Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   OTB22_RS06800 Genome accession   NZ_CP113267
Coordinates   1337747..1338421 (-) Length   224 a.a.
NCBI ID   WP_000590640.1    Uniprot ID   D4I4V1
Organism   Streptococcus pneumoniae strain BC2     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1332747..1343421
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  OTB22_RS06785 (OTB22_06790) - 1335033..1335962 (-) 930 WP_000411857.1 peptidase U32 family protein -
  OTB22_RS06790 (OTB22_06795) - 1336102..1336389 (+) 288 WP_001145225.1 DUF3270 domain-containing protein -
  OTB22_RS06795 (OTB22_06800) ciaH 1336423..1337757 (-) 1335 WP_000491790.1 two-component system sensor histidine kinase CiaH Regulator
  OTB22_RS06800 (OTB22_06805) ciaR 1337747..1338421 (-) 675 WP_000590640.1 two-component system response regulator CiaR Regulator
  OTB22_RS06805 (OTB22_06810) - 1338530..1341076 (-) 2547 WP_001864895.1 M1 family metallopeptidase -
  OTB22_RS06810 (OTB22_06815) - 1341198..1341638 (-) 441 WP_000188806.1 ASCH domain-containing protein -
  OTB22_RS06815 (OTB22_06820) - 1341650..1341847 (-) 198 WP_050199109.1 hypothetical protein -
  OTB22_RS06820 (OTB22_06825) - 1342025..1343371 (-) 1347 WP_268217847.1 IS1380-like element ISSpn5 family transposase -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25466.29 Da        Isoelectric Point: 4.3283

>NTDB_id=761482 OTB22_RS06800 WP_000590640.1 1337747..1338421(-) (ciaR) [Streptococcus pneumoniae strain BC2]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLTYGNIVVNLSTNTVKVEDTPVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTTFAENLQTLRSVGYLLKDVQ

Nucleotide


Download         Length: 675 bp        

>NTDB_id=761482 OTB22_RS06800 WP_000590640.1 1337747..1338421(-) (ciaR) [Streptococcus pneumoniae strain BC2]
ATGATAAAAATCTTATTGGTTGAGGATGACCTAGGTCTGTCAAATTCAGTATTTGACTTTTTAGACGATTTTGCGGATGT
TATGCAGGTATTTGATGGAGAAGAAGGTCTCTACGAAGCTGAGAGTGGTGTCTATGACTTGATTTTGCTGGATTTGATGT
TGCCAGAAAAAAATGGTTTCCAAGTCTTAAAAGAATTGCGTGAAAAGGGAATTACGACACCAGTTCTGATTATGACTGCC
AAGGAAAGTTTGGATGACAAGGGACATGGATTTGAACTGGGAGCGGATGATTATCTGACCAAACCTTTCTACCTAGAAGA
ACTTAAAATGCGAATTCAGGCCCTTCTCAAACGTTCAGGGAAGTTTAATGAAAACACCTTGACTTATGGGAATATCGTGG
TTAATTTATCAACCAATACCGTTAAAGTTGAAGATACTCCTGTCGAATTGCTGGGGAAAGAGTTCGATTTACTAGTTTAT
TTCCTTCAAAATCAAAATGTGATTTTGCCTAAGACGCAGATTTTTGACCGTCTATGGGGATTTGATAGTGATACAACGAT
TTCGGTTGTCGAAGTCTATGTTTCAAAAGTCCGTAAGAAATTAAAGGGAACCACTTTTGCAGAGAATTTGCAAACCTTGC
GTAGTGTTGGGTATCTTTTAAAAGATGTTCAGTAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB D4I4V1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

100

100

1
  ciaR Streptococcus pneumoniae D39

100

100

1
  ciaR Streptococcus pneumoniae R6

100

100

1
  ciaR Streptococcus pneumoniae TIGR4

100

100

1
  ciaR Streptococcus mutans UA159

88.393

100

0.884
  covR Lactococcus lactis subsp. lactis strain DGCC12653

36.726

100

0.371
  vicR Streptococcus mutans UA159

35.622

100

0.371