Detailed information NTG0778753

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: PHA78_RS01270
• Genome accession: NZ_CP116604
• Coordinates: 251733..253886 (-)
• Length: 717 a.a.
• NCBI ID: WP_024376267.1
• Uniprot ID: A0A116LDY3
• Organism: Streptococcus sp. HN38
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 246733..258886

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
PHA78_RS01240	-	246899..247204 (+)	306	WP_044672279.1	hypothetical protein	-
PHA78_RS01245	-	247495..247836 (+)	342	WP_024378069.1	LytTR family DNA-binding domain-containing protein	-
PHA78_RS01250	comE/blpR	247836..248576 (+)	741	WP_024376264.1	response regulator transcription factor	Regulator
PHA78_RS01255	-	248586..249917 (+)	1332	WP_099780237.1	GHKL domain-containing protein	-
PHA78_RS01260	-	250115..250264 (-)	150	WP_079267743.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
PHA78_RS01265	-	250362..251723 (-)	1362	WP_024378067.1	bacteriocin secretion accessory protein	-
PHA78_RS01270	comA/nlmT	251733..253886 (-)	2154	WP_024376267.1	peptide cleavage/export ABC transporter	Regulator
PHA78_RS01275	-	254191..254421 (+)	231	WP_024376268.1	bacteriocin class II family protein	-
PHA78_RS01280	-	254423..254614 (+)	192	WP_024376269.1	hypothetical protein	-
PHA78_RS01285	-	255117..255257 (+)	141	WP_153308671.1	hypothetical protein	-
PHA78_RS01290	-	255277..255417 (+)	141	WP_153308672.1	hypothetical protein	-
PHA78_RS01295	-	255432..256043 (+)	612	WP_024378066.1	type II CAAX endopeptidase family protein	-
PHA78_RS01300	-	256205..256501 (+)	297	WP_024376271.1	bacteriocin immunity protein	-
PHA78_RS01305	-	256645..257700 (+)	1056	WP_024378065.1	thioredoxin fold domain-containing protein	-
PHA78_RS01310	-	257700..258401 (+)	702	WP_272158359.1	type II CAAX endopeptidase family protein	-
PHA78_RS01315	-	258418..258564 (+)	147	WP_153308673.1	hypothetical protein	-

Sequence

Protein

• Length: 717 a.a.
• Molecular weight: 80422.53 Da
• Isoelectric Point: 7.3263

>NTDB_id=778753 PHA78_RS01270 WP_024376267.1 251733..253886(-) (comA/nlmT) [Streptococcus sp. HN38]
MTKIKKTFVPQIDARDCGVAALASIAKYYGSDYSLAHLRELAKTNKEGTTALGIVKAAHEMGFETRAIQADMSLFDMTDI
PYPFIVHVNKEGKLQHYYVVYKNLKDQVLIGDPDPTVKVTKMSKERFASEWTGVAIFLAPEPSYKPHKDKKNGLLDFLPL
IFQQRTLIFYIVLASLLVTLINIAGSYYLQGILDEYIPNQMKSTLGIISIGLIITYILQQMMTFSRDYLLTVLSQRLSID
VILSYIRHIFKLPMSFFATRRTGEVISRFTDANSIIDALASTILSLFLDVTILTIVGGVLLVQNTHLFLLSLISIPIYVV
IIFAFIKPFERMNNAVMQSNSMVSSAIIEDINGIETIKSLTSEEQRYQKIDSEFVDYLEKSFTLSKYSILQSTLKQGAQL
ILNITILWLGSQLVMTGKISIGQLITFNTLLSYFTNPLENIINLQTKLQSAKVANNRLNEVYLVESEFQEGQTLTDPSFL
KGVIQFEDVSYKYGFGRDTLSDIQLTIKEGDKVSLVGISGSGKTTLAKMIVNFFEPYKGRITLNHNDLKMVDKKVLRQYI
NYLPQQAYIFSGSILDNLTLGANQTISQEDILKACEIAEIRSDIEQMPMGYQTELSDGAGLSGGQKQRIALARALLTKAP
VLILDEATSGLDVLTEKKVIDNLMAMTDKTIIFVAHRLSISERTNQVIVLDQGKIIETGSHQELMSRGGFYHHLFSK

