Detailed information NTG0058131

Bioinformatically predicted

Overview

• Name: vicR
• Type: Regulator
• Locus tag: SPN994038_RS10115
• Genome accession: NC_021026
• Coordinates: 1862234..1862941 (+)
• Length: 235 a.a.
• NCBI ID: WP_000166477.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae SPN994038
• Function: repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IS/Tn	1861122..1861592	1862234..1862941	flank	642

Gene organization within MGE regions

Location: 1861122..1862941

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPN994038_RS10105 (SPN994038_18270)	-	1861122..1861679 (-)	558	Protein_1901	transposase	-
SPN994038_RS10110 (SPN994038_18280)	-	1861665..1862150 (+)	486	WP_001821625.1	cupin domain-containing protein	-
SPN994038_RS10115 (SPN994038_18290)	vicR	1862234..1862941 (+)	708	WP_000166477.1	response regulator transcription factor	Regulator

Sequence

Protein

• Length: 235 a.a.
• Molecular weight: 27254.62 Da
• Isoelectric Point: 6.6568

>NTDB_id=58131 SPN994038_RS10115 WP_000166477.1 1862234..1862941(+) (vicR) [Streptococcus pneumoniae SPN994038]
MTKQVLLVDDEEHILRLLDYHLSKEGFSTQLVTNGRKALALAETEPFDFILLDIMLPQLDGIEVCKRLRAKGIKTPIMMV
SAKSDEFDKVLALELGADDYLTKPFSPRELLARVKAVLRRTKGEQEGDDSDNIADDSWLFGTLKVYPERHEVYKANKLLS
LTPKEFELLLYLMKHPNMTLTRERLLERIWGYDFGQETRLVDVHIGKLREKIEDNPKAPQFIRTIRGYGYKFKEL

Nucleotide

• Length: 708 bp

>NTDB_id=58131 SPN994038_RS10115 WP_000166477.1 1862234..1862941(+) (vicR) [Streptococcus pneumoniae SPN994038]
ATGACAAAACAAGTCTTATTAGTGGATGATGAAGAACACATTCTGAGATTGCTTGACTACCATTTAAGTAAGGAAGGCTT
TTCTACTCAATTGGTAACAAATGGACGGAAGGCCTTAGCTTTGGCAGAAACAGAACCCTTTGATTTTATCTTGCTTGATA
TCATGTTACCACAATTAGATGGCATAGAAGTTTGTAAGCGGCTGAGAGCCAAAGGCATCAAAACTCCAATTATGATGGTT
TCTGCGAAAAGTGATGAATTTGATAAGGTTTTGGCCTTGGAATTAGGGGCTGATGACTACCTGACCAAGCCTTTTAGCCC
TAGAGAATTGCTGGCACGTGTCAAGGCTGTCCTCAGGCGAACTAAAGGAGAACAAGAAGGAGATGATTCAGATAATATTG
CTGACGATTCTTGGCTATTTGGGACCTTGAAAGTATACCCTGAGCGTCATGAGGTCTACAAGGCGAATAAGTTACTGAGT
TTGACCCCAAAAGAATTTGAACTCTTGCTCTATCTTATGAAACATCCCAACATGACACTGACTAGAGAGCGTCTTTTGGA
ACGTATCTGGGGATATGACTTTGGGCAGGAAACACGTTTGGTGGACGTTCATATTGGTAAGTTGAGGGAAAAAATTGAAG
ACAATCCTAAAGCCCCTCAATTTATTCGAACCATTCGGGGTTATGGTTATAAGTTCAAGGAGTTATAG

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (5-115)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (159-232)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vicR	Streptococcus mutans UA159	48.707	98.723	0.481
micA	Streptococcus pneumoniae Cp1015	47.845	98.723	0.472
covR	Lactococcus lactis subsp. lactis strain DGCC12653	41.202	99.149	0.409
covR	Streptococcus salivarius strain HSISS4	40.171	99.574	0.4