Detailed information NTG0880117

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: RJW56_RS05640
• Genome accession: NZ_CP134472
• Coordinates: 1153958..1154629 (+)
• Length: 223 a.a.
• NCBI ID: WP_024385291.1
• Uniprot ID: A0A116K182
• Organism: Streptococcus suis strain 1522228
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1148958..1159629

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
RJW56_RS05610 (RJW56_05610)	pstC	1149186..1150103 (+)	918	WP_002937619.1	phosphate ABC transporter permease subunit PstC	-
RJW56_RS05615 (RJW56_05615)	pstA	1150093..1150980 (+)	888	WP_002937616.1	phosphate ABC transporter permease PstA	-
RJW56_RS05620 (RJW56_05620)	pstB	1151005..1151808 (+)	804	WP_002937615.1	phosphate ABC transporter ATP-binding protein PstB	-
RJW56_RS05625 (RJW56_05625)	pstB	1151820..1152578 (+)	759	Protein_1066	phosphate ABC transporter ATP-binding protein PstB	-
RJW56_RS05630 (RJW56_05630)	phoU	1152607..1153263 (+)	657	WP_024394630.1	phosphate signaling complex protein PhoU	-
RJW56_RS10935	-	1153429..1153764 (+)	336	Protein_1068	hypothetical protein	-
RJW56_RS05640 (RJW56_05640)	ciaR	1153958..1154629 (+)	672	WP_024385291.1	response regulator transcription factor	Regulator
RJW56_RS05645 (RJW56_05645)	ciaH	1154622..1156001 (+)	1380	WP_024394629.1	cell wall metabolism sensor histidine kinase WalK	Regulator
RJW56_RS05650 (RJW56_05650)	-	1156325..1157554 (+)	1230	WP_024394628.1	transglutaminase domain-containing protein	-
RJW56_RS05655 (RJW56_05655)	rpsT	1157816..1158064 (-)	249	WP_012027069.1	30S ribosomal protein S20	-
RJW56_RS05660 (RJW56_05660)	coaA	1158123..1159043 (-)	921	WP_024381359.1	type I pantothenate kinase	-

Sequence

Protein

• Length: 223 a.a.
• Molecular weight: 25231.80 Da
• Isoelectric Point: 4.2183

>NTDB_id=880117 RJW56_RS05640 WP_024385291.1 1153958..1154629(+) (ciaR) [Streptococcus suis strain 1522228]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGEEGVYEAETGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLITTA
KESLEDKGHGFELGADDYLTKPFYLEELKMRIQALLKRAGKFNENTLTYGDVTVDLSTNSTTVNGEEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTTFGENLQTLRSVGYILKNA

Nucleotide

• Length: 672 bp

>NTDB_id=880117 RJW56_RS05640 WP_024385291.1 1153958..1154629(+) (ciaR) [Streptococcus suis strain 1522228]
ATGATTAAAATATTGTTAGTGGAAGATGATTTAAGTCTATCAAATTCTGTTTTCGATTTCTTAGATGATTTTGCGGATGT
TATGCAGGTTTTTGATGGTGAAGAGGGCGTTTATGAGGCGGAAACAGGCGTTTATGATTTGATTCTTTTGGATTTAATGT
TGCCTGAAAAAGATGGCTTCCAAGTTTTGAAAGAATTACGTGAAAAAGGTGTTACGACACCTGTTCTGATTACAACAGCC
AAGGAAAGTCTAGAGGATAAAGGCCATGGTTTTGAATTGGGGGCTGATGACTATTTGACGAAACCGTTTTATTTAGAAGA
ATTGAAGATGCGAATTCAAGCTCTATTAAAACGAGCGGGTAAGTTTAATGAAAACACACTAACTTATGGGGACGTGACCG
TTGACTTATCGACAAACTCTACAACTGTAAATGGCGAAGAAGTTGAATTGCTAGGAAAAGAATTCGATCTACTAGTCTAC
TTCTTGCAAAATCAAAATGTTATCTTACCAAAAACTCAAATTTTTGACCGTATTTGGGGATTTGACAGTGACACTACTAT
TTCAGTAGTAGAAGTATATGTTTCTAAAATTAGGAAAAAGTTGAAAGGAACGACCTTCGGGGAAAATCTTCAAACCCTGC
GTAGTGTCGGGTACATTCTAAAAAATGCCTAA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

• Response regulator receiver domain (Response_reg) (4-112)

3D structure

• AlphaFold DB: A0A116K182

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	90.135	100	0.901
ciaR	Streptococcus pneumoniae Rx1	88.789	100	0.888
ciaR	Streptococcus pneumoniae D39	88.789	100	0.888
ciaR	Streptococcus pneumoniae R6	88.789	100	0.888
ciaR	Streptococcus pneumoniae TIGR4	88.789	100	0.888
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.053	100	0.386
vicR	Streptococcus mutans UA159	35.47	100	0.372
covR	Streptococcus salivarius strain HSISS4	36.283	100	0.368