Detailed information    

insolico Bioinformatically predicted

Overview

Name   comGB/cglB   Type   Machinery gene
Locus tag   R8559_RS10375 Genome accession   NZ_AP026926
Coordinates   1962846..1963862 (-) Length   338 a.a.
NCBI ID   WP_073177425.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain PZ900700119     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1957846..1968862
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R8559_RS10335 (PC0116_20180) - 1958256..1958492 (-) 237 WP_001157069.1 hypothetical protein -
  R8559_RS10340 (PC0116_20190) - 1958566..1958691 (+) 126 WP_257885839.1 hypothetical protein -
  R8559_RS10345 (PC0116_20200) - 1958684..1958983 (-) 300 WP_191855094.1 hypothetical protein -
  R8559_RS10350 (PC0116_20210) - 1959058..1959333 (-) 276 WP_050202804.1 hypothetical protein -
  R8559_RS10355 (PC0116_20220) - 1959494..1960246 (+) 753 WP_219566337.1 XRE family transcriptional regulator -
  R8559_RS10360 (PC0116_20230) - 1960248..1961012 (+) 765 WP_219576745.1 hypothetical protein -
  R8559_RS10365 (PC0116_20240) - 1961319..1962764 (+) 1446 WP_317638087.1 recombinase family protein -
  R8559_RS10375 (PC0116_20250) comGB/cglB 1962846..1963862 (-) 1017 WP_073177425.1 competence type IV pilus assembly protein ComGB Machinery gene
  R8559_RS10380 (PC0116_20260) comGA/cglA/cilD 1963810..1964751 (-) 942 WP_000249559.1 competence type IV pilus ATPase ComGA Machinery gene
  R8559_RS10385 (PC0116_20270) - 1964827..1965192 (-) 366 WP_000286415.1 DUF1033 family protein -
  R8559_RS10390 (PC0116_20280) - 1965459..1966714 (+) 1256 WP_370657740.1 ISL3 family transposase -
  R8559_RS10395 (PC0116_20290) - 1966763..1967821 (-) 1059 WP_000649468.1 zinc-dependent alcohol dehydrogenase family protein -

Sequence

Protein


Download         Length: 338 a.a.        Molecular weight: 38420.45 Da        Isoelectric Point: 9.4802

>NTDB_id=82858 R8559_RS10375 WP_073177425.1 1962846..1963862(-) (comGB/cglB) [Streptococcus pneumoniae strain PZ900700119]
MDISQVFRLRRKKLATAKQKNIITLFNNLFSSGFHLVETISFLDRSALLDKQCVIQMRAGLSQGKSFSEMMESLGCSSTI
VTQLSLAEVHGNLHLSLGKIEEYLDNLAKVKKKLIEVATYPLILLGFLLLIMLGLRNYLLPQLDSSNIATQIIGNLPQIF
LGMVGLVSVLALLALTFYKRSSKMSVFSILARLPFIGIFVQTYLTAYYAREWGNMISQGMELTQIFQMMQEQGSQLFKEI
GQDLAQTLKNGREFSQTIGTYPFFRKELSLIIEYGEVKSKLGSELEIYAEKTWEAFFTRVNRTMNLVQPLVFIFVALIIV
LLYAAMLMPMYQNMEVNF

Nucleotide


Download         Length: 1017 bp        

>NTDB_id=82858 R8559_RS10375 WP_073177425.1 1962846..1963862(-) (comGB/cglB) [Streptococcus pneumoniae strain PZ900700119]
ATGGACATATCACAAGTCTTCAGGCTGAGACGGAAAAAATTAGCTACAGCTAAGCAAAAAAATATCATCACCCTATTTAA
CAATCTCTTTTCTAGCGGTTTTCATCTGGTGGAGACTATCTCCTTTTTAGATAGGAGTGCTTTGTTGGACAAGCAGTGTG
TGATCCAGATGCGTGCGGGCTTGTCTCAAGGGAAATCATTCTCAGAAATGATGGAAAGTTTGGGATGTTCAAGTACCATT
GTCACTCAGTTATCCCTAGCCGAAGTTCATGGAAATCTCCACCTGAGTTTGGGAAAGATAGAAGAATATCTGGACAATCT
GGCTAAGGTCAAGAAAAAATTAATTGAAGTAGCGACCTATCCTTTGATTTTGCTGGGTTTTCTTCTCTTAATTATGCTGG
GGCTACGGAATTACCTGCTCCCACAACTGGATAGTAGCAATATTGCCACCCAAATTATCGGTAATCTGCCCCAAATTTTT
CTAGGCATGGTAGGGCTTGTTTCCGTGCTTGCCCTTTTAGCACTAACTTTTTATAAAAGAAGTTCTAAGATGAGTGTCTT
TTCTATCTTAGCACGCCTTCCCTTTATTGGAATCTTTGTGCAGACCTACTTGACAGCCTATTATGCACGTGAATGGGGGA
ATATGATTTCACAGGGAATGGAGCTGACGCAGATTTTTCAAATGATGCAGGAACAAGGTTCCCAGCTCTTTAAAGAAATC
GGTCAAGATCTGGCTCAAACCCTGAAAAATGGCCGTGAATTTTCTCAGACGATAGGAACCTATCCTTTCTTTAGGAAGGA
ATTGAGTCTCATCATAGAGTATGGGGAAGTTAAGTCCAAGCTGGGTAGTGAGTTGGAAATCTATGCTGAAAAAACTTGGG
AAGCCTTTTTTACCCGAGTCAACCGCACCATGAATTTGGTGCAGCCACTGGTTTTTATCTTTGTGGCACTGATTATCGTT
TTACTTTATGCGGCAATGCTCATGCCCATGTATCAAAATATGGAGGTAAATTTTTAA

Domains

Predicted by InterProScan.

Type II secretion system (T2SS), protein F (T2SSF)

(209-329)

Type II secretion system (T2SS), protein F (T2SSF)

(24-141)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comGB/cglB Streptococcus pneumoniae Rx1

98.817

100

0.988
  comGB/cglB Streptococcus pneumoniae D39

98.817

100

0.988
  comGB/cglB Streptococcus pneumoniae R6

98.817

100

0.988
  comGB/cglB Streptococcus pneumoniae TIGR4

98.817

100

0.988
  comGB/cglB Streptococcus mitis SK321

94.97

100

0.95
  comGB/cglB Streptococcus mitis NCTC 12261

94.675

100

0.947
  comGB Streptococcus gordonii str. Challis substr. CH1

71.131

99.408

0.707
  comGB Streptococcus mutans UA140

57.862

94.083

0.544
  comGB Streptococcus mutans UA159

57.862

94.083

0.544
  comGB Lactococcus lactis subsp. cremoris KW2

50.898

98.817

0.503

Multiple sequence alignment