; promotes nicking at oriT; upregulates the P(Y) promoter; binds sby sites" /db_xref="GI:9507786" /db_xref="GeneID:1263531" /codon_start=1 /translation="MKRFGTRSATGKMVKLKLPVDVESLLIEASNRSGRSRSFEAVIR LKDHLHRYPKFNRAGNIYGKSLVKYLTMRLDDETNQLLIAAKNRSGWCKTDEAADRVI DHLIKFPDFYNSEIFREADKEEDITFNTL" /product="conjugal transfer protein TraY" misc_difference 67995 /locus_tag="Fpla075" /gene="traY" /note="A is changed to G in gb:U01159; gb:U01159" gene 68265..68630 /operon="transfer operon" /locus_tag="Fpla076" /db_xref="GeneID:1263548" /gene="traA" CDS 68265..68630 /operon="transfer operon" /locus_tag="Fpla076" /experiment="experimental evidence, no additional details recorded" /protein_id="NP_061453.1" /gene="traA" /transl_table=11 /note="this pilus subunit is processed to propilin and then N-acetylated by TraX; the subunits lying in the inner membrane are assembled to form the pilus, a long extracellular filament that is essential for transfer, contacts the recipient cell and retracts, bring the cells into close contact prior to conjugal DNA transfer" /db_xref="GI:9507787" /db_xref="GeneID:1263548" /codon_start=1 /translation="MNAVLSVQGASAPVKKKSFFSKFTRLNMLRLARAVIPAAVLMMF FPQLAMAAGSSGQDLMASGNTTVKATFGKDSSVVKWVVLAEVLVGAVMYMMTKNVKFL AGFAIISVFIAVGMAVVGL" /product="conjugal transfer pilin subunit TraA" gene 68645..68956 /operon="transfer operon" /locus_tag="Fpla077" /db_xref="GeneID:1263564" /gene="traL" CDS 68645..68956 /operon="transfer operon" /locus_tag="Fpla077" /experiment="experimental evidence, no additional details recorded" /protein_id="NP_061454.1" /gene="traL" /transl_table=11 /note="required for F pilus assembly; inner membrane protein" /db_xref="GI:9507788" /db_xref="GeneID:1263564" /codon_start=1 /translation="MSGDENKLKKYRFPETLTNQSRWFGLPLDELIPAAICIGWGITT SKYLFGIGAAVLVYFGIKKLKKGRGSSWLRDLIYWYMPTALLRGIFHNVPDSCFRQWI K" /product="conjugal transfer pilus assembly protein TraL" misc_feature 68649..68814 /locus_tag="Fpla077" /gene="traL" /note="transfer operon mRNA core stability region" repeat_region 68649..68686 /experiment="experimental evidence, no additional details recorded" /rpt_unit_range="68649..68662" /rpt_type=inverted /note="tra mRNA core stability region" repeat_region 68700..68814 /experiment="experimental evidence, no additional details recorded" /rpt_unit_range="68700..68748" /rpt_type=inverted /note="tra mRNA core stability region" misc_difference 68915 /locus_tag="Fpla077" /gene="traL" /note="T is omitted from in gb:U01159; gb:U01159" misc_difference 68972 /note="T is added to gb:U01159; gb:U01159" gene 68978..69544 /operon="transfer operon" /locus_tag="Fpla078" /db_xref="GeneID:1263497" /gene="traE" CDS 68978..69544 /operon="transfer operon" /locus_tag="Fpla078" /experiment="experimental evidence, no additional details recorded" /protein_id="NP_061455.1" /gene="traE" /transl_table=11 /note="required for F pilus assembly; inner membrane protein" /db_xref="GI:9507789" /db_xref="GeneID:1263497" /codon_start=1 /translation="MEHGARLSTSRVMAIAFIFMSVLIVLSLSVNVIQGVNNYRLQNE QRTAVTPMAFNAPFAVSQNSADASYLQQMALSFIALRLNVSSETVDASHQALLQYIRP GAQNQMKVILAEEAKRIKNDNVNSAFFQTSVRVWPQYGRVEIRGVLKTWIGDSKPFTD IKHYILILKRENGVTWLDNFGETDDEKK" /product="conjugal transfer pilus assembly protein TraE" misc_difference 69385 /locus_tag="Fpla078" /gene="traE" /note="G is added to gb:U01159; gb:U01159" misc_difference 69410 /locus_tag="Fpla078" /gene="traE" /note="T is omitted from gb:U01159; gb:U01159" gene 69531..70259 /operon="transfer operon" /locus_tag="Fpla079" /db_xref="GeneID:1263586" /gene="traK" CDS 69531..70259 /operon="transfer operon" /locus_tag="Fpla079" /protein_id="NP_061456.1" /gene="traK" /transl_table=11 /note="required for F pilus assembly; periplasmic protein" /db_xref="GI:9507790" /db_xref="GeneID:1263586" /codon_start=1 /translation="MRKNNTAIIFGSLFFSCSVMAANGTLAPTVVPMVNGGQASIAIS NTSPNLFTVPGDRIIAVNSLDGALTNNEQTASGGVVVATVNKKPFTFILETERGLNLS IQAVPREGAGRTIQLVSDLRGTGEEAGAWETSTPYESLLVTISQAVRGGKLPAGWYQV PVTKETLQAPAGLSSVADAVWTGNHLKMVRFAVENKTLSALNIRESDFWQPGTRAVMF SQPASQLLAGARMDVYVIRDGEGN" /product="conjugal transfer protein TraK" misc_difference 69563 /locus_tag="Fpla079" /gene="traK" /note="C is changed to G in gb:U01159; gb:U01159" gene 70259..71686 /operon="transfer operon" /locus_tag="Fpla080" /db_xref="GeneID:1263578" /gene="traB" CDS 70259..71686 /operon="transfer operon" /locus_tag="Fpla080" /protein_id="NP_061457.1" /gene="traB" /transl_table=11 /note="required for F pilus assembly; inner membrane protein" /db_xref="GI:9507791" /db_xref="GeneID:1263578" /codon_start=1 /translation="MASINTIVKRKQYLWLGIVVVGTASAIGGALYLSDVDMSGNGET VAEQEPVPDMTGVVDTTFDDKVRQHATTEMQVTAAQMQKQYEEIRRELDVLNKQRGDD QRRIEKLGQDNAALAEQVKALGANPVTATGEPVPQMPASPPGPEGEPQPGNTPVSFPP QGSVAVPPPTAFYPGNGVTPPPQVTYQSVPVPNRIQRKVFTRNEGKQGPSLPYIPSGS FAKAMLIEGADANASVTGNESTVPMQLRITGLVEMPNSKTYDATGCFVGLEAWGDVSS ERAIVRTRNISCLKDGKTIDMPIKGHVSFRGKNGIKGEVVMRNGKILGWAWGAGFVDG IGQGMERASQPAVGLGATAAYGAGDVLKMGIGGGASKAAQTLSDYYIKRAEQYHPVIP IGAGNEVTVVFQDGFQLKTVEEMALERTQSRAEEDNPESPVPVPPSAESHLNGFNTDQ MLKQLGNLNPQQFMSGSQGGGNDGK" /product="conjugal transfer pilus assembly protein TraB" gene 71676..72266 /operon="transfer operon" /locus_tag="Fpla081" /db_xref="GeneID:1263570" /gene="traP" CDS 71676..72266 /operon="transfer operon" /locus_tag="Fpla081" /protein_id="NP_061458.1" /gene="traP" /transl_table=11 /note="not absolutely required for DNA transfer; inner membrane protein" /db_xref="GI:9507792" /db_xref="GeneID:1263570" /codon_start=1 /translation="MANNMSSRQACHAARYVVARVLRGLFWCLKYTVILPLATMALMA LFVLWKDNTTPGKLLVKEINFVRQTAPAGQFPVSECWFSSSDSSGRSEIQGICHYRAA DAADYVRETDRSLMQLVTALWATLALMYVSLAAITGKYPVRPGKMKCIRVVTADEHLK EVYTEDASLPGKIRKCPVYLPDDRTNRNNGDKNEHA" /product="conjugal transfer protein TraP" gene 72253..72450 /operon="transfer operon" /locus_tag="Fpla082" /db_xref="GeneID:1263494" /gene="trbD" CDS 72253..72450 /operon="transfer operon" /locus_tag="Fpla082" /protein_id="NP_061459.1" /gene="trbD" /transl_table=11 /db_xref="GI:9507793" /db_xref="GeneID:1263494" /codon_start=1 /translation="MNMRNINVITVLSVPGKTVSDDFMHAVLSNCATRIVLPAPEKFG SESLPDNFNMTAVGVMKNSEI" /product="conjugal transfer protein TrbD" gene 72462..72713 /operon="transfer operon" /locus_tag="Fpla083" /db_xref="GeneID:1263580" /gene="trbG" CDS 72462..72713 /operon="transfer operon" /locus_tag="Fpla083" /protein_id="NP_061460.1" /gene="trbG" /transl_table=11 /db_xref="GI:9507794" /db_xref="GeneID:1263580" /codon_start=1 /translation="MNKLVSDGSVKKINYPVLYESGITPPLCEVSAPEPDAGGKRIVA YVYKSSRSTVFENPDIVKTCTVRDLKKDFVNCDEKGEGQ" /product="conjugal transfer protein TrbG" gene 72710..73225 /operon="transfer operon" /locus_tag="Fpla084" /db_xref="GeneID:1263566" /gene="traV" CDS 72710..73225 /operon="transfer operon" /locus_tag="Fpla084" /protein_id="NP_061461.1" /gene="traV" /transl_table=11 /note="outer membrane lipoprotein; required for transfer; interacts with TraK" /db_xref="GI:9507795" /db_xref="GeneID:1263566" /codon_start=1 /translation="MKQTSFFIPLLGTLLLYGCAGTSTEFECNATTSDTCMTMEQANE KAKKLERSSEAKPVAASLPRLAEGNFRTMPVQTVTATTPSGSRPAVTAHPEQKLLAPR PLFTAAREVKTVVPVSSVTPVTPPRPLRTGEQTAALWIAPYIDNQDVYHQPSSVFFVI KPSAWGKPRIN" /product="conjugal transfer protein TraV" gene 73360..73581 /operon="transfer operon" /locus_tag="Fpla085" /db_xref="GeneID:1263563" /gene="traR" CDS 73360..73581 /operon="transfer operon" /locus_tag="Fpla085" /protein_id="NP_061462.1" /gene="traR" /transl_table=11 /note="inessential for transfer; contains a zinc-finger domain; cytoplasmic protein" /db_xref="GI:9507796" /db_xref="GeneID:1263563" /codon_start=1 /translation="MSDEADEAYSVTEQLTMTGINRIRQKINAHGIPVYLCEACGNPI PEARRKIFPGVTLCVECQAYQERQRKHYA" /product="conjugal transfer protein TraR" gene 73741..76368 /operon="transfer operon" /locus_tag="Fpla086" /db_xref="GeneID:1263568" /gene="traC" CDS 73741..76368 /operon="transfer operon" /locus_tag="Fpla086" /experiment="experimental evidence, no additional details recorded" /protein_id="NP_061463.1" /gene="traC" /transl_table=11 /note="similar to VirB4" /db_xref="GI:9507797" /db_xref="GeneID:1263568" /codon_start=1 /translation="MNNPLEAVTQAVNSLVTALKLPDESAKANEVLGEMSFPQFSRLL PYRDYNQESGLFMNDTTMGFMLEAIPINGANESIVEALDHMLRTKLPRGIPLCIHLMS SQLVGDRIEYGLREFSWSGEQAERFNAITRAYYMKAAATQFPLPEGMNLPLTLRHYRV FISYCSPSKKKSRADILEMENLVKIIRASLQGASITTQTVDAQAFIDIVGEMINHNPD SLYPKRRQLDPYSDLNYQCVEDSFDLKVRADYLTLGLRENGRNSTARILNFHLARNPE IAFLWNMADNYSNLLNPELSISCPFILTLTLVVEDQVKTHSEANLKYMDLEKKSKTSY AKWFPSVEKEAKEWGELRQRLGSGQSSVVSYFLNITAFCKDNNETALEVEQDILNSFR KNGFELISPRFNHMRNFLTCLPFMAGKGLFKQLKEAGVVQRAESFNVANLMPLVADNP LTPAGLLAPTYRNQLAFIDIFFRGMNNTNYNMAVCGTSGAGKTGLIQPLIRSVLDSGG FAVVFDMGDGYKSLCENMGGVYLDGETLRFNPFANITDIDQSAERVRDQLSVMASPNG NLDEVHEGLLLQAVRASWLAKENRARIDDVVDFLKNASDSEQYAESPTIRSRLDEMIV LLDQYTANGTYGQYFNSDEPSLRDDAKMVVLELGGLEDRPSLLVAVMFSLIIYIENRM YRTPRNLKKLNVIDEGWRLLDFKNHKVGEFIEKGYRTARRHTGAYITITQNIVDFDSD KASSAARAAWGNSSYKIILKQSAKEFAKYNQLYPDQFLPLQRDMIGKFGAAKDQWFSS FLLQVENHSSWHRLFVDPLSRAMYSSDGPDFEFVQQKRKEGLSIHEAVWQLAWKKSGP EMASLEAWLEEHEKYRSVA" /product="conjugal transfer ATP-binding protein TraC" gene 76365..76751 /operon="transfer operon" /locus_tag="Fpla087" /db_xref="GeneID:1263557" /gene="trbI" CDS 76365..76751 /operon="transfer operon" /locus_tag="Fpla087" /protein_id="NP_061464.1" /gene="trbI" /transl_table=11 /note="inner membrane protein; may affect pilus elongation/retraction" /db_xref="GI:9507798" /db_xref="GeneID:1263557" /codon_start=1 /translation="MSSTQKPADVTAERRSHWWWTVPGCLAMVLLNAAVSYGIVRLNA PVTVAFNMKQTVDAFFDSASQKQLSEAQSKALSARFNTALEASLQAWQQKHHAVILVS PAVVQGAPDITREIQQDIARRMRAEP" /product="conjugal transfer protein TrbI" misc_difference 76701 /locus_tag="Fpla087" /gene="trbI" /note="A is changed to T in gb:U01159; gb:U01159" gene 76748..77380 /operon="transfer operon" /locus_tag="Fpla088" /db_xref="GeneID:1263571" /gene="traW" CDS 76748..77380 /operon="transfer operon" /locus_tag="Fpla088" /experiment="experimental evidence, no additional details recorded" /protein_id="NP_061465.1" /gene="traW" /transl_table=11 /note="required for F pilus assembly; periplasmic protein" /db_xref="GI:9507799" /db_xref="GeneID:1263571" /codon_start=1 /translation="MRCRGLIALLIWGQSVAAADLGTWGDLWPVKEPDMLTVIMQRLT ALEQSGEMGRKMDAFKERVIRNSLRPPAVPGIGRTEKYGSRLFDPSVRLAADIRDNEG RVFARQGEVMNPLQYVPFNQTLYFINGDDPAQVAWMKRQTPPTLESKIILVQGSIPEM QKSLDSRVYFDQNGVLCQRLGIDQVPARVSAVPGDRFLKVEFIPAEEGRK" /product="conjugal transfer pilus assembly protein TraW" misc_difference 77059 /locus_tag="Fpla088" /gene="traW" /note="G is changed to C in gb:U01159; gb:U01159" gene 77377..78369 /operon="transfer operon" /locus_tag="Fpla089" /db_xref="GeneID:1263544" /gene="traU" CDS 77377..78369 /operon="transfer operon" /locus_tag="Fpla089" /experiment="experimental evidence, no additional details recorded" /protein_id="NP_061466.1" /gene="traU" /transl_table=11 /note="required for F pilus assembly; periplasmic protein" /db_xref="GI:9507800" /db_xref="GeneID:1263544" /codon_start=1 /translation="MKRRLWLLMLFLFAGHVPAASADSACEGRFVNPITDICWSCIFP LSLGSIKVSQGKVPDTANPSMPIQICPAPPPLFRRIGLAIGYWEPMALTDVTRSPGCM VNLGFSLPAFGKTAQGTAKKDEKQVNGAFYHVHWYKYPLTYWLNIITSLGCLEGGDMD IAYLSEIDPTWTDSSLTTILNPEAVIFANPIAQGACAADAIASAFNMPLDVLFWCAGS QGSMYPFNGWVSNESSPLQSSLLVSERMAFKLHRQGMIMETIGKNNAVCNEYPSPILP KERWRYQMVNMYPDSGQCHPFGRSVTRWETGKNPPNTKKNFGYLMWRKRNCVFL" /product="conjugal transfer pilus assembly protein TraU" gene 78378..79016 /operon="transfer operon" /locus_tag="Fpla090" /db_xref="GeneID:1263546" /gene="trbC" CDS 78378..79016 /operon="transfer operon" /locus_tag="Fpla090" /experiment="experimental evidence, no additional details recorded" /protein_id="NP_061467.1" /gene="trbC" /transl_table=11 /note="inner membrane protein; required for F pilus assembly" /db_xref="GI:9507801" /db_xref="GeneID:1263546" /codon_start=1 /translation="MKLSMKSLAALLMMLNGAVMASENVNTPENRQFLKQQENLSRQL REKPDHQLKAWAEKQVLENPLQRSDNHFLDELVRKQQASQDGKPRQGALYFVSFSIPE EGLKRMLGETRHFGIPATLRGMVNNDLKTTAEAVLSLVKDGATDGVQIDPTLFSQYGI RTVPALVVFCSQGYDIIRGNLRVGQALEKVAATGDCRQVAHDLLAGKGDSGK" /product="conjugal transfer pilus assembly protein TrbC" gene 79013..80821 /operon="transfer operon" /locus_tag="Fpla091" /db_xref="GeneID:1263575" /gene="traN" CDS 79013..80821 /operon="transfer operon" /locus_tag="Fpla091" /experiment="experimental evidence, no additional details recorded" /protein_id="NP_061468.1" /gene="traN" /transl_table=11 /note="TraN; TrhN; involved in stabilizing mating pairs during plasmid conjugation; F plasmid TraN appears to recognize OmpA in the recipient cell" /db_xref="GI:9507802" /db_xref="GeneID:1263575" /codon_start=1 /translation="MKRILPLILALVAGMAQADSNSDYRAGSDFAHQIKGQGSSSIQG FKPQESIPGYNANPDETKYYGGVTAGGDGGLKNDGTTEWATGETGKTITESFMNKPKD ILSPDAPFIQTGRDVVNRADSIVGNTGQQCSAQEISRSEYTNYTCERDLQVEQYCTRT ARMELQGSTTWETRTLEYEMSQLPAREVNGQYVVSITSPVTGEIVDAHYSWSRTYLQK SVPMTITVLGTPLSWNAKYSADASFTPVQKTLTAGVAFTSSHPVRVGNTKFKRHTAMK LRLVVRVKKASYTPYVVWSESCPFSKELGKLTKTECTEAGGNRTLVKDGQSYSMYQSC WAYRDTYVTQSADKGTCQTYTDNPACTLVSHQCAFYSEEGACLHEYATYSCESKTSGK VMVCGGDVFCLDGECDKAQSGKSNDFAEAVSQLAALAAAGKDVAALNGVDVRAFTGQA KFCKKAAAGYSNCCKDSGWGQDIGLAKCSSDEKALAKAKSNKLTVSVGEFCSKKVLGV CLEKKRSYCQFDSKLAQIVQQQGRNGQLRISFGSAKHPDCRGITVDELQKIQFNRLDF TNFYEDLMNNQKIPDSGVLTQKVKEQIADQLKQAGQ" /product="conjugal transfer mating pair stabilization protein TraN" gene 80845..81105 /operon="transfer operon" /locus_tag="Fpla092" /db_xref="GeneID:1263550" /gene="trbE" CDS 80845..81105 /operon="transfer operon" /locus_tag="Fpla092" /protein_id="NP_061469.1" /gene="trbE" /transl_table=11 /note="inner membrane protein" /db_xref="GI:9507803" /db_xref="GeneID:1263550" /codon_start=1 /translation="MMKVIFTSNRFIDFLIRLLITAIVISPVIIWSWDTVKETTADGM LAAAFVILYSGVLLFILYFCFSALTDLQKPDERKSDERNEDE" /product="conjugal transfer protein TrbE" gene 81068..81841 /operon="transfer operon" /locus_tag="Fpla093" /db_xref="GeneID:1263589" /gene="traF" CDS 81068..81841 /operon="transfer operon" /locus_tag="Fpla093" /experiment="experimental evidence, no additional details recorded" /protein_id="NP_061470.1" /gene="traF" /transl_table=11 /note="type IV secretion system pilus assembly protein; similar to F plasmid TraF" /db_xref="GI:9507804" /db_xref="GeneID:1263589" /codon_start=1 /translation="MKEKVMKGMKMNKALLPLLLCCFIFPASGKDAGWQWYNEKINPK EKENKPVPAAPRQEPDIMQKLAALQTATKRALYEAILYPGVDNFVKYFRLQNYWAQQA GLFTMSARKAMLAHPELDYNLQYSHYNGTVRNQLAADQAQQRQAIAKLAEHYGIMFFY RGQDPIDGQLAQVINGFRDTYGLSVIPVSVDGVINPLLPDSRTDQGQAQRLGVKYFPA MMLVDPKQGSVRPLSYGFISQDDLAKQFLNVSEDFKPNF" /product="conjugal pilus assembly protein TraF" gene 81857..82204 /operon="transfer operon" /locus_tag="Fpla094" /db_xref="GeneID:1263573" /gene="trbA" CDS 81857..82204 /operon="transfer operon" /locus_tag="Fpla094" /protein_id="NP_061471.1" /gene="trbA" /transl_table=11 /note="not required for DNA transfer; inner membrane protein" /db_xref="GI:9507805" /db_xref="GeneID:1263573" /codon_start=1 /translation="MSEDYLKMFTGVVLLIFVIIAGYFFSERNDRKMFLLSSLVFLVV NIACLYVLTASLWFLCGAIMSQGAALVVSIVAAALPDVTSFDRFRRIFICIMLSSVWS GVMWFFIRGLMTG" /product="conjugal transfer protein TrbA" gene complement(82206..82520) /locus_tag="Fpla095" /db_xref="GeneID:1263509" /gene="artA" CDS complement(82206..82520) /locus_tag="Fpla095" /protein_id="NP_061472.1" /gene="artA" /transl_table=11 /db_xref="GI:9507806" /db_xref="GeneID:1263509" /codon_start=1 /translation="MEKRSFKEKLEIIRNIIRESLLGNAAIIALIYAASHSLPVNAFP DYLVISLLSIAAGIVVLWLFSIIYIYFCELFRSHWIAVWFIIWSSVINLIILYGFYDR FI" /product="hypothetical protein" gene 82601..82885 /operon="transfer operon" /locus_tag="Fpla096" /db_xref="GeneID:1263562" /gene="traQ" CDS 82601..82885 /operon="transfer operon" /locus_tag="Fpla096" /experiment="experimental evidence, no additional details recorded" /protein_id="NP_061473.1" /gene="traQ" /transl_table=11 /note="required for pilus assembly; inner membrane protein" /db_xref="GI:9507807" /db_xref="GeneID:1263562" /codon_start=1 /translation="MISKRRFSLPRLDITGMWVFSLGVWFHIVARLVYSKPWMAFFLA ELIAAILVLFGAYQVLDAWIARVSREEREALEARQQAMMEGQQEGGHVSH" /product="conjugal transfer pilin chaperone TraQ" gene 82872..83417 /operon="transfer operon" /locus_tag="Fpla097" /db_xref="GeneID:1263514" /gene="trbB" CDS 82872..83417 /operon="transfer operon" /locus_tag="Fpla097" /protein_id="NP_061474.1" /gene="trbB" /transl_table=11 /note="periplasmic protein" /db_xref="GI:9507808" /db_xref="GeneID:1263514" /codon_start=1 /translation="MSLTKSLLFTLLLSAAAVQASTRDEIERLWNPQGMATQPAQPAA GTSARTAKPAPRWFRLSNGRQVNLADWKVVLFMQGHCPYCHQFDPVLKQLAQQYGFSV FSYTLDGQGDTAFPEALPVPPDVMQTFFPNIPVATPTTFLVNVNTLEALPLLQGATDA AGFMARVDTVLQMYGGKKGAK" /product="conjugal transfer protein TrbB" misc_difference 83304..83309 /locus_tag="Fpla097" /gene="trbB" /note="GTCAAC is added to gb:U01159; gb:U01159" gene 83347..83688 /operon="transfer operon" /locus_tag="Fpla098" /db_xref="GeneID:1263554" /gene="trbJ" CDS 83347..83688 /operon="transfer operon" /locus_tag="Fpla098" /protein_id="NP_061475.1" /gene="trbJ" /transl_table=11 /db_xref="GI:9507809" /db_xref="GeneID:1263554" /codon_start=1 /translation="MPPVLWRGWIPFCRCTEEKKVRNKQVVLLIAGISGIVTGIIVSL NIPFIRQGLFYPASPVEIVVSLSLTFSVSVVFFVGAIVGWISVSEIYYSRMTGLNESS EISEGTYNERK" /product="conjugal transfer protein TrbJ" gene 83675..84055 /operon="transfer operon" /locus_tag="Fpla099" /db_xref="GeneID:1263555" /gene="trbF" CDS 83675..84055 /operon="transfer operon" /locus_tag="Fpla099" /protein_id="NP_061476.1" /gene="trbF" /transl_table=11 /note="inner membrane protein" /db_xref="GI:9507810" /db_xref="GeneID:1263555" /codon_start=1 /translation="MRENKSNPELKIRSTERDYKYISRITGRYAGLSLVFLTAGIVLW TVMDIIFDACIDSWKADPELNNSSYMWNILIYAIPYTLYALAAGFLVTFFSVPNVRIN IRKYRDIPAEMSYAPGEHIKGGQE" /product="conjugal transfer protein TrbF" gene 84052..85428 /operon="transfer operon" /locus_tag="Fpla100" /db_xref="GeneID:1263523" /gene="traH" CDS 84052..85428 /operon="transfer operon" /locus_tag="Fpla100" /protein_id="NP_061477.1" /gene="traH" /transl_table=11 /note="required for pilus assembly; periplasmic protein" /db_xref="GI:9507811" /db_xref="GeneID:1263523" /codon_start=1 /translation="MMPRIKPLLVLCAALLTVTPAASADVNSDMNQFFNKLGFASNTT QPGVWQGQAAGYAYGGSLYARTQVKNVQLISMTLPDINAGCGGIDAYLGSFSFINGEQ LQRFVKQIMSNAAGYFFDLALQTTVPEIKTAKDFLQKMASDINSMNLSSCQAAQGIIG GLFPRTQVSQQKVCQDIAGESNIFADWAASRQGCTVGGKSDSVRDKASDKDKERVTKN INIMWNALSKNRMFDGNKELKEFVMTLTGSLVFGPNGEITPLSARTTDRSIIRAMMEG GTAKISHCNDSDKCLKVVADTPVTISRDNALKSQITKLLASIQNKAVSDTPLDDKEKG FISSTTIPVFKYLVDPQMLGVSNSMIYQLTDYIGYDILLQYIQELIQQARAMVATGNY DEAVIGHINDNMNDATRQIAAFQSQVQVQQDALLVVDRQMSYMRQQLSARMLSRYQNN YHFGGSTL" /product="conjugal