Detailed information NTG0972014

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: WOC74_RS05645
• Genome accession: NZ_CP150759
• Coordinates: 1126959..1128002 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain TUM22178
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1121959..1133002

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
WOC74_RS05615 (WOC74_05600)	-	1122387..1123643 (-)	1257	WP_001793428.1	aminopeptidase	-
WOC74_RS05620 (WOC74_05605)	-	1123646..1123846 (-)	201	WP_000180460.1	DUF1128 family protein	-
WOC74_RS05625 (WOC74_05610)	-	1123993..1124457 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
WOC74_RS05630 (WOC74_05615)	-	1124464..1124739 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
WOC74_RS05635 (WOC74_05620)	-	1125017..1126228 (+)	1212	WP_000037091.1	YihY/virulence factor BrkB family protein	-
WOC74_RS05640 (WOC74_05625)	vraR	1126340..1126969 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
WOC74_RS05645 (WOC74_05630)	vraS	1126959..1128002 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
WOC74_RS05650 (WOC74_05635)	liaF	1127999..1128700 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
WOC74_RS05655 (WOC74_05640)	-	1128715..1129101 (-)	387	WP_001110179.1	hypothetical protein	-
WOC74_RS05660 (WOC74_05645)	map	1129318..1130076 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
WOC74_RS05665 (WOC74_05650)	-	1130607..1131593 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
WOC74_RS05670 (WOC74_05655)	-	1132083..1132496 (-)	414	WP_001837236.1	hypothetical protein	-
WOC74_RS05675 (WOC74_05660)	-	1132525..1132636 (-)	112	Protein_1090	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=972014 WOC74_RS05645 WP_001017131.1 1126959..1128002(-) (vraS) [Staphylococcus aureus strain TUM22178]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=972014 WOC74_RS05645 WP_001017131.1 1126959..1128002(-) (vraS) [Staphylococcus aureus strain TUM22178]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1