Detailed information NTG0840577

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: VKP40_RS01195
• Genome accession: NZ_CP142355
• Coordinates: 214974..215714 (+)
• Length: 246 a.a.
• NCBI ID: WP_002986100.1
• Uniprot ID: A0A0H2UT50
• Organism: Streptococcus pyogenes strain A946
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 209974..220714

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
VKP40_RS01180 (VKP40_01180)	gltX	210504..211949 (+)	1446	WP_002986105.1	glutamate--tRNA ligase	-
VKP40_RS01185 (VKP40_01185)	-	212344..213690 (+)	1347	WP_002991186.1	sensor histidine kinase	-
VKP40_RS01190 (VKP40_01190)	-	213687..214970 (+)	1284	WP_002986102.1	sensor histidine kinase	-
VKP40_RS01195 (VKP40_01195)	comE/blpR	214974..215714 (+)	741	WP_002986100.1	response regulator transcription factor	Regulator
VKP40_RS01200 (VKP40_01200)	-	216281..217414 (+)	1134	WP_000564846.1	ISAs1-like element IS1548 family transposase	-
VKP40_RS01205 (VKP40_01205)	rnpA	217579..217938 (+)	360	WP_002992035.1	ribonuclease P protein component	-
VKP40_RS01210 (VKP40_01210)	-	217904..218731 (+)	828	WP_010921871.1	YidC/Oxa1 family membrane protein insertase	-
VKP40_RS01215 (VKP40_01215)	jag	218743..219657 (+)	915	WP_011284488.1	RNA-binding cell elongation regulator Jag/EloR	-
VKP40_RS01220 (VKP40_01220)	rpmH	219972..220106 (+)	135	WP_002885866.1	50S ribosomal protein L34	-

Sequence

Protein

• Length: 246 a.a.
• Molecular weight: 28881.47 Da
• Isoelectric Point: 6.4841

>NTDB_id=840577 VKP40_RS01195 WP_002986100.1 214974..215714(+) (comE/blpR) [Streptococcus pyogenes strain A946]
MMNIFILEDDFIQQTRIESIVVGILKETRIPCNQLEVFSTPQKLFESIQERGDHQLYFLDIEIGEYTRCGLELAAAIRQK
DPNAVIVFVTTHSEFAPISFKYKVSALDFIDKAGGQKQFKEQIEECIRYTYDMMSSRESKDMFLFETPQTRLKLPYKDIL
YFATATTPHKVCLWTQTERLEFYGNLSEIQAVAPKLFLCHRSYLVNLDKVVRIDKSKQLLYFENGDSCMVSRLKMKCLFE
RWEALR

Nucleotide

• Length: 741 bp

>NTDB_id=840577 VKP40_RS01195 WP_002986100.1 214974..215714(+) (comE/blpR) [Streptococcus pyogenes strain A946]
ATGATGAACATTTTTATTCTTGAGGATGATTTTATCCAGCAGACACGCATAGAATCTATCGTAGTAGGCATCTTAAAAGA
GACTAGAATACCATGTAATCAGCTTGAAGTGTTCTCGACTCCTCAAAAATTATTTGAGAGTATCCAAGAAAGAGGAGACC
ATCAGCTGTATTTTTTAGATATTGAAATTGGTGAATATACTCGTTGTGGGCTTGAATTAGCTGCAGCTATTCGACAAAAA
GACCCTAATGCCGTTATTGTGTTTGTCACCACTCATTCAGAATTTGCTCCTATTTCTTTTAAATATAAGGTATCCGCTCT
AGATTTTATTGATAAAGCAGGTGGTCAAAAACAGTTTAAAGAACAAATCGAAGAATGTATCCGATATACTTACGATATGA
TGTCTAGTCGTGAGTCAAAGGACATGTTTTTATTTGAGACTCCACAGACAAGATTAAAATTGCCCTATAAGGATATTTTA
TACTTTGCTACAGCCACAACTCCTCACAAAGTTTGTTTATGGACTCAGACAGAAAGATTAGAGTTTTATGGTAATCTATC
TGAGATTCAAGCAGTAGCACCGAAACTTTTTTTGTGCCATAGATCCTACCTTGTGAATCTAGATAAGGTTGTTCGAATTG
ATAAGAGTAAGCAGCTCCTTTATTTCGAAAATGGTGATTCTTGTATGGTATCACGGTTAAAAATGAAATGTCTGTTTGAA
CGGTGGGAGGCCCTTCGCTAA

Domains

Predicted by InterProScan.

• LytTr DNA-binding domain (LytTR) (152-242)

• Response regulator receiver domain (Response_reg) (4-123)

3D structure

• AlphaFold DB: A0A0H2UT50

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	46.862	97.154	0.455
comE/comE1	Streptococcus equinus JB1	41.597	96.748	0.402
comE/comE2	Streptococcus equinus JB1	39.431	100	0.394
comE	Streptococcus pneumoniae Rx1	38.525	99.187	0.382
comE	Streptococcus pneumoniae D39	38.525	99.187	0.382
comE	Streptococcus pneumoniae R6	38.525	99.187	0.382
comE	Streptococcus pneumoniae TIGR4	38.525	99.187	0.382
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	37.903	100	0.382
comE/comE2	Streptococcus gordonii strain NCTC7865	37.903	100	0.382
comE	Streptococcus mitis NCTC 12261	37.759	97.967	0.37
comE	Streptococcus mitis SK321	37.759	97.967	0.37