transfer pilus assembly protein TraH" gene 85425..88241 /operon="transfer operon" /locus_tag="Fpla101" /db_xref="GeneID:1263567" /gene="traG" CDS 85425..88241 /operon="transfer operon" /locus_tag="Fpla101" /experiment="experimental evidence, no additional details recorded" /protein_id="NP_061478.1" /gene="traG" /transl_table=11 /note="required for pilus assembly and DNA transfer; this inner membrane protein is bifunctional; the N-terminal domain is required for pilus assembly while the periplasmic C-terminal domain is required for mating pair stabilization; may form a cleavage product, TraG*; plasmid-specific interactions with the entry exclusion protein TraS in the inner membrane of the recipient cell result in decreased transfer efficiency" /db_xref="GI:9507812" /db_xref="GeneID:1263567" /codon_start=1 /translation="MNEVYVIAGGEWLRNNLNAIAAFMGTWTWDSIEKIALTLSVLAV AVMWVQRHNVMDLLGWVAVFVLISLLVNVRTSVQIIDNSDLVKVHRVDNVPVGLAMPL SLTTRIGHAMVASYEMIFTQPDSVTYSKTGMLFGANLIVKSTDFLSRNPEIINLFQDY VQNCVLGDIYLNHKYTLEDLMASADPYTLIFSRPSPLRGVYDNNNNFITCKDASVTLK DRLNLDTKTGGKTWHYYVQQIFGGRPDPDLLFRQLVSDSYSYFYGSSQSASQIMRQNV TMNALKEGITSNAARNGDTASLVSLATTSSMEKQRLAHVSIGHVTMRNLPMVQTILTG IAIGIFPLLILAAVFNKLTLSVLKGYVFALMWLQTWPLLYAILNSAMTFYAKQNGAPV VLSELSQIQLKYSNLASTAGYLSAMIPPLSWMMVKGLGAGFSSVYSHFASSSISPTAS AAGSVVDGNYSYGNMQTENVNGFSWSTNSTTSFGQMMYQTGSGATATQTRDGNMVMDA SGAMSRLPVGINATRQIAAAQQEMAREASNRAESALHGFSSSIASAWNTLSQFGSNRG SSDSVTGGADSTMSAQDSMMASRMRSAVESYAKAHNISNEQATRELASRSTNASLGLY GDAYAKGHLGISVLGNGGGVGLQAGAKASIDGSDLDSHEASSGSRASHDARHDIDARA TQDFKEASDYFTSRKVSESGSHTDNNADSRVDQLSAALNSAKQSYDQYTTNMTRSHEY AEMASRTESMSGQMSEDLSQQFAQYVMKNAPQDVEAILTNTSSPEIAERRRAMAWSFV QEQVQPGVDNTWRESRRDIGKGMESVPSGGGSQDIIADHQGHQAIIEQRTQDSNIRND VKHQVDNMVTEYRGNIGDTQNSIRGEENIVKGQYSELQNHHKTEALTQNNKYNEEKLA QERIPGADSPKELLEKAKSYQHKE" /product="conjugal transfer mating pair stabilization protein TraG" gene 88274..88795 /operon="transfer operon" /locus_tag="Fpla102" /db_xref="GeneID:1263588" /gene="traS" CDS 88274..88795 /operon="transfer operon" /locus_tag="Fpla102" /experiment="experimental evidence, no additional details recorded" /protein_id="NP_061479.1" /gene="traS" /transl_table=11 /note="plasmid-specific inner membrane protein; apparently inhibits the function of a plasmid-related TraG protein in the inner membrane of the donor cell from functioning" /db_xref="GI:9507813" /db_xref="GeneID:1263588" /codon_start=1 /translation="MITQQIISSELEVLKKHIDSGDIRIPSLWQGLKPGLIIMGWMIF CPLLMSFLITQKTSETLTAVLAGGWLGLIILFIVARIRMLYFSLPEEFLKTSSVMRVI SSKLKVYFIVYMGVIFLWSFLGGGIIYGFGAILVTVIMAFLIQLDIGRYQFVGVIDAI NSYVKNKKLSRVK" /product="conjugal transfer entry exclusion protein TraS" misc_difference 88700 /locus_tag="Fpla102" /gene="traS" /note="C is omitted from gb:U01159; gb:U01159" gene 88730..89688 /operon="transfer operon" /locus_tag="Fpla103" /db_xref="GeneID:1263516" /gene="traT" mRNA 88730..89688 /operon="transfer operon" /locus_tag="Fpla103" /db_xref="GeneID:1263516" /gene="traT" /product="surface exclusion lipoprotein TraT precursor" repeat_region 88730..88768 /rpt_unit_range="88730..88747" /rpt_type=inverted CDS 88817..89551 /operon="transfer operon" /locus_tag="Fpla103" /experiment="experimental evidence, no additional details recorded" /protein_id="NP_061480.1" /gene="traT" /transl_table=11 /note="plasmid-specific outer membrane lipoprotein; when present in the recipient cell this protein decreases transfer efficiency from a donor with an identical plasmid" /db_xref="GI:9507814" /db_xref="GeneID:1263516" /codon_start=1 /translation="MMKTKKLMMVALVSSTLALSGCGAMSTAIKKRNLEVKTQMSETI WLEPASERTVFLQIKNTSDKDMSGLQGKIADAVKAKGYQVVTSPDKAYYWIQANVLKA DKMDLRESQGWLNRGYEGAAVGAALGAGITGYNSNSAGATLGVGLAAGLVGMAADAMV EDVNYTMITDVQIAERTKATVTTDNVAALRQGTSGAKIQTSTETGNQHKYQTRVVSNA NKVNLKFEEAKPVLEDQLAKSIANIL" /product="conjugal transfer surface exclusion protein TraT" misc_difference 89238 /locus_tag="Fpla103" /gene="traT" /note="C is changed to G in gb:U01159; gb:U01159" misc_difference 89565 /locus_tag="Fpla103" /gene="traT" /note="G is added to gb:U01159; gb:U01159" repeat_region 89594..89688 /rpt_unit_range="89594..89635" /rpt_type=inverted terminator 89594..89688 /operon="transfer operon" /locus_tag="Fpla103" /gene="traT" misc_difference 89730..89732 /note="CGG is added to gb:U01159; gb:U01159" gene 89804..91957 /operon="transfer operon" /locus_tag="Fpla104" /db_xref="GeneID:1263585" /gene="traD" CDS 89804..91957 /operon="transfer operon" /locus_tag="Fpla104" /experiment="experimental evidence, no additional details recorded" /protein_id="NP_061481.1" /gene="traD" /transl_table=11 /note="type IV secretion system coupling protein; similar to F plasmid TraD" /db_xref="GI:9507815" /db_xref="GeneID:1263585" /codon_start=1 /translation="MSFNAKDMTQGGQIASMRIRMFSQIANIMLYCLFIFFWILVGLV LWIKISWQTFVNGCIYWWCTTLEGMRDLIKSQPVYEIQYYGKTFRMNAAQVLHDKYMI WCSEQLWSAFVLAAVVALVICLITFFVVSWILGRQGKQQSENEVTGGRQLTDNPKDVA RMLKKDGKDSDIRIGDLPIIRDSEIQNFCLHGTVGAGKSEVIRRLANYARQRGDMVVI YDRSGEFVKSYYDPSIDKILNPLDARCAAWDLWKECLTQPDFDNTANTLIPMGTKEDP FWQGSGRTIFAEAAYLMRNDPNRSYSKLVDTLLSIKIEKLRTYLRNSPAANLVEEKIE KTAISIRAVLTNYVKAIRYLQGIEHNGEPFTIRDWMRGVREDQKNGWLFISSNADTHA SLKPVISMWLSIAIRGLLAMGENRNRRVWFFCDELPTLHKLPDLVEILPEARKFGGCY VFGIQSYAQLEDIYGEKAAASLFDVMNTRAFFRSPSHKIAEFAAGEIGEKEHLKASEQ YSYGADPVRDGVSTGKDMERQTLVSYSDIQSLPDLTCYVTLPGPYPAVKLSLKYQTRP KVAPEFIPRDINPEMENRLSAVLAAREAEGRQMASLFEPDVPEVVSGEDVTQAEQPQQ PVSPAINDKKSDSGVNVPAGGIEQELKMKPEEEMEQQLPPGISESGEVVDMAAYEAWQ QENHPDIQQQMQRREEVNINVHRERGEDVEPGDDF" /product="conjugal transfer protein TraD" misc_difference 91955 /locus_tag="Fpla104" /gene="traD" /note="T is added to gb: U01159; gb:U01159" gene complement(91966..92364) /locus_tag="Fpla105" /db_xref="GeneID:2845548" /gene="stbORF1" CDS complement(91966..92364) /locus_tag="Fpla105" /protein_id="YP_024416.1" /gene="stbORF1" /transl_table=11 /note="stability determinant protein" /db_xref="GI:48527948" /db_xref="GeneID:2845548" /codon_start=1 /translation="MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMEVI YGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHTGQIRAELALQGRPVGPFDQMIA GHARSRGLIIVTNNTREFERVGGLRIEDWS" /product="plasmid maintenance protein" gene complement(92364..92591) /locus_tag="Fpla106" /db_xref="GeneID:2845549" /gene="stbORF2" CDS complement(92364..92591) /locus_tag="Fpla106" /protein_id="YP_024417.1" /gene="stbORF2" /transl_table=11 /note="on the virulence plasmid pMYSH6000 in Shigella flexneri this protein is involved in plasmid stability and incompatibility through an unknown mechanism" /db_xref="GI:48527949" /db_xref="GeneID:2845549" /codon_start=1 /translation="METTVFLSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAG ETWDEWFDGNSVSADFMDNREQPGMQERESF" /product="stability determinant 2" misc_difference 92597 /note="G is changed to C in gb:U01159; gb:U01159" gene 92673..97943 /operon="transfer operon" /locus_tag="Fpla107" /db_xref="GeneID:1263574" /gene="traI" CDS 92673..97943 /operon="transfer operon" /locus_tag="Fpla107" /experiment="experimental evidence, no additional details recorded" /protein_id="NP_061483.1" /gene="traI" /transl_table=11 /note="cleaves origin of transfer and unwinds; oriT relaxase" /db_xref="GI:9507817" /db_xref="GeneID:1263574" /codon_start=1 /translation="MMSIAQVRSAGSAGNYYTDKDNYYVLGSMGERWAGRGAEQLGLQ GSVDKDVFTRLLEGRLPDGADLSRMQDGSNRHRPGYDLTFSAPKSVSMMAMLGGDKRL IDAHNQAVDFAVRQVEALASTRVMTDGQSETVLTGNLVMALFNHDTSRDQEPQLHTHA VVANVTQHNGEWKTLSSDKVGKTGFIENVYANQIAFGRLYREKLKEQVEALGYETEVV GKHGMWEMPGVPVEAFSGRSQTIREAVGEDASLKSRDVAALDTRKSKQHVDPEIKMAE WMQTLKETGFDIRAYRDAADQRADLRTLTPGPASQDGPDVQQAVTQAIAGLSERKVQF TYTDVLARTVGILPPENGVIERARAGIDEAISREQLIPLDREKGLFTSGIHVLDELSV RALSRDIMKQNRVTVHPEKSVPRTAGYSDAVSVLAQDRPSLAIVSGQGGAAGQRERVA ELVMMAREQGREVQIIAADRRSQMNMKQDERLSGELITGRRQLLEGMAFTPGSTVIVD QGEKLSLKETLTLLDGAARHNVQVLITDSGQRTGTGSALMAMKDAGVNTYRWQGGEQR PATIISEPDRNVRYARLAGDFAASVKAGEESVAQVSGVREQAILTQAIRSELKTQGVL GLPEVTMTALSPVWLDSRSRYLRDMYRPGMVMEQWNPETRSHDRYVIDRVTAQSHSLT LRDAQGETQVVRISSLDSSWSLFRPEKMPVADGERLRVTGKIPGLRVSGGDRLQVASV SEDAMTVVVPGRAEPATLPVSDSPFTALKLENGWVETPGHSVSDSATVFASVTQMAMD NATLNGLARSGRDVRLYSSLDETRTAEKLARHPSFTVVSEQIKTRAGETSLETAISHQ KSALHTPAQQAIHLALPVVESKKLAFSMVDLLTEAKSFAAEGTGFTELGGEINAQIKR GDLLYVDVAKGYGTGLLVSRASYEAEKSILRHILEGKEAVMPLMERVPGELMEKLTSG QRAATRMILETSDRFTVVQGYAGVGKTTQFRAVMSAVNMLPESERPRVVGLGPTHRAV GEMRSAGVDAQTLASFLHDTQLQQRSGETPDFSNTLFLLDESSMVGNTDMARAYALIA AGGGRAVASGDTDQLQAIAPGQPFRLQQTRSAADVAIMKEIVRQTPELREAVYSLINR DVERALSGLESVKPSQVPRQEGAWAPEHSVTEFSHSQEAKLAEAQQKAMLKGEAFPDV PMTLYEAIVRDYTGRTPEAREQTLIVTHLNEDRRVLNSMIHDVREKAGELGKEQVMVP VLNTANIRDGELRRLSTWETHRDALVLVDNVYHRIAGISKDDGLITLQDAEGNTRLIS PREAVAEGVTLYTPDTIRVGTGDRMRFTKSDRERGYVANSVWTVTAVSGDSVTLSDGQ QTREIRPGQEQAEQHIDLAYAITAHGAQGASETFAIALEGTEGNRKLMAGFESAYVAL SRMKQHVQVYTDNRQGWTDAINNAVQKGTAHDVFEPKPDREVMNAERLFSTARELRDV AAGRAVLRQAGLAGGDSPARFIAPGRKYPQPYVALPAFDRNGKSAGIWLNPLTTDDGN GLRGFSGEGRVKGSGDAQFVALQGSRNGESLLADNMQDGVRIARDNPDSGVVVRIAGE GRPWNPGAITGGRVWGDIPDNSVQPGAGNGEPVTAEVLAQRQAEEAIRRETERRADEI VRKMAENKPDLPDGKTEQAVREIAGQERDRAAITEREAALPEGVLREPQRVREAVREI ARENLLQERLQQMERDMVRDLQKEKTLGGD" /product="conjugal transfer nickase/helicase TraI" gene 97963..98709 /locus_tag="Fpla108" /db_xref="GeneID:1263541" /gene="traX" CDS 97963..98709 /locus_tag="Fpla108" /experiment="experimental evidence, no additional details recorded" /protein_id="NP_061484.1" /gene="traX" /transl_table=11 /note="inner membrane protein; acetylates the N-terminal residue of propilin" /db_xref="GI:9507818" /db_xref="GeneID:1263541" /codon_start=1 /translation="MTTDNTNTTRNDSLVARTDTWLQSLLVWSPGQRDIIKTVALVLM VLDHANRILHLDQSWMFLAGRGAFPLFALVWGLNLSRHAHIRQLAINRLWGWAVFSQF WYYFAGFPWYEGNILFAFAVAAQVLTWCETRSGWRTAAAILMMALWGPLSGTSYGIAG LLMLAVSHRLYRAEDRMERLVLVACLLAVIPALNLATSDAAAVAGLVMTVLTVGLVSC AGKLLSRFWPGDFFPTFYACHLAVLGVLAL" /product="conjugal transfer pilus acetylation protein TraX" misc_difference 98794 /locus_tag="Fpla003" /gene="finO" /note="C is changed to T in embl:X57429; gb:U01159" ORIGIN 1 tgatcttacc cagcaatagt ggacacgcgg ctaagtgagt aaactctcag tcagaggtga 61 ctcacatgac aaaaacagta tcaaccagta aaaaaccccg taaacagcat tcgcctgaat 121 ttcgcagtga agccctgaag cttgctgaac gcatcggtgt tactgccgca gcccgtgaac 181 tcagcctgta tgaatcacaa ctctacaact ggcgcagtaa acagcaaaat cagcagacgt 241 cttctgaacg tgaactggag atgtctaccg agattgcacg tctcaaacgc cagctggcag 301 aacgggatga agagctggct atcctccaaa aggccgcgac atacttcgcg aagcgcctga 361 aatgaagtat gtctttattg aaaaacatca ggctgagttc agcatcaaag caatgtgccg 421 cgtgctccgg gtggcccgca gcggctggta tacgtggtgt cagcggcgga caaggataag 481 cacgcgtcag cagttccgcc aacactgcga cagcgttgtc ctcgcggctt ttacccggtc 541 aaaacagcgt tacggtgccc cacgcctgac ggatgaactg cgtgctcagg gttacccctt 601 taacgtaaaa accgtggcgg caagcctgcg ccgtcaggga ctgagggcaa aggcctcccg 661 gaagttcagc ccggtcagct accgcgcaca cggcctgcct gtgtcagaaa atctgttgga 721 gcaggatttt tacgccagtg gcccgaacca gaagtgggca ggagacatca cgtacttacg 781 tacagatgaa ggctggctgt atctggcagt ggtcattgac ctgtggtcac gtgccgttat 841 tggctggtca atgtcgccac gcatgacggc gcaactggcc tgcgatgccc tgcagatggc 901 gctgtggcgg cgtaagaggc cccggaacgt tatcgttcac acggaccgtg gaggccagta 961 ctgttcagca gattatcagg cgcaactgaa gcggcataat ctgcgtggaa gtatgagcgc 1021 aaaaggttgc tgctacgata atgcctgcgt ggaaagcttc tttcattcgc tgaaagtgga 1081 atgtatccat ggagaacact ttatcagccg ggaaataatg cgggcaacgg tgtttaatta 1141 tatcgaatgt gattacaatc ggtggcggcg gcacagttgg tgtggcggcc tcagtccgga 1201 acaatttgaa aacaagaacc tcgcttaggc ctgtgtccat attacgtggg taggatcaag 1261 ctatctgtgt gccatgaaag ccggtgcctg ccggtatgac acggaagggt atgtgacgga 1321 gcatatttct caggaggagg aagcgtatgc ggcagagcgt ctggataaaa tccgccgcca 1381 gaaccggata aaggcagaac ttcaggccgt gcttgatgag aaataaaaaa aagcctccat 1441 cagagagagg aggcagggaa ataaggctta aaaggaaata acttccgtac ccgaaaggaa 1501 gccagtccac tgaattattt accacaataa tactgacgac taaaagggag gggcagaaaa 1561 atgaatggat tcagaaacag ttcacggaac ggtcaggtct ggcgctggca gcgtgccgga 1621 agccgggccg ttattctgga ggtcagtgga cgctggatgg aagcggcaga agcatggcga 1681 cgggctgccg gggaaaggtg taacgaaaaa agcagccttc attactccag gagtcagaag 1741 gctgaataat gcatgagatt tactttttta atctccggtc gggtagtatg accggacaat 1801 tctgagtagc acagagtttt ttttcgtatt aagtcgtgat tttatatttt gtgatttatt 1861 tcacaaaata aggtgttatt caatgtgtgc tgcaatattc aggatgcctg aaatacaggt 1921 gccatttatt tgatatggag aataacatga gggaatatat tccactggta ttatttatct 1981 tttcatagcc ggtattgtct gcagatattt atgggcaggt tgttcgtgta ctgggccagc 2041 aggaaagtct gtgcagaaac ttacggtttg aataagttga cccccataag actctgatta 2101 atataatttg tggcacacag atacttgcgg gaaaagtgtt tcgcactgaa tcttaactgg 2161 aaatgtaaac tatttttaac acccccaaaa tccttttggg gaacaactca tgcttacaat 2221 ttctgcccca tacattttct ccaggcactc ccctcattac cattgtcgag gaacgtagag 2281 gttgcatatg gaatgcctct gatttttgtt gatgtgaatg ggccatcaga cgtcgaagtt 2341 gtacggagtt ttgatgttag tacgtattta ccacttatgc ctttctctgc cagagctctt 2401 gattttatga taactaaatc tgcacatttc tctgcggcta catattgcgg gtctttttca 2461 acctttccag cacatgcagt tatcgttaaa acggtagcgg cggctaacaa cttacctggt 2521 ttcatcttca taccttattg ggtgtattaa aaacagtagg ctgccaaagt cttaaacaag 2581 tttcaattct ccatgactgc tcaacatcag acagagggaa ttcccattct ggaccagcgg 2641 gagcatacga acaataattt acggtttcgc gctatagctg gctcaagtta ggttggaccc 2701 tgaatctcca gacaaccaat atctgatcgc gccagtggtg gcagttatta agcaacaggg 2761 aatgtggtat tatcgcggcg ggtgtctgag cctttctggt tcaggcaaga cgcaggtacc 2821 agaaatgcga agaccccact tgttaatcca ttaactcgtg aggtctgcat gaagtacctt 2881 aacactactg attgtagcct cttccttgca gagaggtcaa agtttatgac gaaatatgcc 2941 cttatcgggt tgctcgccgt gtgcgctacg gtgttgtgtt tttcactgat attcagggaa 3001 cggttatgtg agctgaatat tcacagggga aatacagtgg tgcaggtaac tctggcctac 3061 gaagcacgga agtaagctgc cgggcgggga cggaagtccc cgctttccgg aagtgtgagg 3121 tatttcaggg gcagacaccc gacatgccag aaacagccgg tcccgcccgg ggccggcacc 3181 caggttcagg catttcctgc ttttcagtca tttcattatc aaaatcacat taaacggtcg 3241 taatcagaca tgatttgtgc gccaacacag atcattgtca caattctcaa gtcgctgatt 3301 tcaaaaaact gtagtatcct ctgcgaaacg atccctgttt aaatattgag ggggcgagat 3361 gtcgcagaca gaaaatgcag tgacttcctc atcaggtaac aagcgtgcat accggaaagg 3421 taaccctgtt ccggccagag agaggcaaag ggcttctcta gctcgcagaa gcaacactca 3481 taaggctttt catgcggtta tccaggcccg gttaaaagac aggctgagtg aactggcaga 3541 tgaggaaggt attacccagg cgcagatgct tgaaaaactg attgaatcag agctgaaacg 3601 cagagcgact ttgtaaatat tcacattctt gcttatctca ggcgtgagtg atagattgct 3661 gatcgtttaa ggaattttgt ggctggccac gccataaggt ggcagggaac tggttctgat 3721 gtggatttac aggagccaga aaagcaaaaa ccccgataat cttcatctag tttggcgacg 3781 aggagaagat taccgggatc cacttaaacc gtatagccaa caattcagct atgcggggag 3841 tatagttata tgcccggaaa agttcaagac ttctttctgt gctcactcct tctgtgcatt 3901 gtaagtgcag gatggtgtgg ctaatcatga aacacattca gtaatagcgg gtgggattga 3961 atcagatctt cacattgatt ccagcaagta tcctcacccg ttttgcagcc ttctccagaa 4021 aagggctcat tttgactcct tcaagcatct gatcttcatc agaggtttgc ttgtaatagc 4081 gcatggcaaa cgtaaaaata aaatcagcgc gtcgatggtt agtttttatg tttccctcgt 4141 acaagtaatg tgcgcacact acatccctga tacgaacaaa gttaacttat ggggtttgag 4201 ggccaatgga acgaaaacgt acgtttatgg tataacttat tgattataat acagtataca 4261 aaggtccctt ttcagggacc ctttcgtatg ttgtagctga ttttattttc ttcttttctt 4321 ttgggtgctt ttaatagcca tatatgatgt ttcatataaa gttaaaagtt tccccatctg 4381 tctatctata gcgtcatgtt tttcaggatt tcttaatttc tgcagcagtt tagatatata 4441 tttcgcaggt aactttatta ttaatgaatt atgggattga tacatttcct ttgtccaatc 4501 taaatctttt cctgatttca atacctcact ctcatctcta ttaattataa aaccgagctt 4561 tccatacgga cctgttaaat atgattgtaa ttgtctatac tcagatggac ctaattcttc 4621 aaaattttta gcatcaaaaa caacttgtct tgttttatag tcctccaata ctcgtttcca 4681 aaaatcagat ttgccaccat tggtgcctat aatatctcgt ctctgaactg cgttaccatt 4741 tggatgggac ttgatgtctg ttaggtggga tgcaaatact attcttagtg cgtctaaaca 4801 ccattgttca aattcagtgg caccttcatt tcctatcggt atctgatcta gatgagtagt 4861 tatttgacct attgttttat ttctaatggc tgaattatct gaaataatat taatatcata 4921 ttcgtcattt atctcctctg cttcctctgg agcaagtgca ttacgattta gattcaaacc 4981 aagccagtaa catggatgaa ttaataattt ctcattactt tcaaaacctt tatctggagt 5041 tcgcccgtca tggcaaaatg aataggatga ggtgttttta tcacgaatac caacaaatcc 5101 tacactatac aaactttgga gaattccact tgcctttaac aactgtattt cagacgttat 5161 tttaggatct ccattttctt cgattaattc gaaagatgct tctatttttt ttaagcacgt 5221 ataaactgtt aattcaggtt caatgctacg aaatgcacta gttataacct gtattgaagg 5281 aaagatcttc tgatactctt tccagagatc ttcaagtctg gccatggaaa ttgacttggc 5341 tgcatattct aggtcagtgt ttatgatagt ttctctattc tctctgaatg cggaaaaaaa 5401 agcttcattc aacaatgata gtaaatccct gggccggtaa agggtaaatt gcaaacatcg 5461 cttaaaacca ttcctccctt taagatcatc cgctgtgcat ctatcccaaa ctcgttgatc 5521 tttctcaata tctagcttaa atgctacttt cattctttta gctgacagca ttaggagttg 5581 tgcccagtcc caatgcaacc ttatgacttg accctctata tttctcgagt aatcaggatc 5641 ttcctttgat agcgacctaa atatattatc ccttaaaaaa attattggac gaatgcattt 5701 tgctttttga tttaattcaa tagatgcata tgctagacct gcaatgattc caattcctat 5761 attatccggt tcatacgcct catctagctt atccattaat atgacaactt tcctgtctga 5821 gcgttcaaga agtgatacta tattattttc tatttctgag atattcaaat tgaattgaag 5881 atcaccaatt gattcttctg ggttattttc atctaaatac tcctttgcga caagcctaca 5941 ctttcttaaa atgtcacctt gtgcagaatt ccattttttc aaatgttcat tcaacaatgt 6001 ttctgatgat atttgagatg acaatttgta atgagatgat atatatgatg ctatctccat 6061 tagcatagcg tatcgccata atagtcttgt tgctgccctt gctaaattaa atgatcctgt 6121 aaatggtttc aacattgatc tgaaaccaat aatttgagaa tcgtctggtg agaaactcag 6181 gattaatatt tttttgtctt tcttccaatg ctcatttagc tgaataaata aagcactttt 6241 acctgtccct cgtctaccaa caacaatggt cctgtcatca gtttcaatta gagtcctaaa 6301 gtcagcagtt tcaatgaaag cattactcaa catcttttta tcattttctg ctgtcgtatc 6361 accaaacgga ttagactttg aagtaatatt caattccata ttcaaccttt tatgttagtt 6421 gctttcattt attactttat atactgttga acgagcaata ttcattgttt ttgatatatg 6481 tgaggcacct aacccctgtt gccacatatt taatactgca tctctatcta tttttctttt 6541 tctaccaaaa acaactcctt ttgccattgc ctcttggcga ccttcattgg tacgctctag 6601 tattctctgt cgttctgcct gggccactgc agatagaata gtgacaacca ttttacccat 6661 ctccccatcg gtactgattc cgtcatcaat aaaccgaatg gatacacctt gggcgtcaaa 6721 ctcttttatt aactggatca tgtcagcagt atcgcgccca aggcggtcaa gtttcttcac 6781 caagatgacg tcaccttcct ccaccttcat cctcagcaag tccagccctt tccgatcgct 6841 tgaactgccc gatgccttgt cagtaaagat gcgatttgct ttcacgcctg cgtctttgag 6901 tgcccgaacc tgaatatcga gagattgctg gctggttgat acccgtgcgt aaccaaaaag 6961 tcgcataaaa atgtatccta aatcaaatat cggacaagca gtgtctgtta taacaaaaaa 7021 tcgatttaat agacacatta acagcactgt ttttatgtgt gcgataattt ataatatttc 7081 ggacggttgc aaaattgtta atgaataact gtcaggtagg gagcctgata tgcctgtcga 7141 ctttctaacc tctgaccaaa aacagaatta cggttgttat gctgcagaac ctaatgacgt 7201 gcaactggcg cgctattttc