Detailed information NTG0502485

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: HWI50_RS04535
• Genome accession: NZ_CP064504
• Coordinates: 975199..976245 (+)
• Length: 348 a.a.
• NCBI ID: WP_002486322.1
• Uniprot ID: -
• Organism: Staphylococcus epidermidis strain UMCG377
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 970199..981245

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HWI50_RS04510 (HWI50_04505)	isaB	971340..971876 (+)	537	WP_001830372.1	immunodominant staphylococcal antigen IsaB family protein	-
HWI50_RS04515 (HWI50_04510)	-	972027..973013 (-)	987	WP_002457091.1	aromatic acid exporter family protein	-
HWI50_RS04520 (HWI50_04515)	map	973187..973942 (+)	756	WP_002457092.1	type I methionyl aminopeptidase	-
HWI50_RS04525 (HWI50_04520)	-	974100..974486 (+)	387	WP_001830382.1	hypothetical protein	-
HWI50_RS04530 (HWI50_04525)	liaF	974501..975202 (+)	702	WP_002457093.1	cell wall-active antibiotics response protein LiaF	-
HWI50_RS04535 (HWI50_04530)	vraS	975199..976245 (+)	1047	WP_002486322.1	sensor histidine kinase	Regulator
HWI50_RS04540 (HWI50_04535)	vraR	976235..976864 (+)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
HWI50_RS04545 (HWI50_04540)	-	976921..978099 (-)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
HWI50_RS04550 (HWI50_04545)	-	978506..978790 (-)	285	WP_001830401.1	YtxH domain-containing protein	-
HWI50_RS04555 (HWI50_04550)	-	978798..979262 (-)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
HWI50_RS04560 (HWI50_04555)	-	979403..979618 (+)	216	WP_001830421.1	DUF1128 domain-containing protein	-
HWI50_RS04565 (HWI50_04560)	-	979620..980861 (+)	1242	WP_002457094.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40039.46 Da
• Isoelectric Point: 5.8512

>NTDB_id=502485 HWI50_RS04535 WP_002486322.1 975199..976245(+) (vraS) [Staphylococcus epidermidis strain UMCG377]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVSIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=502485 HWI50_RS04535 WP_002486322.1 975199..976245(+) (vraS) [Staphylococcus epidermidis strain UMCG377]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAGTATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GATTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	92.733	98.851	0.917