Nucleotide

• Length: 2154 bp

>NTDB_id=778753 PHA78_RS01270 WP_024376267.1 251733..253886(-) (comA/nlmT) [Streptococcus sp. HN38]
ATGACCAAGATAAAGAAAACCTTCGTCCCTCAGATAGATGCCCGAGATTGCGGAGTCGCTGCTCTCGCTTCTATCGCCAA
ATACTACGGCTCAGACTACTCCTTGGCCCACTTGCGAGAGTTAGCAAAGACTAATAAAGAAGGAACAACAGCCCTCGGTA
TCGTGAAAGCTGCACATGAAATGGGCTTTGAAACCAGGGCTATCCAAGCCGATATGAGCCTCTTTGATATGACTGATATT
CCTTATCCCTTCATTGTCCATGTCAATAAAGAGGGAAAACTCCAGCATTACTATGTGGTCTATAAAAATTTGAAAGATCA
GGTCCTCATTGGCGATCCCGACCCGACTGTAAAAGTTACCAAGATGAGCAAGGAGAGATTCGCTTCCGAATGGACAGGAG
TAGCCATCTTTCTTGCACCTGAACCGAGCTATAAACCGCACAAGGATAAGAAAAATGGTCTGCTCGACTTCCTTCCCCTC
ATCTTCCAACAACGAACACTTATCTTTTATATCGTTCTAGCCAGCTTACTCGTCACCCTCATCAACATTGCTGGCTCCTA
CTATCTGCAAGGGATTTTAGATGAATACATTCCAAACCAGATGAAATCCACTCTCGGCATCATCTCCATCGGACTGATTA
TCACCTATATTCTCCAGCAAATGATGACCTTCTCCAGAGACTACCTATTAACTGTTCTCAGTCAACGGCTCAGCATTGAT
GTCATTCTCTCCTATATCCGACATATCTTCAAACTCCCCATGTCCTTCTTTGCGACACGGCGAACAGGTGAAGTCATCTC
TCGTTTTACAGATGCCAACTCAATCATCGATGCCCTAGCCTCTACAATCCTCTCCCTCTTCCTAGATGTGACTATTTTAA
CCATTGTGGGCGGGGTCTTATTGGTACAAAACACGCACCTCTTCCTCCTCTCACTGATTTCAATCCCAATCTACGTGGTC
ATCATCTTTGCCTTTATCAAACCCTTTGAAAGAATGAACAACGCTGTTATGCAGAGTAATTCGATGGTAAGCTCTGCTAT
TATCGAAGATATCAATGGTATTGAGACCATTAAGTCATTGACAAGCGAAGAACAACGCTACCAAAAGATTGACAGCGAAT
TTGTGGATTATCTGGAAAAATCCTTTACCCTCAGCAAGTATTCGATCCTGCAATCCACTCTGAAGCAAGGAGCCCAGCTG
ATCCTCAACATTACTATTCTCTGGCTCGGCTCTCAACTAGTCATGACAGGAAAAATCTCTATCGGACAACTCATCACCTT
CAATACCCTCCTCTCTTACTTCACCAATCCCTTGGAAAATATCATCAACCTCCAGACCAAGCTCCAATCTGCCAAAGTTG
CCAACAATCGCCTTAATGAAGTCTACTTGGTTGAGTCAGAATTTCAAGAAGGACAGACCCTAACCGATCCAAGCTTCTTA
AAAGGAGTTATTCAGTTTGAAGATGTTTCCTATAAATACGGATTTGGACGAGACACCCTATCTGATATTCAACTGACCAT
CAAAGAAGGGGACAAGGTTAGTTTAGTCGGTATCAGTGGTTCTGGAAAAACAACACTAGCTAAAATGATTGTGAACTTTT
TTGAACCCTATAAGGGACGCATCACGCTCAATCATAACGATCTAAAAATGGTTGATAAGAAAGTCCTACGCCAATACATC
AACTACCTCCCCCAACAAGCCTATATCTTTAGTGGCTCTATCTTGGACAATCTGACTCTCGGTGCCAACCAAACTATCAG
TCAAGAGGATATCCTAAAAGCCTGTGAAATTGCAGAAATCCGCTCGGATATTGAACAGATGCCAATGGGCTATCAGACTG
AGCTTTCTGACGGAGCTGGTCTATCTGGCGGGCAAAAACAACGGATTGCTCTTGCACGAGCCCTCTTGACCAAGGCACCT
GTGCTTATACTGGATGAAGCGACTAGCGGGCTGGATGTTCTCACCGAAAAGAAAGTCATTGACAACCTCATGGCCATGAC
AGACAAAACCATTATCTTTGTTGCCCATCGTCTCAGCATTTCCGAACGTACCAACCAAGTCATTGTGCTGGACCAGGGCA
AGATTATTGAAACCGGCTCTCACCAAGAATTAATGTCTCGCGGCGGTTTCTATCACCATTTGTTCAGTAAGTAA

Domains

Predicted by InterproScan.

• ABC transporter (ABC_tran) (500-649)

• ABC transporter transmembrane region (ABC_membrane) (168-438)

• Peptidase C39 family (Peptidase_C39) (7-142)

3D structure

• AlphaFold DB: A0A116LDY3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	73.202	98.884	0.724
comA	Streptococcus mitis NCTC 12261	68.776	99.163	0.682
comA	Streptococcus mitis SK321	68.073	99.163	0.675
comA	Streptococcus pneumoniae Rx1	67.792	99.163	0.672
comA	Streptococcus pneumoniae D39	67.792	99.163	0.672
comA	Streptococcus pneumoniae R6	67.792	99.163	0.672
comA	Streptococcus pneumoniae TIGR4	67.511	99.163	0.669
comA	Streptococcus gordonii str. Challis substr. CH1	67.089	99.163	0.665