Detailed information
Bioinformatically predicted
Overview
| Name | comM | Type | Regulator |
| Locus tag | IRE31_RS09040 | Genome accession | NZ_CP063829 |
| Coordinates | 1760799..1761419 (-) | Length | 206 a.a. |
| NCBI ID | WP_000839909.1 | Uniprot ID | A0A098Z2X2 |
| Organism | Streptococcus pneumoniae strain 19A-ST320_99-176 | ||
| Function | fratricide immunity (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 1749254..1793174 | 1760799..1761419 | within | 0 |
Gene organization within MGE regions
Location: 1749254..1793174
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IRE31_RS08970 (IRE31_08925) | - | 1749551..1750102 (-) | 552 | WP_001111247.1 | hypothetical protein | - |
| IRE31_RS08975 (IRE31_08930) | - | 1750092..1750289 (-) | 198 | WP_000890144.1 | hypothetical protein | - |
| IRE31_RS08980 (IRE31_08935) | - | 1750293..1751087 (-) | 795 | WP_001101215.1 | hypothetical protein | - |
| IRE31_RS08985 (IRE31_08940) | - | 1751495..1751920 (-) | 426 | WP_000204068.1 | hypothetical protein | - |
| IRE31_RS08990 (IRE31_08945) | - | 1752049..1752408 (-) | 360 | WP_000749821.1 | ImmA/IrrE family metallo-endopeptidase | - |
| IRE31_RS08995 (IRE31_08950) | - | 1752454..1752660 (-) | 207 | WP_000366087.1 | hypothetical protein | - |
| IRE31_RS09000 (IRE31_08955) | - | 1752647..1752808 (-) | 162 | WP_000289348.1 | helix-turn-helix domain-containing protein | - |
| IRE31_RS09005 (IRE31_08960) | lytA | 1753167..1754123 (-) | 957 | WP_000405240.1 | N-acetylmuramoyl-L-alanine amidase LytA | - |
| IRE31_RS09010 (IRE31_08965) | - | 1754499..1755869 (-) | 1371 | WP_001036271.1 | MATE family efflux transporter | - |
| IRE31_RS09015 (IRE31_08970) | recA | 1756176..1757342 (-) | 1167 | WP_001085462.1 | recombinase RecA | Machinery gene |
| IRE31_RS09020 (IRE31_08975) | cinA | 1757397..1758653 (-) | 1257 | WP_000642704.1 | competence/damage-inducible protein A | Machinery gene |
| IRE31_RS09025 (IRE31_08980) | - | 1758738..1759754 (-) | 1017 | WP_000239278.1 | LCP family protein | - |
| IRE31_RS09030 (IRE31_08985) | - | 1759762..1760280 (-) | 519 | WP_000455536.1 | GNAT family N-acetyltransferase | - |
| IRE31_RS09035 (IRE31_08990) | tsaE | 1760270..1760713 (-) | 444 | WP_000288230.1 | tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE | - |
| IRE31_RS09040 (IRE31_08995) | comM | 1760799..1761419 (-) | 621 | WP_000839909.1 | hypothetical protein | Regulator |
| IRE31_RS09045 (IRE31_09000) | - | 1761725..1762588 (-) | 864 | WP_001093609.1 | helix-turn-helix domain-containing protein | - |
| IRE31_RS09050 | - | 1762781..1762951 (+) | 171 | WP_001227863.1 | PhrA family quorum-sensing system peptide | - |
| IRE31_RS09055 (IRE31_09005) | - | 1763353..1763667 (+) | 315 | WP_000420682.1 | YdcP family protein | - |
| IRE31_RS09060 (IRE31_09010) | - | 1763683..1764069 (+) | 387 | WP_000985015.1 | YdcP family protein | - |
| IRE31_RS09065 (IRE31_09015) | - | 1764098..1765483 (+) | 1386 | WP_000813494.1 | FtsK/SpoIIIE domain-containing protein | - |
| IRE31_RS09070 (IRE31_09020) | - | 1765486..1765638 (+) | 153 | WP_000879507.1 | hypothetical protein | - |
