Detailed information NTG0709654

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: NMJ60_RS10220
• Genome accession: NZ_CP101314
• Coordinates: 2047568..2048611 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain #492
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2042568..2053611

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
NMJ60_RS10190	-	2042989..2044245 (-)	1257	WP_001795108.1	aminopeptidase	-
NMJ60_RS10195	-	2044248..2044448 (-)	201	WP_000180460.1	DUF1128 family protein	-
NMJ60_RS10200	-	2044595..2045059 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
NMJ60_RS10205	-	2045066..2045341 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
NMJ60_RS10210	-	2045619..2046836 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
NMJ60_RS10215	vraR	2046949..2047578 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
NMJ60_RS10220	vraS	2047568..2048611 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
NMJ60_RS10225	liaF	2048608..2049309 (-)	702	WP_233231723.1	cell wall-active antibiotics response protein LiaF	-
NMJ60_RS10230	-	2049324..2049710 (-)	387	WP_001110179.1	hypothetical protein	-
NMJ60_RS10235	map	2049927..2050685 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
NMJ60_RS10240	-	2051216..2052202 (+)	987	WP_000999717.1	FUSC family protein	-
NMJ60_RS10245	-	2052633..2053046 (-)	414	WP_001557448.1	hypothetical protein	-
NMJ60_RS10250	-	2053075..2053185 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=709654 NMJ60_RS10220 WP_001017131.1 2047568..2048611(-) (vraS) [Staphylococcus aureus strain #492]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=709654 NMJ60_RS10220 WP_001017131.1 2047568..2048611(-) (vraS) [Staphylococcus aureus strain #492]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1