Detailed information NTG0720515

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: NW979_RS09345
• Genome accession: NZ_CP102959
• Coordinates: 1941849..1942892 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 12-G-51
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1936849..1947892

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
NW979_RS09315 (NW979_09315)	-	1937271..1938527 (-)	1257	WP_001793428.1	aminopeptidase	-
NW979_RS09320 (NW979_09320)	-	1938530..1938730 (-)	201	WP_000180460.1	DUF1128 family protein	-
NW979_RS09325 (NW979_09325)	-	1938877..1939341 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
NW979_RS09330 (NW979_09330)	-	1939348..1939623 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
NW979_RS09335 (NW979_09335)	-	1939901..1941118 (+)	1218	WP_000037079.1	YihY/virulence factor BrkB family protein	-
NW979_RS09340 (NW979_09340)	vraR	1941230..1941859 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
NW979_RS09345 (NW979_09345)	vraS	1941849..1942892 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
NW979_RS09350 (NW979_09350)	liaF	1942889..1943590 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
NW979_RS09355 (NW979_09355)	-	1943605..1943991 (-)	387	WP_001110179.1	hypothetical protein	-
NW979_RS09360 (NW979_09360)	map	1944208..1944966 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
NW979_RS09365 (NW979_09365)	-	1945497..1946483 (+)	987	WP_258413450.1	aromatic acid exporter family protein	-
NW979_RS09370 (NW979_09370)	-	1946856..1947269 (-)	414	WP_258413856.1	hypothetical protein	-
NW979_RS09375 (NW979_09375)	-	1947298..1947408 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=720515 NW979_RS09345 WP_001017131.1 1941849..1942892(-) (vraS) [Staphylococcus aureus strain 12-G-51]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=720515 NW979_RS09345 WP_001017131.1 1941849..1942892(-) (vraS) [Staphylococcus aureus strain 12-G-51]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1