| IRE31_RS09075 (IRE31_09025) | mobT | 1765661..1766923 (+) | 1263 | WP_001814870.1 | MobT family relaxase | - |
| IRE31_RS09080 (IRE31_09030) | - | 1766868..1767080 (+) | 213 | WP_029645760.1 | peptide-binding protein | - |
| IRE31_RS09085 (IRE31_09035) | - | 1767129..1767212 (+) | 84 | WP_001814874.1 | 23S rRNA methyltransferase attenuation leader peptide | - |
| IRE31_RS09090 (IRE31_09040) | erm(B) | 1767337..1768074 (+) | 738 | WP_001038795.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) | - |
| IRE31_RS09095 (IRE31_09045) | - | 1768331..1769578 (-) | 1248 | WP_000019067.1 | ISL3 family transposase | - |
| IRE31_RS09100 (IRE31_09050) | - | 1769758..1769979 (+) | 222 | WP_001009056.1 | hypothetical protein | - |
| IRE31_RS09105 (IRE31_09055) | - | 1770096..1770593 (+) | 498 | WP_000342539.1 | antirestriction protein ArdA | - |
| IRE31_RS09110 (IRE31_09060) | - | 1770682..1771074 (+) | 393 | WP_000723888.1 | conjugal transfer protein | - |
| IRE31_RS09115 (IRE31_09065) | - | 1771058..1773505 (+) | 2448 | WP_000331160.1 | ATP-binding protein | - |
| IRE31_RS09120 (IRE31_09070) | - | 1773508..1775685 (+) | 2178 | WP_001814875.1 | CD3337/EF1877 family mobilome membrane protein | - |
| IRE31_RS09125 (IRE31_09075) | - | 1775682..1776683 (+) | 1002 | WP_000769868.1 | lysozyme family protein | - |
| IRE31_RS09130 (IRE31_09080) | - | 1776680..1777612 (+) | 933 | WP_001224318.1 | conjugal transfer protein | - |
| IRE31_RS10950 | - | 1777926..1777973 (+) | 48 | Protein_1791 | hypothetical protein | - |
| IRE31_RS09140 (IRE31_09090) | tet(M) | 1777989..1779908 (+) | 1920 | WP_000691729.1 | tetracycline resistance ribosomal protection protein Tet(M) | - |
| IRE31_RS09145 (IRE31_09095) | - | 1780272..1780517 (+) | 246 | WP_001813542.1 | hypothetical protein | - |
| IRE31_RS09150 (IRE31_09100) | - | 1780514..1780849 (+) | 336 | WP_000806926.1 | hypothetical protein | - |
| IRE31_RS09155 (IRE31_09105) | - | 1780862..1781230 (+) | 369 | WP_000567222.1 | hypothetical protein | - |
| IRE31_RS09160 (IRE31_09110) | - | 1781217..1781516 (+) | 300 | WP_001072467.1 | DUF5960 family protein | - |
| IRE31_RS09165 (IRE31_09115) | msr(D) | 1781634..1783097 (-) | 1464 | WP_000420313.1 | ABC-F type ribosomal protection protein Msr(D) | - |
| IRE31_RS09170 (IRE31_09120) | mef(A) | 1783217..1784434 (-) | 1218 | WP_000417519.1 | macrolide efflux MFS transporter Mef(A) | - |
| IRE31_RS09175 (IRE31_09125) | - | 1784820..1784990 (-) | 171 | WP_000873143.1 | hypothetical protein | - |
| IRE31_RS09180 (IRE31_09130) | - | 1785512..1785703 (+) | 192 | WP_001860868.1 | cysteine-rich KTR domain-containing protein | - |
| IRE31_RS09185 (IRE31_09135) | - | 1785763..1786116 (-) | 354 | WP_001227347.1 | helix-turn-helix transcriptional regulator | - |
| IRE31_RS09190 (IRE31_09140) | - | 1786621..1787043 (+) | 423 | WP_000804885.1 | sigma-70 family RNA polymerase sigma factor | - |
| IRE31_RS09195 (IRE31_09145) | - | 1787040..1787270 (+) | 231 | WP_000857133.1 | helix-turn-helix domain-containing protein | - |
