Detailed information NTG0911534

Bioinformatically predicted

Overview

• Name: comEC/celB
• Type: Machinery gene
• Locus tag: U0450_RS00605
• Genome accession: NZ_CP139863
• Coordinates: 125116..127356 (-)
• Length: 746 a.a.
• NCBI ID: WP_050210311.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain 15P2112
• Function: ssDNA transport into the cell (predicted from homology) DNA binding and uptake

Genomic Context

Location: 120116..132356

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
U0450_RS00570	-	121026..121406 (-)	381	WP_050219036.1	VOC family protein	-
U0450_RS00575	rplT	121464..121823 (-)	360	WP_000124836.1	50S ribosomal protein L20	-
U0450_RS00580	rpmI	121875..122075 (-)	201	WP_001125943.1	50S ribosomal protein L35	-
U0450_RS00585	infC	122108..122638 (-)	531	WP_000848180.1	translation initiation factor IF-3	-
U0450_RS00590	-	122945..124126 (-)	1182	WP_000655935.1	membrane protein	-
U0450_RS00595	-	124130..124717 (-)	588	WP_050210313.1	ATP-binding cassette domain-containing protein	-
U0450_RS00600	-	124749..124937 (-)	189	WP_050210312.1	hypothetical protein	-
U0450_RS00605	comEC/celB	125116..127356 (-)	2241	WP_050210311.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
U0450_RS00610	comEA/celA/cilE	127340..127990 (-)	651	WP_050210310.1	helix-hairpin-helix domain-containing protein	Machinery gene
U0450_RS00615	-	128058..128627 (-)	570	WP_000443775.1	GNAT family N-acetyltransferase	-
U0450_RS00620	ald	128804..129915 (+)	1112	Protein_124	alanine dehydrogenase	-
U0450_RS00625	-	130216..130542 (-)	327	Protein_125	TfoX/Sxy family protein	-
U0450_RS00630	-	130545..131045 (-)	501	WP_000566988.1	GNAT family N-acetyltransferase	-
U0450_RS00635	-	131225..132193 (-)	969	WP_000658183.1	PhoH family protein	-

Sequence

Protein

• Length: 746 a.a.
• Molecular weight: 84606.14 Da
• Isoelectric Point: 9.2732

>NTDB_id=911534 U0450_RS00605 WP_050210311.1 125116..127356(-) (comEC/celB) [Streptococcus pneumoniae strain 15P2112]
MLQWIKNIPIPLIYLSFLLLWFYYAIFSASYLALLGFVFLLVCLFFQFPWKSAGKVLVICGVFGFWFLFQNWQQSQASQN
LADSVERVRILPDTVKVNGDSLSFRGKADGRIFQVYYKLQSEEEKEAFQALTDLHEIGLEGKLSEPEGQRNFGGFNYQAY
LKTQGIYQTLNIKKIQSLQKIGSWDIGENLSSLRRKAVVWIKTHFPDPMRNYMTGLLLGHLDTDFEEMNELYSSLGIIHL
FALSGMQVGFFMNGFKKLLLRLGLTQEKLKWLTYPFSLIYAGLTGFSASVIRSLLQKLLAQHGVKGLDNFALTVLVLFIV
MPNFFLTAGGVLSCAYAFILTMTSKEGEGLKAVASESLVISLGILPILSFYFAEFQPWSILLTFVFSFLFDLTFLPLLSI
LFVLSFLYPVIQLNFIFEWLEGIIRLVSQVTSRPLVFGQPNAWFLILLLISLALVYDLRKNIKKLTVLCLLITGLFLLTK
HPLENEITMLDVGQGESIFLWDITGKTILIDVGGKAESYKKIEKWQEKMTTSNAQRTLIPYLKSRGVAKIDQLILTNTDK
EHVGDLSEVTKAFHVGEILVSKDSLKQKEFVAELQATQTKVRSMTVGENLPIFGSQLEVLSPRKMGDGGHDDTLVLYGKF
LDKQFLFTGNLEEKGEKDLLKQYPYLEVDVLKAAQHGSKKSSSPAFLEKLKPELTLISVGKSNRMKLPHQETLTRLEGIN
SKVYRTDQQGAIRFKGLDSWKIESVR

