NTDB

Overview

Name	cclA/cilC	Type	Machinery gene
Locus tag	L1A11_RS08595	Genome accession	NZ_CP090881
Coordinates	1671089..1671748 (+)	Length	219 a.a.
NCBI ID	WP_000565024.1	Uniprot ID	A0A4J1XTA1
Organism	Streptococcus pneumoniae strain BR1268
Function	processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1666089..1676748

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
L1A11_RS08570 (L1A11_08570)	-	1666394..1666711 (-)	318	WP_001151646.1	PTS sugar transporter subunit IIB	-
L1A11_RS08575 (L1A11_08575)	-	1666726..1667622 (-)	897	WP_000825665.1	PEP phosphonomutase	-
L1A11_RS08580 (L1A11_08580)	-	1667625..1668887 (-)	1263	WP_000413345.1	PTS sugar transporter subunit IIC	-
L1A11_RS08585 (L1A11_08585)	-	1669167..1670345 (+)	1179	WP_000175878.1	ROK family transcriptional regulator	-
L1A11_RS08590 (L1A11_08590)	-	1670573..1671019 (-)	447	WP_000155412.1	GNAT family N-acetyltransferase	-
L1A11_RS08595 (L1A11_08595)	cclA/cilC	1671089..1671748 (+)	660	WP_000565024.1	A24 family peptidase	Machinery gene
L1A11_RS08600 (L1A11_08600)	-	1671800..1672951 (-)	1152	WP_000481758.1	XRE family transcriptional regulator	-
L1A11_RS08605 (L1A11_08605)	-	1672966..1673697 (-)	732	WP_000934017.1	hypothetical protein	-
L1A11_RS08610 (L1A11_08610)	-	1673926..1674027 (+)	102	Protein_1709	prepilin peptidase	-
L1A11_RS08615 (L1A11_08615)	trpA	1673999..1674775 (-)	777	WP_001127028.1	tryptophan synthase subunit alpha	-
L1A11_RS08620 (L1A11_08620)	trpB	1674768..1675991 (-)	1224	WP_074189428.1	tryptophan synthase subunit beta	-
L1A11_RS08625 (L1A11_08625)	-	1675969..1676568 (-)	600	WP_000169899.1	phosphoribosylanthranilate isomerase	-

Sequence

Protein

Download Length: 219 a.a. Molecular weight: 24951.16 Da Isoelectric Point: 8.2409

                                >NTDB_id=645544 L1A11_RS08595 WP_000565024.1 1671089..1671748(+) (cclA/cilC) [Streptococcus pneumoniae strain BR1268]

MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFRCRYCKVRYPVWYALFELVLG

LLFLLYSWKLLSLGQVVLITAGLTLGIYDFHHQEYPLLVWMTFHLILITSSGWNLVMVSFLILGILAHFIDIRMGAGDFL

FLASCALVFSVTELLILIQFASATGILAFILQKKKERLPFVPFLLLATCLIIFGKLLLV

Nucleotide

Download Length: 660 bp

                                >NTDB_id=645544 L1A11_RS08595 WP_000565024.1 1671089..1671748(+) (cclA/cilC) [Streptococcus pneumoniae strain BR1268]

ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA

ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC

AGGTCTTCAATCGCTTTCGCTGTCGCTACTGCAAAGTTCGCTATCCTGTCTGGTATGCCCTCTTTGAATTAGTCTTAGGA

CTCCTCTTTCTGCTTTACTCTTGGAAATTGCTTTCCTTGGGGCAAGTCGTCCTAATCACCGCTGGTTTGACCTTGGGTAT

CTACGACTTTCACCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAACTTCCTCTGGCTGGA

ATCTGGTCATGGTCTCCTTCCTCATACTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGCGCAGGGGATTTCCTC

TTTTTAGCTTCTTGTGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTTGCTTCTGCGACGGGTATCCT

GGCCTTTATCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTACTTGTTTGATTATTTTTG

GTAAGCTACTGCTTGTCTGA

Domains

Predicted by InterproScan.

Bacterial Peptidase A24 N-terminal domain (A24_N_bact)

(8-89)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	A0A4J1XTA1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
cclA/cilC	Streptococcus pneumoniae TIGR4	96.804	100	0.968
cclA/cilC	Streptococcus pneumoniae Rx1	95.434	100	0.954
cclA/cilC	Streptococcus pneumoniae D39	95.434	100	0.954
cclA/cilC	Streptococcus pneumoniae R6	95.434	100	0.954
cclA/cilC	Streptococcus mitis SK321	91.324	100	0.913
cclA/cilC	Streptococcus mitis NCTC 12261	85.388	100	0.854

Detailed information NTG0645544