Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   EW021_RS06850 Genome accession   NZ_LR130236
Coordinates   1315314..1315955 (-) Length   213 a.a.
NCBI ID   WP_010922536.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain 5448 isolate 5448     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1310314..1320955
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EW021_RS06825 comFA/cflA 1310400..1311725 (-) 1326 WP_010922534.1 DEAD/DEAH box helicase Machinery gene
  EW021_RS06830 - 1311781..1312413 (+) 633 WP_009880468.1 YigZ family protein -
  EW021_RS06835 cysK 1312541..1313482 (+) 942 WP_010922535.1 cysteine synthase A -
  EW021_RS06840 - 1313500..1313877 (-) 378 WP_002991882.1 S1 RNA-binding domain-containing protein -
  EW021_RS06845 - 1313877..1315277 (-) 1401 WP_011285657.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  EW021_RS06850 vraR 1315314..1315955 (-) 642 WP_010922536.1 response regulator transcription factor Regulator
  EW021_RS06855 - 1315948..1316952 (-) 1005 WP_002991890.1 sensor histidine kinase -
  EW021_RS06860 liaF 1316949..1317641 (-) 693 WP_011054833.1 cell wall-active antibiotics response protein LiaF -
  EW021_RS06865 pknB 1317764..1319662 (-) 1899 WP_010922538.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  EW021_RS06870 - 1319659..1320399 (-) 741 WP_002983660.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -

Sequence

Protein


Download         Length: 213 a.a.        Molecular weight: 23693.40 Da        Isoelectric Point: 5.3506

>NTDB_id=994142 EW021_RS06850 WP_010922536.1 1315314..1315955(-) (vraR) [Streptococcus pyogenes strain 5448 isolate 5448]
MSKIKVILVDDHEMVRMGLKSFLNLQADIDVVGEASNGREGVDLALALKPDVLVMDLVMPELGGVEATLEVLKKWKEAKV
LVLTSYLDNEKIYPVIDAGAKGYMLKTSSAAEILNAIRKVSKGELAIETEVDKKIKAHDQHPDLHEELTAREYDILHLLA
KGYDNQTIADELFISLKTVKTHVSNILAKLEVGDRTQAVVYAFRHHLVPQDDN

Nucleotide


Download         Length: 642 bp        

>NTDB_id=994142 EW021_RS06850 WP_010922536.1 1315314..1315955(-) (vraR) [Streptococcus pyogenes strain 5448 isolate 5448]
ATGAGTAAGATAAAAGTGATATTGGTCGATGATCATGAAATGGTCCGCATGGGACTCAAGAGTTTTTTGAATTTACAAGC
TGATATTGATGTCGTTGGTGAGGCCTCTAATGGACGTGAAGGGGTTGATTTGGCATTGGCTTTGAAGCCAGATGTTTTGG
TTATGGATCTAGTGATGCCAGAGTTAGGCGGTGTTGAGGCAACTTTAGAAGTCCTAAAAAAATGGAAAGAGGCTAAGGTA
CTTGTGTTAACTTCCTATCTAGATAATGAAAAGATATACCCTGTCATTGATGCAGGAGCGAAGGGTTATATGTTAAAAAC
ATCGAGTGCGGCTGAAATTTTAAATGCCATTCGCAAGGTTTCAAAGGGAGAGTTAGCTATTGAAACAGAAGTTGACAAAA
AAATTAAGGCGCATGATCAACACCCTGACTTGCATGAGGAACTAACAGCGCGTGAGTATGACATTTTACACCTTTTAGCT
AAAGGGTATGATAATCAGACCATCGCTGATGAACTCTTTATTTCCTTAAAAACCGTCAAAACACATGTGTCCAATATTCT
AGCCAAGTTAGAAGTTGGTGACCGAACCCAAGCGGTTGTCTATGCTTTTCGACATCATTTAGTCCCCCAAGACGATAATT
AA

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(148-202)

Response regulator receiver domain (Response_reg)

(6-118)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.913

96.714

0.512
  degU Bacillus subtilis subsp. subtilis str. 168

36.283

100

0.385