Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   R6U80_RS11975 Genome accession   NZ_CP137623
Coordinates   2403694..2404920 (+) Length   408 a.a.
NCBI ID   WP_012898631.1    Uniprot ID   Q66RU3
Organism   Lactococcus lactis strain NCK401     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2398694..2409920
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R6U80_RS11950 (R6U80_11950) - 2399784..2400587 (-) 804 WP_003130590.1 phosphatidate cytidylyltransferase -
  R6U80_RS11955 (R6U80_11955) - 2400587..2401321 (-) 735 WP_003130589.1 isoprenyl transferase -
  R6U80_RS11960 (R6U80_11960) yajC 2401695..2402027 (-) 333 WP_003130588.1 preprotein translocase subunit YajC -
  R6U80_RS11965 (R6U80_11965) - 2402122..2402820 (-) 699 WP_023189024.1 DNA alkylation repair protein -
  R6U80_RS11970 (R6U80_11970) rlmH 2402839..2403318 (-) 480 WP_003130585.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  R6U80_RS11975 (R6U80_11975) htrA 2403694..2404920 (+) 1227 WP_012898631.1 S1C family serine protease Regulator
  R6U80_RS11980 (R6U80_11980) - 2405046..2406044 (+) 999 WP_023189027.1 glycosyltransferase family 4 protein -
  R6U80_RS11985 (R6U80_11985) - 2406170..2407510 (+) 1341 WP_012898632.1 glycosyltransferase family 4 protein -
  R6U80_RS11990 (R6U80_11990) - 2407618..2407842 (+) 225 WP_003130579.1 YkuJ family protein -
  R6U80_RS11995 (R6U80_11995) - 2407984..2408988 (+) 1005 WP_313791888.1 hypothetical protein -
  R6U80_RS12000 (R6U80_12000) - 2409029..2409781 (-) 753 WP_010906333.1 tRNA1(Val) (adenine(37)-N6)-methyltransferase -

Sequence

Protein


Download         Length: 408 a.a.        Molecular weight: 41637.93 Da        Isoelectric Point: 4.9794

>NTDB_id=899425 R6U80_RS11975 WP_012898631.1 2403694..2404920(+) (htrA) [Lactococcus lactis strain NCK401]
MAKANIGKLLLTGVVGGAIALGGSAIYQSTTNQSANNSRSNTTSTKVSNVSVNVNTDVTSAIKKVSNSVVSVMNYQKDNS
QSSDFSSIFGGNSGSSSSTDGLQLSSEGSGVIYKKSGGDAYVVTNYHVIAGNSSLDVLLSGGQKVKASVVGYDEYTDLAV
LKISSEHVKDVATFADSSKLTIGEPAIAVGSPLGSQFANTATEGILSATSRQVTLTQENGQTTNINAIQTDAAINPGNSG
GALINIEGQVIGITQSKITTTEDGSTSVEGLGFAIPSNDVVNIINKLEADGKISRPALGIRMVDLSQLSTNDSSQLKLPS
SVTGGVVVYSVQSGLPAASAGLKAGDVITKVGDTAVTSSTDLQSALYSHNINDTVKVTYYRDGKSNTADVKLSKSTSDLE
TSSSSSSN

Nucleotide


Download         Length: 1227 bp        

>NTDB_id=899425 R6U80_RS11975 WP_012898631.1 2403694..2404920(+) (htrA) [Lactococcus lactis strain NCK401]
ATGGCAAAAGCTAATATAGGAAAATTGCTATTAACAGGTGTCGTGGGCGGAGCCATCGCACTTGGAGGAAGTGCAATCTA
TCAAAGCACTACAAATCAATCGGCAAATAATAGTCGTTCAAATACAACTAGTACAAAGGTTAGTAACGTTTCGGTAAATG
TCAATACCGATGTTACCTCTGCAATTAAAAAAGTTTCAAATTCTGTCGTTTCTGTTATGAATTATCAAAAAGATAACTCA
CAAAGTAGTGACTTCAGTTCAATTTTTGGTGGAAATAGCGGTTCAAGTTCATCGACTGATGGCTTACAGCTTTCTAGTGA
AGGCTCTGGTGTCATCTACAAAAAATCTGGTGGTGATGCCTACGTTGTAACTAACTACCACGTTATTGCTGGTAATAGCT
CACTTGATGTTCTGCTTTCTGGTGGACAAAAAGTCAAAGCTTCTGTGGTTGGTTATGATGAATACACAGACCTTGCTGTT
CTTAAAATCAGTTCTGAACATGTCAAAGATGTGGCGACATTCGCTGATTCTAGTAAATTAACAATTGGTGAACCTGCCAT
TGCCGTTGGCTCACCTTTAGGTAGTCAATTTGCAAACACCGCAACTGAAGGAATTTTATCTGCAACAAGCCGTCAAGTGA
CTTTGACCCAAGAAAATGGTCAAACAACTAATATCAATGCAATTCAAACAGATGCTGCCATTAACCCTGGTAACTCTGGA
GGGGCTTTGATTAATATTGAAGGACAAGTTATTGGAATTACTCAAAGTAAAATTACAACAACTGAAGATGGTTCTACTTC
TGTCGAAGGTTTAGGATTTGCGATTCCTTCTAATGATGTCGTAAATATCATTAATAAACTTGAAGCTGATGGTAAGATTT
CACGCCCTGCTTTAGGTATCCGAATGGTTGACCTTTCACAATTATCAACAAATGACAGTTCTCAATTGAAATTACCAAGC
AGTGTAACAGGTGGGGTTGTTGTTTACTCCGTCCAATCTGGACTTCCTGCTGCCTCAGCTGGTTTGAAAGCTGGAGATGT
AATTACAAAGGTTGGCGATACAGCAGTAACTTCTTCAACAGACTTGCAAAGTGCTCTTTACTCACACAATATCAATGATA
CAGTAAAAGTTACTTATTATCGTGATGGTAAATCAAATACAGCAGATGTTAAACTTTCTAAATCAACCAGTGACTTAGAA
ACAAGCAGTTCATCTTCTTCTAATTAA

Domains

Predicted by InterproScan.

PDZ domain (PDZ_2)

(296-392)

Peptidase family M50 (Peptidase_M50)

(250-396)

Trypsin-like peptidase domain (Trypsin_2)

(108-253)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q66RU3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mitis NCTC 12261

56.283

93.627

0.527
  htrA Streptococcus gordonii str. Challis substr. CH1

54.476

95.833

0.522
  htrA Streptococcus pneumoniae D39

58.309

84.069

0.49
  htrA Streptococcus pneumoniae TIGR4

58.309

84.069

0.49
  htrA Streptococcus pneumoniae R6

58.309

84.069

0.49
  htrA Streptococcus pneumoniae Rx1

58.309

84.069

0.49
  htrA Streptococcus mutans UA159

52.989

90.196

0.478