atcttgatga acgggatctg gccttcatta accaacgacg 7261 gggcaaacat aataggctgg gcattgcgct tcagctcacc acagcccgtt ttctgggaac 7321 atttctgacg gatttaactc aggttctgcc tggtgttcaa cattttgtcg cggtacagct 7381 taatatccac cgtccagaag ttctctcccg ctatgctgaa cgggacacta cccttagaga 7441 acatactgca ttaattaagg aatattacgg ctatcatgaa tttggtgatt ttccatggtc 7501 tttccgcctg aagcgtctgc tatatacccg ggcgtggctc agtaatgagc gaccgggtct 7561 gatgtttgat tttgccactg catggttgct tcaaaataag gtattactgc ccggagcaac 7621 cacactagta cgtctcatca gtgaaattcg tgaaagggca aatcagcggc tgtggaaaaa 7681 gctggccgca ctgccgaaca aatggcaggc agctcaagtg atggagcttc tggtcattcc 7741 ggaaggtcag cgtgtatcag cactggaaca gttgaaaaaa ggccctgtta cagtcagtgg 7801 acctgcgttt aatgaagcgc tggaacgata tatccgatta cgaagtcttg agttttcccg 7861 actgaacttt tccggtctgc ctgccattca actgcgtaat ctggctcgtt atgctggcat 7921 ggcgtcggta aaatatatcg ctcgaatgcc acagcagaga aagcttgctg tacttactgc 7981 attcgttaaa gcacaggaaa taacggcatt agacgatgcc gttgatgtgc ttgatatgct 8041 aattctggac attatccgcg aagcaaagaa aaccgggcaa aaaaaaagac tcaggacact 8101 gaaagatctt gatcaggccg cattgttact ggcgcgggca tgtgcattgt tgctggatga 8161 taatacagat gtcccagatc tcaggcaggt tatcttcaag tgcgtaccca aaaacagact 8221 ggcagaatct gtaagcaagg ttaatgaact tgctcgtcca cagaacaata atttccatga 8281 cgaaatggtt gagcagtacg gtcgggttaa acgttttctt ccggcggtgt tgcgggacct 8341 gcatttccgt gcggcaccgg caggtgaaca tgtactggct gcgattcatt atctggcaga 8401 actgaatggt tcgaaaaagc gcatccttga tgatgcgcct gaacatatta tcaccggtcc 8461 ctggaaacgc ctcgtatacg atgcggaggg acggatacag cgtgcaggtt attcactatg 8521 tttgctggaa cgccttcagg atgcactgcg ccgccgggac atctggcttg aaaacagtga 8581 tcgctgggga gatcctcgcg agaagttgtt gcaaggtgaa gagtggcaga ctcagcgtat 8641 tcctgtctgt cgggcactgg gacatcctgt cgatggacgt aaaggtgtgc aacaactggc 8701 tattcagctg gatgagacct ggaaagccgt ggcatcacga tttgaaaaga atgcggaagt 8761 tcatatctgt aatgaaggta aatatccatc cctgactatc agttgtctgg agaaacagga 8821 agagccacca tcattgcttc gtctaaataa tcggatcaaa cagctactcc caccggtaga 8881 tttaacggaa ctgttacttg agatagatgc ccagacagga tttacacatg agtttgcgca 8941 tgtcagtgaa tctggtgctc gagcgcaaga tttgcacatc agtttatgtg cggtattgat 9001 ggctgaagcc tgtaatatcg gactggaacc gctgataaag cacaatatac cagcactgac 9061 ccgccatcgg ctcagttggg tgaaacagaa ttaccttcgt gcagaaacgc tggtcagcgc 9121 caatgcccgc ctggttgatt ttcagtccac actggagctt gctggtcgtt ggggaggtgg 9181 agaagtggca tcagctgacg gcatgcgctt tgtcacacca gtgaagacca tcaactcagg 9241 atctaacaga aaatattttg gttctggacg aggcatcacc tggtataact tcgtatctga 9301 tcagtactct gggttccatg gcattgtggt acccggtaca ttacgggatt cgatttttgt 9361 actggaagga cttcttgagc agcagacagg gctgaatcca gttgaaatca tgacagacac 9421 tgcgggtagc agcgatatta ttttcggtct gttctggcta ctggggtatc agttttcccc 9481 ccggcttgcc gatgcaggtg aggcggtgtt ctggcgggtg aataaatcgg caaactacgg 9541 agtactggat aagttggccc gaggatatgc agatctgtca aaagcggaga gtcagtggga 9601 tgagatgatg cgaaccgctg gttcgctgaa gttgggtaca attcatgcgt cagaactcat 9661 tcgctcttta ctgaaaagct cgcgcccatc aggactggca caggcaatta tggaagtagg 9721 gcgtgtaaac aaaacgctat atctcctcaa ttatattgat gatgaagatt atcgtcggcg 9781 gatcctgacg cagcttaatc gaggagaagg ccgccacgct gtggctcgtg cgatttgtta 9841 cggacaacgc ggagagatca gaaagcgtta tcgtgaaggg caggaagatc aactgggggc 9901 gctgggcctg gttactaatg cagtggttct gtggaacacg ctctatatgg aggaagcgtt 9961 gagctggatg cgccgtaatg gcgaagaaat tatagatgaa gatatcgctc ggctatctcc 10021 cctgatgcac gggcatatca atatgttggg ccattataca ttcacgttgc cagaggatat 10081 tttaaaaggg gaactgagag ctctaaattt aaatataaac aacgaattat ctccttaacg 10141 tacgttttcg ttccattggc cctcaaaccc catatactgg tgacgatcac caaactgccc 10201 ctattctgaa aagtcaacct gtcggttgtt ttgttatgcg cgccattctc tactcagtgc 10261 tttcttctga cagcatgttg atttaatgta aatatcccag ccttctccgg agaatcgcaa 10321 tggaacttcg ccagctacgt tattgtttgg tgaccgccat gacaattacc cttgagcaaa 10381 gaaatttacc ccaaaatggg caatagattt aaatttagga atttacacat cacatttaac 10441 attaagaaca ggtataaata agaaacttcc attgatagtg ggggtgactt gaagtaagcc 10501 ttatttttct cctcctttga attcaaagga ggtttttttc ttatttcata ccaataaacc 10561 cttaatcttt ttgttgttta acaaatcgga caggttttgc gcactcgaaa attataatct 10621 tcgctgatat caattttaag aaaattcata tcaaatgaaa atggtataat atttaccagg 10681 tgatattaaa aaaatcagaa ccacccgcta tatgggtggt tctgattttt agacttgttt 10741 taatgaagct aacaattttc gtacaaatgc atctgcaggt agcggtgatg ataatgcaat 10801 gccttttaaa tatttaactc ctctttcaat catataacct gcctgtttct tcgtttctat 10861 accatcagca ataacatcta tatgcagttg ttttgataaa tcaataattg tagttgctat 10921 tatatctgtt aaactattgc tttctatatc atggaacatt gttttatgta ggtttacata 10981 ggagaaaggt atgttttgca agtgtgaaag ctcagcatat cccataccga aatcattaag 11041 cgataaataa acattattat ttctgatacg tcttaaagaa gactggtatc ttcttattat 11101 gtaaagttct tctttagttg aaaactgcaa gacaagtctt atccgttccg ttccgaaaac 11161 tttaataaaa tgtaaacact ccctttcgat atcacaggta agaatatctt caggattaat 11221 gtttatcgta ataaaaaaac catgcggaag attattttta atcggtgaga atagtttgtt 11281 gatatgtcca aacaaataag atactttgtt atcattgggg ttataattaa ttctgtcaga 11341 atctagtgca aaagcactac catctgaatt ttttaacgca atagtaacat cacatccagc 11401 aatatttcca ttttttgcgt tatagatcgg ttggtaatat atgttgtagt gcgccatact 11461 ctccccttta gatgaaacaa ctggtaaaac agagctatta aaattatcac agatgatatt 11521 tttaggttgt aggtaggctt taaatcttaa aaaaacatct cgccataaag tcagatcgct 11581 ttttacgtta agttttttat ataatttcat tttttggcac gagactgttt tgatacttct 11641 gtttcttcgc ttggaaatct catttacaga ataccccttc agtaattgag ataataactc 11701 tatctctatt tcagatagaa gacagggaaa ttcaatattt acaattgaat cataatcaat 11761 taggtttagc tttattttta tagtattcat aaagagtctc atgaaatata ttaatcatcc 11821 ccatctaatg tgaggatgat agataaagta tattttctgc aataactgaa ttgcattacc 11881 ttggcatttg ttttttctat tattggaatt tgtttttaag gtgctgaaag ctttcaaact 11941 ttactcttga gcagaggaca tcctttttaa catttaaccc tcttaccaat aattcaattg 12001 aatctttatt catgaatgtt ctgttatcat caagaaaacg atacccctct gcaattttat 12061 gataatcatt tatataatcg ctatatttct cggggtcctc ttcacttaaa aaaaccaagg 12121 cttcaataca tccactgttg atattttttg taagctccat ctgtccgtgt tcatattttt 12181 ttatgctatc cgaaccataa attattgcga acatatcttc ggggatatct tctttcttta 12241 aattattatt agtacaccct gtcatgtata cgcttaaaat aataataatt aaatatcgaa 12301 atataatcat catattatcc acacgtaatc attacattaa atgtaatcac ttgtatacat 12361 cggaatatac atgtatttct ttgtagtaat cattcgcttc aattaaattt gttattacaa 12421 aataaaacat aatgacaaga acaaggagta agataacatt ctcgaatttc atatttttaa 12481 ctttctctcg cttttactaa ctcagataca ttgttttgca cttcgtcagt caccttgttt 12541 acaatccctg taatacatcc gccattacga atctccagaa atcgatagct aacttctcct 12601 tgtaaaaaac cattttcata aacatctaac gtggagcaac agcattcacc atacaattca 12661 ccatttaaaa tcattttttc acataaaacc ctaccattaa caactcctcc tttatcaata 12721 aataccacac cattgttagt atttatatta ccattaattt ttccgtgaat tattattttt 12781 tcaccagaac taatatcgcc aacaaacgaa gtattttttg aaataattgt cgtggtcgaa 12841 tcactttcct ttatttttcc tttagaaaac atattctctc caataaaata taaagtatat 12901 aaaatgatta tcagtaatac agaaatgata taaaagagca atgaataaaa tccagtcccc 12961 cataacacaa ttagagaaaa ccaacacagt gatgcgatcc aaaataacat aaattgataa 13021 tgagggcagt aagccctcat tcctgtttat aagtccataa cttttttcat tttcccataa 13081 atacctacaa atgaggcgtt atcgactcgt acacatacca tatctagttt agaatcaaga 13141 acgcttgcca ttaactcttt agagtcttta ttcattaaat caacatttct tttataaaaa 13201 aagtatgcat catttatctc atcgaactga tttctataca tgctaaactt atccgtgttt 13261 aatttttgca gtagcgaaaa gctccttgag cattgtgatt gagcttgtat tttctcctgg 13321 gatcgaggta ttatttttag ctgcgtatta acatacgtag catttgcatc cctagaggca 13381 aatctattag atgaacaacc tgataacatg aatacagcac aggaaaaaac agacagaaat 13441 aagacgcgcc tattaaacat aatatctcct ttgatttgtc aaaagaatat gatactcttc 13501 ggtagatgat gctataatat tatctataat atatttatat aaagaatcac tatatggaag 13561 aataaaataa gttgtaagcc ccccaagata attaactaat gttctcgcat taatgttaag 13621 aaaattcaca atttcagcaa aagaaaatcc tttttttata caggcaataa tcacctgttt 13681 ttttcctgta aatacagata tatggtagag gccacataaa aataaaaagc atataagcaa 13741 gttactatta caataacgaa gtttttttaa atgtctactc cagttgcgta tgctatcttt 13801 tgtatccaga aaaaaaatgt ttcttggttt ttctttgctg tgtataaacc tatcggaaca 13861 gagaaatatt atattttctt ttcttctctc cttaaataac tgtattaatt tgtaggcaac 13921 atcctctatt ttaaaaaacc ttaaatcata gatcttaata ctatggcaat aacgcctgtc 13981 atcaaaatac ttttcgtgca gtagctgctc tattgcaatc tttgtatatg tgcaatcagt 14041 atttatacaa tacatcttat aattatgtga tttggttgtt ttgatgctct gaaaatttaa 14101 ttagataact tgatatgtta tctattaaaa tatttatacg cctgcaacca tcaatttcta 14161 caatacttac cttgctatct tctcccgtcc tttttaaaat aacagatttt atctctttta 14221 tcatcaggtc tattttttca ttatctgtca tatcatcttc ttaaaagaag ccctcttttt 14281 gagggcaagc acaaagtcgg agtttatatt gtttattata atgaatgctg cccccccatt 14341 ttatgggtat tattatgatg aaaaataagt gttattttcc aattttatta tttagcatta 14401 tttgatttta aaattctaaa atcctttatg ttaaatcaaa acaaaaagga gaaagaatgg 14461 ttgcactgat gttattatca tgttaattct ttgagctata aactaaacac ctcctgtccg 14521 tgatgatttt tttattttaa acgtgaaaat tcttaaagaa aatgtaatga attgaataaa 14581 gcataaattg ttaacatggt ttattaagac attgaaaact ataactttta ttgttgttta 14641 aatttgtgat tattcttata gttatcattt tttaaatgac tagcgtctaa aaaataaata 14701 ccaaacaaga gttattctgt gttatctaat atctaaatac ttgaacatta agcaatcaga 14761 tacataaagc ttaatttaac ataaaataaa ttgtacgcct aattgttgta taggttaaat 14821 tgtagtgctg ttttagcact aaaccgttca tcacagctat cgctgatttc aatggattag 14881 actcatgaag gcatacggaa cggagttttt ctcaatgcat gctcaaaact tgtcggacta 14941 agcacacggc tgaaggcaaa gcggccagtg cggattcttt gttatttatt cggtgttcac 15001 cgtaccgttt attgcgcgca ggtgaagcgt cctgtttatg tacaaagaat tgaattacga 15061 agccgggcaa tcagccagac gttgcgccag agtgatctta cccagcaata gtggacacgc 15121 ggctaagtga gtaaactctc agtcagaggt gactcacatg acaaaaacag tatcaaccag 15181 taaaaaaccc cgtaaacagc attcgcctga atttcgcagt gaagccctga agcttgctga 15241 acgcatcggt gttactgccg cagcccgtga actcagcctg tatgaatcac agctctacaa 15301 ctggcgcagt aaacagcaaa atcagcagac gtcttctgaa cgtgaactgg agatgtctac 15361 cgagattgca cgtctcaaac gccagctggc agaacgggat gaagagctgg ctatcctcca 15421 aaaggccgcg acatacttcg cgaagcgcct gaaatgaagt atgtctttat tgaaaaacat 15481 caggctgagt tcagcatcaa agcaatgtgt cgcgtgctcc gggtggcccg cagcggctgg 15541 tatacgtggt gtcagcggcg gacaaggata agcacgcgtc agcagttccg ccaacactgc 15601 gacagcgttg tcctcgcggc ttttacccgg tcaaaacagc gttactgtgc cccacgcctg 15661 acggatgaac tgcgtgctca gggttacccc tttaacgtaa aaaccgtggc ggcaagcctg 15721 cgctgtcagg gactgagggc aaaggcctcc cggaagttca gcccggtcag ctaccgcgca 15781 cacggcctgc ctgtgtcaga aaatctgttg gagcaggatt tttacgccag tggcccgaac 15841 cagaagtggg caggagacat cacgtactta cgtacagatg aaggctggct gtatctggca 15901 gtggtcattg acctgtggtc acgtgccgtt attggctggt caatgtcgcc acgcatgacg 15961 gcgcaactgg cctgcgatgc cctgcagatg gcgctatggc ggcgtaagag gccctggaac 16021 gttatcgttc acacggaccg tggaggccag tactgttcag cagattatca ggcgcaactg 16081 aagcggcata atctgcgtgg aagtatgagc gcaaaaggtt gctgctacga taatgcctgc 16141 gtggaaagct tctttcattc gctgaaagtg gaatgtatcc atggagaaca ctttatcagc 16201 cgggaaataa tgcgggcaac ggtgtttaat tatatcgaat gtgattacaa tcggtggcgg 16261 cggcacagtt ggtgtggcgg cctcagtccg gaacaatttg aaaaccagaa cctcgcttag 16321 gcctgtgtcc atattacgtg ggtaggatca gagtggtgtt gatgcaggcc agtggctggc 16381 acggttgaag aagcaacagg acaccatctg ccagatggat gaatacaacc gcctgctctc 16441 atcgcaggtg gcgacttatg cttccgaaac caaccggctg aaggcgctgg ttgcaaaact 16501 gcagcgcatg cagttcggta aaagctcaga aaaacttcgc gcaaaaatcg aacggtaaat 16561 acaggaagca caggagcgaa tcagcgcact tcaggaggaa atggcagaaa cactggtgag 16621 caatatgacc cggcactgcc atcttccctg cgccagtctt cagcccgtaa atcgttacca 16681 gcctcacttc cctatgaagc cagggtcatc cggccggaag aggaatgctg cccggcctgt 16741 ggtggtgagc tcagccctct ggggtgtaat gtgtcagagc tgctagagct tatcagctgc 16801 acctttaagg ttatcgaaac acaacgcccg aaacaggcct gttgccggtg caactatatc 16861 gtgcagacac ctgagccttc agcagttatt ccggaccggg gctttaggcc catgtagtca 16921 ccgggaaata tgcagaccat ctgccattat accgcgagtc agaaatatac cgtcgccagg 16981 gcgtgtagct gaggcgtgcc acgctggatc tgttccgttg cgaactactg gagctgctgt 17041 ataacatact gcgccagtat gtgctgatgg ccggtaaaac tcgaaccgtc cggcagtggt 17101 gctacgtccg tgatgaccgt gatgccggct cggagatgcc cccggcggtc tggttcgcgt 17161 acagtcctgc tggaaaggta tccattcaca aaatcacctg gccggttaca gcggtgtgtt 17221 tcaagccgat gcttacggtg gctaccgggc gttatacgaa tcaggcagaa taacggaagc 17281 cgcgtgtatg gcccatgccc ggagaaaaat ccacgatgtg catgcaagag cgccaaccga 17341 cgtcaccacg gaagccctgc agcgtatcag tgaactgtat gccatcgagg ttgcggtccg 17401 gggctgttca gcagaacagc gtctggcggc aagaaaagcc agacctgcgc cactgatgca 17461 gtcactgtac gactggatac agactcagat gaaaacactg gcgcgtcact cggatacggc 17521 aaaagcgttt gcatacctgc tgcagtagcg ggatgctcgg aacgtgtact gcagtaatgg 17581 ttgggtggaa atcgacaaca acatcgcaga gaacgcctta cggggagtgg ccataggccg 17641 gaagaactgg ctcttcgcgg gtggatttgc ccctatattt ccagacatct gttatcactt 17701 aacccattac aagcccgctg ccgcagatat tcccgtggcg agcgataacc cagcgcacta 17761 tgcggatgcc attcgttata atgctcgaac gcctctgcaa ggttctttgc tgccgttaac 17821 ccgtctggtt tgggcatgat actgatgtag tcacgcttta tcgttttcac gaagctctct 17881 gctattccgt tactctccgg actccgcacc gccgtgttct tcggttcaag tcccaacatc 17941 cgggcgaact ggcgtgtttc attagcccgg tagcatgaac cattatccgt cagccactcc 18001 actggagacg acggaagatc gttgccgaag cggcgttcca ccgctcccag catgacgtcc 18061 tgtactgttt cactgttgaa gccgccggta gtgaccgccc agtgcagtgc ctcacgatca 18121 cagcagtcca gcgcgaacgt gacacgcagt ctctctccgt tatcacagca gaactcgaac 18181 ccgtcagagc accatcgctg attgctttct ttcacggcca ctctgcctgt atgtgcccgt 18241 ttcgatggcg gtacagcagg ttttcgctca agcaacagcg cattctggcg catgatccgg 18301 taaacacgtt tggcattgat cgcaggcata ccatcaagtt ctgcctgtct gcgaagcagc 18361 gcccataccc gacgataacc atacgttggc agctctccga taacatggtg tatacggaga 18421 agcacatccg tatcatcagt gtgacgactg cggcggccat ccatccagtc atcggttcgt 18481 ctgagaatga cgtgcaactg cgcacgcgac acccggagac aacggctgac taagcttact 18541 ccccatcccc gggcaataag ggcgcgtgcg ctatccactt ttttgcccgt ccatattcaa 18601 cggcttcttt gaggagttca ttttccatcg ttttcttgcc gagcaggcgc tggagttctt 18661 taatctgctt catggcggca gcaagttcag aggcaggaac aacctgttct ccggcggcga 18721 cagcagtaag acttccttcc tggtattgct tacgccagag aaataactgg ctggctgcta 18781 caccatgttg ccgggcaacg agggagaccg tcatccccgg ttcaaagctc tgctgaacaa 18841 ttgcgatctt ttcctgtgtg gtacgccgtc tgcgtttctc cggccctaag acatcaatca 18901 tctgttctcc aatgactagt ctaaaaacta gtattaagac tatcacttat ttaagtgata 18961 ttggttgtct ggagattcag ggggccagtc tagcgggttc cggcagtggt ggcgaacatg 19021 cggcggtgct gtactcgctg atcggcacat gccgtctgaa taatgtggag ctggaaaaat 19081 ggctgtgtta cggcattgaa catatccagg actggtcggc aaacctggta cgcgatctgt 19141 aaccctgaaa agttgatctg gccgctcagt aaatatcaat actgttctgt tgagccgttt 19201 acttgcatag tgctcaggaa acacaaccgc gtgatggcca cctgatgttg cattcagatc 19261 aaggtgttca atataaaagc aataaataca aaattttact ctgccgttat gaggcgatgc 19321 aaagtatgag tcgcagaggg aattacctgg ataattcgcc gatgggaaga gtctttcgca 19381 gatttaaaag taaatggctt gcgaagggtg gttatggtga ttttagtcat gcagtacgcg 19441 atataaagca gtagataaat tgttattaca acgtttatcg acctcataca aacaatggtg 19501 gtttatcgcc ttgcttacat gaagaaaagt ggaaacaggt tattccagtg tcctgatttt 19561 gtgaaccact acaaacaacc ctgaatatat gtaatagcaa agttgttatg tactctcttg 19621 actaagttaa gatgtctgtc atgtagcttt accattgtaa tattattatg aatactcatg 19681 caaaggagtt tttcattttg ggtgacgtaa atcgacttaa aaaacttcag gatagtgtca 19741 agcgacacat gagaaaataa gtgaccatat gtcgcttgac taccttcaat cggtaaagat 19801 gctctctttg cgttactgag agcaaaggtc tattgatatg gctaaaattc ataggagaaa 19861 gcctggcaat aataattccc cgtagttctt tccctatata atctcaacac attccgcaag 19921 cgctacatca acttttggca gacgctcatt tgtgatgtct aaccgttcaa agaaacattt 19981 tcttgcttat ggttaaaact gatcccggga gcaccataaa tggcaataac aaatgttatt 20041 cgttattaat aataatagac agtctcccat gtgttatttt attttagagt agcagtcatg 20101 tgaaatttct ttttatcttt atagtcatat ctattatcat ttttaaattt tgtaaatata 20161 gcaatttttg tttgaaaaac atattcatca atgatgtgta aagtataaaa aacatgatgg 20221 cgacaataat tttatcacca gtctccccaa caaaaatacc atctatgcta cctccattaa 20281 cgatacaaat agccgaatac gataggcata aaattgatat aattgctgtt ttcccgcctc 20341 cccataagaa acattttgat tttattttgg gaattcttac ctgtatacag tttgacacat 20401 atgtcaactc ttctaatgaa taaggtaaca atgcttcaat atgttgctca tcactatcaa 20461 tgtcatatat taattcattg accacctccc ctttaaaatt atatatatac tttattgtat 20521 taattacagg aactgataaa tatgtaactc ccataatgac attaataaaa taaagagata 20581 atgcgctaat aaaactcaag ttactttttg tattaaacgg tccatatgtc aaagtaatta 20641 tggcaagaag aaaaaaagaa ataacagaga tgcaaaaaga tattttttgc accttactca 20701 accgttcagc aattctgttt actttcatgt gcggagtata agaactcatt tcatttattg 20761 ttctcataat atgattaact ctatacatca ctcctccagg ttaaatggct tctttttgtc 20821 ttttaatagt atatttacat aagcatgatt tctttaagtt caacttgaga ataaatcaac 20881 cgcaatgatt aatttcatgc cgcaaggcct aacgctgata ttacaccata taaaaaagat 20941 attaaaaaca acataatcat aactccacct gaaaatataa atatacttaa ggcaaaaagt 21001 ccagagcatg atgccttgtt atcataaaac cacatgacta ttactgtaga ccaaagtaca 21061 acccctatcc aaaacatata atcgatcata tacactgtcg gaaattattt aattcgaatc 21121 aacaacatac aaagcatata tttactttga ttatggtaga tacatgcaca aaaaagaaaa 21181 tattaatgtt acatttgata aaacattcta tttttacata tttatttttt caactcatca 21241 atcattcccc tgattatttc tttatcattt gcgtccaaac cgtctgtgct gaaatctatt 21301 aattctaact cgtcctcatt gaaggataat tctcgaatta tatgaagatg attacaattt 21361 gatgtatctc tctttttcgt tagcttctta caaaaaaagt aacgtccaga ttgttgataa 21421 acatagtatg taaattcgcc atgatatctt accattgtta cctcaaaaaa ccaatgaaag 21481 aatatagcaa tcatcctgca aataatttgc tggacgattg ctaaccctca ccagtaacga 21541 ttaaaaataa taattgccac caagaataaa actcaagttg cgatcattat ttattgagta 21601 tgaggatgtt aataaaagac gtgcatcctt caaaaattca aattcaacac cactcttaag 21661 agcgaaatta tccgatgtat tatattcaac catatctgaa tcaaagttag tacgactata 21721 atttccagtt ttaaatgaat accccccacc aaaccatgca tcgactacag attgttttat 21781 ataatcttta aacattgctt catcattgga agtcgattca tgagtttttc gataagagaa 21841 aaatactcct ggttcaataa tagttagcga attcggataa gttattttcc ctccctgaag 21901 atcttcaact acacctccag acaactcagt atgcgaaagg tataacttag gttcaacgta 21961 gaaatcgctt ggttgtatgc cacctatatt ttttagataa ccaacctcac ctgtcaggcg 22021 aaaaccattt acaccataat tagccttgaa attatttgtt gaactgacgc tgttatcata 22081 atccatgtat tgtatagacg aataagtcca cagcccctga cgttctgact catttagtcc 22141 atcactgata ttttgttgaa atacatgata aagcccaaga gtataaccgt ctacatttcc 22201 ggtagctctt ttattatttg ttgacgttgt tttgttagcg gcactcccca tcccgcccat 22261 tatcccgata tgtgaatagt tatatccatc agtccaattg tatatatccc cgccaatcat 22321 catagtattt aaactataac tggtcttgag attatcatac acctcactat tactacctga 22381 gttgttgtta aattgaatcc acatcccatt gttatataag ttttcaaaca atgtaggata 22441 acgatgttgc ccgggtatgt cataccgttg tagagcaaac atatctaaca tacttttact 22501 attgtttata aacgcacctg gctcaggacg catatccaca ctcagatacc aattcttcct 22561 tttcttgttc