Detailed information    

insolico Bioinformatically predicted

Overview

Name   comEA/celA/cilE   Type   Machinery gene
Locus tag   R4699_RS04735 Genome accession   NZ_CP137105
Coordinates   936663..937313 (-) Length   216 a.a.
NCBI ID   WP_000387336.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain 16H2092     
Function   dsDNA binding to the cell surface (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 931663..942313
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R4699_RS04715 - 932268..933449 (-) 1182 WP_000655951.1 membrane protein -
  R4699_RS04720 - 933453..934040 (-) 588 WP_000933542.1 ATP-binding cassette domain-containing protein -
  R4699_RS04725 - 934072..934260 (-) 189 WP_001809102.1 hypothetical protein -
  R4699_RS04730 comEC/celB 934439..936679 (-) 2241 WP_317786088.1 DNA internalization-related competence protein ComEC/Rec2 Machinery gene
  R4699_RS04735 comEA/celA/cilE 936663..937313 (-) 651 WP_000387336.1 ComEA family DNA-binding protein Machinery gene
  R4699_RS04740 - 937381..937950 (-) 570 WP_000443744.1 GNAT family N-acetyltransferase -
  R4699_RS04745 ald 938127..939238 (+) 1112 Protein_923 alanine dehydrogenase -
  R4699_RS04750 - 939539..939865 (-) 327 Protein_924 TfoX/Sxy family protein -
  R4699_RS04755 - 939868..940368 (-) 501 WP_000566988.1 GNAT family N-acetyltransferase -
  R4699_RS04760 - 940561..941529 (-) 969 WP_000658183.1 PhoH family protein -
  R4699_RS04765 - 941615..941830 (-) 216 WP_001232082.1 YozE family protein -

Sequence

Protein


Download         Length: 216 a.a.        Molecular weight: 23189.54 Da        Isoelectric Point: 5.5171

>NTDB_id=895480 R4699_RS04735 WP_000387336.1 936663..937313(-) (comEA/celA/cilE) [Streptococcus pneumoniae strain 16H2092]
MEAIIEKIKEYKIIVICTGLGLLVGGFFLLKPAPQTPVKETNLQAEVAAVSKDLVSEKEVNKEEKEEPVEQDLITVDVKG
AVKSPGIYDLPVGSRVNDAVQKAGGLTEQADSKSLNLAQKVSDEALVYVPTKGEEAVSQQTGSGTASSISKEKKVNLNKA
SLEELKQVKGLGGKRAQDIIDHREANGKFKSVDELKKVSGIGGKTIEKLKDYVTVD

Nucleotide


Download         Length: 651 bp        

>NTDB_id=895480 R4699_RS04735 WP_000387336.1 936663..937313(-) (comEA/celA/cilE) [Streptococcus pneumoniae strain 16H2092]
ATGGAAGCAATTATCGAGAAAATCAAAGAGTATAAAATCATCGTCATCTGTACTGGTCTGGGCTTGCTTGTAGGCGGATT
TTTCCTGCTAAAGCCAGCTCCACAAACACCTGTAAAGGAAACGAATTTGCAGGCTGAAGTTGCAGCTGTTTCCAAGGATT
TGGTATCCGAAAAGGAAGTGAACAAGGAAGAGAAGGAAGAACCAGTTGAACAAGATCTAATCACAGTAGATGTCAAAGGT
GCTGTCAAATCGCCAGGGATTTATGACTTGCCTGTAGGTAGTCGAGTCAATGATGCTGTTCAGAAGGCTGGTGGCTTGAC
AGAGCAAGCAGACAGCAAGTCGCTCAATCTAGCTCAGAAAGTTAGTGATGAGGCTCTGGTTTACGTTCCTACTAAGGGAG
AAGAAGCAGTTAGTCAACAGACTGGTTCGGGGACAGCTTCTTCAATAAGCAAGGAAAAGAAGGTCAATCTCAACAAGGCC
AGTCTGGAAGAACTCAAGCAGGTCAAGGGACTGGGAGGAAAACGAGCTCAGGACATTATCGACCATCGTGAGGCAAATGG
CAAGTTCAAGTCAGTAGACGAGCTCAAGAAGGTCTCTGGCATTGGTGGCAAAACAATAGAAAAGCTTAAAGACTATGTTA
CAGTGGATTAA

Domains

Predicted by InterproScan.

SLBB domain (SLBB)

(76-126)

Helix-hairpin-helix motif (HHH_3)

(151-214)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comEA/celA/cilE Streptococcus pneumoniae Rx1

99.074

100

0.991
  comEA/celA/cilE Streptococcus pneumoniae D39

99.074

100

0.991
  comEA/celA/cilE Streptococcus pneumoniae R6

99.074

100

0.991
  comEA/celA/cilE Streptococcus pneumoniae TIGR4

97.222

100

0.972
  comEA/celA/cilE Streptococcus mitis NCTC 12261

95.833

100

0.958
  comEA/celA/cilE Streptococcus mitis SK321

91.204

100

0.912
  comEA Lactococcus lactis subsp. cremoris KW2

43.612

100

0.458
  comEA Bacillus subtilis subsp. subtilis str. 168

41.579

87.963

0.366
  comEA Latilactobacillus sakei subsp. sakei 23K

33.476

100

0.361