NTDB

Overview

Name	mecA	Type	Regulator
Locus tag	ST4052_RS01000	Genome accession	NZ_CP065476
Coordinates	172943..173692 (+)	Length	249 a.a.
NCBI ID	WP_011225365.1	Uniprot ID	Q5M699
Organism	Streptococcus thermophilus strain 4052
Function	degradation of ComX (predicted from homology) Competence regulation

Genomic Context

Location: 167943..178692

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ST4052_RS00970 (ST4052_00975)	-	168518..168688 (+)	171	WP_011225360.1	hypothetical protein	-
ST4052_RS00975 (ST4052_00980)	-	168775..168882 (+)	108	WP_011226802.1	LPXTG cell wall anchor domain-containing protein	-
ST4052_RS00980 (ST4052_00985)	-	168969..169709 (-)	741	WP_002949253.1	amino acid ABC transporter ATP-binding protein	-
ST4052_RS00985 (ST4052_00990)	-	169709..171259 (-)	1551	WP_011225362.1	ABC transporter substrate-binding protein/permease	-
ST4052_RS00990 (ST4052_00995)	-	171462..172316 (+)	855	WP_041828107.1	undecaprenyl-diphosphate phosphatase	-
ST4052_RS00995 (ST4052_01000)	-	172462..172677 (-)	216	WP_011225364.1	DUF3021 family protein	-
ST4052_RS01000 (ST4052_01005)	mecA	172943..173692 (+)	750	WP_011225365.1	adaptor protein MecA	Regulator
ST4052_RS01005 (ST4052_01010)	-	173696..174853 (+)	1158	WP_002947632.1	MraY family glycosyltransferase	-
ST4052_RS01010 (ST4052_01015)	sufC	175014..175784 (+)	771	WP_002947634.1	Fe-S cluster assembly ATPase SufC	-
ST4052_RS01015 (ST4052_01020)	sufD	175821..177083 (+)	1263	WP_002947640.1	Fe-S cluster assembly protein SufD	-
ST4052_RS01020 (ST4052_01025)	-	177137..178369 (+)	1233	WP_022096530.1	cysteine desulfurase	-

Sequence

Protein

Download Length: 249 a.a. Molecular weight: 29157.70 Da Isoelectric Point: 4.0659

                                >NTDB_id=509927 ST4052_RS01000 WP_011225365.1 172943..173692(+) (mecA) [Streptococcus thermophilus strain 4052]

MEMKQINETTLKIMITMEDLEEHGMELKDFLIPQEKTEEFFYTVMDELDLPDNFKNSGMLSFRVTPRKDRVDVFVTKSDL

KEALDFNDLSDMEDYSGLSPEEFLKALEDNFMDKGDIEAHHKLEEHDKTLKEVDETMTEPAKEVAEETIREDYTHYVLAF

SDFDQVVTFAQGLKNVSVEGSEFYKLGDVYYMTILLYLADEPDYYANNMYARFLEYANVADRTRPYLQEHATILMEEDAL

PVLQATKWS

Nucleotide

Download Length: 750 bp

                                >NTDB_id=509927 ST4052_RS01000 WP_011225365.1 172943..173692(+) (mecA) [Streptococcus thermophilus strain 4052]

ATGGAAATGAAACAAATAAACGAGACAACTCTAAAAATCATGATTACCATGGAAGATCTTGAAGAACATGGTATGGAGCT

GAAAGATTTCTTGATTCCCCAGGAAAAAACAGAGGAATTTTTCTATACTGTCATGGATGAGTTGGACTTGCCTGATAATT

TTAAAAATAGTGGGATGTTGAGCTTCCGTGTCACGCCACGAAAGGATCGTGTGGATGTTTTTGTGACTAAATCAGATCTT

AAGGAAGCCCTTGATTTCAATGATTTGTCAGATATGGAAGACTATTCAGGACTTTCTCCAGAAGAATTCCTCAAAGCTCT

TGAAGATAACTTTATGGATAAGGGAGATATTGAAGCCCACCATAAGCTCGAAGAGCATGATAAGACCTTGAAAGAGGTTG

ATGAGACTATGACAGAGCCGGCTAAGGAAGTGGCTGAGGAAACTATTCGTGAAGATTATACTCACTATGTCTTGGCTTTC

TCTGACTTTGATCAAGTAGTGACCTTTGCGCAAGGTTTGAAGAATGTGTCAGTGGAGGGTTCTGAATTTTATAAACTTGG

TGATGTCTACTATATGACTATCCTTCTTTACTTGGCTGATGAGCCTGATTATTACGCGAACAATATGTATGCGCGTTTTC

TTGAATATGCGAATGTGGCAGACCGAACACGTCCCTATCTACAAGAGCATGCAACAATCTTGATGGAAGAGGACGCCTTA

CCGGTATTACAAGCAACGAAATGGAGCTAG

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-242)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	Q5M699

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
mecA	Streptococcus thermophilus LMG 18311	100	100	1
mecA	Streptococcus thermophilus LMD-9	99.197	100	0.992
mecA	Streptococcus mutans UA159	57.377	97.992	0.562
mecA	Streptococcus pneumoniae Rx1	46.185	100	0.462
mecA	Streptococcus pneumoniae D39	46.185	100	0.462
mecA	Streptococcus pneumoniae R6	46.185	100	0.462
mecA	Streptococcus pneumoniae TIGR4	46.185	100	0.462

Detailed information NTG0509927