agcgcatact cccaggcccc cacatcaatg tagtcacctg tcaccttata 22621 ctccttacca ttcttaatca gtgagttaag gtaaaaacta cctgatgagt ccccattaac 22681 ctcaacaaga agaatgtcgc cacctttctt tattttattt ttactgtttg tcgtgacaac 22741 tatacctgaa ctcccggatg tatcaccttt aacatgcatc acatccgcct ctttctgccc 22801 gaaaatcccg aactgtacac cggaaccatc atgtgcaaca taatctttat ccagatacac 22861 atctgatgaa gcacttccgt cagaaagata aatcatccct ttattatcta tccctgtcat 22921 atgctgcgag tatccgttaa agtcaacctg tgcttctttg ctgacattca gtataccatc 22981 aacggcatca ttcccccttg catccagtcg ggttccgtca taaacattta tctgcccttt 23041 ccagtcattt gttcctgaca gagaaactgt ccctctgttt acatttatga cagtgtctgc 23101 acatgaaccg gaatccatac aaatgaaatt agttgagagt gtatagccat taacaccatc 23161 aaaatttact tccgcataac catctcctgc tcccatagat acaggattga actgtccgga 23221 attcatatta ctaacattca cgattgcttt actgcccagt cctgtagcaa gtgaaatgtt 23281 gttggcatta gttactgcat tatcctgaag attaagtact gcaaaactat tattaccttt 23341 tgccaaagtt aatgaaccat caccataaac tgatgcatca ttaatggtga ctaacgactg 23401 gctgtaatca ccttcaccaa tggttgattc ctgagatgat ccgaaatcaa atatggaatt 23461 tccagttata cttatagaat tttttgaata tgaaccatta ccaatattta tacgttctcc 23521 tttaaacaca gagtgatcag atatagaaag attagttatg gcattatcac ctttaccgat 23581 gatgattcca tcagatgcaa caaatttact gttatccaat gataaatctg ttttgactcc 23641 ggaacctgca cctagtatac cattcccaag attaatatct gagtttttgt aaatcaacgt 23701 tgcttctgaa ccatcacctt ttgctactgt ataatcccct acaacagata tttctgaatt 23761 attagcgctc atagaaacaa ctgcattgtt agccgtccca agcaacaggc cgccactata 23821 aagctgagaa tgctcaacag acatttctgc ttcggtacta ttcccctgtc cgagaaccag 23881 gctactacct atattcagca cactatcttt tactgaaaat tttgctttag cctgatctcc 23941 aacgccaata ctagcattcc cttttattga catgttacta ccagccccga cagaaacatt 24001 agctatagtg gagctgcctt tacctatatc aatattccca gcggcatgga aagttgagtt 24061 gtctagtttt agtaatgtat gagatttttc gcccacaccg atatatccat taccgatatt 24121 aatttttgaa tcagagtagt ccagcgttgc agatgcgtta ttacctcttg cgaccgtaaa 24181 agtattgccg ctgctaatcg ttgctccgtt tccggtcatt gtcactgctg ctgtatcgcc 24241 ttcaccaatc gacatggagt tcgcagataa atctgcattg tccacaatca ctttggctga 24301 agcggcatta ccttgcgcaa tagacatatt cccggatact tttatggatg actgggggct 24361 tagcgtcagg tctgtctgag tttcctgccc ctgtcccata attacatcac cggttgcagc 24421 taacgcagaa tccttcaacg tcagcactgt ctgggctttt tcacccccac cgatatatcc 24481 attaccgata ttaatttttg aatcagagta gtccagtgtt gcagatgcgt tattacctct 24541 tgcgaccgta aaagtattgc cgctgctaat cgttgctccg tttccggtca ttgtcactgc 24601 tgctgtatcg ccttcaccaa tcgacatgga gttcgcagat aaatctgcat tgtccacaat 24661 cactttggct gaagcggcat taccttgcgc aatagacata ttcccggata cttttataga 24721 tgactggggg cttagcgtca ggtctgtctg agtttcctgc ccctgtccca taattacatc 24781 accggttgca gctaacgcag aatccttcaa cgtcagcact gtctgggctt tttcaccccc 24841 accgatatat ccattaccga tattaatttt tgaatcagag tagtccagtg ttgcagatgc 24901 gttattacct tttgcgaccg tgaaagtatt gccgctgcta atcgttgccc tgtttccggt 24961 cattgtgact ttagcagcct cacctccccc cagagacaga gagtcagcag acagcactgc 25021 attagtgatt gtcacatcta ccgaagcaga acttccctgg gccactgaca tctcgtcgct 25081 cacatttact gacgacttat catttaatgt caggtttgtt tgggttgtat ttccctgccc 25141 gataaatacc ttaccactgg cagtcagtgc cgaattattc agctccagct gggtcttagc 25201 agcctcgccc tctccgatat aaccgctacc gatatctatt ttcgaatcag tgtaatccag 25261 cgtcgctgat gcattattac cttttgcgac agtgaaggta tttttactgc tgacagtagc 25321 tcccgaaccg gtcattgtga ctttagcagc ctcacctccc cccagagaca gagagtcagc 25381 agacagcact gcattagtgg ctgtcacatc tactgaagca gaacttccct gggccactga 25441 catctcgccg ctcacattta ctgacgactt atcatttaat gtcaggtttg tttgggttgt 25501 atttccctgc ccgataaata ccttaccact ggcagtcagt gctgaattat tcagctccag 25561 ctgggtctta gcagactcac cctctccgat ataaccacta ccgatatcta tctttgaacc 25621 agtgtaattc agcgtcgctg atgcattgtt accttttgca acagtgaagg tctttttact 25681 gctgacagaa gctcctgaac cggtcatttt gacatcagca ttatccccct caccaactga 25741 tagcgagcca gtatttaact ccgaagagga tatatttata ttagcctgtg tacctttacc 25801 tttagccaaa gtcatatcac tgctgcttgt tacaacagag ccgttcttaa tatcaaattt 25861 agttatggag ccatctccac ttccgatggt agagactcca ttcactgaca ggtttgaggc 25921 atctaatttt agattagcat tcgaattgtt tcctgtagct acagtaaaat tcccatctga 25981 aaatatagag ctttctctag acgcgcttac agtaatattt gattcacgcc caatgcccac 26041 agcaatattc ttatcaacat gcaggttgga actattatcc atatttaaat ttaacttgcc 26101 tgcagcagaa atacctcctt tcatgtcccc atgaactgag aaattacttt cattttttat 26161 atttatctcc gaaggttttt cattaggaat accatctacc cccgtagata caactacatc 26221 attttttaca tctagttttg aattgttatc tatgtcaata atgccattgc ctgttttacc 26281 caagactaaa tccccggagg aaaccgtccc atctgttata ttatttcctt gtgaaataat 26341 attttggttc cattttactg agttggtttt aaatggcgta tcatcttgag atgatacaac 26401 aaaaacattg cttccattgt taatgctcaa tgacccatta ctgtcatcac tgacattgct 26461 ggtcttgtca ttatcattcc cagagaccca taattgctgt gtatatagag tgctaccacc 26521 atctatattt aattccccct ttgaagagtc accaacaata gtaacacttg caccaacact 26581 tgctgattta tcaatctttg cagatgcatt taatccacct tcagggcagg tgctagattg 26641 accattgcaa gtagccaccg aaaaataatc tttaatattt acggtgccgt taatatcaat 26701 atttgcatct ttattaatcc ctatatttaa tgatcctgaa atatccctat tgctaatggt 26761 actgctgccg tcaatatttt cggcatatgc taagcgagat cccaaaaaga aacacattat 26821 atatctattg atctttttta attctttcat aatagataaa gtaaaaataa aacaaaatta 26881 aaactgagaa aatagataac gattttttta cagaataccc tcaacatcac gaaaaatcag 26941 aatattcttt tcagtttgag cacaaatcat caagtgccat cgtaatgcta tgtattttat 27001 gacaaaaaaa atgttaactt tcgtgcaaac tcccaaagaa gggctctctt ttgctatgac 27061 tacttatctg aatttgtttg tgaaattgct tatttttctt tatattcaaa ataccaaagc 27121 atgtctatcc ataaacaatg ttaacaataa tagcaagaac aagttgcgta gtggtgtttc 27181 ttactacatc atcaacttaa agatgagtat gttatttact gaacagatag ttaccatata 27241 taataaattg atattctgag agcacctgat tcaggttaaa catattaata tctttatgta 27301 tattacagat gacatgaatg gataaaatta attatatttt atgctctttt atttgtattt 27361 acttcttgtt gttattctta attctgtttt gtcagtaatt agtatgaaat tatcagccat 27421 ttaatttatg attaaacttg actcaaaata aactaagtat attttgaatt tacagaaaac 27481 catagtcaga atgtatactt cacacccagc atggctgagg tgtcgttata ccctttatca 27541 ccaacttgaa ctctcacatt cccccacagg ttcagatggg gatttatttg accttccaca 27601 ccagttttga cctctccgat attacgggta ccatcctgat acaccggttc gccgttcata 27661 cgaaccccaa aatcacgggt attatgcaac cagttcacct ccacaaatgg gctgaactca 27721 cgtgatttac catcatccat tttattgagc cttttaatcc aggttttcac gcccagacgg 27781 gtatggacat taccgtctcc ggtgctttca ataagagtac cgttactttc atagagttca 27841 tcagctttaa cccccatcca gacaagctgg gcctgaggct gaacatacca ttcgttcaga 27901 ttgccatagt tgctgctgaa ttccccgatt ttccaggcat aacctgtttc cagtgaggcg 27961 gtaagtcctt ttgatttcca ggattcaccc ggcagtccgt cacctttcac atggttatcg 28021 aaccagccgt actgagccca ggtatccaga taagctccgt tatgagtctc atcatcagca 28081 taccaggtag catacagccc ggtactgtaa ccatttacgc tgccttttga atggtatccg 28141 gtgcgtactg cacctgtact gctatggttg ttaccgtaac cagccataac ccccagatgc 28201 cagcggttag ttccacccca atcccattgt gcgatatcac cacccagttg aatcacataa 28261 cgattacttt gagttttcag ttgaccagaa ccgtcgcgcc agcggttatg tcctccttca 28321 tggcgcatcc acatactggt tgctttcggt tctccggtaa ttgcatcgac gtattgcgtc 28381 tgccccagac gttcatgaag gcgggtcaca aacatggtgt ttgccgcagc tatattcgcg 28441 gtataggagc tggcttccgg gcgcaggttg ttatcatgcc cttccggagt gggttcagga 28501 tcaggccttg gttctggagt atttttacta ctgctcagat accagtttcc atagttgctt 28561 cccggcccac gtccaagagt gtagtcataa gcgccggccg ctatacgtcc ggcctgaata 28621 aattcagcgt tagctgcatt accatcaaca tgaataactt caatactatt cagcgtatta 28681 gcgcctgaac caccaacatt cgtaacagcc actcgggtct taccggacgc atcgccttta 28741 attaccagtt tgtcggttgc agaagagcta tcatccagca ctgtgttaat gagcagcgtg 28801 ccattattac cggtgtagtt acctccaatc gtcagaatat ttcccggagc cgccgatcgc 28861 aggtcaaggc ttccactatt ggttacgttc cctactacgc caccaaatcc ggtaagttta 28921 ccgttctttg caatattgac caggctactg gcgagcatga caggtgcatc agattgccca 28981 agaatcagag agccgtcatc aatatctgtc tgtccgctcc aggcagcatt gcttcggaca 29041 gtcagtgaac cggaaccggt tttacggaca ttaccggttc cagtaacatt atttataagt 29101 tgccagtctg ttgtgttgtt cagctgcaag attccacggt tactcacgga agcaatccca 29161 agattctgcg ctccagtggc agtcaactga gagctggtat ctactacaaa cagccctgag 29221 tagttactgt tatttcctga aatctgggta tcactattga tcaaagatac tgtaccagaa 29281 ccactcagat tattacttag caagcctgag gcatgagtaa gagataatgt cccagcgtta 29341 ctgatgttac cagtacccag tccggaaaca tcgttcattc ggacagttgc atcttttgct 29401 attatggtgc tgacagcaaa agtgtggttg cctcctgtaa tatcgaggac gccgccgctg 29461 atattcagga agccacctcc agtcagagta ccggcagata cgccatcatc agtcagggtc 29521 aaattcccgc cattgatgtt cagtacagaa cctgcagcac cattaagctt accaacagtc 29581 tggctatgac cgttcatgtc cagccgggta tcagtagcca gacgaatctc gctggtctgt 29641 cccagaacac tgttgctgtt catgaggaca ttaccaccgc ggatagctgt aactcctgtg 29701 taatcattat cctgattcga cagagaaacg gtttctcctt tctgactgtt gaaagccagg 29761 tctccggcac ctgtgatacg ggcactcatg tctgctgcat ttccagttgt acctgcagca 29821 tcaagcacga gtgcatcaac accagaggct agcaaatcaa gctgagtcag agcataacct 29881 atatacagtc catcattatg gggccctgat gtcagacgat aatcgtatac ccccttagca 29941 acattttttc cctgttgaac tatattcctt tgcttacctg aggatattac ttgcccggag 30001 gcatcctgca gttgaaggtt tccaccattc ccctttacaa ctgcggaact tgcatctaca 30061 agtttaatgg tggcattact gtcatcctgt tccagcaatg aaagtgaaga attaatgacc 30121 tgtggaatac cattcacatc tgtgggtgtt gaaacccgta cagcaccatt tccattgata 30181 tacagattgt cagtaacctg aatctgggat tcagtttgct gagctccctg agttacggca 30241 ccgaaattta cggctccacc gtcaaatgaa aatccgttaa taacctgagt tccagtacct 30301 gcagttatca cactcccgac cccagcaagc actagtgctg aagttagtgc agtggtattg 30361 tcgtcactca agtcaaagag tgtatcagac aatgccagcg tacctgtaaa ttcctgtgta 30421 ttcgttgaat tctggaaagc aaaattatgt ccaccagtat gaacattaag ataaccgtta 30481 ccagtcatat tattattgaa tgtccagtca tcctggctgg ttatttgcag caccccatta 30541 ttaacaatta ctgacttgcc gatatttttt tgactactga tatcaatact tgccgtgggt 30601 aaaatattca acaaaccact ataatcggta ttatctcccg tgagatgcgt ctcgccactc 30661 tctgcattaa ttataccatt acctgtgttt ttagaaatta aaggtgatga aaaagcataa 30721 ttgtcagagt tatgtttaaa aatcaactct gccttcccaa caccaaaaag aatcccttta 30781 gattcaatag ttccaggcat gtcgctattg atgaataatt tcccttttgt gtcatttgcc 30841 gtagttatat tgatgtagtt atctacatta agaattcctt gatctgctat gtaaatgccc 30901 ggcgcaccag aacttcctga tatggttatc atatttgcaa ttaatctgga atcagtaccg 30961 cttatattaa caatggctct accattacct cctatatata agttactggc agataactga 31021 cctccatttt ttaaggaaat atcaccatta ccataaagcc cgacatatgc ctcagaaaaa 31081 tctgcggtca tcttgctgtt gctgccatca atcacgatac tgccatctcc cccaccagga 31141 gtatctgaac ctacatatat attagtacta tttaaaactt caaatactcc accattaaaa 31201 atattaatcc atcctgttgc accaggccca aaaccgacat aaatagattc gttatgtcca 31261 gaactgctgg gcgtatctct atatgatact atactgtttc tgccagaaat attaagtttt 31321 cctgcaatat cattaccgaa tgcacctaca ataagaggtg cgcttcctga acgattatcc 31381 atatgtaaag cagcaccatt aataacatca acagcaccat tatatccatt accaatatga 31441 agtgtggaaa atataccatc ctcaatatcc gcatgattat caataattaa tagcccgtca 31501 ctttgtgaac caaccagaac tggcttgttt tgatattctt cgggagcagt ccttatttca 31561 acaatgccat taacaaaaca aaaataacgt tggcaattca tttcatcacc tatcgaaggt 31621 gatgatgcca gagagagaag gaaagagata acataataaa atttatggct catatgattt 31681 ttaacaaacc ttaagtgata attgacatga cttttatgta tattgtaata tacaaattta 31741 aaagtgctat gctatgaggt ctgttttttt gtatacaata gcaaaatcat tatcaatgca 31801 acttactgca ataattacaa gatctttttt gaagtaaaaa gataaaaaaa tcttaaaaaa 31861 tccaacaatc catcagaaaa aactgaggac tttatccagg cccggataag ttaagaaagc 31921 gactataata tttcactatg ccatatcagg acgatatttt cacctcatat cctgtagttg 31981 cgtcaggccc tccatttagt agctaaactc ttacctcatt acagaaccat atcagtatat 32041 caaatagata atgtgccaga tgtattaaga taaaaatgac tatctatata aacaaatagc 32101 catgttaaca ttaagttctg tctatacaga ctatccataa agaatgttca gatgacatac 32161 acaccattac cgcatatcat ttagatatat tgatatacct cacaaaaaca aactattagg 32221 ttaaacaaaa gctaaacaaa ttaagtactg ataattgact taccggtgta catcaaaaga 32281 atcatataca tatgtagaag tgacagaagg gagtcattgt tatgcaaact aagcttctgg 32341 caattatgct tgcagcacct gtggtattca gttctcagga agcttctgct tctgatttct 32401 tcggcccgga gaaaataagt acagagatta atttaggtac actgagtggc aaaacaaaag 32461 aacgggttta tgagcctgaa gaaggtggac gtaaagtcag ccaactggac tggaaataca 32521 gtaacgccgc cattcttaaa ggcgccgtta actgggagct gaatccatgg ttatctgttg 32581 gtgcagctgg ctggaccact ctcaatagtc ggggggggaa tatggttgat caggactgga 32641 tggattccgg gactcccgga acatggacag atgaaagcag gcatcctgat acacgtctta 32701 attatgccaa cgaatttgat ttgaacgtta aaggctggtt tttaaaagaa tctgattatc 32761 gccttgctat tatggcaggt tatcaggaaa gccgttacag ttttaatgct acaggaggaa 32821 cttatattta tagtgagaat ggtggtttcc ggaatgaaac gggagcgtta cctgataaaa 32881 taaaagtgat tggttataaa caacatttta aaattcctta tgtcggtctg acaggaaact 32941 accgttacga taattttgag tttggtggtg catttaaata cagcgggtgg gtcaggggat 33001 ctgataatga tgagcattat gtaagacaaa ctacattccg aagcaaagta ataaaccaga 33061 attactattc tgttgcagtt aatgccggtt actatattac cccagaggca aaagtgtaca 33121 tcgagggtgt atggagtcgt ctcacaaata aaaaagggga tacatctctt tacgaccgta 33181 gtgataatac ttcggagcat aataataacg gggctggaat tgaaaattac aacttcatta 33241 cgacggccgg tctgaagtac acgttttaac aactttaact gtcatcatcc ccggtgagaa 33301 ttataccgcc ggggattctg tctgttggtc agggtaataa tttaccaatg caggagatgc 33361 aatgcgtgtg ataatgaagc ctttaagaag gactttagta ttctttatct tttctgtttt 33421 tctttgcgga actgtgtctg ccagacagat cgagtggcaa tcctgtatga ccagcccata 33481 cagtgactgg tttggtaaag aaagctcttc acctgagttg ttatgcggat atctatctgt 33541 accgctaaaa tataccgaca caggtaagga tgtgtcagat gaaaatatac cacttgtcag 33601 actggcgatg acaaagttgc cggcaaaaag taaacgtaaa gggagtgtta ttataataag 33661 tggcggacct ggattacccg gaattaatcc ttatatcaat tttgactggc cggtcacaaa 33721 tcttcgggaa tcatgggata ttatcggttt tgatccacga ggtgtcggtc agtcctttcc 33781 tgccataaac tgccagcaat ccaatcaaga aagattggtg aatgtaagtg aaaagcaact 33841 aattttacag aaaattaatg cctgtatcca taatacagga gctgaagtca ttcgccatat 33901 tggatctcat gaggctgtat atgatattga acgcatcaga caagctctgg gagataaaca 33961 actgacagct gtagcatatt catacggtac acagattgca gccttatatg ccgaacgctt 34021 tccatccagt atcagatcta tagtttttga cggtgtcgtt gatattgatg atttaaatga 34081 taatttttca tggaaactca ggcaggccca cagttatcag gaaacgtttg atcgttttgc 34141 tgcatggtgt gccaggacaa aaagttgtcc actttcttca gacaggaatc aggcaataca 34201 tcagttccat cagcttttat taaaattaca taattctcct ttaacagaca gcagggggga 34261 aagtatatct tcagatgatc tcatatcatt aacgacagag cttctgttat ggcgctcatc 34321 atggccaaca cttgcaacgg ccgtacgtca gttctctcag ggtattgtca gcaatgaaat 34381 tgaaactgca cttaattctt ccatagcatc ggaaaaagtc agtgatgctc tgggtgtaat 34441 attatgtgtt gatcagagtg atgaacaatt atcacaggaa caacgaaaat cgcgaaaaaa 34501 agcccttgct gacgcatttc cggccgttaa ttttgagagg gaacagtccg atttacctga 34561 attttgtgaa ttatggccaa ttcatcgcga tctgcaacag acacgcctga agaatactgt 34621 tttaccatcc ggtttactgt ttgtggcaca caaatatgat ccgacaactc cctggataaa 34681 tgcccgtaaa atggcagata aattttcagc tccgttactg actattaacg gtgacgggca 34741 tacgctggcg cttgctggca ctaatttatg tgtggatgag gctgttgttc gtcacctcct 34801 gtttccgggg aaatctgaag atataacgtg tcagggaagt ggtaccggag acactaactg 34861 atattaaata aaatattact cccgacatta aataacatca gtgctttgat gtcagggcct 34921 gctaaccctc ttttgatatc agttgagcgc aggaaacgcc agttaagagg ggacaggact 34981 taggataaat aagagagtgg caatcatgag taagattcat gtacatgcag gttacggaaa 35041 gaggatatca ggcaatgaat aaggcactaa tataatatca tatctcagac ttgatacatt 35101 ttagttacat atattttctt attttatgcg gaaaatgcta tatggaaatg tagtaattat 35161 atacatctta tcgaaagtga ttttctgcat aatcattatt atgatttata ttaatcatgg 35221 gcaggattgc atataaatca gtcattatgc tgagtctgca accttcctgt gtaaagtcaa 35281 actgtcaggg ggacggtgac gtcccgggcc agaatacacg tggtgcacct tctccctttc 35341 tgttcccttt ctctgttttc tccgatccca ttcatcctgg cattacccca attctcccaa 35401 aaacggcaaa ccagccctca gcccgcgcca cgactggctt aatacgggat ccctgctgca 35461 aaacatacct ttacgtattt ggttttaccc gcaataatgc gtgataagca aacaaaagga 35521 tccgcgcgct gcgatttatt gtcgtggaag gatccgggcg ttcaggtcag aatacctgta 35581 tccataaaca gtgcgtgtgc tacgtgaaaa ataactcatg aacaatgtca ttcccctgca 35641 gaattcacca gaacgcgttt ccctgttacc cattgcgccg ggggtggatt ttgcaacagc 35701 gctctccctt agaagaatgg ccacttccac gggggccaca ccggcctacc tgctggcccc 35761 ggaagtgagt gcccttctct tctatatgcc ggatcagcgt caccatatgc tgttcgccac 35821 cctctggaat accggaatgc gtattggcga agcccggatg ctgacgccgg aatcatttga 35881 cctggatgga gtaagaccgt ttgtgcggat cctgtccgaa aaagtgcgtg cgcgacgcgg 35941 acgcccgcca aaagatgaag tccgcctggt tccgctgacg gatataagct atgtcaggca 36001 gatggaaagc tggatgatca ccacccggcc ccgtcgtcgt gaaccattat gggccgtgac 36061 cgacgaaacc atgcgcaact ggctgaagca ggctgtcaga cgggccgaag ctgacggagt 36121 acacttttcg attccggtca caccacacac cttccggcac agctatatca tgcacatgct 36181 ctatcaccgc cagccccgga aagtcatcca ggcactggct ggtcacaggg atccacgttc 36241 gatggaggtt tataccagag tgtttgcact ggatatggct gccacgctgg cagtgccttt 36301 cacaggtgac ggtcgggatg ctgcggagat cctgcgtaca ctgcctcccc tgaagtgacg 36361 gcatacgcgc ttccttatat aagctgtggt cagcagaaca gacataacat aagctggagc 36421 aggtagataa gctgtagtga gtaaaccatg ttttatgaag ggagcaatgc ctcagcatca 36481 ggttacgggg tgactcacgt aagggacagg cagatggcag ctcagccaca ggcagcactg 36541 caggaaactg aatataaaca gcagtgagca gaccactcac tgcacctgat aatataagct 36601 gtagtcagta aaggagcact cttcactgac tacagtttat gttcagcggg atttgaagag 36661 tttttccagg tcatccagtg tgatgcccag tttttcaagc agggcaagtt tctccgccat 36721 ctccggactg actttttccg caggtgaagg tggcaacgga ttttccttac tctcatcatt 36781 cggcgctttt aaccggggac gccggtagtg aatacagaag aattttgtcc gcccccgctg 36841 gatctccgtg taatcaagat atccaatctc gcgcaactgc tccattgccc gtctgaccgt 36901 ctggttctgg gaaaatacag gagacttcag attgaggcgt gcacgcagcc gcgccagcga 36961 tatcggtgcc ggatcccggg gcaggctctc tataaaggtg tagagtgcct gggcggactc 37021 ccgtcgcttc agggcattaa tcgccttaag ctggagaagg acttttctgt caaactggta 37081 cagttcaaac agacggggat cagcctgtaa ctgaacaata tcccgctcag tatcgtagta 37141 ggctgactgt accagatggg tgatgtattc ccgggtgtgc ttctcatcgg tacgggaaaa 37201 cgagatcacg gtaccggcaa tgcgcttcag ggaagggctg atgcgctcac gcagcctgcg 37261 ggatgactgg cttgaaggta taccacacag ttttgcaaac tcaacaaaag gcagttcaac 37321 tttgtcacca atcacgttat ggcgggcaaa ggaatgaatg atccccaccc aggtcttgaa 37381 atcgttatcc atatccaggc gggggccggt gatctcaacc ttatcgaatc cctcagcacg 37441 ggccagggaa agacgagtca gctcttccgt ggcatcagta cgtgacagtg tatttttttt 37501 actgttcttc agtgatttaa gggtcggtac aaaaacgccc agacgcatca gcgccacagg 37561 ttgtacggtg ttgttattgt ttggtgtcag tgtcaccagc tcaccggacg acttatccac 37621 ctcgccgaac agttttttga tgtctgaatt ttcgttttcc agaaagcctt ctgcctgtgg 37681 acagtaaaag aataaacaga aaatcgtgtg tcagaacccc gtcaactgac tgaagaaaaa 37741 cctgcagtct gtatttaaca actgagtctg gcgtactgac catagtttat gtcattaact 37801 tacttcagta tatgcattac tgaatacagc ttatcatgaa cctgttacag tttatccata 37861 acatgccaca gcttatgtga acgtggtccc