Detailed information NTG0098879

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: R8570_RS02325
• Genome accession: NZ_AP026932
• Coordinates: 469772..470509 (+)
• Length: 245 a.a.
• NCBI ID: WP_001219146.1
• Uniprot ID: A0A1C0UQ30
• Organism: Streptococcus pneumoniae strain PZ900701549
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 464772..475509

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R8570_RS02290 (PC1528_04560)	-	465702..465941 (-)	240	WP_001813906.1	hypothetical protein	-
R8570_RS02295 (PC1528_04570)	-	466103..466390 (-)	288	WP_000777760.1	hypothetical protein	-
R8570_RS02300 (PC1528_04580)	-	466400..466810 (-)	411	WP_001278301.1	HIT family protein	-
R8570_RS02305 (PC1528_04590)	pptA	466878..467609 (+)	732	WP_000889919.1	ABC transporter ATP-binding protein	Regulator
R8570_RS02310 (PC1528_04600)	-	467606..468655 (+)	1050	WP_000653771.1	ABC transporter permease	-
R8570_RS02315 (PC1528_04610)	-	468823..469152 (-)	330	WP_000132572.1	hypothetical protein	-
R8570_RS02320 (PC1528_04620)	-	469429..469767 (+)	339	WP_000682132.1	LytTR family DNA-binding domain-containing protein	-
R8570_RS02325 (PC1528_04630)	comE/blpR	469772..470509 (+)	738	WP_001219146.1	response regulator transcription factor	Regulator
R8570_RS02330 (PC1528_04640)	-	470523..471863 (+)	1341	WP_001099895.1	sensor histidine kinase	-
R8570_RS02335 (PC1528_04650)	blpC	471908..472063 (-)	156	WP_000358814.1	quorum-sensing system pheromone BlpC	-
R8570_RS02340 (PC1528_04660)	-	472120..473481 (-)	1362	WP_001069060.1	bacteriocin secretion accessory protein	-
R8570_RS02345 (PC1528_04670)	comA/nlmT	473492..475168 (-)	1677	WP_196300924.1	peptide cleavage/export ABC transporter	Regulator

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28768.87 Da
• Isoelectric Point: 6.0454

>NTDB_id=98879 R8570_RS02325 WP_001219146.1 469772..470509(+) (comE/blpR) [Streptococcus pneumoniae strain PZ900701549]
MRIFVLEDDFSQQTRIETTIEKLLKEHHITPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIREQD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSTRPHRVILYTKTDRLEFTASLEEVLKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide

• Length: 738 bp

>NTDB_id=98879 R8570_RS02325 WP_001219146.1 469772..470509(+) (comE/blpR) [Streptococcus pneumoniae strain PZ900701549]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGGATTGAAACGACGATTGAGAAACTCTTGAAGGAACA
TCATATCACTCCCAGCTCTTTTGAGGTATTTGGCAAGCCAGACCAACTGCTGGCAGAGGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAGGAGATGAAGGGGCTGGAAGTGGCTAGAAAGATTCGGGAACAAGAC
CCCTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCCTTTCGCTACCAAGTGTCTGCTCTGGA
CTATATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGAATCGAGACAGCTCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCCACAAGACCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTCTAGAGGA
GGTTCTCAAGCAGGAGCCTCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCCAATGTGGTGCATTTAGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: A0A1C0UQ30

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.321	99.184	0.539
comE/comE1	Streptococcus equinus JB1	43.46	96.735	0.42
comE/comE2	Streptococcus equinus JB1	38.843	98.776	0.384
comE	Streptococcus infantis strain Atu-4	36.179	100	0.363