Detailed information NTG0797917

Bioinformatically predicted

Overview

• Name: pepF
• Type: Regulator
• Locus tag: P0D81_RS04760
• Genome accession: NZ_CP119159
• Coordinates: 918010..919821 (+)
• Length: 603 a.a.
• NCBI ID: WP_002387169.1
• Uniprot ID: A0A855UCR5
• Organism: Enterococcus faecalis strain GENOMIC22-006
• Function: degradation of XIP; competence shut-off (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
ICE	906214..926881	918010..919821	within	0

Gene organization within MGE regions

Location: 906214..926881

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
P0D81_RS04705 (P0D81_04705)	trpS	906807..907817 (-)	1011	WP_002378619.1	tryptophan--tRNA ligase	-
P0D81_RS04710 (P0D81_04710)	-	908171..909364 (-)	1194	WP_010706472.1	site-specific integrase	-
P0D81_RS04715 (P0D81_04715)	-	909443..909646 (-)	204	WP_002607397.1	excisionase	-
P0D81_RS04720 (P0D81_04720)	-	909646..910656 (-)	1011	WP_009274733.1	replication initiation factor domain-containing protein	-
P0D81_RS04725 (P0D81_04725)	-	911227..911898 (+)	672	WP_002322214.1	helix-turn-helix transcriptional regulator	-
P0D81_RS04730 (P0D81_04730)	-	912209..912688 (+)	480	WP_002322212.1	MGMT family protein	-
P0D81_RS04735 (P0D81_04735)	dfrF	912996..913490 (+)	495	WP_002322211.1	trimethoprim-resistant dihydrofolate reductase DfrF	-
P0D81_RS04740 (P0D81_04740)	-	913960..915132 (+)	1173	WP_000195429.1	IS256-like element IS256 family transposase	-
P0D81_RS04745 (P0D81_04745)	spxA	915292..915690 (+)	399	WP_002356477.1	transcriptional regulator SpxA	-
P0D81_RS04750 (P0D81_04750)	-	916032..916694 (+)	663	WP_002356478.1	adaptor protein MecA	-
P0D81_RS04755 (P0D81_04755)	-	916784..917962 (+)	1179	WP_002387170.1	competence protein CoiA family protein	-
P0D81_RS04760 (P0D81_04760)	pepF	918010..919821 (+)	1812	WP_002387169.1	oligoendopeptidase F	Regulator
P0D81_RS04765 (P0D81_04765)	-	919913..920572 (-)	660	WP_002368840.1	ClpXP adapter SpxH family protein	-
P0D81_RS04770 (P0D81_04770)	-	920636..921214 (-)	579	WP_002356483.1	CYTH domain-containing protein	-
P0D81_RS04775 (P0D81_04775)	-	921411..922085 (+)	675	WP_002356484.1	GTP pyrophosphokinase family protein	-
P0D81_RS04780 (P0D81_04780)	-	922098..922895 (+)	798	WP_002356486.1	NAD kinase	-
P0D81_RS04785 (P0D81_04785)	-	922903..923796 (+)	894	WP_002356487.1	RluA family pseudouridine synthase	-
P0D81_RS04790 (P0D81_04790)	mgtE	923827..925188 (+)	1362	WP_002362548.1	magnesium transporter	-
P0D81_RS04795 (P0D81_04795)	cutC	925306..925935 (-)	630	WP_002356490.1	copper homeostasis protein CutC	-

Sequence

Protein

• Length: 603 a.a.
• Molecular weight: 68848.16 Da
• Isoelectric Point: 4.6861

>NTDB_id=797917 P0D81_RS04760 WP_002387169.1 918010..919821(+) (pepF) [Enterococcus faecalis strain GENOMIC22-006]
MSEIKQLPTRDEVPTPLTWDLTKIFKDDAAFDVAYNQLIEELNQAESFKGTLGDGAEAFLAALEYVLDVYRKVETLYVYS
HLKNDQDTTNTAYQALYARASSLYAQVSEAVSWFDPEVLTLSDEQIWGYFEEQPKLAVYRHYIQNILDERPHVLSMEQEA
LLAGASEIFGASSNTFSILNNADLEFPTVQNAEGETIQLSHGVYGQLMESVDPSVREAAFKGLYKVYKQFRNTLASTLGA
HVKTHNYKAKIRNYDSARAASLASNHIPESVHETLVAVVNKHLPLLHRYVKLRKKLLNVEELHMYDLYAPLLGEAPIRYS
YEEAKEKAIEALKPLGEDYLSIVKEAFSSRWIDVIENQGKRSGAYSSGAYDTAPYILMNWHDSLDQLFTLVHEMGHSVHS
YYTRNNQPYVYGDYSIFLAEIASTTNENILTEYLLQTETDPKVRAYVLNHYLDGFKGTIFRQTQFAEFEHFIHTEDAKGT
PLTSEYLSEYYGELNAKYYGPEVVRDEEISYEWARIPHFYYNYYVYQYATGFSAASALSKHILAGEEGALENYLNYLKAG
SSDFPIEVMKKAGVDMTQAAYIEDAMKVFEERLTELEALVEKL

