Detailed information NTG0526768

Bioinformatically predicted

Overview

• Name: comYH
• Type: Machinery gene
• Locus tag: I6J12_RS00055
• Genome accession: NZ_CP068060
• Coordinates: 5050..6003 (+)
• Length: 317 a.a.
• NCBI ID: WP_003035359.1
• Uniprot ID: I0SGR4
• Organism: Streptococcus anginosus strain FDAARGOS_1155
• Function: dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
Prophage	57..6003	5050..6003	within	0

Gene organization within MGE regions

Location: 57..6003

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I6J12_RS00010 (I6J12_00010)	-	845..1387 (+)	543	WP_003038192.1	DUF1366 domain-containing protein	-
I6J12_RS00015 (I6J12_00015)	-	1405..1806 (+)	402	WP_003038210.1	hypothetical protein	-
I6J12_RS00020 (I6J12_00020)	-	1808..2140 (+)	333	WP_003038184.1	phage holin	-
I6J12_RS00025 (I6J12_00025)	-	2143..2892 (+)	750	WP_003038204.1	PlySs2 family phage lysin	-
I6J12_RS00030 (I6J12_00030)	comYC	3315..3584 (+)	270	WP_003035361.1	competence type IV pilus major pilin ComGC	Machinery gene
I6J12_RS00035 (I6J12_00035)	comYD	3544..3972 (+)	429	WP_020999411.1	competence type IV pilus minor pilin ComGD	Machinery gene
I6J12_RS00040 (I6J12_00040)	comGE/cglE	3944..4237 (+)	294	WP_003035318.1	competence type IV pilus minor pilin ComGE	Machinery gene
I6J12_RS00045 (I6J12_00045)	comGF/cglF	4221..4658 (+)	438	WP_003035329.1	competence type IV pilus minor pilin ComGF	Machinery gene
I6J12_RS00050 (I6J12_00050)	comGG	4639..4965 (+)	327	WP_020999447.1	competence type IV pilus minor pilin ComGG	-
I6J12_RS00055 (I6J12_00055)	comYH	5050..6003 (+)	954	WP_003035359.1	class I SAM-dependent methyltransferase	Machinery gene

Sequence

Protein

• Length: 317 a.a.
• Molecular weight: 36018.86 Da
• Isoelectric Point: 4.3141

>NTDB_id=526768 I6J12_RS00055 WP_003035359.1 5050..6003(+) (comYH) [Streptococcus anginosus strain FDAARGOS_1155]
MNFEKIEQAYSLLLENVQELQNTLLTNFYDALVEQNGVYLDGNTELAIVKKNNETLKSLKLDKEEWRRAYQFLLMKAAQT
EPLQANHQFTPDSIGFILTFLIDQLSKKEHIDILEIGSGMGNLAETILNNTQKNVDYLGLELDDLLIDISASIADVMDAK
VSFVQGDAVRPQVLKESDVIISDLPVGFYPDDNIATRYEVASRQEHTYAHHLLMEQSLKYLKSGGYAIFLAPNDLLTSSQ
SDLLKTWLQKHAQIVAMIALPEALFGNAAYAKTIFVLQKQEEQAVQLFVYALSDLRDQDDLLEFSEKFQNWSRESEI

Nucleotide

• Length: 954 bp

>NTDB_id=526768 I6J12_RS00055 WP_003035359.1 5050..6003(+) (comYH) [Streptococcus anginosus strain FDAARGOS_1155]
ATGAATTTTGAAAAAATAGAACAGGCTTATTCGCTTTTGTTAGAAAATGTCCAGGAGCTCCAAAATACTCTTTTGACGAA
TTTTTATGATGCTTTGGTCGAGCAAAATGGGGTTTATCTGGATGGAAATACAGAGCTAGCTATTGTCAAAAAAAATAATG
AAACACTTAAATCTTTGAAATTAGATAAAGAAGAATGGCGCCGAGCCTACCAATTTTTGCTGATGAAAGCAGCTCAAACA
GAGCCTTTGCAAGCCAATCATCAATTTACTCCAGATTCTATCGGGTTTATCTTAACTTTTCTCATTGACCAATTGAGTAA
AAAAGAACACATTGATATTTTGGAAATTGGTAGCGGAATGGGGAATTTAGCTGAGACGATTCTCAATAATACACAAAAAA
ATGTGGATTATCTAGGACTGGAATTGGACGATCTGCTAATTGATATATCAGCCAGTATCGCAGATGTGATGGATGCAAAA
GTTAGTTTTGTGCAAGGTGATGCAGTGCGTCCGCAAGTATTGAAAGAAAGCGATGTGATTATCAGTGATTTACCAGTTGG
CTTTTATCCTGATGATAACATTGCGACGCGCTATGAAGTGGCTAGTAGACAGGAGCATACTTATGCTCATCATTTGTTAA
TGGAACAATCGCTCAAGTATCTCAAATCAGGCGGTTATGCTATTTTCCTTGCACCAAATGATTTATTGACTAGTTCGCAA
AGTGATTTGCTGAAAACTTGGCTGCAAAAGCATGCCCAGATAGTTGCGATGATTGCATTGCCAGAAGCACTTTTTGGAAA
TGCCGCTTATGCCAAGACAATTTTTGTGCTGCAAAAGCAAGAAGAACAAGCTGTTCAACTGTTTGTTTATGCTTTGTCTG
ATTTGCGAGATCAGGACGATTTATTGGAATTTAGCGAAAAGTTTCAAAATTGGAGCAGAGAAAGTGAAATTTAA

Domains

Predicted by InterproScan.

• N-6 DNA Methylase (N6_Mtase) (68-299)

3D structure

• AlphaFold DB: I0SGR4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comYH	Streptococcus mutans UA140	60.952	99.369	0.606
comYH	Streptococcus mutans UA159	60.635	99.369	0.603