ggcccatgag tgacaaggtt tgtagcgata 37921 tggggatctt taatggatcc tttattgatc attcatggat ctatttactg gatcgggcct 37981 ctggatatgt ggataaatca ttccggaaaa acagcataca ctaccgatta tgaaggcttc 38041 agggcgtacc tgctcactgt gattacagat ccattgcgct tcctcgccgg ttcgcgggct 38101 tcgcccggtc accggtctgc ggcgagcacc gttttttctg aagtctgtct ttacaggtaa 38161 tttttgacgg aatctgccgt acttcctgag cgtacagtca tatccgaaat acacttcata 38221 tgtttgtttc aacgccagag gcgcatacag actggctcca tgaatatcct gatgacaggc 38281 actgctgcgc agacaccggt catggatgta acggaaatac cagctgaacc acaggtcttc 38341 cagtcgggga cactgagtac agggctggag cttgtggata cgtatctctg gatcttcaaa 38401 cactttatgg aaggaaaggt gttaaccaga tcccttgcct gcctggttta tatcaagccc 38461 tatagcgaca ggacggacag tgtcaccttc cagtcagtag ctaaacgatc taaggtgttc 38521 ctggacaaac tgcaggagcc aacgtctgaa atgataaata agcgagggaa tatctggtgc 38581 tggaagagtt gagatgactg gcacattggt ataaatcttg ccgtcattct gatcagtttg 38641 taacattctg taatgatcac cattggctgg cgatttttct gttcagtaat gtaattaacc 38701 ttatctgatg cgctggccac tattccatca gctgtactga tggcaggctc cctgttgagg 38761 tctgccgcga gctgtccgcc ggactcaacg ggctctgcca caatccggtt atgatagcct 38821 ggaaactgat caagggtcag gtcgatatag tccctggcag gggcggcaat gacgtggccg 38881 tatctgccag gaccattatc ccactgcata ccgacaatac aggagtacag gttgctgccg 38941 tcttccgtca gataatcagt cagcgtctgg ctggccagct cgctgcaacc ggccgggaaa 39001 tccttcaggt gatcataccc ggcggtgaga gaagcctcac aggaagtcag ctccagagca 39061 tgtcggaagg cctgcaggcg ggtccaggtg tccgcattca ctttttcacc ttcccgtcat 39121 gacgggccag ggactgaagt ttacggacgt cctcccggga tcctttcagc tcagctttcg 39181 tatccagcag ctgcgccgcc agcggtcttt ttcccgggag ccgactttcc tggcacatat 39241 tcttttcgca gttatcccca gaatctgtgg ataactgttg ctcctctttt gagagagaag 39301 gctttactca ccgcctgaat gcggcagata tgtctggacg atatatctgc atacgccggt 39361 actgcttcgt cagattgcac ggcaggtgaa ttgccgggct ggtaccatac catatttgcg 39421 ccgaacccgt ccggggcggt gccgataaca gatgttaaat gattggtcgt ttttacatct 39481 gtaaaagcaa cagggcccca tgattatatc atggggccct gttactctga ttcttcgcaa 39541 tagattgctc tgaattagat gcgccttctc cattagacta acagttctat attattttac 39601 catctttaaa tgtgtaagag ttttctgttt tttattggtg tttatctgta ttttttgttt 39661 taggaacgtt tttgtaagaa ttatctttta tatttgaggt gatatcttat tgtggttgtt 39721 gtaatagttt agagtcgtaa taaatatgat tgatcgccac tttaaatgaa gttaatctac 39781 tggagatgaa gtaacttcat taatgcgtca taaaaataaa aattcctgtt ttgggaaata 39841 tgaatgtgtc tgtcccctcc ttcgggaggg tgttttttat ctggaaactg gtttctggtt 39901 ctgatttttc tttttgtatt atagcgagtt acgcatattt accaatcgat gtctggcaaa 39961 cagagtatgg cgatggtgtg atttgtgttt attggtaaaa aaaacacccc cgtagtgggg 40021 gtgttgaaac ttcaacctat gtactcatta tccttggatg gatgagtagc gtgcgatatt 40081 gaatcatatt cagcaggaat aataatattc gcaaaaaaat ggatgtgcaa ggaaattttt 40141 tatatgcttt tgtgtgtggt ggttaggtaa tcaagaagat aaatgatgaa gtgtgccagt 40201 tcaggatcaa tgtttccatg ggaaagccat ttattaataa tatcaattaa gttcgaaagc 40261 tcagggaaga tttgttcaat gttttcctct gtctcccgca cagtcatata gcgacgtctc 40321 cttggggatt gaaaacaaaa acaataatac aacaagtatg aaacagaagg taggtggcag 40381 gggcggaaca ggaaaacgca tgagggcgct tcctggggga gatgcctggt atctttaggg 40441 ttcagttttg agatcgggaa tttttgtaca ttaagtgcat tatttaatca attgaaacgc 40501 gtaatggatt gattttatca gcaactatcg cgtttaagtt gtcgatcata tttgagttgt 40561 ctcattaagg tcgaatcccc tgaaagcggc gtataacgta ggagttcccc tctatagcaa 40621 taggtaaggc tgttcaaaaa aggcttaccg tacaataatt cgctatatcc agacggcccc 40681 ccttgtcata caagctcgta agcggccctg acggcctgtc aatgcggtac tgccctgtcg 40741 ggactgctct acccacataa gtttctacat agcttgaagc tggatgggga ggtattacgg 40801 ctttagccgt aatactttct tcgtcctcgc agcgctgaca gttttcaggg atcaaattta 40861 ggtccgccat acactccgta aagactctgt cagttcacag gtattaccta gtgaagacgt 40921 atcataaaat gaaaactgta gttgggtagt tgctccccct cacggcatgc aggggctgag 40981 ggggaaaatt tccttatctt gttgttgcta tttctggctt agtcagtttt gaattttgct 41041 tcctaagcaa taatcccctc accgcaacaa tcgttcttct acactaataa gatccgaaaa 41101 aaggtaaaac cggaacttaa tgaaattacg gagaatttga ctgatatcca ctaccccatt 41161 cttccggcgt gctatctata caggctggta catctcattt agtccggagg ttgttatggg 41221 cgtcaaaatc acaggtttag acaaaatgca gaaacagcta aaagaggttg agagagcaac 41281 ggaggcctta aacggaagtt atgatgttcg ttttgatgct aacgatccta gcagcattga 41341 gaacgcaatt caggaagcct actccatggt ggacgaacgc gcttctggtt atgccactaa 41401 tcctatggtc agtccattaa tcgaacacat gaaagaaaat ctgcgccaac agattctgga 41461 cagtgcagaa caacaaagac aggagagcgg acaggatggc gattgatatc tttcagtcac 41521 ttaaaaattg cgtattcgac cttcagcgcg ctgacgttca gaactatcag caacctctta 41581 agcaattggc ccggctcttg aactcagaga atctgcagtc agttaatgca catctgaccc 41641 gcaatgttga acttgatacc tttctggcca ggagtgaaga tactgaatcc agcatggctg 41701 gttccgctgt tctacagtgg cctgatgagc ccgctgatat tttgggcctg aagttgctgc 41761 tgatcgagaa aatggcagac gataacaatt tttcctttaa tttctgtcat acatttttct 41821 atgatcgaaa cattattgaa tccattcgaa aattcacgtc gtcattagtt gccccgttcg 41881 tgcgcgatta ccagttgtat gtggaaaacc aacatgatcc tgagcctgca gtgtttcggc 41941 cggtttcccg aaaaattttt attgttcatg gccatgataa tgatgccctt cagtctgttg 42001 cccgttttat atcccggata ggtcttgagg aaatcattct ttcagaacgt cctgacggct 42061 ccaggacgat tatcgagaaa tttgaagcag agtcagggga tgtcagtttt gccatcgtgc 42121 tgatgacgcc cgacgatagc ggcagtgctc tggcatctga aagcacacgt ctccgcgcac 42181 gccagaatgt cctgtatgag ctcggatatt tcgccgggaa gcttggacgc gggaaagtac 42241 ttgtactcag gaagggagat atcgaaatcc cttcagatct tgccggggtt ctctataccg 42301 agcttgatga gcatggtgga tggaaacgca aactgctgag tgagcttgcg tatgccggtg 42361 ttccttttga caaggataaa gcattaagcg cctgatctcc ttcatttagt aagaaaaagg 42421 ccgctaagcg gccttaattt ttggtcagtc gtcattttcc agcgctgttt tgagcgcttc 42481 ctgctccgga gtcagctcgt tgccggacag cataaccttc aacttctctt cgactgctgg 42541 ccagtcatca aagaacggac tgacctggtc acgcgcaatc cggcgatatg cccctcggtg 42601 ggagctgaag acactggtct gtaatcgtat caacaggtta acaaggcctt catcagtggt 42661 agtaacttct ctgacccatt gcttcacggt ttcacctgaa ctcatgtctc tccaggcgta 42721 gagatacccg agaagagact tgcgcaggag aagctgttgc tgaagttctg gttgattcat 42781 acgttccgca aacctgtcac gcaaccgttc cgtaatatcg cgactgaaaa gagcgtctga 42841 aggcgaaggt actgcattct gagcaagtcc atgttcccag ataagatccc gcataaaatc 42901 ggctatccag aacggcgaag cacccgtaac gatcagtttt tccataagcg tgatcgttct 42961 ggtctcatca atatcctgca tatgcttcag cagatgccgt acaacctcat taatggccat 43021 ttcacgcagg gaaaaccatg ggttacggat actgaagcga gtgctcacct catcggtgtg 43081 atcgaagaaa aaatgaacca gtcctgcgca ctcttcgaaa ttacgttctc ttatcaggcc 43141 tggagtcagt ctgctcagta tatgttcaaa ccaggttccg gacagactgc ccacactgtt 43201 gatttttgag agcagcaatt cagaaagctg ctgctgtttt tccgatacgc cagcctgttc 43261 aaaaagctgt ctgaagaatt caggtggcag aacattctgt ggtgaggaga aggcaaaata 43321 atatcgccag tgcgtcaggc tgctgagtcg tttaccggtc gtctggatat gacgaaaatc 43381 ctcactgacg ggctcaaaaa gattcagata ttcatcatta tgtccactga tacctgggat 43441 ccagtctgca agtgtcagaa acgagtctgc atttgatgcc ctgaacgtct tcatacatct 43501 gataagcccc tcccggaagt ctgctttctc tccgtcagaa agcataccct gaccggtttc 43561 aatcacggac cgttctgtca ggtaatgctc tgtccagtca tacagagccg ggtttgtcac 43621 ccgtataagc tgaagcaggc acaaatcagg gaaataaaca aaatcccgca tccccggata 43681 aagaaaaatc agggaattaa tggcctgatg gatttcccgt ggcgtcgaaa gtgcggcacc 43741 ataggtatca gtcaccgcga tgagatccct taccattcca gagtctggcg gttgattatt 43801 aatttgctga tatagagcct cagcccgctg gcgaaattca ttacgtaaat caaaggcttc 43861 aggtcggggt aatttaaaac taagctgaat gattttctgg agataacggc tgccatcttc 43921 gatattcagc gcatgttcaa cggcatgagt gataatctgc ctgtcataac agagaatatg 43981 ggtaaagcgg ggcagatcgg ctactgcacg cacaagcctg aacacttccg ccacctggga 44041 tggctccagt cggtccagat catccatgac aacaatgaac ttcagatcca gactcaccag 44101 ttgtcctgca atttcagccc gaagctttgt cgtggttttc tgatcaacag ccagacggct 44161 gtctgaaaat acctttattc cgcctgctat ccagttaata atgctggaaa actgtccgat 44221 atattgaacc agtggaagga cgcgcgatga agtatcctga gcatactcaa tcactttttg 44281 agcttccggt gacaacagat atttacgcca gagctttttg aagcccttcg ggggatagcg 44341 tatttccatt tcctgctgga taaccgtggc aaccggaaga aagagcgctt caaccggact 44401 gccgccactc agccagggag aaatatgcag cacatgtgtg tgagcatctt ttttcagggc 44461 aaggtttctc aggatcagat taaggaggct tgttttaccc gatccccatg caccttctat 44521 tccgacaaca tttgaagcct ccagaggaag agtaaggatg gaacgggata tattttctgc 44581 gatattaccg aaaccgtatc gatcctcagg tacatcttca actgccgcat caagcccttt 44641 ctggttccac agctgcctca gtatcttcat attacagatc tccgtacagg cagcgcagcc 44701 cggtcagggc ctccgccagc gggccttctt gacaccgcgt ggcgagctcc cggaccagcg 44761 tctcaaaggc ctccgccggc ataaaaatcc gcaggccgtc tatcccgaag aagccctccg 44821 gcgtgacgtt tccgggcggg gagaacatca ctcgctcccc ctggtgaccg tgcgtcaggg 44881 cttccggatg ccgggcatac agcgtgaaca ggcccagcag ttcggataac gcttcccagc 44941 cgtacggcac cacgaagtcc tggccggtga tcagcaggtg cagacggggt gtggtgtacc 45001 aggcccccgg gcgttctccg gggtgctggc cgtcaacgcg gatctccagg cgcagcgtgc 45061 cggcctcaat ggtttccgtg acggcagaaa taaccgggcg cagctcctgt gccagcgttc 45121 ttgcctgttc tgtgttccag tccaggccgc gcagcatcaa cgggaaaaca gctttcagcc 45181 gcggcagggt gaagatttct gccagcaccg cgtccggcac ctccgccagg ccaaaacagt 45241 cgctctcgag cggacgcagg aggtgttcgg catacatctg atccaccacg gggcgcagcg 45301 ctgcccggaa ggcttcaaac tcttccgtcc agtttttccc ggccaggcgg aaaatcccct 45361 tcaggtagtg accgtccaca gggcgatcgt gctccacctg ccaggccagc aggttgccag 45421 tgatgtccag cagcgtgtcc agggccggga gtgtggccag cctattatgc ccgcgcagga 45481 aggcctccct gacgtgaacc aggacaaagc gcagttcgtc gcgggagagc gctgacgtgc 45541 cgaaggtctg gcccagaatg atatgccggt acagctgccg gaccgtggcc tccggatcgg 45601 caatgagctg aaaatacccg tcaccgggcg cgaccgtttt caggccgtca tcgaggaagc 45661 gttcggctag ggcgttgacc gaagtatttt cccgaccggc acgcgttttc agcgcctcga 45721 taagtttttt gtgaaaacgc aggttaagct ggcttagcat catcgatcct ttaatgtttg 45781 ttttgttctt aatgctaacc tagcatttta ttattagcta ttaatcagtt ttttagtttt 45841 tgaaaattgt gatgcttcta aaattactaa aattgaggat tttaatgcta caacaatgcc 45901 tgcctcttct tatttctccg gagatccgaa aaccccaagt tacggatctt cctctccctc 45961 cgcacagcgt tacatcccgt cagcacagca tgtagtgcct catacagttg cccatggcac 46021 tatatgttgt gttgtatctc tggactgtga tgcgccgcgc aggggcggaa aacagcgata 46081 tgatgatttt ctcagcgttg tacacttccg gaaagtcgtt tattcaaata aagtcggatc 46141 catacgaaac gggaatgcgg taattacgct ttgtttttat aagtcagatt ttaattttta 46201 ttggttaaca taacgaaagg taaaatacat aaggcttact aaaagccaga taacagtatg 46261 cgtatttgcg cgctgatttt tgcggtataa gaatatatac tgatatgtat acccgaagta 46321 tgtcaaaaag aggtgtgcta tgaagcagcg tattacagtg acagttgaca gcgacagcta 46381 tcagttgctc aaggcatatg atgtcaatat ctccggtctg gtaagcacaa ccatgcagaa 46441 tgaagcccgt cgtctgcgtg ccgaacgctg gaaagcggaa aatcaggaag ggatggctga 46501 ggtcgcccgg tttattgaaa tgaacggctc ttttgctgac gagaacaggg actggtgaaa 46561 tgcagtttaa ggtttacacc tataaaagag agagccgtta tcgtctgttt gtggatgtac 46621 agagtgatat tattgacacg cccgggcgac ggatggtgat ccccctggcc agtgcacgtc 46681 tgctgtcaga taaagtctcc cgtgaacttt acccggtggt gcatatcggg gatgaaagct 46741 ggcgcatgat gaccaccgat atggccagtg tgccggtctc cgttatcggg gaagaagtgg 46801 ctgatctcag ccaccgcgaa aatgacatca aaaacgccat taacctgatg ttctggggaa 46861 tataaatgtc aggctccgtt atacacagcc agtctgcagt catggtaccg gcagtgtatt 46921 ctgccgggca gcctgcatcg ctgcctgttg ccattgatta tccggcagct ctggcacttc 46981 gccagatgtc gatggtccat gatgaactgc caaaatatct gctggctccg gaagtgagtg 47041 ccctgctcca ttacgtcccg gatctgcacc gcaagatgct gctggccaca ctgtggaaca 47101 ccggagcacg cattaatgaa gcactggcgc tgacgcgggg ggatttttcg cttgcgcctc 47161 cgtatccgtt tgtgcagctt gcgaccctga aacaacggac cgaaaaagct gccaggacgg 47221 cggggagaat gcccgccggt cagcagactc accggctggt tccgctctct gactcctggt 47281 acgtcagcca gctgcagacg atggtggcaa cactgaaaat acccatggag cggcgtaacc 47341 gtcgcacagg aaggacagag aaagcgcgga tctgggaagt gacggacaga acggtcagga 47401 cctggattgg ggaggcggtt gccgccgctg ctgctgacgg tgtgacgttc tctgttccgg 47461 tcacaccaca tacgttccgc cattcctatg cgatgcacat gctgtatgcc ggtataccgc 47521 tgaaagttct gcaaagcctg atgggacata agtccatcag ttcaacggaa gtctacacga 47581 aggtttttgc gctggatgtg gctgcccggc accgggtgca gtttgcgatg ccggagtctg 47641 atgcggttgc gatgctgaaa caattatcct gagaataaat gccttggcct ttatatggaa 47701 atgtggaact gagtggatat gctgtttttg tctgttaaac agagaagctg gctgttatcc 47761 actgagaagc gaacgaaaca gtcgggaaaa tctcccatta tcgtagagat ccgcattatt 47821 aatctcagga gcctgtgtag cgtttatagg aagtagtgtt ctgtcatgat gcctgcaagc 47881 ggtaacgaaa acgatttgaa tatgccttca ggaacaatag aaatcttcgt gcggtgttac 47941 gttgaagtgg agcggattat gtcagcaatg gacagaacaa cctaatgaac acagaaccat 48001 gatgtggtct gtccttttac agccagtagt gctcgccgca gtcgagcgac agggcgaagc 48061 cctcgagtga gcgaggaagc accagggaac agcacttata tattctgctt acacacgatg 48121 cctgaaaaaa cttcccttgg ggttatccac ttatccacgg ggatattttt ataattattt 48181 tttttatagt ttttagatct tcttttttag agcgccttgt aggcctttat ccatgctggt 48241 tctagagaag gtgttgtgac aaattgccct ttcagtgtga caaatcaccc tcaaatgaca 48301 gtcctgtctg tgacaaattg cccttaaccc tgtgacaaat tgccctcaga agaagctgtt 48361 ttttcacaaa gttatccctg cttattgact cttttttatt tagtgtgaca atctaaaaac 48421 ttgtcacact tcacatggat ctgtcatggc ggaaacagcg gttatcaatc acaagaaacg 48481 taaaaatagc ccgcgaatcg tccagtcaaa cgacctcact gaggcggcat atagtctctc 48541 ccgggatcaa aaacgtatgc tgtatctgtt cgttgaccag atcagaaaat ctgatggcac 48601 cctacaggaa catgacggta tctgcgagat ccatgttgct aaatatgctg aaatattcgg 48661 attgacctct gcggaagcca gtaaggatat acggcaggca ttgaagagtt tcgcggggaa 48721 ggaagtggtt ttttatcgcc ctgaagagga tgccggcgat gaaaaaggct atgaatcttt 48781 tccttggttt atcaaacgtg cgcacagtcc atccagaggg ctttacagtg tacatatcaa 48841 cccatatctc attcccttct ttatcgggtt acagaaccgg tttacgcagt ttcggcttag 48901 tgaaacaaaa gaaatcacca atccgtatgc catgcgttta tacgaatccc tgtgtcagta 48961 tcgtaagccg gatggctcag gcatcgtctc tctgaaaatc gactggatca tagagcgtta 49021 ccagctgcct caaagttacc agcgtatgcc tgacttccgc cgccgcttcc tgcaggtctg 49081 tgttaatgag atcaacagca gaactccaat gcgcctctca tacattgaga aaaagaaagg 49141 ccgccagacg actcatatcg tattttcctt ccgcgatatc acttccatga cgacaggata 49201 gtctgagggt tatctgtcac agatttgagg gtggttcgtc acatttgttc tgacctactg 49261 agggtaattt gtcacagttt tgctgtttcc ttcagcctgc atggattttc tcatactttt 49321 tgaactgtaa tttttaagga agccaaattt gagggcagtt tgtcacagtt gatttccttc 49381 tctttccctt cgtcatgtga cctgatatcg ggggttagtt cgtcatcatt gatgagggtt 49441 gattatcaca gtttattact ctgaattggc tatccgcgtg tgtacctcta cctggagttt 49501 ttcccacggt ggatatttct tcttgcgctg agcgtaagag ctatctgaca gaacagttct 49561 tctttgcttc ctcgccagtt cgctcgctat gctcggttac acggctgcgg cgagcgctag 49621 tgataataag tgactgaggt atgtgctctt cttatctcct tttgtagtgt tgctcttatt 49681 ttaaacaact ttgcggtttt ttgatgactt tgcgattttg ttgttgcttt gcagtaaatt 49741 gcaagattta ataaaaaaac gcaaagcaat gattaaagga tgttcagaat gaaactcatg 49801 gaaacactta accagtgcat aaacgctggt catgaaatga cgaaggctat cgccattgca 49861 cagtttaatg atgacagccc ggaagcgagg aaaataaccc ggcgctggag aataggtgaa 49921 gcagcggatt tagttggggt ttcttctcag gctatcagag atgccgagaa agcagggcga 49981 ctaccgcacc cggatatgga aattcgagga cgggttgagc aacgtgttgg ttatacaatt 50041 gaacaaatta atcatatgcg tgatgtgttt ggtacgcgat tgcgacgtgc tgaagacgta 50101 tttccaccgg tgatcggggt tgctgcccat aaaggtggcg tttacaaaac ctcagtttct 50161 gttcatcttg ctcaggatct ggctctgaag gggctacgtg ttttgctcgt ggaaggtaac 50221 gacccccagg gaacagcctc aatgtatcac ggatgggtac cagatcttca tattcatgca 50281 gaagacactc tcctgccttt ctatcttggg gaaaaggacg atgtcactta tgcaataaag 50341 cccacttgct ggccggggct tgacattatt ccttcctgtc tggctctgca ccgtattgaa 50401 actgagttaa tgggcaaatt tgatgaaggt aaactgccca ccgatccaca cctgatgctc 50461 cgactggcca ttgaaactgt tgctcatgac tatgatgtca tagttattga cagcgcgcct 50521 aacctgggta tcggcacgat taatgtcgta tgtgctgctg atgtgctgat tgttcccacg 50581 cctgctgagt tgtttgacta cacctccgca ctgcagtttt tcgatatgct tcgtgatctg 50641 ctcaagaacg ttgatcttaa agggttcgag cctgatgtac gtattttgct taccaaatac 50701 agcaatagta atggctctca gtccccgtgg atggaggagc aaattcggga tgcctgggga 50761 agcatggttc taaaaaatgt tgtacgtgaa acggatgaag ttggtaaagg tcagatccgg 50821 atgagaactg tttttgaaca ggccattgat caacgctctt caactggtgc ctggagaaat 50881 gctctttcta tttgggaacc tgtctgcaat gaaattttcg atcgtctgat taaaccacgc 50941 tgggagatta gataatgaag cgtgcgcctg ttattccaaa acatacgctc aatactcaac 51001 cggttgaaga tacttcgtta tcgacaccag ctgccccgat ggtggattcg ttaattgcgc 51061 gcgtaggagt aatggctcgc ggtaatgcca ttactttgcc tgtatgtggt cgggatgtga 51121 agtttactct tgaagtgctc cggggtgata gtgttgagaa gacctctcgg gtatggtcag 51181 gtaatgaacg tgaccaggag ctgcttactg aggacgcact ggatgatctc atcccttctt 51241 ttctactgac tggtcaacag acaccggcgt tcggtcgaag agtatctggt gtcatagaaa 51301 ttgccgatgg gagtcgccgt cgtaaagctg ctgcacttac cgaaagtgat tatcgtgttc 51361 tggttggcga gctggatgat gagcagatgg ctgcattatc cagattgggt aacgattatc 51421 gcccaacaag tgcttatgaa cgtggtcagc gttatgcaag ccgattgcag aatgaatttg 51481 ctggaaatat ttctgcgctg gctgatgcgg aaaatatttc acgtaagatt attacccgct 51541 gtatcaacac cgccaaattg cctaaatcag ttgttgctct tttttctcac cccggtgaac 51601 tatctgcccg gtcaggtgat gcacttcaaa aagcctttac agataaagag gaattactta 51661 agcagcaggc atctaacctt catgagcaga aaaaagctgg ggtgatattt gaagctgaag 51721 aagttatcac tcttttaact tctgtgctta aaacgtcatc tgcatcaaga actagtttaa 51781 gctcacgaca tcagtttgct cctggagcga cagtattgta taagggcgat aaaatggtgc 51841 ttaacctgga caggtctcgt gttccaactg agtgtataga gaaaattgag gccattctta 51901 aggaacttga aaagccagca ccctgatgcg accacgtttt agtctacgtt tatctgtctt 51961 tacttaatgt cctttgttac aggccagaaa gcataactgg cctgaatatt ctctctgggc 52021 ccactgttcc acttgtatcg tcggtctgat aatcagactg ggaccacggt cccactcgta 52081 tcgtcggtct gattattagt ctgggaccac ggtcccactc gtatcgtcgg tctgattatt 52141 agtctgggac cacggtccca ctcgtatcgt cggtctgata atcagactgg gaccacggtc 52201 ccactcgtat cgtcggtctg attattagtc tgggaccatg gtcccactcg tatcgtcggt 52261 ctgattatta gtctgggacc acggtcccac tcgtatcgtc ggtctgatta ttagtctggg 52321 accacggtcc cactcgtatc gtcggtctga ttattagtct gggaccacgg tcccactcgt 52381 atcgtcggtc tgattattag tctgggacca cgatcccact cgtgttgtcg gtctgattat 52441 cggtctggga ccacggtccc acttgtattg tcgatcagac tatcagcgtg agactacgat 52501 tccatcaatg cctgtcaagg gcaagtattg acatgtcgtc gtaacctgta gaacggagta 52561 acctcggtgt gcggttgtat gcctgctgtg gattgctgct gtgtcctgct tatccacaac 52621 attttgcgca cggttatgtg gacaaaatac ctggttaccc aggccgtgcc ggcacgttaa 52681 ccgggctgca tccgatgcaa gtgtgtcgct gtcgacggcc tcctcacccg gtcacgtttc 52741 gtcgtttctc ctccacgcgc tgcggcttcg gggccgcacc tgcattcgta tgcggtcgcc 52801 cggttacagg tgcggcacgg cctgatggag gccgcatgtg agaggagaat tcccatgcca 52861 aactggtgct cgaatcgtat gtatttttct ggtgaaccgg cacagatcgc tgagattaaa 52921 cgactggcca gcggtgcagt cacaccgctt tatcgccgcg ccacaaatga aggtattcag 52981 ctgtttctgg ccggaagtgc cggacttctg cagaccactg aagatgtgcg gtttgaacca 53041 tgccccggac tgacggctgc tgggcgtggc gttgtatcgc cggagaatat cgcgttcacc 53101 cgctggctga cacacctgca ggacggtgta cttctggatg agcaaaactg cctgatgctg 53161 catgaactct ggctgcagag cggtactggc cggcgtcgct gggaagaatt