Detailed information NTG0613799

Bioinformatically predicted

Overview

• Name: hexA
• Type: Machinery gene
• Locus tag: NPS17_RS09745
• Genome accession: NZ_CP101985
• Coordinates: 2044911..2047460 (-)
• Length: 849 a.a.
• NCBI ID: WP_002271567.1
• Uniprot ID: -
• Organism: Streptococcus mutans strain COCC33-14R
• Function: DNA mismatch repair (predicted from homology) Homologous recombination

Genomic Context

Location: 2039911..2052460

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
NPS17_RS09725 (NPS17_09725)	-	2041039..2041599 (-)	561	WP_258969005.1	DNA-3-methyladenine glycosylase I	-
NPS17_RS09730 (NPS17_09730)	ruvA	2041681..2042274 (-)	594	WP_002266975.1	Holliday junction branch migration protein RuvA	Machinery gene
NPS17_RS09735 (NPS17_09735)	hexB	2042458..2044413 (-)	1956	WP_258969006.1	DNA mismatch repair endonuclease MutL	Machinery gene
NPS17_RS09740 (NPS17_09740)	-	2044638..2044916 (+)	279	Protein_1873	transposase	-
NPS17_RS09745 (NPS17_09745)	hexA	2044911..2047460 (-)	2550	WP_002271567.1	DNA mismatch repair protein MutS	Machinery gene
NPS17_RS09750 (NPS17_09750)	-	2047453..2047800 (-)	348	WP_002264540.1	YlbF family regulator	-
NPS17_RS09755 (NPS17_09755)	argR	2047797..2048234 (-)	438	WP_002262400.1	arginine repressor	-
NPS17_RS09760 (NPS17_09760)	-	2048658..2049086 (-)	429	WP_226718080.1	cyclic nucleotide-binding domain-containing protein	-
NPS17_RS09765 (NPS17_09765)	-	2049163..2049801 (-)	639	Protein_1878	B3/4 domain-containing protein	-
NPS17_RS09770 (NPS17_09770)	-	2050009..2050479 (+)	471	Protein_1879	arginine repressor	-
NPS17_RS09775 (NPS17_09775)	argS	2050580..2052271 (+)	1692	WP_258969007.1	arginine--tRNA ligase	-

Sequence

Protein

• Length: 849 a.a.
• Molecular weight: 95234.54 Da
• Isoelectric Point: 4.9476

>NTDB_id=613799 NPS17_RS09745 WP_002271567.1 2044911..2047460(-) (hexA) [Streptococcus mutans strain COCC33-14R]
MTKEKLSPGMQQYLDIKKDYPDAFLLFRMGDFYELFYDDAIKAAQILEISLTSRNKNADNPIPMAGVPYHSAQQYIDVLI
DLGYKVAIAEQMEDPKKAVGVVKREVVQVITPGTVVDSTKPDSANNFLVSLDTDGSQFGLSYMDLSTGEFYATTLADLSA
VRSEVLNLKARELVIGFELSENEEQLFRKQMNLLLSFEKTVYDDVHLLDDQLKAIELAAAGKLLQYVHNTQKRELSHLQK
LVHYEIKDYLQMAYATKSSLDLLENARSGKKHGSLYWLLDETKTAMGTRLLRTWIDRPLVSSSLISKRQDIIQTFLDHFF
ERSDLSDSLKGVYDIERLASRVSFGKANPKDLLQLGQTLSQVPVIKTILESFASSSLESLINQIDTLPELEALIRSAIDS
NAPITITEGGMIREGFDETLDKYRTVMREGTSWIADIETKERQKSGISTLKIDYNKKDGYYFHVTNSNLSLVPDYFFRKA
TLKNSERFGTAELAKIEGEMLEAREESANLEYDIFMCIRSQVESYIERLQNLAKSLATVDVLQSLAVVAENNHYVRPSFN
HQQEISIENGRHAVVEKVMGSQEYIPNTINFDQKTSIQLITGPNMSGKSTYMRQLALTVIMAQLGSFVAADSADLPIFDA
IFTRIGAADDLISGQSTFMVEMMEANHAIKAATPNSLILFDELGRGTATYDGMALAQAIIEYIHNKVGAKTLFATHYHEL
TDLSTRLTSLVNVHVATLEKDGEVTFLHKIADGPADKSYGIHVAKIAGLPKDLLNRADHILVDLEKMSAAVSVSLKNETK
ESQPVEEQLSLFAIDNNYEELIKKLKQLDLTNLTPRESMNALFDLKELL

