Detailed information NTG0514246

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: STMM8_RS01475
• Genome accession: NZ_CP065787
• Coordinates: 264863..265762 (+)
• Length: 299 a.a.
• NCBI ID: WP_002946143.1
• Uniprot ID: -
• Organism: Streptococcus thermophilus strain MM8
• Function: activate transcription of comX; activate transcription of comS (predicted from homology) Competence regulation

Genomic Context

Location: 259863..270762

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
STMM8_RS01455 (STMM8_01440)	trkA	261000..262349 (-)	1350	WP_011225444.1	Trk system potassium transporter TrkA	-
STMM8_RS01460 (STMM8_01445)	-	262608..263147 (+)	540	WP_371851917.1	tRNA (cytidine(34)-2'-O)-methyltransferase	-
STMM8_RS01465 (STMM8_01450)	-	263458..264015 (+)	558	WP_002946140.1	ECF transporter S component	-
STMM8_RS01470 (STMM8_01455)	-	264018..264668 (+)	651	WP_022096567.1	phosphatase PAP2 family protein	-
STMM8_RS01475 (STMM8_01460)	comR	264863..265762 (+)	900	WP_002946143.1	helix-turn-helix domain-containing protein	Regulator
STMM8_RS01480	-	266000..267178 (+)	1179	Protein_238	ABC transporter transmembrane domain-containing protein	-
STMM8_RS01485	comA	267200..267409 (+)	210	WP_002946147.1	hypothetical protein	Regulator
STMM8_RS01490 (STMM8_01485)	-	267464..268032 (+)	569	Protein_240	ATP-binding cassette domain-containing protein	-
STMM8_RS01495 (STMM8_01490)	-	268140..268451 (+)	312	WP_022096570.1	DUF805 domain-containing protein	-
STMM8_RS01500	-	268672..269019 (-)	348	WP_232089310.1	DUF4173 domain-containing protein	-
STMM8_RS01505	-	268944..269840 (-)	897	WP_224103642.1	urease cluster protein	-
STMM8_RS01510 (STMM8_01500)	-	270245..270760 (+)	516	WP_002949547.1	AmiS/UreI family transporter	-

Sequence

Protein

• Length: 299 a.a.
• Molecular weight: 35303.77 Da
• Isoelectric Point: 5.1073

>NTDB_id=514246 STMM8_RS01475 WP_002946143.1 264863..265762(+) (comR) [Streptococcus thermophilus strain MM8]
MNLKDSIGLRIKTERERQQMSREVLCLDGAELTVRQLIRIEKGESLPSLDRLSYIAKRLGKSMTELLDQDNITIPDEYYE
MKNRLIKFPTYRNPDRIKSKLTLIEEVYEKFFDILPEEELLTLDILENILSFTSWEESPKVEEIYEDLFEQVKRKRKFST
NDLLVIDYYFFHLYGRKQYDKKLFERIIKRVLNQEIWTDDVYNIVLFNDLMAIAALKIFHNSFSDFLTVVDKALAVIEKS
QLYSYKPSVFVLKAKYELLHKENKKEAAENYDKAIMFASVLEDSVLEESIKAGKLADGL

Nucleotide

• Length: 900 bp

>NTDB_id=514246 STMM8_RS01475 WP_002946143.1 264863..265762(+) (comR) [Streptococcus thermophilus strain MM8]
TTGAACTTAAAAGACAGCATTGGACTAAGAATCAAAACTGAGCGTGAACGCCAACAGATGTCACGTGAAGTGCTATGTTT
AGATGGTGCGGAATTGACTGTTCGCCAGTTAATTCGTATTGAAAAGGGGGAGTCTCTCCCGTCTTTAGATAGATTATCGT
ATATTGCTAAACGTTTAGGAAAAAGTATGACAGAGTTATTGGATCAAGACAATATTACCATTCCTGACGAATATTATGAA
ATGAAGAATCGTTTGATTAAGTTTCCAACGTACAGAAACCCTGACAGAATAAAGTCTAAACTTACTTTGATTGAGGAAGT
CTATGAGAAATTTTTTGATATTCTTCCAGAAGAAGAATTATTAACTCTAGACATTCTCGAAAATATATTGAGTTTTACTA
GCTGGGAGGAGAGTCCAAAAGTTGAGGAGATATATGAAGACTTGTTTGAACAAGTCAAAAGGAAGAGGAAATTCTCAACT
AACGATTTATTAGTCATTGACTATTATTTCTTTCATCTTTATGGGAGAAAACAGTATGACAAAAAACTATTTGAAAGAAT
TATAAAGAGAGTATTAAATCAGGAAATTTGGACAGATGATGTTTACAATATTGTTTTATTTAATGATTTGATGGCTATTG
CTGCTTTAAAGATTTTTCACAATTCCTTCTCAGACTTCTTAACAGTTGTGGATAAAGCCTTAGCTGTCATAGAAAAATCA
CAATTATATAGCTACAAGCCTAGTGTTTTTGTACTTAAGGCTAAATATGAACTTCTGCATAAAGAAAACAAGAAAGAGGC
TGCAGAGAATTATGATAAGGCCATAATGTTTGCTTCCGTTTTGGAAGACTCGGTTTTAGAGGAAAGTATAAAGGCAGGAA
AATTGGCAGATGGTTTATAG

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (11-66)

• ComR tetratricopeptide (ComR_TPR) (75-292)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus thermophilus LMG 18311	99.666	100	0.997
comR	Streptococcus thermophilus LMD-9	99.666	100	0.997
comR	Streptococcus salivarius strain HSISS4	94.983	100	0.95
comR	Streptococcus salivarius SK126	94.314	100	0.943
comR/comR2	Streptococcus sobrinus strain NIDR 6715-7	42.14	100	0.421
comR/comR1	Streptococcus sobrinus strain NIDR 6715-7	41.806	100	0.418