Nucleotide

• Length: 2241 bp

>NTDB_id=911534 U0450_RS00605 WP_050210311.1 125116..127356(-) (comEC/celB) [Streptococcus pneumoniae strain 15P2112]
ATGTTACAGTGGATTAAGAACATCCCCATTCCCCTAATTTACCTGAGTTTTTTGTTACTTTGGTTTTATTACGCTATTTT
CTCAGCATCCTATCTTGCTTTGTTGGGCTTTGTTTTTCTGCTAGTCTGTCTCTTTTTCCAATTTCCATGGAAATCAGCAG
GCAAAGTTCTAGTGATTTGTGGAGTCTTTGGCTTCTGGTTTCTGTTTCAAAATTGGCAACAGAGCCAAGCGAGTCAAAAT
CTGGCGGATTCTGTTGAAAGGGTACGGATTCTGCCTGACACTGTTAAGGTCAATGGTGATAGTCTGTCCTTTCGCGGCAA
GGCTGATGGACGCATTTTTCAAGTCTATTATAAACTCCAGTCCGAGGAGGAGAAAGAAGCCTTTCAAGCTTTAACCGACC
TGCATGAGATAGGACTAGAAGGGAAGCTTTCGGAGCCAGAAGGGCAGAGAAATTTTGGTGGCTTTAATTACCAAGCCTAT
CTGAAGACTCAGGGAATTTACCAGACTCTCAATATCAAAAAAATCCAGTCACTTCAAAAGATTGGCAGTTGGGATATAGG
AGAAAACTTGTCCAGTTTACGTCGAAAGGCTGTGGTTTGGATTAAGACGCACTTTCCAGACCCTATGCGCAATTACATGA
CAGGACTTTTGCTGGGACATCTGGACACCGACTTTGAGGAGATGAATGAGCTTTATTCCAGTCTAGGAATTATCCACCTC
TTTGCCCTATCTGGCATGCAGGTAGGTTTTTTCATGAATGGATTTAAGAAACTTCTCTTGCGATTGGGCTTGACCCAAGA
AAAGTTGAAATGGCTAACTTATCCCTTTTCCCTTATCTATGCGGGACTAACTGGATTTTCAGCATCGGTTATTCGCAGTC
TCTTGCAAAAGCTACTGGCTCAACATGGGGTTAAGGGCTTGGATAATTTTGCCTTGACGGTGCTTGTCCTCTTTATTGTC
ATGCCAAACTTTTTCTTGACAGCAGGAGGAGTCTTGTCCTGCGCTTATGCTTTTATCCTGACCATGACCAGCAAAGAAGG
GGAGGGGCTCAAGGCTGTTGCTAGTGAAAGTCTAGTCATCTCCTTGGGCATATTGCCCATTCTATCCTTCTATTTTGCGG
AATTTCAACCTTGGTCTATCCTTTTGACCTTTGTCTTTTCCTTTCTATTTGACTTGACCTTCTTACCGCTCTTGTCTATT
TTATTTGTCCTTTCCTTTCTCTATCCAGTCATTCAGCTGAACTTTATCTTTGAATGGTTGGAGGGCATTATTCGCTTGGT
GTCACAGGTGACAAGTAGACCTCTGGTCTTTGGACAACCCAATGCATGGTTTTTAATCCTATTGTTAATTTCCTTGGCTT
TGGTCTATGATTTGAGAAAAAACATTAAAAAGCTAACGGTATTGTGCTTATTGATTACAGGGCTCTTTCTCCTGACCAAG
CATCCACTGGAAAATGAAATCACCATGCTGGATGTGGGGCAAGGAGAAAGTATTTTCCTATGGGATATAACTGGGAAAAC
CATTCTCATAGATGTCGGTGGCAAGGCAGAATCTTATAAGAAAATCGAAAAATGGCAAGAAAAGATGACGACCAGCAATG
CCCAGCGAACCTTGATTCCCTATCTCAAAAGTCGAGGAGTAGCTAAGATTGACCAGCTAATTTTGACTAACACGGACAAG
GAGCATGTTGGAGATTTGTCAGAGGTGACCAAGGCTTTCCATGTAGGGGAGATTCTAGTATCAAAAGACAGTCTGAAACA
GAAGGAATTTGTGGCAGAACTACAGGCGACTCAAACAAAGGTGCGTAGTATGACAGTAGGGGAGAACTTGCCCATTTTTG
GAAGTCAGTTAGAAGTTCTATCTCCAAGGAAAATGGGAGATGGAGGACACGATGATACCCTAGTTCTGTATGGGAAATTC
TTGGATAAGCAATTTCTCTTCACGGGAAATTTGGAGGAGAAAGGAGAGAAGGACTTGCTGAAGCAATATCCTTACTTAGA
GGTGGATGTATTGAAAGCTGCCCAACATGGCTCTAAAAAGTCATCAAGTCCAGCCTTTCTAGAAAAACTCAAACCAGAGC
TTACTCTTATCTCAGTTGGAAAGAGCAATCGAATGAAACTCCCCCATCAGGAAACATTGACACGACTGGAAGGTATCAAT
AGCAAAGTTTACCGAACTGACCAGCAAGGAGCTATACGTTTTAAGGGGTTGGATAGTTGGAAAATCGAAAGTGTTCGATA
G

Domains

Predicted by InterproScan.

• Metallo-beta-lactamase superfamily (Lactamase_B) (492-697)

• Competence protein (Competence) (216-458)

• Domain of unknown function (DUF4131) (DUF4131) (31-177)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEC/celB	Streptococcus pneumoniae Rx1	96.917	100	0.969
comEC/celB	Streptococcus pneumoniae D39	96.917	100	0.969
comEC/celB	Streptococcus pneumoniae R6	96.917	100	0.969
comEC/celB	Streptococcus pneumoniae TIGR4	95.576	100	0.956
comEC/celB	Streptococcus mitis SK321	92.091	100	0.921
comEC/celB	Streptococcus mitis NCTC 12261	91.409	99.866	0.913
comEC	Lactococcus lactis subsp. cremoris KW2	44.355	99.732	0.442