Detailed information NTG0098394

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: R8507_RS10805
• Genome accession: NZ_AP026925
• Coordinates: 2088964..2090145 (+)
• Length: 393 a.a.
• NCBI ID: WP_317643318.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain PZ900700097
• Function: degrading CSP; selective degradation of ComEA and ComEC (predicted from homology) Competence regulation

Genomic Context

Location: 2083964..2095145

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R8507_RS10765 (PC0094_20930)	-	2085015..2085557 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
R8507_RS10780 (PC0094_20940)	comE	2085800..2086552 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
R8507_RS10785 (PC0094_20950)	comD/comD1	2086549..2087874 (-)	1326	WP_000362880.1	competence system sensor histidine kinase ComD	Regulator
R8507_RS10790 (PC0094_20960)	comC/comC1	2087895..2088020 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
R8507_RS10800 (PC0094_20970)	rlmH	2088302..2088781 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
R8507_RS10805 (PC0094_20980)	htrA	2088964..2090145 (+)	1182	WP_317643318.1	S1C family serine protease	Regulator
R8507_RS10810 (PC0094_20990)	spo0J	2090203..2090961 (+)	759	WP_000410383.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 393 a.a.
• Molecular weight: 41869.73 Da
• Isoelectric Point: 6.8902

>NTDB_id=98394 R8507_RS10805 WP_317643318.1 2088964..2090145(+) (htrA) [Streptococcus pneumoniae strain PZ900700097]
MKHLKTFYKKWFQLLVVIVISFFSGALGSFSITQLTQKSSVNNSNNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSA
NRQNSVFGNDDTDTDSQRISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISS
EKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNISLRSEDGQAISTKAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNVSTSDIRRLNIPSNVTSGVV
VRSVQSNMPANGHLEKYDVITKVDDKEIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLNKSSGDLES

Nucleotide

• Length: 1182 bp

>NTDB_id=98394 R8507_RS10805 WP_317643318.1 2088964..2090145(+) (htrA) [Streptococcus pneumoniae strain PZ900700097]
ATGAAACATCTAAAAACATTTTACAAAAAATGGTTTCAATTATTAGTCGTTATCGTCATTAGCTTTTTTAGTGGAGCCTT
GGGTAGTTTTTCAATAACTCAACTAACTCAAAAAAGTAGTGTAAACAACTCTAACAACAATAGTACTATTACACAAACTG
CCTATAAGAACGAAAATTCAACAACACAGGCTGTTAACAAAGTAAAAGATGCTGTTGTTTCTGTTATTACTTATTCGGCA
AACAGACAAAATAGCGTATTTGGCAATGATGATACTGACACAGATTCTCAGCGAATCTCTAGTGAAGGATCTGGAGTTAT
TTATAAAAAGAATGATAAAGAAGCTTACATCGTCACCAACAATCACGTTATAAATGGCGCCAGCAAAGTAGATATTAGAT
TGTCAGATGGGACTAAAGTACCTGGAGAAATTGTCGGAGCTGACACTTTCTCTGATATTGCTGTCGTCAAAATCTCTTCA
GAAAAAGTGACAACAGTAGCTGAGTTTGGTGATTCTAGTAAGTTAACTGTAGGAGAAACTGCTATTGCCATCGGTAGCCC
GTTAGGTTCTGAATATGCAAATACTGTCACTCAAGGTATCGTATCCAGTCTCAATAGAAATATATCCTTAAGATCGGAAG
ATGGACAAGCTATTTCTACAAAAGCCATCCAAACTGATACTGCTATTAACCCAGGTAACTCTGGCGGCCCACTGATCAAT
ATTCAAGGGCAGGTTATCGGAATTACCTCAAGTAAAATTGCTACAAATGGAGGAACATCTGTAGAAGGTCTTGGTTTCGC
AATTCCTGCAAATGATGCTATCAATATTATTGAACAGTTAGAAAAAAACGGAAAAGTGACGCGTCCAGCTTTGGGAATCC
AGATGGTTAATTTATCTAATGTGAGTACAAGCGACATCAGAAGACTCAATATTCCAAGTAATGTTACATCTGGTGTAGTT
GTTCGTTCGGTACAAAGTAATATGCCTGCCAATGGTCACCTTGAAAAATACGATGTAATTACAAAAGTAGATGACAAAGA
GATTGCTTCATCAACAGACTTACAAAGTGCTCTTTACAACCATTCTATCGGAGACACCATTAAGATAACCTACTATCGTA
ACGGGAAAGAAGAAACTACCTCTATCAAACTTAACAAGAGTTCAGGTGATTTAGAATCTTGA

Domains

Predicted by InterproScan.

• Trypsin-like peptidase domain (Trypsin_2) (103-248)

• PDZ domain (PDZ_2) (289-384)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus pneumoniae Rx1	99.237	100	0.992
htrA	Streptococcus pneumoniae D39	99.237	100	0.992
htrA	Streptococcus pneumoniae R6	99.237	100	0.992
htrA	Streptococcus pneumoniae TIGR4	99.237	100	0.992
htrA	Streptococcus mitis NCTC 12261	96.947	100	0.969
htrA	Streptococcus gordonii str. Challis substr. CH1	66.667	100	0.672
htrA	Streptococcus mutans UA159	54.569	100	0.547