accggatgat 53221 gccagggaaa gcattaccgc tcttttcacc ccaaaaagag gtgactggtg cgacatctgg 53281 agtaacgagg atgtatcggt gtggtggaac cgtctgtgtg acaacgtcct gccggaaaaa 53341 ccatgccgtt tgacctgctg acggttctgt tcactcgcct ggatgttgaa gtgaatggct 53401 ttaacggtgg tgttctgaac ggtgttcctt ctgcatatca ctggtatacg gaacagtatg 53461 gcgtgaaggg gccttgtggg tatgaggtga atatcagcag tcagggagac aacttcattc 53521 aggttgattt cgacacgccg tggtgtcagc cggaaagcga cgttattgca gtattaagcc 53581 gccgtttcag ttgcacgctg gagcactggt acgccgagca gggctgcaat ttctgtggct 53641 ggcagcgata tgagcgtgga gagcttgttg atgtgctgtg gggggaactg gaatggtctt 53701 ccccgacaga tgatgatgag ctgccggaag tcaccgcgcc ggagtggata gtcgacaagg 53761 tggcgcatta cggtggatga agtatgacgg agactggcgg gcaaccgccc gtttcttttc 53821 cggtaaagga tgtcgccggg ctcctctttt tactgcgccg gctgacgcgg cgcggcagga 53881 acgctgcctg tggtcagtgt cccgcgtccg gctgggcacg ggacgggcgc ttttaccgct 53941 cccggctggc atcggtgaca gtgtacgcca gcccgtcgcc cttttctgat gaacgccctt 54001 caagccgctt tcgcggcata ttctcgccgt caaaaagacg acggctgcga tattccacgg 54061 tcggcctgac ccgttaccgg acgcggtgaa cagcccacag gccgcgggga acgggcgcca 54121 caggggcgcc ctcccggtgc cctctgtaag agaaggagtg ctgttatgtc ccgttttatc 54181 cagggtgact gcgtgcgtgt tatggccacg tttccgggca atgctgtcga tttcatcctc 54241 accgacccgc catatctcgt cggtttccgt gaccgtcagg ggcgtaccat cgccggcgat 54301 aaaaccgatg aatggctgca accggcctgt aatgaaatgt accgcgtgct gaaaaaagat 54361 gcgctgatgg tgagcttcta tggctggaac cgcgtcgatc gctttatggc cgcctggaaa 54421 aatgcgggat tcagcgtggt tggccacctg gtgtttacca aaacctacac atcgaaggcc 54481 gcatatgtgg gctatcgcca cgaatgcgct tacatcctgg caaaagggcg tccggcgctg 54541 cctcagaagc cattgcccga cgtgctgggc tggaaatatt caggcaatcg tcatcacccg 54601 acggaaaagc ctgttaccag cctgcaacca ctgattgaga gcttcacaca cccgaacgcg 54661 attgtgctgg acccgtttgc aggcagcggc tcaacctgtg tggccgccct tcagtccgga 54721 cgccggtata tcggtatcga gctgcttgaa cagtatcacc gtgccggaca gcaacgtctg 54781 gctgccgtac agcgggccat gcagcagggg gctgcaaatg atgactggtt tatgccggag 54841 gctgcgtaaa tgaactatgc cggacataaa aaacttcgcg ccgacgtggc ggaggtggcc 54901 aacaccatgt gtgaccttcg ggccaggctg aacgatatgg agcatcgctg tcgctttgat 54961 tccgatgtgc ttgttgaacg cctggcacgc cagacgctgt atcgcgccaa tcgcctgttc 55021 atggaggcgt ataccgaaat tctggaactg gatgcgtgct ttaaagattg agaaggagac 55081 gagaatgtac ggaacatgcg aaacgctatg ccgggagctg gcagcaaagt atccgggata 55141 tacaccgctg atgctggtta tctggtcccc ggaagagatt caggccctcg ctgacggaat 55201 ggatatttcc ctgtccgatc ctgaaatcag gaccgtcctg gcgcgcctgg aggacatccc 55261 ggaagaccag cgaattgagt ccggtatttc ttctgccgcg gcgatggaga ttatcagcaa 55321 cgtgagcgaa aaccgccagg tgaccgtccc ggctgaactg ctggcgtccc tgattcagac 55381 cgccgaacag gcactgtgga aacgtgaatg ggccgcccgt gattacggcc tcgccgtccc 55441 ggaatgcgtt acccgccgtc aggcggtggt taatcaggcc cgcatcctgc tgaaaaacaa 55501 cacacacgaa aacggctgat gttatcgccg cctgcgggcg gcgatacagg gagaacgatt 55561 aatcatgaac gaaaacacaa cgctgaacgc actgatttgt cgtcacgccc gtaacctgct 55621 gctggcgcag ggctggccgg aagagacgga tgtcgaccag cgtaacccga agtatccggg 55681 ctggatcagc atttatgttc tgctggatgc gccccggctg gcgacgttac tcgttaaccg 55741 ccacggcggc gtactgccgc cgcacctggc ctccgccatt cagaaactga ccggaaccgg 55801 agcggaactt gttctgtccg gcagtcagtg gcagtcgctg ccggtgcttc cggcagacgg 55861 aacgcaggtg tcttttccgt atgccggtga atggctgacc gaagacgaaa tcagggctgt 55921 acttgcggcg gtgcgcgatg cggtacgcag tgtcagttgc cgggtggcag aagatatgcg 55981 gcgtatccgg gcggcgctga ccaccaccgg tcagacgtta ctgacccgcc agactcgccg 56041 ctttcgcctg gtcgtgaagg aaagcgatca cccctgctgg ctcgatgagg acgacgaaaa 56101 cctgcccgtg gtgctcgatg ccatcctgaa ccggggcgca cgtttttcgg cggtggaaat 56161 gtatctggtc agcgattgta ttgaacatat cctgtctagt gggctggcct gcgatgtgct 56221 gcgtataccg gatgaaccgc cccgccagtg gtttgaccgt ggtgttctgc gggaagttgt 56281 ccgggaagcc cgggccgaaa tccgcagcat ggcggatgcc ctggcaaaaa tcaggggctg 56341 atgatggcgg ggaaaatccc cgcttttttt ctgccggtcc ccggacagag cacaaaggaa 56401 gtcgccgccg gctccgcttt acccggccat gcaggcatgg ccttgtgggt tttcagttat 56461 gtggccgccg tgtcgtgtgc gggcggtgcc gtgcctccat cttagccggg ctggcgggga 56521 tgcaagggta cgcttcgccg ctgcggtcac ccggtccctc cttcccgtct gccgtgattt 56581 tccggtcgtt cacccgctca ggtttcgcgg tctcaccctc caactcccgt cagccgtgtg 56641 cgtcaggctg cggcttccct tgcgccctgt gcatccccgc cttatcgccc ggcttttatg 56701 gaggcacggc accgcccggt gtcgcggaat atgtgaataa cggaggaaaa catcatgcaa 56761 tatgcgaaac ctgtcactct gaacgttgaa gagtgcgacc gtctctcctt tctgccttac 56821 ctgtttggca acgattttct gtatgccgag gcgtatgtgt acgcgctggc gcaaaaaatg 56881 atgccggaat atcagggagg cttctggcac ttcatccgcc tgccggacgg tggcggttac 56941 atgatgccgg atggcgaccg ttttcatctg gtcaacggtg aaaactggtt tgaccgcacg 57001 gtcagcgccg atgccgcagg catcattctg acttcccttg tgattaaccg ccagttgtgg 57061 ctgtaccacg acagcgggga tgtaggactg acccagcttt accggatgcg cgatgcgcag 57121 ttgtggcgtc acatcgaatt tcaccccgaa tgcaacgcga tttacgcggc actggactga 57181 ttaacggacg gggcggcaat gccgcccctg taaaggagac gagaacatgt actgtactgt 57241 taaagaaatc atccgcgatg tactggatac agacgtgccg gacagtgaat gcgtttttgc 57301 cgtggtgctg acccgtgggg atgtgcgcca catagcccag gactggaacc tgtcagacga 57361 tgagctggaa accgtcatgc agcggctgga cgatgccttt gaatatggtg cggatgtcag 57421 cattgttcac gacgttgttc gtgagctgat ggaagaaaag cgtgccagcc gtcaggtgac 57481 agttccggcg gtgatgctgg aaaaagtgat ggcgctggca ggcagtgaaa tgaagcgcct 57541 gtatgccgtc gggagtgaga acgggggcga cggtgatgcg ttcgtcaggg aggaacgcga 57601 agcaatggac gttgtgttac aggcgctgga cggggagcac atgtcatgaa tatcagcaca 57661 gaaacccgcg aaattctgcg caattacaaa gccgtgatta atgcgcgacg tcgtgaaatg 57721 gggcagaaac cgctcaccac cgcgcagatt gttgatgaaa tctgcgattt tgtggcgaat 57781 cagcaggctg ttttcctggg cggtcactac atcttacagg gcagcagaaa caggtgatac 57841 agggcaggcg gtggaggccg cctgtcagcc cgcgcgaaaa cccctggcag gctgacgcct 57901 gccggaaggg aagcgggcca cgctgacgcg tcgcccgtta cccttcctgt ttgtgatgtg 57961 tccggaatgt ttttttctga tgttattttt ctgtggttac cgtgcctgtt actgttcttc 58021 ttctttttcc tcttcctctt cttcctcttc ttcctcttct ttccgttcct ctcctgctta 58081 tggcttttcc gggcgtcccc ctggtggggc gggctgtcgt gaacggagcc agcgaagctg 58141 tctccgccct ggcgggcttc catccctgac gcgaaaccct ggcttgcagc gaccgttccg 58201 gtcgcgccgc ctctgtcgcg ccgtggcctg cgctcccggc atcccggcaa aaggccgccg 58261 ggatgtaagg ggcaacgccg tttcgcaaac cgcgcttcac gtcgttgcgg cgggtccctg 58321 ctcattgcct gccgggtgcc acacacccgt atgagtccct gtcgccgggg ctgatacagc 58381 cacaacctgc cgcactgact gtccagggta aatgaacagc ccacaaaatt ttttacccaa 58441 aacccggtaa aaaattttgc gttctgccca ggacaggtgt gtcaggccgt ggcagtgatg 58501 ccccttgcgg cgaaggttct caaaaaggtg atggtgaata ccggagggaa caaaaggcag 58561 gtccccgcaa aacgtcaaaa ccgcggctcc cgaaactcaa aagatgatgg gggctgaaaa 58621 catcaacaga aggagacaca tcatggcagt tcgtggcatt aacaaggtca tcctcgtagg 58681 acgcctggga aaggatccgg aagtccgtta catccccaac gggggcgcag tggcaaacct 58741 gcaggtggcc acgtcagaaa gctggcgtga caaacagacg ggggagatgc gggagcagac 58801 agaatggcat cgcgtggtgc tgttcggcaa gctcgcggaa gtggcaggtg aatgtctgcg 58861 caagggcgcg caggtctaca tcgaaggtca gcttcgcacc cgtagctggg aggataacgg 58921 tatcacccgt tacgtcaccg aaattcttgt taagaccacg ggcaccatgc agatgctggt 58981 acgtgccgca ggtgctcaga ctcagccgga agaggggcaa cagttcagcg gtcagcctca 59041 gccggaacca caggcggagg ccggtacgaa aaaaggtggc gcaaaaacga aaggccgtgg 59101 acgtaaggcc gcgcagccgg agcctcagcc gcaaccgccg gagggtgacg attacgggtt 59161 ttcagacgat atcccgttct gaacgactga ctgtgacaac cgccccgtcc tgtgcggggc 59221 atcaccggag agatgaggat gagcgaatat ttcagaatac ttcagggact gcctgacggt 59281 ccttttaccc gcaaacatgc cgaagccgtt gccgcacagt accggaacgt ctttatcgag 59341 gatgaccacg gcgaacagtt tcgcctggtt gtccgtaata acggtgcaat ggtctggcgt 59401 acctggaatt ttgaggacgg tgccgggtac tggatgaacc atgtcatccg tgatttcggg 59461 attcttaagt aagagaggtg ccggacggga acgcgtccgg cagacaatca ttattaccgt 59521 tttgggaggt actaactatg tcagttacag agtctaaggc aaaaacggag cgtaaatcca 59581 gccgtaaacc tgcaaaaacg caggaaacag tcctgtcggc cctgctggcg cagacggagg 59641 aagtgagcgt gccgctggcc tcgctgatta agtctccgct gaatgtgcgc acggtgccgt 59701 attctgcgga gtccgtcagc gaactggcgg actccattaa aggtgtcggc ctgttacaga 59761 atctggttgt tcatgccctg ccaggtgacc gttacggtgt cgccgcaggt ggtcgccgac 59821 tggcagcact caacatgctg gcagagcgtg acatcattca ggttgactgg cctgtccgtg 59881 tgaaggtcat tccgcaggag ctggcgactg ccgcatcgat gaccgagaac ggtcatcgtc 59941 gggatatgca ccctgccgaa cagattgccg gattccgtgc aatggcgcag gaaggcaaaa 60001 cacctgcaca aatcggtgat ttgctgggtt attcgccccg ccacgttcag cgaatgctga 60061 aactggcaga ccttgcgcct gtcatcctcg atgcgctggc agaagaccgc atcaccaccg 60121 agcactgtca ggcgctggcg ctggagaacg acaccgcgcg tcaggtgcag gtgtttgaag 60181 cggcctgcca gtcaggatgg ggcggtaaac cggatgtgcg ggttatccgc aatctgatta 60241 cggaaagtga agtggcggtg aaggacaaca ctaaattccg cttcgtgggg gctgatgctt 60301 tctcacctga cgaactgcgt actgatttgt tcagcgatga cgagggtggc tatgtggact 60361 gcgtggcgct cgatgccgcc ctgctggaaa aactccaggc tgtcgctgaa caccttcggg 60421 aagccgaagg ctgggaatgg tgcgccggac gcatggagcc tgtcggtgag tgccgtgaag 60481 attcccgggc ataccgcaac ctgccggagc cggaagcggt gctgacggag gcagaagaag 60541 aacgcctgaa cgaactgatg atgcgttacg acgcgctgga aaaccagtgt gaggaatctg 60601 acctgctggc agcagaaatg aagctgattg actgcatggc gaaggtcagg gcgtggacgc 60661 cggagatgcg tgccggaagt ggcgtggtgg tgtcctggcg ttacggtaat gtgtgtgtcc 60721 agcgtggtgt gcagttgcgc agtgaagatg acgtgactga cgacgctgac cgcacggaac 60781 aggtgcagga aaaagcgtca gtggaggaaa tcagtctgcc actactgacg aaaatgtcct 60841 cagagcgcac gctggcagtc caggcagcgc tgatgcaaca gccggacaaa tctctggcac 60901 tgctgacatg gacgctctgc ctgaatgtgt ttggcagcgg ggcgtacagt aaaccagcac 60961 aaatcagcct ggaatgtaaa cattattcgc tgaccagcga tgcgccgtca gggaaggaag 61021 gtgccgcatt catggcgctg atggcagaaa aagcacgttt ggtcgtcctg ttgccggagg 61081 gatggtcacg ggacatgacg acgttcctgt cactcagcca ggaggtgctg ttatccctgc 61141 tcagtttctg cactgcgtgc agcatccacg gcgttcagac ccgcgagtgt ggtcacacgt 61201 cacgcagtcc gcttgacccg ctggaaaccg ctatcggatt ccacatgcgc gactggtggc 61261 agccgacaaa agcaaacttc ttcggacacc tgaaaaagcc gcagattatc gcagccctga 61321 atgaggccgg actgtccggt gctgcacggg acgcggagaa gatgaagaaa ggcgatgcgg 61381 ctgaacatgc agagttccac atgaaagaca accgctgggt gcctggctgg atgtgtgcac 61441 cacgcccaca gacggatgcc actgaacgta ccgataacct ggctgatgcc gcctgatgaa 61501 caaccacacc gccccgccgg agacggggcg gcagcaaggg agataccgtg atgaaaactg 61561 aactgaccct gaatgtatta cagaccatga acgcacagga atatgaagat atccgggctg 61621 ccggaagtga tgaacgccgt gagctgactc acgccgtgat gcgggagctg gatgcgccgg 61681 ataactggac gatgaacggc gagtacggca gcgagtttgg cggctttttc cccgtccagg 61741 tccgtttcac gcctgcccac gaacgttttc acctggcgtt atgttcaccg ggcgatgtct 61801 ctcaggtctg ggtgctggtt ctggtgaatg ccggtggtga gccgtttgcg gtggttcagg 61861 tacagcggcg gtttgcatcg gaagccgtca gccattcact ggcactggcg gcgtcactgg 61921 atacgcaggg gtacagcgtt aacgacatca tccatatctc gatggcggaa ggaggtcagg 61981 tatgagcgta cgttcacagg cactggttcc cctcagcaca gagcaacagg ccgcatggcg 62041 ggcggtggcg gagacagaaa aacgccgcca tcagggtaac acgctggcgg aatatccgta 62101 tgcgggggcg tttttccgct gtctgaacgg aagccgcagg atatcgctgt ctgacctgcg 62161 atttttcatg ccgtccctga ccgcagaaga actgcacggc aaccgtcttc agtggctgta 62221 tgccatcgat gtgctgattg aaacacaggg cgaggtctgc ctccttcccc ttcccggtga 62281 tgcagcagag cggttgtttc cgtcggtgcg gtttcgtgtc agggagcgca gtcgccataa 62341 atccgcgctg gtcatgcaga agtacagccg ccagcaggca cgggaggcag agcagaaagc 62401 ccgtgcgtac caggcgctgg tcgctcaggc tgaaatcgaa ctggcattcc attcgccgga 62461 aacagtcgga agctggcatg cacgctggag tgaccgggtg gcagagcatg acctggaaac 62521 cctgttctgg cagtggggcg agcgttttcc gtcactggcc ggaatggaac gctggcagtg 62581 gcaggatatg ccgttctggc aggttattgc ggaagccagt cttgcagcaa gagaggccgg 62641 tcacgctgtc cgtgagatgg agcggtggat ggtgccgaac aaactccggg aggcagcgtg 62701 atgcggcaac aatcacacag attacccgta aacagcctga atgagcgggt tattttcagg 62761 aaaagtgagt gtggtcagcg tgcagggata tgggctatga tgtgcccggc gcttgaggct 62821 ttctgcctca tgacgtgaag gtggtttgtt gccgtgttgt gtggcagaag gacaaaagcc 62881 ccgtagttaa tttttcatta acccacgagg cccctgcatg cttagacaac atcaggatag 62941 cctcttactg cgctttgcgc aaggagaaga aggccatgaa actaccacgc agctctcttg 63001 tctggtgtgt gttgatcgtg tgtctcacac tgttgatatt cacttatctg acacgaaaat 63061 cgctgtgcga gattcgttac agagacggat acagggaggt ggcggctttc atggcttacg 63121 aatccggtaa gtagcaacct ggaggcgggc gcaggcccgc cttttcaggg ctgatgctgg 63181 tctgactgca ctgaagcgcc tttataaagg ggctgctggt tcgccggtgg cccctttctc 63241 cttgctggca ttgtacgggc atgaacaacc agactgccag gaaggccgtt tccctctggg 63301 aacggggaag aacgtgcgcc tgcggcgccc gttcttttcc cccgccttct ctgtttatga 63361 cctgtcagaa atcacatcac cttccctttg attattctct ttttcctcct gttctgactc 63421 tgattactgc tgccctgatt cctgtctgtt ttgttgttct cctggcagtg tcttttccgg 63481 gcgtcccccc tggcggggcg gctgtcgtga acggagccag cgaagttgtc tccgccctgg 63541 cgggcttcca tccctgacgc gaaaccccgg gcttgcagcg accgttccgg tcgcgccgcc 63601 tctgtcgcgc cgtggcctgc gctcccggca tcccggcaaa aggccaccgg gatgcaaggg 63661 gcaacgccgt ttcgcaaacc gcgcttcacg tcgttgcggc gggtgcctgc ccgttgttgt 63721 gtccggtgcc attcacctgt ttaagcccct gtcaccgggg gcaaagacag ccacaaccgt 63781 ctccgccagt ccaggggtga aatgcacatc ccgcaaaact ttttgcccaa aagcaggcaa 63841 agattttgcg gtctgccccc ggacagtcgt ttccggccgt ggcagtgatg ccccttgcgg 63901 cgaaggttct caaaaaggtg atggtgaata ccggagggaa caaaaggcag gtccccgcaa 63961 aacgtcaaaa ccgcggctcc cgaaactcaa aagatgatgg gggctgaaaa ccagagagag 64021 gagaaagcag gatgagtacc cgaaatatcc acgttaacac cgcgtcgtac acgcttcttg 64081 ttgccgggaa gaaaaaaaac accggggaag agtgggacgt cctggaattc agcagcctga 64141 ctgagctgaa aaaatatcgc aaaagccacc cggaaaagat ggccttcagc tatagctacg 64201 cgctcagccg gggtgtggat acgcagttcc gccatatcaa cattgcggaa gccgatcact 64261 tcaaacagtt cctgcgtcag attaagcgtg ccggcctcga tatccgggcg atctgctgac 64321 cggatgtgat gaatatccct cctgattgtt gcaatcttgt taattgtgac caggggggat 64381 gatattaagc ggaaaaattt tttattaaat ttattctttc ataaaggagt agctgttatg 64441 cgattagctt cccgttttgg tcggtataat tccatccacc gtgaacgtcc tttaacggat 64501 gatgaattaa tgcagttcgt gccttcggta ttttccggtg ataaacatga gtcccggagt 64561 gaacgttata cgtatattcc aacaatcaat atcatcaata agttacgtga tgaaggtttc 64621 cagccattct ttgcctgtca gagtcgggtt cgtgatttgg gacgtcgcga atacagtaaa 64681 catatgttac gtcttcgcag ggaagggcat attaacgggc aggaagttcc tgaaattatc 64741 ctgcttaatt cacatgatgg ttcatccagt tatcagatga tccccggaat ttttcgtttt 64801 gtctgcacaa atggcctggt gtgcggaaat aattttggcg aaatccgcgt tccacataaa 64861 ggtgatattg tcgggcaggt tatagagggc gcgtatgaag tgctcggtgt ctttgataag 64921 gtcactgata atatggaggc gatgaaagaa attcatctta acagtgacga gcaacattta 64981 tttggcagag ctgcactgat ggtcaggtat gaagatgaaa ataaaacgcc agtgacgcct 65041 gaacaaataa ttactccccg tcgttgggag gataaacaga acgatctctg gacaacctgg 65101 cagcgggttc aggagaatat gataaaaggt ggattatcgg ggcgaagtgc ctccgggaaa 65161 aataccagga caagagccat tacaggtatt gatggtgata taagaatcaa caaggcgttg 65221 tgggtgattg ccgaacagtt cagaaagtgg aagtcatgat aatataagta aagccccgaa 65281 aaaatttcgg ggctttactt atattatcat tcttcggcat cgctgtgtcg tctgatatac 65341 ctcaatttca tcaactggct tttcggttgt ctgtaaatat tgtgcccgcg aaaaatggtc 65401 tggcaggagg ctgcgcagtt accgggtata tataagatgg gttacttgct tcgcggggct 65461 tcggccagtc agtattgtca ctcatatgat atttttgtgt gtggccttcc atgccgcttt 65521 tgcggcataa ccggtatctg acaatgcctg taagattaat tgttctgcac gctgttaatt 65581 tccggaagtg atttcttcgt ggccggaatc cggatacctt tactgctttt tatcccggta 65641 taaatccggt aaacatctga tgcgtaggca agacgtctct ggttctggcg ttcggtcttc 65701 ctgaatccag cattgtatgc accaacggcc tcccaggaga cgccccattt tttaaaggct 65761 attgccagat aataagcacc ggtataaatg ttcatgcagg gatctgttgt cagatgttcc 65821 ggcttaattc catagcgggc cagttcgtta aaatgctggg aatctacctg catcagtccg 65881 ctgccatatc ccgttaccgg attaataccg atggcattaa cccggtaacg ggattctttc 65941 catgatattg ctctcagtaa atcaggatct attttgtaat cccggcctgc aagatcaaag 66001 caatcagtgg catggcagat ctcatttata aacatcaggc agatggctaa catccatttt 66061 ttcatttttc cacctctggt gactttatcc gtaaataatt taacccactc cacaaaaagg 66121 ctcaacaggt tggtggttct caccaccaaa agcaccacac cccacgcaaa aacaagtttt 66181 tgctgatttt tctttataaa tagagtgtta tgaaaaatta gtttctctta ctctctttat 66241 gatatttaaa aaagcggtgt cggcgcggct acaacaacgc gccgacaccg ttttgtaggg 66301 gtggtactga ctatttttat aaaaaacatt attttatatt aggggtgctg ctagcggcgc 66361 ggtgtgtttt tttataggat accgctaggg gcgctgctag cggtgcgtcc ctgtttgcat 66421 tatgaatttt agtgtttcga aattaacttt attttatgtt caaaaaaggt aatctctaat 66481 ggctaaggtg aacctgtata tcagcaatga tgcctatgaa aaaataaatg cgattattga 66541 gaagcgtcga caggaagggg caagggaaaa agatgtcagt ttttcagcaa cagcttcaat 66601 gcttcttgaa ctggggcttc gtgtacatga ggctcagatg gagcgtaaag agtctgcatt 66661 taatcagact gagtttaata aattgcttct tgaatgcgtt gtaaaaacac aatcatcagt 66721 agcgaaaatt ttgggtattg agtctctcag tcctcatgtc tccggaaatt caaagtttga 66781 atatgccaat atggttgaag atatcaggga gaaggtatca tctgagatgg aacgattttt 66841 tccaaaaaat gatgatgaat aaacgaaatt tgacttcgtt caaatatcag agtttttatg 66901 atttaaaaag gtgacagtac gaaagataat tagtatatta attacgtggt taatgccacg 66961 ttaaaatttg aaattgaaaa tcgccgatgc agggagacgt gaactccctg catcgactgt 67021 ccatagaatc ctttgtgagg aggttcctat gtatccgatg gatcgtattc aacaaaaaca 67081 tgctcgtcaa atagatctgc tggaaaatct gacggcagtt attcaggatt atccaaatcc 67141 agcctgtatc agggacgaaa ctggaaaatt tattttttgc aatacgctgt ttcatgagtc 67201 atttcttaca caagatcaaa gtgctgaaaa atggcttctg tcgcagagag atttttgtga 67261 attgatctct gtcacagaga tggaagcata taggaatgag catacgcatc ttaatcttgt 67321 agaggatgtt tttattcaga atagattctg gacaatatct gtccagtcat ttcttaatgg 67381 acacagaaat attattctgt ggcaatttta tgatgctgct catgttcgtc ataaagacag 67441 ttataatcaa aaaacgattg tcagtgatga tatcagaaat ataatcagaa gaatgagtga 67501 tgattcttct gtatcatcat atgtaaatga tgtcttttac ttatatagca ccggaatcag 67561 tcataatgct atagcaagaa tattaaatat atccatctcc acatcaaaga aacacgcatc 67621 tctgatatgc gactacttct ctgtttctaa taaagatgag ttaattatct tactctacaa 67681 taaaaagttt atttattatt tatacgagaa ggctatgtgt atcataaata cgcgttaata 67741 aggtgttaat aaaatataga ctttccgtct atttaccttt tctgattatt ctgcaaacat 67801 aagtggtaac cagaagataa acagcgggag gtgttattga aaagatttgg tacacgttct 67861 gcaacaggta agatggtaaa actaaaatta cctgtagatg tggaaagtct attaattgag 67921 gcaagtaaca gaagcggaag aagtcgatcg tttgaggcag taataagact taaagatcat 67981 cttcaccgct atccaaagtt taacagggca gggaatatct atggtaagtc gctggttaag 68041 tatctgacaa tgcgtctgga tgatgaaact aaccagctac ttattgcagc caaaaatcgt 68101 agtggatggt gtaaaacaga tgaggctgca gacagagtta ttgatcattt gatcaagttt 68161 cctgattttt ataactcgga gatattcagg gaggcagata aagaggaaga tataacattt 68221 aatacactct agttttattc atttatccga aattgaggta acttatgaat gctgttttaa 68281 gtgttcaggg tgcttctgcg cccgtcaaaa agaagtcgtt tttttccaaa ttcactcgtc 68341 tgaatatgct tcgcctggct cgcgcagtga tcccggctgc tgttctgatg atgttcttcc 68401 cgcagctggc gatggccgcc ggcagcagtg gtcaggacct gatggcaagc ggtaacacca 68461 cggttaaggc gaccttcggt aaggactcca gtgttgttaa atgggttgtt ctggctgaag 68521 