Detailed information NTG0503373

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: HWI25_RS04590
• Genome accession: NZ_CP064593
• Coordinates: 989946..990992 (+)
• Length: 348 a.a.
• NCBI ID: WP_002486322.1
• Uniprot ID: -
• Organism: Staphylococcus epidermidis strain UMCG352
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 984946..995992

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HWI25_RS04565 (HWI25_04565)	isaB	986087..986623 (+)	537	WP_001830372.1	immunodominant staphylococcal antigen IsaB family protein	-
HWI25_RS04570 (HWI25_04570)	-	986774..987760 (-)	987	WP_002457091.1	aromatic acid exporter family protein	-
HWI25_RS04575 (HWI25_04575)	map	987934..988689 (+)	756	WP_002457092.1	type I methionyl aminopeptidase	-
HWI25_RS04580 (HWI25_04580)	-	988847..989233 (+)	387	WP_001830382.1	hypothetical protein	-
HWI25_RS04585 (HWI25_04585)	liaF	989248..989949 (+)	702	WP_002457093.1	cell wall-active antibiotics response protein LiaF	-
HWI25_RS04590 (HWI25_04590)	vraS	989946..990992 (+)	1047	WP_002486322.1	sensor histidine kinase	Regulator
HWI25_RS04595 (HWI25_04595)	vraR	990982..991611 (+)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
HWI25_RS04600 (HWI25_04600)	-	991668..992846 (-)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
HWI25_RS04605 (HWI25_04605)	-	993253..993537 (-)	285	WP_001830401.1	YtxH domain-containing protein	-
HWI25_RS04610 (HWI25_04610)	-	993545..994009 (-)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
HWI25_RS04615 (HWI25_04615)	-	994150..994365 (+)	216	WP_001830421.1	DUF1128 domain-containing protein	-
HWI25_RS04620 (HWI25_04620)	-	994367..995608 (+)	1242	WP_002457094.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40039.46 Da
• Isoelectric Point: 5.8512

>NTDB_id=503373 HWI25_RS04590 WP_002486322.1 989946..990992(+) (vraS) [Staphylococcus epidermidis strain UMCG352]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVSIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=503373 HWI25_RS04590 WP_002486322.1 989946..990992(+) (vraS) [Staphylococcus epidermidis strain UMCG352]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAGTATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GATTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	92.733	98.851	0.917