Detailed information NTG0603857

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: K8227_RS10415
• Genome accession: NZ_CP082948
• Coordinates: 2135235..2136431 (+)
• Length: 398 a.a.
• NCBI ID: WP_012028059.1
• Uniprot ID: D5AF49
• Organism: Streptococcus suis strain SZ1908
• Function: require for competence development (predicted from homology) Competence regulation

Genomic Context

Location: 2130235..2141431

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
K8227_RS10385 (K8227_10360)	-	2130894..2133473 (+)	2580	WP_012028056.1	YfhO family protein	-
K8227_RS10405 (K8227_10380)	-	2133874..2134557 (-)	684	WP_012775416.1	YoaK family protein	-
K8227_RS10410 (K8227_10385)	rlmH	2134582..2135061 (-)	480	WP_012028058.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
K8227_RS10415 (K8227_10390)	htrA	2135235..2136431 (+)	1197	WP_012028059.1	S1C family serine protease	Regulator
K8227_RS10420 (K8227_10395)	spo0J	2136492..2137256 (+)	765	WP_012775418.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 398 a.a.
• Molecular weight: 41866.92 Da
• Isoelectric Point: 4.6543

>NTDB_id=603857 K8227_RS10415 WP_012028059.1 2135235..2136431(+) (htrA) [Streptococcus suis strain SZ1908]
MERIPYMKKYLKFAILFVIGFFGGLIGALSASFFQPQVQQANSAITSVSNVQYNNETSTTKAVEKVQNAVVSVINYQKSA
NNSLGVIFGNIESSDELAVAGEGSGVIYKKYGQYAYIVTNTHVINNAEKIDILLASGEKISGELVGSDTYSDIAVIKISA
DKVTAVAEFADSDTIKVGETAIAIGSPLGSVYANTVTQGIISSLSRTVTSQSKDGQTISTNAIQTDTAINPGNSGGPLIN
TQGQVIGITSSKITSSSANSSGVAVEGLGFAIPANDAVAIINQLEKTGQVSRPALGVHMVNLTTLSTSQLEKAGLSNTEL
TSGVVIVSTQSGLPADGKLETFDVITEIDGEAIQNKSDLQSALYKHQIGDTITVTYYRNNQKQTVDIKLTHSTEELSE

Nucleotide

• Length: 1197 bp

>NTDB_id=603857 K8227_RS10415 WP_012028059.1 2135235..2136431(+) (htrA) [Streptococcus suis strain SZ1908]
ATGGAAAGGATTCCTTATATGAAAAAATATTTGAAATTTGCGATTTTATTTGTAATTGGATTTTTTGGGGGTCTTATCGG
GGCCTTGTCAGCCTCTTTCTTCCAGCCACAGGTGCAACAAGCAAATTCTGCTATCACTAGTGTCAGCAATGTTCAATATA
ATAATGAAACTTCCACCACAAAAGCTGTAGAGAAAGTACAAAATGCTGTTGTGTCTGTTATTAATTACCAAAAATCAGCC
AACAATAGTCTTGGTGTTATCTTTGGAAATATTGAATCATCTGACGAACTAGCTGTTGCTGGAGAGGGGTCTGGGGTTAT
CTATAAAAAATATGGTCAATATGCCTATATTGTGACAAATACGCATGTTATTAATAACGCAGAAAAGATTGATATCCTTT
TAGCATCTGGAGAAAAAATTAGCGGTGAACTTGTTGGTTCCGATACATATTCTGATATAGCTGTTATAAAAATATCAGCA
GATAAAGTCACTGCTGTTGCTGAATTTGCTGATTCCGATACAATTAAAGTTGGAGAAACTGCTATCGCAATTGGTAGTCC
TCTAGGTAGCGTCTACGCCAATACAGTTACCCAGGGTATTATTTCTAGCTTAAGTCGGACAGTTACTTCACAATCAAAAG
ATGGACAAACAATCTCAACTAACGCTATTCAAACTGATACAGCTATCAACCCTGGAAACTCTGGCGGACCGTTAATCAAT
ACCCAAGGACAAGTGATAGGCATTACCTCTAGCAAAATTACCTCAAGTTCTGCAAATAGCTCAGGCGTGGCTGTAGAAGG
GTTGGGATTTGCTATTCCTGCAAATGATGCCGTAGCTATTATCAATCAGCTTGAAAAAACTGGACAAGTTAGCCGACCTG
CTCTTGGAGTTCATATGGTTAACTTGACGACCTTGTCAACTAGTCAATTAGAAAAAGCTGGATTATCAAATACGGAATTA
ACATCCGGTGTAGTAATTGTCTCTACACAAAGTGGGCTACCTGCAGATGGAAAATTAGAAACTTTTGATGTTATTACTGA
GATTGACGGAGAAGCTATTCAAAATAAGAGTGACCTCCAGAGCGCTCTCTACAAACATCAAATTGGAGATACAATCACTG
TAACTTATTACCGCAATAATCAGAAACAAACTGTTGACATTAAGTTGACACATTCTACAGAAGAACTTAGCGAATAA

Domains

Predicted by InterproScan.

• Trypsin-like peptidase domain (Trypsin_2) (103-248)

• PDZ domain (PDZ_2) (293-389)

3D structure

• AlphaFold DB: D5AF49

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus mutans UA159	59.194	99.749	0.59
htrA	Streptococcus gordonii str. Challis substr. CH1	58.987	99.246	0.585
htrA	Streptococcus pneumoniae D39	57.252	98.744	0.565
htrA	Streptococcus pneumoniae TIGR4	57.252	98.744	0.565
htrA	Streptococcus mitis NCTC 12261	57.252	98.744	0.565
htrA	Streptococcus pneumoniae R6	57.252	98.744	0.565
htrA	Streptococcus pneumoniae Rx1	57.252	98.744	0.565