| IRE31_RS09200 | - | 1787496..1787747 (-) | 252 | WP_001845478.1 | hypothetical protein | - |
| IRE31_RS09205 (IRE31_09150) | - | 1787731..1787934 (+) | 204 | WP_000814511.1 | excisionase | - |
| IRE31_RS09210 (IRE31_09155) | - | 1788016..1789233 (+) | 1218 | WP_001291561.1 | tyrosine-type recombinase/integrase | - |
| IRE31_RS09215 (IRE31_09160) | - | 1790124..1792139 (+) | 2016 | WP_000732395.1 | DUF1430 domain-containing protein | - |
| IRE31_RS09220 (IRE31_09165) | - | 1792141..1792773 (+) | 633 | WP_000571425.1 | ABC transporter ATP-binding protein | - |
Sequence
Protein
Download Length: 206 a.a. Molecular weight: 23540.66 Da Isoelectric Point: 10.1254
>NTDB_id=496931 IRE31_RS09040 WP_000839909.1 1760799..1761419(-) (comM) [Streptococcus pneumoniae strain 19A-ST320_99-176]
MKSMRILFLLALIQISLSSCFLWKECILSFKQSTAFFIGSMVFVSGICAGVNYLYTRKQEVHSVLASKKSVKLFYSMLLL
INLLGAVLVLSDNLFIKNTLQQELVDFLLPSFFFLFGLDLLIFLPLKKYVRDFLAMLDRKKTVLVTILATLLFLRNPMTI
VSLLIYTGLGLFFAAYLVPNSVKKEVSFYGHIFRDLVLVIVTLIFF
MKSMRILFLLALIQISLSSCFLWKECILSFKQSTAFFIGSMVFVSGICAGVNYLYTRKQEVHSVLASKKSVKLFYSMLLL
INLLGAVLVLSDNLFIKNTLQQELVDFLLPSFFFLFGLDLLIFLPLKKYVRDFLAMLDRKKTVLVTILATLLFLRNPMTI
VSLLIYTGLGLFFAAYLVPNSVKKEVSFYGHIFRDLVLVIVTLIFF
Nucleotide
Download Length: 621 bp
>NTDB_id=496931 IRE31_RS09040 WP_000839909.1 1760799..1761419(-) (comM) [Streptococcus pneumoniae strain 19A-ST320_99-176]
ATGAAATCAATGAGAATCTTATTTTTGTTAGCTTTAATTCAAATCAGTTTGAGTAGCTGTTTCCTATGGAAGGAATGCAT
CTTGTCCTTTAAACAAAGTACAGCTTTTTTCATCGGAAGCATGGTTTTCGTTTCAGGAATCTGTGCTGGAGTAAATTATC
TTTATACCCGTAAGCAAGAAGTCCATAGTGTCCTAGCCAGTAAGAAGTCGGTGAAGCTTTTTTACAGTATGTTACTCTTA
ATTAATTTGTTAGGAGCTGTTCTTGTTTTGTCAGATAACTTGTTCATCAAAAATACGCTGCAGCAAGAATTAGTTGACTT
TTTATTGCCATCCTTCTTTTTCCTATTTGGGCTAGATTTGCTGATTTTTTTACCCTTGAAAAAATACGTGCGCGATTTTC
TTGCTATGCTAGACAGAAAAAAGACAGTGTTGGTGACTATTTTAGCAACACTTCTTTTCTTAAGAAATCCAATGACCATT
GTCTCACTTCTGATTTATACTGGACTGGGCTTGTTTTTTGCAGCCTATCTTGTCCCAAATTCGGTTAAGAAGGAAGTTTC
CTTTTATGGTCATATTTTCCGAGATCTTGTATTGGTCATTGTTACGCTCATTTTCTTTTAG
ATGAAATCAATGAGAATCTTATTTTTGTTAGCTTTAATTCAAATCAGTTTGAGTAGCTGTTTCCTATGGAAGGAATGCAT
CTTGTCCTTTAAACAAAGTACAGCTTTTTTCATCGGAAGCATGGTTTTCGTTTCAGGAATCTGTGCTGGAGTAAATTATC
TTTATACCCGTAAGCAAGAAGTCCATAGTGTCCTAGCCAGTAAGAAGTCGGTGAAGCTTTTTTACAGTATGTTACTCTTA
ATTAATTTGTTAGGAGCTGTTCTTGTTTTGTCAGATAACTTGTTCATCAAAAATACGCTGCAGCAAGAATTAGTTGACTT
TTTATTGCCATCCTTCTTTTTCCTATTTGGGCTAGATTTGCTGATTTTTTTACCCTTGAAAAAATACGTGCGCGATTTTC
TTGCTATGCTAGACAGAAAAAAGACAGTGTTGGTGACTATTTTAGCAACACTTCTTTTCTTAAGAAATCCAATGACCATT
GTCTCACTTCTGATTTATACTGGACTGGGCTTGTTTTTTGCAGCCTATCTTGTCCCAAATTCGGTTAAGAAGGAAGTTTC
CTTTTATGGTCATATTTTCCGAGATCTTGTATTGGTCATTGTTACGCTCATTTTCTTTTAG
Domains
No domain identified.
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| comM | Streptococcus pneumoniae D39 |
99.515 |
100 |
0.995 |
| comM | Streptococcus pneumoniae R6 |
99.515 |
100 |
0.995 |
| comM | Streptococcus pneumoniae TIGR4 |
99.515 |
100 |
0.995 |
| comM | Streptococcus mitis NCTC 12261 |
38.462 |
94.66 |
0.364 |
| comM | Streptococcus mitis SK321 |
38.462 |
94.66 |
0.364 |