ttctggtcgg tgctgtcatg tacatgatga ccaaaaacgt caagttcctg gccggttttg 68581 ccatcatctc tgtatttatt gctgtgggta tggccgtcgt tggcctctga caggaaataa 68641 aacgatgtcg ggagacgaga ataaacttaa gaaatatcgt ttcccggaaa cactgaccaa 68701 ccagagccgc tggtttggcc tgccactgga tgaactgatc cccgcagcaa tctgtattgg 68761 ctggggtatc acaacatcga aatatctgtt cggtattggt gcagcggttc tggtttattt 68821 cgggattaaa aaactgaaaa aagggcgggg cagttcctgg ttacgtgacc tgatttactg 68881 gtatatgcca acagccctgc tgcgcggtat ttttcataat gttcccgatt cgtgtttccg 68941 gcagtggatt aaatagaact gataccagga ttgttatatg gaacacggtg cccgtttaag 69001 taccagtcgt gtaatggcca tcgcctttat atttatgtca gtgcttattg ttctcagcct 69061 ctctgttaac gtcattcagg gggtgaataa ctaccgtctt cagaatgagc aacgcactgc 69121 cgtgacgcca atggcattta atgccccctt tgccgtgtca cagaacagtg ccgacgcctc 69181 ttatttacag cagatggcgc tgtcatttat tgccctccgt ctgaatgttt catcagaaac 69241 cgtcgatgcc tcacatcagg cgcttctgca atatatccgc ccgggcgcac agaaccagat 69301 gaaagttatt ctggctgaag aagcgaagcg tattaaaaac gataacgtga actcagcctt 69361 tttccagacc agtgttcgtg tctggcctca gtatggccgt gtggaaattc gaggtgtgct 69421 taaaacctgg attggtgatt caaaaccttt cactgatatc aaacattaca tccttattct 69481 gaagcgggaa aacggggtga cctggctgga taatttcggg gaaacagacg atgagaaaaa 69541 ataatacggc aataatattc ggcagcctgt ttttttcctg cagcgtgatg gccgcaaacg 69601 gtacgctggc ccccaccgtg gtgccaatgg tgaacggtgg tcaggccagt attgccatca 69661 gcaataccag cccgaatctg tttaccgttc ccggtgaccg gattatcgcc gtgaacagtc 69721 tggatggtgc cctgaccaat aatgagcaga ccgcctccgg cggtgtggtg gttgccaccg 69781 tcaacaaaaa gccctttacg ttcattctgg aaacagaacg tggtctgaat ctttccattc 69841 aggccgttcc ccgtgaaggc gcggggcgta ccattcagct ggtcagtgac ctgcgcggaa 69901 ccggagaaga agccggtgcg tgggaaacgt ccacgcctta cgaatccctg cttgtaacca 69961 tcagccaggc cgtccgtggc ggaaaattac ccgcaggctg gtatcaggtc ccagtgacaa 70021 aggaaaccct gcaggccccg gcggggctgt cttcagtggc agatgccgta tggacgggga 70081 atcacctgaa gatggtccgc tttgccgtgg aaaataaaac gctgtctgcc ctgaatatcc 70141 gggaaagtga cttctggcag ccgggaaccc gtgccgtgat gttcagccag cctgccagcc 70201 agttactggc aggtgcgcgc atggatgtgt atgtcatccg tgacggggag ggcaactgat 70261 ggccagtatc aataccattg tgaaacgcaa gcagtacctg tggctgggga ttgtggttgt 70321 cggtacagcc tccgcgattg gtggggcact gtatctgtct gatgtggaca tgtccggtaa 70381 cggtgaaacc gtggctgaac aggagcctgt gccggatatg accggtgtgg tggatacgac 70441 ctttgatgac aaggtgcgtc agcatgccac caccgagatg caggtgacgg cagcgcagat 70501 gcagaagcag tatgaggaaa tccgtcgtga gctggatgtt ctgaacaaac agcgcggtga 70561 tgaccagcgt cgtattgaaa agttgggaca ggacaatgcc gccctggcag agcaggtaaa 70621 agccctgggt gctaatcccg tcacggcgac cggtgagcct gtaccgcaga tgcctgcctc 70681 accgcccggc ccggaaggcg aaccacagcc aggaaacacc cccgtatcct tcccgccgca 70741 gggcagcgtt gctgttccac cgccgacggc gttttatccc gggaatggtg tcacgccacc 70801 accacaggtg acgtaccagt ctgtgccggt gcctaaccgg atacagcgta aggtgtttac 70861 ccgtaatgag ggaaaacagg gaccatcact gccgtacatt ccgtcaggaa gttttgcgaa 70921 agccatgctg attgaagggg cggatgccaa tgcctctgtc accggtaatg aatccacggt 70981 gccgatgcag ctgcgtatca ccggcctggt ggaaatgccg aacagcaaga cgtatgacgc 71041 aacgggatgt tttgtgggtc tggaagcctg gggggatgtg tccagtgagc gtgccattgt 71101 acgcacccgc aatatcagtt gcctgaagga cggcaaaact attgatatgc cgattaaggg 71161 gcatgtcagc ttccggggta aaaacggtat caagggcgaa gtggtgatgc gtaacggcaa 71221 aatcctcggc tgggcatggg gcgcgggatt tgttgacggt atcggtcagg gaatggagcg 71281 cgcctcccag ccggctgtcg ggctgggtgc cacagccgct tacggggctg gtgatgtcct 71341 gaaaatgggt atcggtggcg gcgcatcgaa agccgcacag acgctcagtg actactacat 71401 caaacgtgcc gaacagtatc acccggtgat accgattggt gcgggcaacg aagtgaccgt 71461 ggtgttccag gacggcttcc agctgaaaac cgtggaagag atggcgctgg aacgcacgca 71521 gagcagagcg gaagaagaca atccggaaag tccggttcct gttccgccat cggctgaaag 71581 tcatcttaac ggctttaata ctgaccagat gctgaagcag ctgggcaacc tgaatccgca 71641 gcagtttatg tccggcagcc agggaggggg caacgatggc aaataatatg tcgtcccgtc 71701 aggcgtgcca tgccgcccgg tatgttgtcg cccgggttct gcgaggactg ttctggtgtc 71761 tgaagtacac cgtcattctg ccactggcca caatggccct gatggctctg tttgttttat 71821 ggaaggacaa caccacgccg gggaaattac tggttaagga gattaacttc gtaagacaaa 71881 cagcacctgc cggacagttc ccggtcagtg aatgctggtt ttcttcctct gattcttcag 71941 gcagatcaga aatacagggt atctgccatt accgcgcggc tgatgctgca gattatgtca 72001 gggagactga ccggtcactg atgcaactgg tcaccgcatt atgggcaaca ctggcactga 72061 tgtatgtctc gctggcagcg atcaccggga aatatccggt gcgacccgga aaaatgaaat 72121 gtatccgggt ggtaaccgca gatgaacatc tgaaggaagt ttatacggaa gacgcttccc 72181 tgccgggaaa aatcaggaaa tgccctgttt atcttcctga tgacagaaca aacagaaaca 72241 acggagataa aaatgaacat gcgtaatatt aatgttatta cagtcctctc tgtgccgggt 72301 aaaaccgtgt cagatgattt tatgcatgct gttctcagta actgcgccac aagaatcgta 72361 cttcctgcac cggagaaatt cggttctgag tcattgccgg acaattttaa tatgactgct 72421 gtcggtgtga tgaagaattc agaaatataa ggaacccttc gatgaataag ctggtttctg 72481 atggcagcgt caaaaaaata aattatccgg tgctgtatga gtccggaata acacctccgt 72541 tatgtgaagt cagtgcacca gaacctgatg cgggtgggaa acgcattgtg gcatatgttt 72601 ataaatcatc acggagtacg gtttttgaaa atcctgacat tgtaaaaacc tgtacggtca 72661 gggatttgaa gaaggatttt gtgaactgcg atgagaaagg tgagggacaa tgaaacagac 72721 ttctttcttt attcctctgc tggggacctt attactttac ggctgtgccg gaaccagtac 72781 ggaatttgag tgtaacgcca ccacatccga tacctgtatg acgatggagc aggccaatga 72841 gaaggccaaa aaactggagc ggtcctcaga agcaaagccg gttgcggcat cactgccgcg 72901 cctggctgaa gggaacttcc ggacaatgcc ggtgcagacc gtcaccgcga ccactccgtc 72961 cggcagcaga cctgcggtga cagcacatcc ggagcagaaa ctgctggcac ctcgcccgct 73021 gtttaccgct gcccgggaag tgaaaacggt tgttccggtc agttcagtta cgccggtaac 73081 acctcctcgt ccgctaagaa cgggtgagca gacggcagca ttatggatag cgccttatat 73141 tgataaccag gatgtttatc atcagccatc cagcgtgttt tttgttatta aaccgtctgc 73201 gtggggaaaa ccacgtatta attaactggc cctgaagttg tatatcagcc ggcaatgccg 73261 gcgggctttc tgtattcaaa atctgcctgt aaaacgagtg ccctgtgcgt gaaaagggat 73321 gggcggtagc gtgtcagaac atgtcgggag gaatattccg tgagtgatga agccgatgaa 73381 gcatattcag tgacagaaca actgaccatg acaggaataa accggatacg ccagaaaata 73441 aatgctcatg gtattcctgt ttatctctgt gaagcatgcg gaaatcctat tccggaagcc 73501 cggcggaaaa tatttcccgg tgtgacgttg tgcgttgaat gtcaggcgta tcaggaaaga 73561 cagagaaaac attatgcata agtcagtcgc agaacatagt gatttaattc cggatgaaca 73621 tgagtggata ttcagaaaac agaaatcttt gtatatgcgc cgggaaatgg cgcgttaatt 73681 acaggtattc ccttcatggc taccgcattt ctcgctttat ttttcaacta aggaattcat 73741 gtgaataacc cacttgaggc cgtcactcag gcggttaact ccctcgtcac agcactgaaa 73801 ctgcctgacg aatccgcaaa ggccaatgaa gttctgggcg aaatgagctt cccgcagttc 73861 agccgtctgc tgccgtaccg tgattacaac caggaatccg gtctgttcat gaatgacacc 73921 acgatgggct ttatgctgga agccattccc atcaatgggg cgaatgagtc cattgtggag 73981 gccctcgatc atatgctgcg caccaaactg ccgcgcggta ttccgttgtg tatccatctg 74041 atgtccagtc agctggttgg tgacaggatt gaatacgggc tgcgtgagtt ctcctggtct 74101 ggcgaacagg ccgaacggtt taacgcgatt acccgggcct attatatgaa agcggcagcg 74161 acacagtttc cgctgccgga gggaatgaat ctgcccctga ccctgcgcca ttaccgggtg 74221 tttatctcgt actgttctcc ctcgaagaaa aaaagccggg ccgacattct ggaaatggaa 74281 aacctggtga aaatcatccg ggcgtcgtta cagggggcca gtatcaccac acagacggtg 74341 gatgcacagg cctttatcga tattgtcggg gagatgatta accataaccc ggattccctg 74401 tacccgaaaa gacgtcagct ggacccgtat tctgatctga attatcagtg tgtggaggac 74461 agttttgatc tgaaagttcg ggctgattac ctgacactgg gcctgcgtga gaacggcagg 74521 aacagcacgg cccgcatcct gaatttccat ctggcccgta acccggaaat cgccttcctg 74581 tggaacatgg ccgacaacta cagcaacctg ctgaacccgg aactgtccat ctcctgtccg 74641 ttcatcctga cgctgactct ggtggtggaa gaccaggtga aaacccacag cgaagccaac 74701 ctgaagtaca tggacctgga gaaaaagtcg aagacctcct atgccaaatg gtttccgtcc 74761 gtggagaaag aggcgaagga gtggggggaa ctgcgtcagc ggctgggctc cggtcagtcc 74821 tctgtcgtgt cctacttcct caacatcaca gccttctgca aggacaataa tgaaacggca 74881 ctggaagtgg agcaggacat cctgaacagc ttccgtaaaa acggttttga gctgatttca 74941 ccgcgcttta accacatgcg caatttcctg acctgtctgc cctttatggc cgggaaaggg 75001 ttgtttaaac agctgaaaga ggccggagtg gtacagcgcg cagagagctt taatgtggcc 75061 aacctgatgc cgttagtggc ggataacccc ctgacaccgg caggtctgct ggcacccacc 75121 taccgtaacc agctggcgtt tatcgatatt ttcttccggg ggatgaataa caccaactat 75181 aacatggcgg tctgtggcac ctccggggcc ggtaaaaccg ggctgataca gccacttatc 75241 cgcagcgtgc tggactccgg aggctttgcc gtggtgttcg acatggggga tggatacaag 75301 tccctgtgtg agaacatggg cggggtgtat ctggacggtg aaaccctgcg ttttaacccg 75361 tttgcgaaca tcaccgatat tgaccagtca gcggagcgtg tccgtgacca gttgtcagtg 75421 atggccagcc ccaacggtaa cctggatgaa gtgcatgaag gtctgctgtt gcaggcggtc 75481 agagcctcct ggctggccaa agagaacaga gcacgtattg atgacgtggt ggatttcctg 75541 aaaaacgcca gtgacagcga gcagtatgcc gagtcaccga ctatccgcag ccgtctggac 75601 gaaatgattg tgctgcttga ccagtacact gccaacggca cttacggcca gtattttaac 75661 tctgatgagc cgtccctgcg ggatgacgca aaaatggtgg tgctggagct gggcggactg 75721 gaagaccgtc cgtcactgct ggttgcggtg atgttctccc tgattatcta catcgagaac 75781 aggatgtacc gcacgccgcg taacctcaag aaactgaacg ttattgatga aggctggcgt 75841 ctgctggact tcaaaaatca caaggtcggt gaatttattg agaaaggcta ccgtacggcc 75901 cgccgtcata ccggtgccta tatcaccatc acacagaaca tcgtcgactt tgactctgat 75961 aaggcctcca gtgctgcccg cgcggcatgg ggtaactcct cctacaaaat tatcctcaaa 76021 cagagtgcga aggagttcgc gaaatacaac caactgtatc cggaccagtt cctgccactg 76081 cagcgcgaca tgattggtaa gtttggtgcg gccaaagacc agtggttcag ttccttcctg 76141 ctgcaggtgg aaaaccattc ctcctggcac cgtctgtttg tggacccgtt aagccgcgcc 76201 atgtacagct ctgacggccc ggattttgag tttgtgcagc agaagcgtaa agaggggctg 76261 agtattcatg aggcagtgtg gcagctggcg tggaagaagt cagggccgga aatggcttcg 76321 ctggaagcct ggctggaaga acatgagaaa tacaggagtg tggcatgagt tcaacgcaga 76381 aacccgccga cgtcacggca gaacgacgca gccactggtg gtggacggtg ccgggatgcc 76441 tggcaatggt gttactgaac gcagccgtca gttacggcat tgtcagactg aacgcaccgg 76501 tgactgtcgc cttcaacatg aaacagaccg tggatgcgtt ttttgacagc gccagtcaga 76561 aacaactgtc agaagcgcag tcaaaagccc tttcagcgcg ttttaacacg gcactggaag 76621 ccagcctgca ggcgtggcag cagaaacacc acgcggtcat tctggtgtcg cctgctgtgg 76681 tacagggggc accggatatc acccgggaaa tccagcagga tattgcccgg cgaatgaggg 76741 cggaaccatg agatgccggg ggctgattgc cctgctgata tgggggcaga gtgtggccgc 76801 cgccgatctt ggtacctggg gcgatctgtg gccggtaaag gagccggaca tgctgacggt 76861 gatcatgcag cgcctgacgg cactggagca gtccggtgag atgggccgga aaatggatgc 76921 ctttaaggag cgggtgatcc gcaacagtct gcggccccct gccgtgcccg gtatcggacg 76981 cacggagaaa tacggcagcc ggttgtttga cccgtccgtc agactggctg cggatatccg 77041 ggataacgaa gggcgggtgt ttgcccgtca gggtgaagtg atgaatccgc tgcagtatgt 77101 tccttttaac cagacgctgt atttcatcaa tggcgatgat ccggcgcagg tggcctggat 77161 gaaacgccag acgccgccca cactggagag caaaattatc ctcgtgcagg gcagtatccc 77221 ggagatgcag aagtctctgg acagccgtgt ttactttgac cagaacggtg tgctctgcca 77281 gcgcctcggc attgatcagg tcccggcacg ggtgagcgcc gttcccggcg atcgcttcct 77341 gaaggtggaa tttattccgg cagaggaggg cagaaaatga agcgaaggct gtggctgctg 77401 atgttattcc ttttcgccgg tcatgtccct gcggcgtctg cggattctgc ctgtgagggg 77461 cgttttgtaa acccgatcac agatatctgc tggagctgta ttttcccgct ctcgctgggc 77521 agtatcaaag tcagtcaggg caaggtcccc gacacggcga acccgtcgat gcccattcag 77581 atttgtccgg caccgccgcc gctgttcagg cgtatcgggc tggccattgg ttactgggag 77641 ccgatggcgt tgacggacgt cacccggtca ccgggatgca tggtgaacct gggcttcagc 77701 ctgccggctt ttggtaaaac ggcacaggga acggcgaaaa aggatgagaa gcaggtaaat 77761 ggggcgttct atcacgttca ctggtacaaa tacccgctga cgtactggct gaacatcatc 77821 acatcgctgg gctgtctgga aggtggtgac atggatatcg cttatctttc tgaaatcgac 77881 cccacctgga cggacagcag cctgaccacc attctcaatc cggaagctgt catctttgcc 77941 aatccgatag cacagggagc ctgcgcagca gatgcgattg ccagcgcctt taatatgcct 78001 ctcgatgttc tgttctggtg tgccggttcg cagggaagta tgtacccgtt caatggctgg 78061 gtgagtaatg agtccagtcc gttgcagtcc tccctgctgg tcagtgaacg catggcgttc 78121 aagctgcacc gtcagggcat gattatggaa accatcggga aaaataacgc cgtctgtaat 78181 gaatatccgt ccccaatcct gcccaaagaa cgctggcgtt accagatggt gaatatgtat 78241 ccggacagcg ggcagtgcca cccgttcggg cgcagcgtga cccgctggga aaccgggaaa 78301 aatccgccca acacaaagaa aaacttcggc tacctgatgt ggcgtaaacg taactgtgtc 78361 ttcctgtgag gtgaatgatg aagctgagta tgaaatctct ggcagcactg ctgatgatgc 78421 tgaacggggc ggttatggcg tcagaaaacg tgaacactcc tgaaaaccgc cagttcctga 78481 agcagcagga aaatttaagc agacaactgc gtgaaaaacc tgaccatcag ctgaaagcct 78541 gggcggagaa acaggtgctg gaaaaccccc ttcagcgttc agataaccat ttcctggatg 78601 agctggttcg taaacagcag gcttcgcagg acgggaaacc ccggcagggt gctctgtatt 78661 ttgtgtcgtt ttccattccc gaagaggggc tgaaacgaat gctgggcgaa acccggcact 78721 tcggtattcc ggccacactg cggggcatgg tgaacaatga cctgaagacc accgctgaag 78781 ctgtgttgtc cctggtgaaa gacggcgcga ctgatggtgt tcagatcgac ccgacgctgt 78841 tttcacagta cggcattcgc actgtaccgg cactggtggt gttctgcagt cagggatacg 78901 acatcatccg gggaaacctg cgggtcggcc aggcgctgga gaaagtggcc gccacgggtg 78961 actgccggca ggtggctcat gatttactgg cagggaaagg agattccggg aaatgaaacg 79021 tattttacct ctgatactgg ctctggttgc cggcatggca caggctgaca gcaacagtga 79081 ttaccgggcc ggctctgatt ttgctcacca gatcaaagga cagggaagca gcagtattca 79141 gggctttaag ccacaggaga gtatccccgg ctataacgcg aatccggacg agacaaaata 79201 ctacggtggc gtgactgccg gcggggatgg cggcctgaaa aatgacggca ccacggaatg 79261 ggcgaccggt gaaaccggaa aaaccatcac agagtccttc atgaacaagc cgaaagacat 79321 tctttcaccg gatgcaccgt ttatccagac cggcagggat gtggtgaacc gggctgacag 79381 cattgtggga aacaccgggc agcagtgcag tgcgcaggag attagccgga gtgaatacac 79441 gaattacacc tgtgagcggg atttacaggt ggagcagtac tgcacacgaa ctgcccgtat 79501 ggagctgcag gggagtacca catgggaaac ccggacgctg gagtatgaaa tgagtcagct 79561 acctgcacgt gaagtgaatg gtcagtatgt tgtctccatt acctctcccg ttaccggtga 79621 aattgtcgat gcgcattaca gctggagtcg tacttacctg cagaagagtg tacctatgac 79681 aattacagta ctgggaaccc cactgagctg gaatgccaaa tactcagcag atgcctcatt 79741 tacaccagta cagaaaacac tgacggccgg tgttgctttt acgtcatctc accccgtccg 79801 ggtcgggaat acaaaattca aacgtcatac ggcaatgaag ctgcgtctgg ttgtcagggt 79861 aaaaaaagcc tcgtacaccc cgtatgttgt ctggtctgaa agctgcccgt tcagcaagga 79921 gctggggaaa ctgacaaaaa cagaatgtac ggaggctggc gggaacagga cgctggtgaa 79981 agacggtcag tcatacagca tgtaccagag ctgctgggca taccgggaca cgtatgtcac 80041 acagtcagca gacaagggaa cctgtcagac ctacaccgac aatcctgcct gtaccctggt 80101 gtcacaccag tgcgcctttt actccgaaga aggtgcctgt ctgcatgaat atgccacgta 80161 ctcctgtgag tcaaaaacat ccgggaaagt gatggtctgt gggggagacg tcttctgtct 80221 cgatggcgaa tgcgataagg ctcagagcgg gaagagtaat gattttgccg aagccgtttc 80281 tcagctggcg gcactggccg cagcaggtaa ggatgttgcg gcgctgaacg gggtggatgt 80341 ccgtgctttc accggtcagg cgaaattttg taagaaggct gcagccggat acagcaactg 80401 ctgtaaggac agcggctggg gacaggatat cgggctggcc aaatgcagca gtgatgaaaa 80461 agccctggct aaagcaaaat caaacaaact gaccgtcagc gtcggggagt tctgttcgaa 80521 gaaagtgctg ggtgtctgtc tggagaaaaa acgcagctac tgtcagtttg attcgaagct 80581 ggcgcagata gtccagcagc aggggcgcaa cggtcagttg cgtatcagtt ttggtagtgc 80641 gaagcatcct gactgtcggg ggattacggt tgatgagctg cagaaaattc agttcaacag 80701 actggatttc actaacttct acgaagacct gatgaataac cagaaaatcc cggacagtgg 80761 cgttctgacg cagaaagtga aagagcagat tgctgaccag ctgaaacagg caggacagta 80821 aggtatggga aataaccggg ggaaatgatg aaagtcatat tcacgtcgaa ccgttttatt 80881 gattttctta tccggctttt gattacagcg attgtcattt ctccggtaat tatctggtcg 80941 tgggatacgg taaaagaaac cacggcagac gggatgcttg ccgctgcttt cgttatcctt 81001 tactccggtg tgctcctgtt tattctgtat ttttgttttt ctgccctgac tgacctgcag 81061 aaacctgatg aaagaaaaag tgatgaaagg aatgaagatg aataaagcat tactgccact 81121 gttactctgc tgctttattt ttccggcgtc aggaaaagat gcaggctggc agtggtataa 81181 cgagaaaata aatccgaagg aaaaagaaaa taaacctgta cctgcagccc cccgtcagga 81241 accggatatt atgcagaaac tggccgcact gcagacggca acaaagcggg cgctgtacga 81301 agccattctg tatcccggcg tggataattt tgtgaaatat ttccggctgc aaaattactg 81361 ggctcagcag gccgggcttt tcaccatgag cgccagaaag gccatgctgg cacatcctga 81421 actggactat aacctgcagt acagtcatta caacggcacg gtacggaacc agctggcagc 81481 agaccaggcg cagcagcgac aggccattgc gaaactggct gaacactacg gcatcatgtt 81541 tttttaccgg gggcaggacc ccatcgacgg gcaactggcg caggtcatta atggcttccg 81601 ggatacgtat ggtctgagtg ttattcccgt ttccgtggat ggcgtgatta atccgctgtt 81661 gccggattcc cggactgacc aggggcaggc gcagcgcctc ggcgtgaaat atttcccggc 81721 catgatgctg gttgacccga aacagggcag tgttcgcccg ttatcatacg gctttatttc 81781 gcaggacgac ctggcaaaac agttcctgaa cgtttctgaa gattttaaac ccaattttta 81841 atcgcggatt tgatttatga gtgaagatta tttgaaaatg tttacaggtg ttgttctgtt 81901 aatatttgtc attattgccg gttatttctt ttctgagcgt aatgacagga aaatgtttct 81961 cctgagctca ctggttttcc ttgttgttaa tatcgcgtgt ttatatgtgc ttaccgccag 82021 tctctggttt ctgtgtggtg caattatgag tcagggcgca gcactggttg tttcaatagt 82081 tgcggccgca ttaccggacg ttacgagctt cgacaggttc agaagaatat ttatctgtat 82141 tatgttgtca tcggtatggt ccggagtgat gtggtttttt ataagggggc ttatgacagg 82201 ctaagtcata taaaacggtc ataaaaacca tacaaaataa tgaggttgat tactgaagac 82261 catatgataa accataccgc aatccagtgg cttctgaata gctcacaaaa ataaatatag 82321 ataattgaaa ataaccataa tacaacgatg cctgctgcga tacttaataa acttattaca 82381 agatagtcag ggaaagcatt gaccggtaat gaatgtgatg ctgcatatat cagcgcaata 82441 attgccgcat ttcccagtaa cgactctctt attatgtttc tgattatttc cagtttttct 82501 ttaaaagatc gcttttccat ttgtacctct gattaatatc acacaaacgc gaatattaca 82561 gacatgaata ctctcatgta aataataacc ggagtttaac atgataagta aacgcagatt 82621 ctctttaccc cggcttgata ttacgggaat gtgggtattt tccctgggtg tctggtttca 82681 tatcgtcgcc cgtcttgttt acagcaaacc ctggatggct ttttttctgg cggagctgat 82741 tgcggccatt ctcgtactgt tcggcgcata ccaggtgctg gatgcatgga ttgcccgtgt 82801 cagccgggaa gagcgtgagg cactggaagc caggcaacag gccatgatgg aagggcagca 82861 ggagggcgga catgtctctc actaaatcac tgctgttcac cctgttgctg agcgccgctg 82921 ctgtgcaggc ctccacccgg gatgaaatag agcgactctg gaatccgcag ggtatggcta 82981 cgcagcctgc acaaccggca gcaggcacgt cagccaggac agcaaagccg gctccccgct 83041 ggttccgtct cagtaatggc aggcaggtta acctggccga ctggaaggtg gtgctgttta 83101 tgcaggggca ttgcccttac tgtcaccagt ttgacccggt actgaaacag ctggcacagc 83161 agtacggctt ttccgttttt tcctacaccc tggatggtca gggggatacg gcctttcctg 83221 aagcattacc ggtgccaccg gacgtgatgc agaccttctt cccgaatatc ccggtggcca 83281 caccgaccac cttcctggtc aacgtcaaca cgcttgaggc attaccgctt ttacaggggg 83341 caacggatgc cgccggtttt atggcgcggg tggataccgt tttgcagatg tacggaggaa 83401 aaaaaggtgc gaaataagca ggtggtgtta ctcattgccg gaatatccgg catcgtgacg 83461 ggaataatcg tcagcctgaa tatccccttt atccgtcagg ggctttttta tcccgccagc 83521 cctgtagaaa ttgtcgtttc gctgagtctt accttttctg tttctgttgt gttttttgtg 83581 ggggcaattg tgggatggat ttcggtgtct gaaatatatt acagccgcat gaccggtctg 83641 aatgaatcat cggaaatatc agagggaact tataatgaga gaaaataaaa gtaatcctga 83701 actcaaaatc agaagtacag aacgagatta taaatacatt tccagaatta ctggcaggta 83761 tgctggattg tctctggtat tcctgactgc cggaattgtt ttatggacag ttatggatat 83821 tatttttgat gcctgtattg