Detailed information NTG0929943

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: V2I05_RS12845
• Genome accession: NZ_CP143587
• Coordinates: 2635892..2637190 (+)
• Length: 432 a.a.
• NCBI ID: WP_002368406.1
• Uniprot ID: R3K7C6
• Organism: Enterococcus faecalis strain IDRL-7415
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 2630892..2642190

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
V2I05_RS12840	rlmH	2635012..2635491 (-)	480	WP_002355021.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
V2I05_RS12845	htrA	2635892..2637190 (+)	1299	WP_002368406.1	S1C family serine protease	Regulator
V2I05_RS12850	ytpR	2637237..2637857 (-)	621	WP_002361057.1	YtpR family tRNA-binding protein	-
V2I05_RS12855	-	2637961..2638785 (-)	825	WP_002385250.1	PTS system mannose/fructose/sorbose family transporter subunit IID	-
V2I05_RS12860	-	2638769..2639539 (-)	771	WP_002365320.1	PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC	-
V2I05_RS12865	-	2639561..2640034 (-)	474	WP_002359087.1	PTS sugar transporter subunit IIB	-
V2I05_RS12870	-	2640037..2640780 (-)	744	WP_002359086.1	BtpA/SgcQ family protein	-
V2I05_RS12875	-	2640792..2641202 (-)	411	WP_002365322.1	PTS sugar transporter subunit IIA	-
V2I05_RS12880	-	2641217..2641948 (-)	732	WP_002365323.1	GntR family transcriptional regulator	-

Sequence

Protein

• Length: 432 a.a.
• Molecular weight: 44831.95 Da
• Isoelectric Point: 4.9968

>NTDB_id=929943 V2I05_RS12845 WP_002368406.1 2635892..2637190(+) (htrA) [Enterococcus faecalis strain IDRL-7415]
MQRKDVTPNSDKKSLLQKFGIGLAGGLLGGALILGGAYSGIIPTPNGGNNAATTTSTNHGDTKVSNVSYNVSSDVTKAVK
KVQNSVVSVINMQSASNNSSADDPFGGLFGGNEGTQDSSGNNGNDLEAASEGSGVIYKKDGKTAYVVTNNHVVDKAQGLE
VVLSDGTKVKGELVGTDAYTDLAVIKISSDKVDQVAEFGNSSKITVGEPAIAIGSPLGSDYANSVTQGIISSVNRNITNK
NESGETININAIQTDAAINPGNSGGPLINIEGQVIGINSVKIVQSTSQVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPA
LGITMSDLTGISSQQQEQILKIPASVKTGVVVRGVEAATPAEKAGLEKYDVITKVDGQDVSSTTDLQSALYKKKVGDKME
VTYYRGSKEMKATIDLTIDKSALTQQNNRSNQ

Nucleotide

• Length: 1299 bp

>NTDB_id=929943 V2I05_RS12845 WP_002368406.1 2635892..2637190(+) (htrA) [Enterococcus faecalis strain IDRL-7415]
ATGCAACGAAAAGATGTTACACCTAATTCAGATAAAAAAAGTTTATTGCAAAAATTTGGGATTGGTTTAGCTGGCGGCTT
ACTTGGTGGCGCCCTTATTCTAGGAGGCGCTTATTCTGGGATTATTCCCACACCCAACGGCGGAAATAATGCGGCGACGA
CGACGTCCACTAATCACGGCGACACAAAAGTCAGCAATGTGAGTTACAATGTGTCTAGCGATGTCACAAAAGCCGTGAAA
AAAGTTCAAAATTCTGTGGTTTCTGTCATTAATATGCAAAGTGCTAGCAACAATTCTTCGGCAGATGATCCTTTTGGGGG
ATTGTTCGGTGGGAATGAAGGTACTCAAGACTCTTCCGGCAACAATGGTAACGATTTAGAAGCAGCCAGTGAAGGTAGTG
GGGTTATTTATAAGAAAGATGGTAAAACGGCTTATGTCGTGACAAATAACCACGTCGTAGATAAAGCGCAAGGATTGGAA
GTTGTTTTATCTGATGGTACCAAAGTGAAAGGCGAATTAGTCGGAACCGATGCTTACACGGATTTAGCCGTGATTAAAAT
TTCTTCCGACAAAGTTGATCAAGTCGCTGAGTTTGGGAATTCTAGTAAAATCACAGTCGGTGAGCCTGCTATTGCGATTG
GTTCCCCTCTAGGCTCTGATTATGCTAACTCTGTCACACAAGGAATCATCTCTTCTGTGAATAGAAATATTACCAATAAA
AACGAGTCTGGTGAAACCATCAATATTAATGCCATTCAAACCGATGCTGCCATCAATCCAGGAAACTCTGGTGGTCCACT
AATCAATATTGAAGGACAAGTCATTGGAATTAACTCAGTAAAAATTGTGCAATCAACTAGTCAAGTGAGCGTTGAAGGGA
TGGGCTTTGCCATTCCAAGTAATGACGTAGTCAACATTATCAACCAATTAGAAAAAGATGGTAAAGTGACGCGGCCAGCT
CTCGGGATTACGATGTCTGATTTAACAGGTATCTCTTCACAACAACAAGAACAAATTTTAAAAATTCCAGCTTCTGTAAA
AACTGGCGTAGTGGTTCGTGGTGTTGAAGCAGCGACCCCTGCTGAAAAGGCTGGATTGGAAAAATACGATGTTATCACGA
AAGTTGACGGCCAAGACGTAAGCTCTACTACAGATTTACAAAGCGCGCTTTACAAGAAAAAAGTTGGCGACAAAATGGAA
GTGACTTATTATCGTGGTTCTAAAGAAATGAAAGCAACCATCGATTTAACCATTGATAAATCAGCTTTAACACAACAAAA
TAATCGCAGCAATCAATAA

Domains

Predicted by InterproScan.

• Trypsin-like peptidase domain (Trypsin_2) (132-277)

• Peptidase family M50 (Peptidase_M50) (9-416)

• PDZ domain (PDZ_2) (319-416)

3D structure

• AlphaFold DB: R3K7C6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus gordonii str. Challis substr. CH1	53.171	94.907	0.505
htrA	Streptococcus mutans UA159	58.63	84.491	0.495
htrA	Streptococcus mitis NCTC 12261	55.135	85.648	0.472
htrA	Streptococcus pneumoniae TIGR4	55.807	81.713	0.456
htrA	Streptococcus pneumoniae Rx1	55.807	81.713	0.456
htrA	Streptococcus pneumoniae D39	55.807	81.713	0.456
htrA	Streptococcus pneumoniae R6	55.807	81.713	0.456