Detailed information NTG0717758

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: MGCS35957_RS10115
• Genome accession: NZ_CP117288
• Coordinates: 2018441..2019181 (-)
• Length: 246 a.a.
• NCBI ID: WP_003061418.1
• Uniprot ID: Q8KQN2
• Organism: Streptococcus dysgalactiae subsp. equisimilis strain MGCS35957
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 2013441..2024181

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MGCS35957_RS10090 (MGCS35957_04122)	-	2014340..2015044 (-)	705	WP_003056091.1	N-acetylmannosamine-6-phosphate 2-epimerase	-
MGCS35957_RS10095 (MGCS35957_04124)	rpmH	2015374..2015508 (-)	135	WP_002885866.1	50S ribosomal protein L34	-
MGCS35957_RS10100 (MGCS35957_04126)	jag	2015821..2016735 (-)	915	WP_003056081.1	RNA-binding cell elongation regulator Jag/EloR	-
MGCS35957_RS10105 (MGCS35957_04128)	-	2016747..2017574 (-)	828	WP_100249539.1	YidC/Oxa1 family membrane protein insertase	-
MGCS35957_RS10110 (MGCS35957_04130)	rnpA	2017540..2017899 (-)	360	WP_003056083.1	ribonuclease P protein component	-
MGCS35957_RS10115 (MGCS35957_04134)	comE/blpR	2018441..2019181 (-)	741	WP_003061418.1	LytTR family DNA-binding domain-containing protein	Regulator
MGCS35957_RS10120 (MGCS35957_04136)	-	2019185..2020468 (-)	1284	WP_084916681.1	sensor histidine kinase	-
MGCS35957_RS10125 (MGCS35957_04138)	-	2020469..2021812 (-)	1344	WP_015058070.1	GHKL domain-containing protein	-
MGCS35957_RS10130 (MGCS35957_04140)	gltX	2022427..2023875 (-)	1449	WP_014612594.1	glutamate--tRNA ligase	-

Sequence

Protein

• Length: 246 a.a.
• Molecular weight: 28977.28 Da
• Isoelectric Point: 4.8645

>NTDB_id=717758 MGCS35957_RS10115 WP_003061418.1 2018441..2019181(-) (comE/blpR) [Streptococcus dysgalactiae subsp. equisimilis strain MGCS35957]
MMNIFILEDDFIQQTRIESVVADILEEAKIPCNQLEVFANPHKLFESIQERGDHQLYFLDIEIGDEDRRGLELAADIRQK
DPNAVIVFVTTHSEFAPISFKYKVSALDFIDKAVDKQQFRDQIEECIRYTYEMMSSRESEDMFLFETPQTRLKLPYKDIL
YFATATTPHKVCLWTQTERLEFYGNLSEIQAVAPKLFLCHRSYLVNLDKVVRIDKSKQLLYFDNGDSCMVSRLKMKCLFE
KWEALH

Nucleotide

• Length: 741 bp

>NTDB_id=717758 MGCS35957_RS10115 WP_003061418.1 2018441..2019181(-) (comE/blpR) [Streptococcus dysgalactiae subsp. equisimilis strain MGCS35957]
ATGATGAATATTTTTATTCTTGAAGATGATTTTATCCAACAGACACGTATTGAATCTGTAGTGGCAGACATCTTGGAAGA
AGCTAAAATCCCTTGTAATCAGCTAGAAGTGTTTGCCAATCCTCATAAATTATTTGAAAGCATTCAAGAAAGAGGCGATC
ACCAGCTATATTTTTTAGACATTGAGATTGGTGATGAGGATCGCCGAGGGCTTGAATTGGCAGCAGATATTCGACAAAAA
GACCCCAATGCGGTCATTGTGTTTGTTACCACACATTCTGAATTTGCTCCTATTTCTTTTAAATACAAAGTGTCTGCCTT
AGATTTTATTGACAAAGCAGTTGATAAACAACAATTTAGGGATCAGATTGAAGAATGTATCCGCTATACCTATGAGATGA
TGTCTAGCCGAGAATCAGAAGACATGTTTTTATTTGAGACCCCTCAGACAAGGTTAAAATTACCTTACAAAGATATCCTT
TATTTTGCTACTGCTACGACACCCCACAAGGTGTGTTTGTGGACTCAGACGGAGAGACTGGAGTTTTATGGTAATTTATC
TGAGATACAAGCTGTGGCTCCAAAGCTTTTCTTATGCCATAGATCTTACTTGGTTAATCTAGATAAGGTTGTGCGTATTG
ATAAATCCAAACAGCTCCTCTATTTCGATAATGGGGATTCCTGTATGGTCTCACGCTTAAAAATGAAATGCCTTTTTGAA
AAATGGGAAGCCTTACATTAA

Domains

Predicted by InterProScan.

• Response regulator receiver domain (Response_reg) (4-123)

• LytTr DNA-binding domain (LytTR) (152-242)

3D structure

• AlphaFold DB: Q8KQN2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	47.699	97.154	0.463
comE/comE1	Streptococcus equinus JB1	42.437	96.748	0.411
comE/comE2	Streptococcus equinus JB1	40.408	99.593	0.402
comE/comE2	Streptococcus gordonii strain NCTC7865	39.113	100	0.394
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	39.113	100	0.394