Nucleotide

• Length: 2550 bp

>NTDB_id=613799 NPS17_RS09745 WP_002271567.1 2044911..2047460(-) (hexA) [Streptococcus mutans strain COCC33-14R]
ATGACTAAGGAAAAACTCTCTCCAGGAATGCAGCAGTATTTGGATATCAAAAAAGACTATCCAGATGCTTTTTTGCTTTT
CCGCATGGGAGACTTTTATGAACTATTTTATGATGATGCTATCAAGGCCGCTCAAATTTTAGAAATTAGCTTAACAAGTC
GTAATAAAAATGCTGACAATCCTATTCCGATGGCTGGTGTCCCTTATCATTCAGCTCAACAGTATATTGATGTTTTGATT
GATTTGGGTTATAAGGTTGCCATTGCTGAGCAGATGGAAGATCCTAAAAAAGCTGTTGGCGTTGTCAAACGTGAAGTGGT
TCAAGTGATTACCCCGGGTACTGTTGTTGATTCAACTAAGCCAGACAGTGCTAATAATTTTTTAGTCTCTCTGGATACTG
ATGGCAGTCAGTTTGGCCTTTCTTACATGGATTTATCTACTGGGGAATTTTATGCGACAACATTAGCAGATTTGTCAGCA
GTGAGAAGCGAAGTCCTCAATCTCAAGGCGCGTGAATTAGTTATTGGTTTTGAACTGAGTGAGAATGAAGAACAGCTTTT
TCGTAAGCAGATGAACCTGCTCTTATCTTTTGAAAAAACTGTCTATGACGATGTACATTTATTAGATGATCAATTAAAAG
CAATAGAACTTGCTGCAGCTGGTAAACTCTTGCAATATGTTCATAACACACAAAAACGTGAGTTGAGTCATTTGCAAAAG
TTGGTGCATTATGAAATCAAAGATTACTTGCAGATGGCTTATGCTACAAAATCTAGCTTGGATCTGTTAGAAAATGCCAG
AAGCGGGAAAAAACATGGCAGTCTCTACTGGCTTTTAGATGAGACAAAAACAGCTATGGGGACACGCCTTTTGCGAACTT
GGATTGATCGTCCCTTGGTCAGTTCAAGCCTTATCAGTAAACGTCAAGATATTATTCAGACTTTTCTAGATCACTTTTTT
GAGCGCAGTGATCTTAGTGACAGCCTAAAAGGTGTTTATGATATTGAACGTTTGGCCAGCCGTGTTTCATTTGGGAAGGC
CAATCCTAAGGATTTATTGCAATTGGGTCAGACCTTAAGTCAAGTTCCTGTCATTAAGACTATTCTTGAAAGTTTTGCCA
GTTCTAGTTTGGAAAGCCTAATTAATCAAATTGATACTCTTCCAGAATTGGAAGCATTGATTCGTTCGGCTATTGACTCT
AATGCACCTATAACTATTACAGAAGGCGGTATGATTCGAGAGGGGTTTGATGAAACTTTAGATAAGTATCGAACGGTAAT
GCGCGAAGGGACGAGTTGGATTGCTGACATTGAGACTAAGGAACGTCAGAAAAGCGGCATCTCAACCTTGAAGATTGATT
ATAACAAAAAAGACGGTTATTATTTCCATGTCACCAACTCTAATTTGTCTTTAGTACCAGATTACTTCTTTAGAAAGGCA
ACGCTTAAAAATTCTGAGCGCTTTGGGACAGCAGAGCTTGCAAAAATTGAAGGTGAAATGTTAGAAGCGCGTGAAGAATC
AGCCAATTTAGAATATGATATTTTCATGTGTATCAGATCACAGGTTGAATCTTATATTGAGCGTCTTCAAAATCTGGCCA
AGAGTCTAGCAACTGTTGATGTTTTGCAAAGTTTAGCAGTAGTAGCTGAGAATAATCATTATGTCAGACCTTCTTTTAAT
CATCAGCAGGAAATCAGTATTGAAAATGGTCGCCATGCTGTTGTTGAGAAGGTTATGGGAAGCCAAGAATATATTCCCAA
TACTATCAATTTTGACCAAAAGACTAGTATTCAACTGATTACTGGACCTAATATGAGCGGTAAGTCAACTTACATGCGGC
AATTAGCTCTGACAGTTATTATGGCTCAATTAGGTTCTTTTGTAGCAGCTGATTCAGCTGATTTGCCGATTTTTGATGCT
ATTTTTACACGTATTGGTGCTGCAGATGATTTGATTTCAGGACAGTCCACCTTTATGGTAGAGATGATGGAAGCTAATCA
TGCTATCAAGGCAGCGACACCTAATTCACTCATTTTATTTGATGAATTAGGACGTGGTACAGCAACTTATGATGGTATGG
CTTTAGCACAGGCTATTATTGAGTATATTCATAATAAAGTTGGGGCTAAAACGCTATTTGCTACCCATTATCATGAGTTG
ACAGACTTGTCAACTAGATTGACAAGTCTTGTCAATGTACATGTTGCTACTCTTGAAAAAGATGGAGAGGTCACTTTTCT
TCATAAAATTGCTGATGGACCAGCTGATAAATCTTATGGAATCCATGTTGCTAAAATTGCCGGCTTGCCTAAAGATTTAC
TTAATCGAGCTGATCACATATTAGTTGATTTAGAAAAAATGAGTGCAGCTGTCTCAGTCAGTCTAAAAAACGAGACCAAA
GAAAGCCAACCTGTGGAAGAGCAGTTGTCACTTTTTGCTATTGATAATAATTATGAAGAATTAATCAAAAAATTGAAACA
GTTGGACCTTACCAATTTAACACCAAGAGAATCCATGAATGCCTTATTTGATTTGAAGGAACTATTATAA

Domains

Predicted by InterProScan.

• MutS domain II (MutS_II) (126-239)

• MutS domain I (MutS_I) (8-118)

• MutS family domain IV (MutS_IV) (415-506)

• MutS domain V (MutS_V) (599-785)

• MutS domain III (MutS_III) (256-546)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
hexA	Streptococcus pneumoniae R6	72.15	100	0.723
mutS	Pseudomonas stutzeri strain ATCC 17587	37.34	100	0.377