Nucleotide

• Length: 1812 bp

>NTDB_id=797917 P0D81_RS04760 WP_002387169.1 918010..919821(+) (pepF) [Enterococcus faecalis strain GENOMIC22-006]
ATGAGCGAAATTAAACAATTACCAACACGTGATGAAGTTCCAACTCCATTGACTTGGGATTTAACCAAAATTTTTAAAGA
TGATGCTGCTTTTGATGTTGCGTATAATCAGTTGATAGAAGAGCTAAATCAAGCAGAATCATTTAAAGGTACCTTAGGGG
ATGGTGCAGAAGCTTTTCTAGCTGCGTTAGAATACGTTTTAGATGTCTATCGAAAAGTGGAAACATTATATGTCTATTCT
CATTTAAAAAATGATCAAGACACTACAAATACAGCTTACCAAGCTTTATATGCCAGAGCTAGTTCTTTATATGCACAAGT
TAGTGAAGCTGTTTCTTGGTTTGACCCAGAGGTTTTAACATTAAGTGATGAACAAATCTGGGGATATTTTGAAGAGCAGC
CGAAATTAGCTGTTTATCGTCACTATATTCAAAATATTTTAGATGAACGTCCCCATGTTTTATCGATGGAACAAGAAGCT
TTACTGGCGGGGGCTAGTGAAATTTTTGGTGCCTCAAGTAATACATTTTCAATTTTAAATAATGCAGACTTAGAATTTCC
AACTGTGCAAAATGCTGAAGGCGAAACGATTCAACTTTCTCATGGCGTTTATGGTCAGTTAATGGAAAGTGTCGATCCAT
CTGTTCGTGAAGCAGCATTTAAAGGTTTGTACAAAGTATACAAACAATTTAGAAATACATTAGCCTCAACTTTAGGTGCA
CATGTTAAAACACATAATTATAAAGCAAAAATTAGAAATTATGATTCTGCTCGAGCAGCCTCTTTAGCAAGTAATCATAT
CCCTGAAAGTGTTCACGAAACATTAGTAGCTGTAGTAAATAAACATTTACCTTTGCTACATCGTTATGTAAAATTAAGAA
AAAAATTATTAAACGTAGAAGAATTACACATGTACGACTTGTATGCGCCTTTGCTAGGTGAAGCACCAATTCGTTACAGC
TATGAAGAAGCAAAAGAAAAAGCAATTGAGGCTTTAAAACCACTAGGTGAAGACTATTTATCTATTGTTAAAGAAGCTTT
TTCAAGTCGCTGGATTGATGTGATTGAAAATCAAGGAAAACGAAGCGGCGCATATTCTTCAGGAGCTTATGATACAGCCC
CATACATTTTAATGAATTGGCATGATAGTTTGGATCAACTATTTACATTAGTCCATGAGATGGGCCATAGTGTTCATAGT
TACTATACAAGAAATAATCAGCCGTATGTTTATGGCGACTATTCAATTTTCTTAGCTGAGATTGCTTCAACCACAAATGA
AAATATTTTAACAGAATATTTATTACAAACAGAAACAGATCCTAAAGTACGTGCGTATGTCTTAAATCACTATTTAGACG
GCTTTAAGGGAACCATTTTCCGTCAAACGCAATTTGCGGAATTTGAACATTTTATTCACACGGAAGATGCTAAAGGCACG
CCATTAACAAGTGAATATTTGAGTGAGTATTATGGCGAGCTCAATGCTAAATATTATGGACCAGAAGTAGTTAGAGACGA
AGAAATCAGTTACGAATGGGCGAGAATTCCACATTTTTATTACAATTACTATGTTTATCAATATGCAACTGGCTTCTCAG
CCGCTTCGGCATTGTCTAAACATATTTTAGCTGGAGAAGAGGGAGCTTTAGAGAATTATCTTAACTACTTGAAAGCAGGA
AGTAGTGACTTCCCAATTGAAGTGATGAAAAAAGCGGGCGTGGATATGACACAAGCCGCGTATATCGAAGATGCAATGAA
AGTTTTTGAAGAACGTTTAACGGAATTAGAAGCTTTGGTTGAAAAATTATAG

Domains

Predicted by InterproScan.

• Peptidase family M3 (Peptidase_M3) (207-587)

• Oligopeptidase F (Peptidase_M3_N) (117-186)

3D structure

• AlphaFold DB: A0A855UCR5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
pepF	Streptococcus salivarius strain HSISS4	54.806	98.342	0.539