attcgtggaa agcggacccg gaattaaata attcgagtta 83881 tatgtggaat atcctgatat atgccattcc gtatacgtta tatgcgcttg cagccgggtt 83941 tcttgttaca tttttttctg tccccaatgt acgaattaat atacggaaat atcgagatat 84001 tcctgctgaa atgtcgtatg caccgggaga acacattaag ggagggcaag aatgatgcca 84061 cgcattaaac ctcttctggt tctttgtgcc gccttactga cggtgacgcc tgcagcgtca 84121 gcggatgtga acagcgacat gaatcagttc tttaataagc tgggatttgc ttccaatacc 84181 acacagccgg gcgtctggca ggggcaggcc gccggctatg cttacggtgg ctccctgtat 84241 gcccgtactc aggtcaaaaa tgttcagcta atttccatga cgctgccgga tatcaatgct 84301 ggatgtggcg gcatcgacgc ctatctcggc tcgttcagtt ttattaatgg tgagcagttg 84361 cagcgttttg ttaagcagat tatgagcaat gctgccggtt acttttttga ccttgccctg 84421 cagacaacgg tgccggaaat aaaaaccgca aaagacttcc tgcagaaaat ggcaagcgac 84481 attaacagta tgaacctcag ttcctgccag gctgcacagg ggattatcgg cgggcttttc 84541 ccccggacgc aggtgtccca gcaaaaagtc tgtcaggaca ttgccggtga gagcaatatt 84601 tttgctgact gggcggcttc ccggcaggga tgtaccgttg gcgggaaatc tgacagcgtc 84661 agggataaag ccagcgacaa ggataaggag cgggtgacca aaaacatcaa catcatgtgg 84721 aatgcgcttt ccaaaaacag aatgtttgac ggcaacaaag agctgaaaga gtttgtgatg 84781 acgctgaccg gctcactggt gtttggtccc aacggcgaaa tcacaccgct gtcagccaga 84841 accactgacc gttcaattat ccgggccatg atggaaggcg gcacagcaaa aatttctcac 84901 tgcaacgatt ctgataaatg cctgaaagtg gtggcagaca caccggtgac catcagccgg 84961 gataatgcac tgaagtctca gattactaaa cttctggcca gcattcagaa caaggctgtc 85021 agtgacacgc ctctggatga caaggaaaaa ggctttattt ccagtaccac catccccgtc 85081 ttcaaatacc tggttgaccc gcagatgctc ggtgtttcca acagtatgat ttaccagctg 85141 acggactata tcggttacga catcctgctg cagtacattc aggagctgat acagcaggca 85201 cgggcgatgg tggccacggg aaattatgac gaagcggtta tcgggcatat taacgacaac 85261 atgaatgatg ccacccggca gattgcggcg tttcagtcac aggtgcaggt acagcaggat 85321 gcgctgctgg ttgtcgatcg tcagatgagc tacatgcgtc agcagctttc cgcccgcatg 85381 ctcagtcgtt accagaacaa ctatcacttc ggagggagca cgctgtgaat gaagtttatg 85441 tgattgccgg tggtgagtgg ttgcggaata acctgaacgc cattgccgcc tttatgggaa 85501 cctggacgtg ggattccatt gaaaaaattg cgctcacatt gtctgttctc gcggtggccg 85561 taatgtgggt acagcggcac aacgtgatgg atttgctggg ctgggtggcc gtgtttgtgc 85621 ttatcagcct gctggttaat gtccgcacat cggtgcagat tattgataac agtgacctgg 85681 tcaaagttca ccgggtggat aatgtgccgg tcggtctggc gatgccactt tcactgacga 85741 cccgtatcgg gcatgcaatg gtggccagtt acgagatgat cttcacgcaa ccggacagcg 85801 tcacctacag caaaacgggg atgctgttcg gggcgaatct gattgtgaaa agcaccgatt 85861 tcctgtcccg gaatccggaa atcatcaatc tgttccagga ctacgtccag aactgcgtgc 85921 tgggtgatat ttacctgaat cataaataca cgctggaaga cctgatggcc tccgctgacc 85981 cctacacgct gattttttcc cgccccagcc cgctacgggg cgtttatgac aacaataata 86041 atttcataac ttgtaaggat gcgtcggtca cgctgaaaga caggctgaat ctcgatacaa 86101 agacgggagg caagacctgg cattattatg tgcagcagat atttggcggc agaccggacc 86161 cggacctgtt attcagacaa ctggtcagtg acagttacag ttatttctac ggctccagtc 86221 agtctgccag ccagattatg cgccagaacg tcaccatgaa tgccctgaaa gagggtatca 86281 ccagtaatgc agcccgtaac ggtgacaccg ccagcctggt aagtctggcc accacgtcat 86341 cgatggagaa acaacgtctg gcacatgtct ccattggtca tgtaactatg cgaaacctgc 86401 cgatggtcca gactatcctg acggggattg ccattggtat attcccgctc ctgatactgg 86461 cggctgtctt taacaagctg acattgtctg tattaaaggg gtatgtgttt gccctgatgt 86521 ggctgcagac ctggccgttg ttgtatgcca ttctgaacag tgccatgaca ttctatgcga 86581 aacagaatgg tgcgccggtc gtgttgtctg aactctctca gatacagctg aaatactcta 86641 acctggcctc cactgccggg tatctttcag ccatgatccc cccgttgtca tggatgatgg 86701 taaaaggcct tggcgcaggt ttttccagcg tgtacagcca cttcgcctct tcatctatca 86761 gtccaacggc cagtgcagca ggcagtgtgg ttgacggtaa ttactcctac ggcaacatgc 86821 agacggaaaa cgtgaacggc ttcagctgga gcaccaacag caccacgtcg tttggtcaga 86881 tgatgtacca gaccggcagt ggcgcaaccg ccacacagac ccgtgacggt aatatggtga 86941 tggatgcaag cggagcgatg tcccggttac cggtcggtat caatgcaacg cgtcagattg 87001 cagcggcaca acaggaaatg gcccgggagg cgtcgaacag agccgaaagt gccctgcatg 87061 gtttcagcag cagtattgcc agtgcctgga acacactcag tcagtttggc tctaaccggg 87121 ggagcagtga ctctgtcact ggtggtgctg acagcacgat gagtgctcag gactccatga 87181 tggccagccg tatgcgcagt gcagtggaaa gctatgcgaa ggcgcataat atcagtaatg 87241 agcaggcgac gagagaactg gcctcgagaa gtacaaatgc gtcgcttggc ctttacggtg 87301 atgcttatgc taaagggcat ttaggcataa gtgtattggg taacggtgga ggggttggtc 87361 tccaggccgg agctaaggca agcattgatg gcagtgatct tgactcacat gaagccagta 87421 gtggttcacg ggccagccat gatgctcgtc atgatatcga tgccagagct acacaagact 87481 ttaaagaagc cagcgattac tttaccagcc gcaaagtcag tgaatccggc agccatactg 87541 acaataatgc tgattcccgt gtggatcagt tgtctgcagc cctgaattca gcgaaacaga 87601 gttacgacca gtacacgacg aatatgaccc gcagccatga atatgctgaa atggcatccc 87661 gtactgagag tatgagtggg cagatgagtg aagatctgtc gcaacagttt gcacagtatg 87721 tgatgaaaaa cgcaccgcag gatgttgaag ctattctgac aaataccagt tcgccggaga 87781 ttgcagaacg ccgtcgggct atggcgtggt cttttgtgca ggaacaggta cagcctggtg 87841 ttgataacac ctggcgtgaa tcccgtagag atataggtaa aggaatggag agcgtacctt 87901 cgggtggtgg cagccaggat attattgctg atcatcaggg acatcaggcc attattgagc 87961 aaagaacgca ggacagtaat atccgtaatg atgtaaaaca tcaggttgat aatatggtca 88021 cagaatatcg aggtaatatc ggagatactc agaacagcat ccgaggcgag gaaaatattg 88081 taaaagggca gtattctgaa ctacaaaatc atcataaaac agaagcatta actcagaata 88141 ataaatataa tgaagaaaag ctggctcagg aaagaatacc tggtgctgat agtccgaaag 88201 agcttttaga gaaagcaaag agttaccagc ataaagaata atcataacat gttgggtagg 88261 gtatggagag accatgatta cacaacaaat tatcagtagt gagttggaag ttttaaagaa 88321 acatattgac tcaggagata ttagaattcc gtcactatgg cagggattaa aacccgggct 88381 tatcatcatg gggtggatga ttttttgtcc cttgctaatg tcatttctaa taacacaaaa 88441 gacaagtgaa acactcactg ctgtgttagc cggaggatgg cttggactta ttattctgtt 88501 tattgtggca aggattagaa tgttatattt ctctctgccg gaagaattcc taaagacatc 88561 atccgtaatg agggttatat catcaaaact taaagtgtat ttcattgtgt atatgggagt 88621 tatattttta tggtcttttt taggtggagg gattatatac ggttttggcg caattttagt 88681 gacggttatt atggcgttct tgattcaatt agatatcggt agatatcaat ttgttggtgt 88741 tattgatgca atcaatagtt acgtcaaaaa caagaagtta tcaagagtaa aataaaagat 88801 attagagagt aaatatatga tgaaaacaaa aaaactaatg atggttgcac tggtcagttc 88861 cactctggcc ctttcagggt gtggtgcgat gagcacagca atcaagaagc gtaaccttga 88921 ggtgaagact cagatgagtg agaccatctg gcttgaaccc gccagcgaac gcacggtatt 88981 tctgcagatc aaaaacacgt ctgataaaga catgagtggg ctgcagggca aaattgctga 89041 tgctgtgaaa gcaaaagggt atcaggtggt gacttctccg gataaagcct actactggat 89101 tcaggcgaat gtgctgaagg ccgataagat ggatctgcgg gagtctcagg gatggctgaa 89161 ccgtggttat gaaggcgcag cagttggtgc agcgttaggt gccggtatca ccggatataa 89221 ttccaattct gccggtgcca cactcggtgt gggccttgct gccggtctgg tgggtatggc 89281 tgcagatgcg atggtggaag atgtgaacta taccatgatc acggatgtgc agattgcaga 89341 gcgtactaag gcaacggtga caacggataa tgttgccgcc ctgcgtcagg gcacatcagg 89401 tgcgaaaatt cagaccagta cagaaacagg taaccagcat aaataccaga cccgtgtggt 89461 ctcaaatgcg aacaaggtta acctgaaatt tgaagaggcg aagcctgttc tcgaagacca 89521 gctggccaaa tcaatcgcaa atattctctg attatcttcc ggaggctggt ctgaccggcc 89581 tcctgactga cgcctcgctt tgctcgttgt ccaaccccgg aaagaaataa aataaatttt 89641 atttctcccc ggcgtttccg aaataaatat gaaaacactg agcggttgtg caaattcttt 89701 gtgcgaccgt gaagtgttgc cggcgaagcc ggaatttaac ggttattaat cttttcatca 89761 ttaataatca gtccgactga ctttttttct tcggaatatc atcatgagtt ttaacgcaaa 89821 ggatatgacc cagggcggtc agattgcgtc catgcgtatc cgcatgttca gccagatcgc 89881 caatatcatg ctttactgcc tgtttatttt tttctggata ctcgttggtc tggttttatg 89941 gataaaaata agctggcaga cgtttgtgaa cggctgtatt tactggtggt gtaccacgct 90001 ggaaggcatg cgggatttaa tcaaatccca gccggtctat gagatccagt attacggtaa 90061 aaccttccgc atgaacgctg ctcaggtact gcatgacaaa tatatgatct ggtgcagtga 90121 gcagttatgg tccgccttcg tgctggctgc tgttgtggca ctggttattt gcctgattac 90181 cttctttgtt gtctcctgga ttctggggcg tcagggtaaa caacagagcg aaaatgaagt 90241 cacaggtggt cgtcagctga cagacaatcc gaaagacgtt gcccggatgc tgaaaaaaga 90301 cggcaaggac tccgatatcc ggattggaga cctgccgatt atccgggatt ccgaaatcca 90361 gaacttctgt ctgcacggca cggtcggggc cggtaagtcg gaagttatcc gtcgtctggc 90421 caactacgcc cgtcagcgcg gtgatatggt ggtgatttat gaccgttcgg gggaatttgt 90481 taaaagttac tatgatccct ccatcgataa aatcctgaat ccgctggatg cccgctgtgc 90541 cgcctgggat ttgtggaagg agtgcctgac acagccggat tttgataata ccgcaaatac 90601 tctgatcccg atgggtacaa aagaggaccc gttctggcag ggttcaggac gtaccatttt 90661 tgcggaagcg gcgtatctga tgcgtaatga ccccaaccgc agctacagca aactggtgga 90721 cacactgctt tccatcaaaa ttgaaaaact gcgtacctac ctgcgtaatt caccggcggc 90781 caacctggtg gaagagaaaa ttgagaaaac ggcgatttcc atccgtgctg tgctgaccaa 90841 ctacgtgaaa gccatccgtt acctgcaggg gattgagcat aacggtgagc cttttaccat 90901 ccgtgactgg atgcgtggtg tccgggaaga tcagaaaaac ggctggctgt ttatttcgtc 90961 gaatgccgac acccatgcct ccctgaagcc ggtgatctcc atgtggctgt ccattgccat 91021 tcgtggtctg ctggcaatgg gagaaaaccg taaccgtcgt gtgtggtttt tctgtgatga 91081 gttacccacg ttacacaaac tgccggacct ggtggagatc ctgccggaag cccgtaagtt 91141 cggtggctgt tatgtgtttg gtatccagtc ctatgcccag ctggaagata tctacggtga 91201 gaaagcggct gcctcgctgt ttgacgtcat gaacacccgt gcctttttcc gttctcccag 91261 ccataagatt gcagagttcg ctgccggtga aattggtgag aaagagcacc tgaaagccag 91321 cgagcagtat tcctacggtg ctgatccggt acgtgacggg gtatcgaccg gtaaggatat 91381 ggagcgccag acgctggtca gttattccga cattcagtct ctgccggatc tgacctgtta 91441 tgtcaccctg cccggaccgt atccggcagt aaaactctct ctgaaatatc agacacgacc 91501 gaaggtcgct ccggagttta ttccgcgtga catcaacccg gaaatggaga accgtctgag 91561 tgccgtactt gccgcaaggg aagcagaagg tcgtcagatg gccagcctct tcgaaccgga 91621 tgtcccggag gttgtttccg gagaagacgt gactcaggct gaacagccgc aacagccggt 91681 gtctcctgcc atcaacgata agaagtcaga ttcaggtgtg aatgttccgg caggggggat 91741 cgagcaggag ctgaaaatga aaccggaaga agagatggaa cagcaactgc cacccgggat 91801 cagtgaatcc ggtgaagtgg tggatatggc cgcttatgag gcatggcaac aggaaaatca 91861 tccggacatc cagcagcaga tgcagcgtcg tgaagaggtg aacattaatg tgcaccggga 91921 gcgcggggag gatgttgagc cgggagatga tttctgatga acaggtcaac tccagtcttc 91981 aattctcagg ccgcccacac gttcaaattc ccgggtgtta ttagtcacaa taatcagtcc 92041 ccgactgcgg gcatgacctg cgatcatttg atcaaatggc ccgacagggc gtccctgaag 92101 ggcaagttct gctcttatct ggccggtgtg tgtggcagca gcagcgtcgt aatccagaac 92161 gtcaatgcgg gaaacaaatc cctcgatcac agcgagatta cgttcaggca tctggctttt 92221 ttctgcacca tatatcacct ccatcagagt gaccgaactg atgcacattc tcccctggtt 92281 caggttaaaa cgttccctga cactggcggg tttgttcttt atcgtaaaaa tgcagatgtt 92341 ggtatcgagc ataaacttca gcatcagaat gactcccttt cctgcatacc aggctgttcc 92401 ctgttatcca taaaatcagc gctgacactg tttccgtcga accattcgtc ccatgtctct 92461 ccggcaggcg taatgattcg ggttcgtccg acagcaatca cttcaacgcg ttttacgttt 92521 tccggcaatg caaccgcttt tggcagtctg accgcctggc tgcggttgct gagaaatacg 92581 gtggtttcca ttatttgcct ccttatgtgg atatgtcttg tgtatatcca ttgtgggatt 92641 gatgccggga tatgtcaaag ggatatacgt ttatgatgag tattgcgcag gtcagatcgg 92701 ccggaagtgc cgggaactat tataccgaca aggataatta ctatgtgctg ggcagcatgg 92761 gagaacgctg ggccggcagg ggggctgaac agctggggct gcagggcagt gtcgataagg 92821 atgtttttac ccgtcttctg gagggcaggc tgccggacgg agcggatcta agccgcatgc 92881 aggatggcag taacaggcat cgtcccggct acgatctgac cttctccgcc cccaaaagtg 92941 tctccatgat ggccatgtta ggtggcgata agcgcctgat tgatgcacat aatcaggccg 93001 tggattttgc tgtccgtcag gtggaggcgc tggcctccac acgggtgatg acggacggac 93061 agtcagaaac ggtgctgacc ggtaatctgg tgatggcact gtttaaccac gacaccagtc 93121 gcgatcagga accacagtta cacacgcatg cggtggtggc taatgtcacg cagcataatg 93181 gcgaatggaa gacactgagc agtgacaaag tggggaaaac ggggttcatt gagaatgtgt 93241 acgctaatca gattgccttt ggcaggctct accgggaaaa actgaaagag caggttgagg 93301 cgctgggcta tgaaactgaa gtggttggta agcacggtat gtgggaaatg ccgggtgtac 93361 cggtggaggc cttttccgga cgctcacaga ctatccggga ggccgtcggg gaagacgcct 93421 cgctgaaatc ccgggatgtg gcggcgctgg atacgcgtaa atccaaacag catgtcgatc 93481 cggagatcaa aatggccgag tggatgcaga cgctgaagga aaccgggttc gacatccggg 93541 catatcgtga cgcggcggat cagcgtgcgg atctccgcac gctgacgccc gggcctgctt 93601 cacaggacgg gccggatgtg cagcaggcgg tgacacaggc gattgccgga ttaagtgaac 93661 gaaaagtgca gttcacgtac acggacgtac tggccagaac ggtcggcata ctgccgccgg 93721 aaaatggtgt gattgaacgg gcacgcgccg gtatcgatga ggccatcagc cgtgagcagc 93781 ttatccccct cgaccgtgag aaggggctgt tcacgtccgg gattcatgtg ctcgatgagc 93841 tgtcagtccg ggcactcagt cgtgacatca tgaaacagaa ccgggtgacc gtacatccgg 93901 agaaaagtgt tccccggacg gccggttaca gcgatgccgt cagcgtgctg gcacaggatc 93961 gcccgtcgct ggccattgtg tccgggcagg gcggtgcagc cgggcagcgt gagcgggtgg 94021 ctgaactggt catgatggcc cgggagcagg ggcgggaggt gcagattatc gctgctgacc 94081 gtcgctcgca gatgaacatg aagcaggatg aacggttgtc cggtgagctg ataaccggac 94141 gtcgtcagct gctggaaggc atggccttca cgccgggcag tactgttatc gttgaccagg 94201 gcgaaaaact ctccctgaaa gagacgttaa ccctgctgga cggtgccgca cgtcataacg 94261 tacaggtcct gataaccgac agcgggcagc gaaccggtac aggcagtgca ctgatggcca 94321 tgaaggatgc cggggtgaac acatatcgct ggcagggggg agaacagcga ccggccacca 94381 tcatcagtga accggaccgt aatgtccgct atgcccggct ggcaggagat tttgcggcca 94441 gcgtgaaagc cggagaagag agcgtggcac aggtcagcgg ggtacgggaa caggccatac 94501 tgacacaggc cattcgcagt gagctgaaaa cacagggcgt gctcggactc ccggaggtga 94561 ccatgactgc cctttcaccg gtctggctgg acagccggag ccgttatctg cgggatatgt 94621 accgtccggg gatggtgatg gagcagtgga acccggagac acgcagtcat gaccgctatg 94681 ttatcgaccg ggtgacggcg cagagtcaca gcctgaccct gcgggatgcg cagggtgaaa 94741 cgcaggtggt gcgtatttcc tccctggaca gcagctggtc gctgttccgg ccggaaaaaa 94801 tgccggtggc agacggcgag cgactgaggg tgacagggaa aattcccgga ctccgcgtct 94861 ccggcggtga ccgcctgcag gtggcatccg tcagtgaaga tgcgatgacg gttgttgtgc 94921 cgggacgggc tgaaccggcc accctgcctg tgagcgattc accgttcacg gcactgaagc 94981 tggagaacgg ctgggtggaa acgcccgggc attccgtcag cgacagtgcg acggtttttg 95041 cctccgtcac acagatggca atggacaatg ccaccctgaa cggtctggcc cgcagtggtc 95101 gtgatgtccg gctgtattcc tcactggatg aaacccgtac tgcggaaaaa cttgcccgcc 95161 atccgtcctt tacggtggtt tctgagcaga taaagacgcg ggccggtgag acatcgctgg 95221 aaacggctat cagtcatcag aagtccgcac ttcacacgcc ggcacagcag gccattcatc 95281 ttgcccttcc ggtggtggaa agtaaaaaac tggccttcag catggtggac ctgctgacag 95341 aggcaaagtc gtttgctgca gaaggaaccg gttttactga actgggaggg gaaatcaatg 95401 cgcagataaa acggggtgat ttactgtatg tggatgtggc aaaaggctat ggcacaggtc 95461 tgctggtttc ccgtgcgtcg tatgaggcag aaaagagcat tcttcgccat attctcgaag 95521 gtaaggaggc ggtcatgccg ctgatggaga gagtacctgg cgaactcatg gagaaactga 95581 catcaggaca gcgtgccgcc acccgcatga tactggaaac gtccgaccgt ttcacggtgg 95641 tacagggcta tgccggtgtg ggtaagacca cacagttccg ggcggtgatg tcagccgtga 95701 acatgctgcc ggagagtgag cgtccccgag tcgtggggct gggtcccaca caccgtgcgg 95761 tcggggagat gcgcagcgcc ggcgtggatg cgcagacact ggcgtccttt ctgcatgaca 95821 cgcagctgca gcagcgcagc ggagaaacgc cggatttcag caacacgctg ttcctgctcg 95881 atgagagctc aatggtgggc aataccgaca tggcacgggc atacgccctg attgcggccg 95941 gtggcggtag ggcggtggcc agtggtgaca cggaccagct gcaggccatc gcgcccggtc 96001 agcctttccg tctccagcag acgcgcagtg ctgccgatgt ggccatcatg aaggagattg 96061 tgcgtcagac gccggaactg cgggaggcgg tatacagcct gattaaccgg gatgtggaaa 96121 gggcactgtc cgggcttgag agtgtgaaac cgtctcaggt gccacgtcag gagggcgcat 96181 gggcaccgga gcactccgtg acggagttca gtcacagcca ggaagcgaaa ctggcagaag 96241 cgcagcagaa ggcgatgctg aaaggcgagg cttttccgga tgtccccatg acactgtatg 96301 aagccattgt ccgcgactat accggcagaa caccggaagc acgggagcag acgctgattg 96361 tcacgcacct gaatgaggac cggcgcgtac tgaacagcat gattcatgat gtacgggaaa 96421 aggccggtga gctggggaaa gagcaggtca tggtgcctgt cctgaacaca gcgaatatac 96481 gtgacgggga gctgcgtcgt ctctccacct gggagacaca tcgggacgca cttgtcctgg 96541 tggataatgt gtatcaccgg attgccggta tcagtaagga tgacgggctg ataaccctgc 96601 aggatgcgga aggtaacacg cggttgattt ctccccggga ggcggtggct gaaggtgtca 96661 cactgtacac cccggacacc atcagggtgg ggaccggtga ccggatgcgc ttcacgaaga 96721 gtgaccggga gcgcggttat gtggccaaca gcgtctggac ggtgacagca gtttccggtg 96781 acagtgtcac gctgtcggac ggacagcaga cccgggagat tcgccccggc caggagcagg 96841 cagagcaaca tattgacctg gcctatgcca tcaccgctca cggtgcgcag ggggcaagtg 96901 aaacctttgc cattgcgctt gaaggaacgg aaggtaaccg gaaactgatg gccggctttg 96961 agtcagccta cgtggccctg tcgcgtatga agcagcatgt gcaggtgtac accgataacc 97021 gtcagggctg gacggatgcc attaacaatg ccgtacagaa aggaacggcc cacgatgtat 97081 ttgagccgaa accggaccgg gaggtcatga atgcagagcg gctgttcagt acggcgcggg 97141 aactgcggga cgtggcggca gggcgtgctg ttctccgtca ggcggggctg gccgggggag 97201 acagtccggc acggtttatt gcaccggggc gcaaatatcc gcagccgtat gtggcactgc 97261 cggcgtttga ccgtaacggc aagtcagcag gtatctggct gaacccactg accacggatg 97321 acggaaacgg gctgcgggga ttcagtggtg aaggacgggt gaaaggcagc ggggatgcgc 97381 agttcgtggc cctgcagggc agccgtaacg gagagagcct gctggctgat aatatgcagg 97441 atggtgtccg gattgcccgt gataatcctg acagcggtgt ggtggtgaga atcgccggtg 97501 aaggtcgtcc gtggaatccc ggtgccatca ccggtggtcg cgtgtggggg gatatcccgg 97561 acaacagtgt ccagccggga gccggaaatg gcgaaccggt cacggcagag gtgctggcac 97621 agcggcaggc tgaagaggcc atccgtcgtg aaacggaacg ccgcgcagat gaaattgtcc 97681 gtaaaatggc agagaacaaa cctgacctgc cggatggcaa aacagagcag gctgtcaggg 97741 agattgccgg gcaggagcgt gaccgggctg ccataactga acgggaagcc gcgctgccgg 97801 agggtgtact gcgtgaacct caacgggtgc gggaagctgt cagggaaatt gcccgggaaa 97861 atctgctgca ggagcgactt cagcagatgg agcgggatat ggtccgcgac ctgcagaaag 97921 agaaaaccct gggtggagac tgatacagga agacaaacgc tgatgacaac ggataacacg 97981 aacacgacac gtaacgattc actggttgcc cggaccgata cctggttgca gtcgttgctg 98041 gtctggtcac ccggacagcg ggatatcatc aaaacggtgg cactggtgct gatggttctg 98101 gaccatgcaa accgtattct gcatctggac cagtcgtgga tgtttctagc cgggcgcggg 98161 gcctttccgc tgtttgccct ggtgtggggg ctgaatctgt cccgtcatgc gcatatccgg 98221 caactggcca ttaaccggct gtggggatgg gcagtttttt cccagttctg gtattacttt 98281 gccggctttc cctggtatga ggggaatatc ctgtttgcct ttgcagtggc ggcacaggtg 98341 ctgacatggt gtgaaacgcg cagtgggtgg cgtactgcag cggccattct catgatggca 98401 ctgtgggggc ctttgtccgg caccagttac ggcattgccg ggctgctgat gctggctgtc 98461 agccaccggc tgtaccgggc ggaagacaga atggaacgtc tggtgcttgt cgcttgcctg 98521 ctggccgtga ttccggcgct taaccttgcc accagtgatg cggcggctgt agccggcctt 98581 gtgatgacgg tgctgaccgt tggtctggtg tcgtgtgcag ggaaattatt atcccgtttc 98641 tggcccggag actttttccc gacgttctat gcctgtcatc tggctgtgct gggcgttctg 98701 gcgctgtgac gggtgtggta tctttggccg caagaggatg attcgtcaga ggcagaacac 98761 agcatgacag agcagaagcg accggtactg acactgaagc ggaagacaga aggggagacg 98821 cttgtccgca gccggaaaac catcatcaat gtcaccacgc caccaaagtg gaaggtgaaa 98881 aagcagaagc tggccgagaa agccgcccgg gaagcagagc tggcggcaaa aaaagcgcag 98941 gccagacagg cgctgtccat ttatctgaat ctgcccacgc tggatgatgc cgtgaacacc 99001 ctgaagccct ggtggccggg attatttgac ggtgacacgc cccggcttct ggcctgcggt 99061 atccgggacg tgttactgga agacgtggcg cagcggaata tcccgctctc gcataaaaaa 99121 ctgcgcaggg cgctgaaggc catcacccgt tcagaaagc //