Detailed information NTG0484834

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: J7U34_RS08145
• Genome accession: NZ_CP072778
• Coordinates: 1570131..1570916 (-)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus strain S24748
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1565131..1575916

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
J7U34_RS08110 (J7U34_08050)	gatC	1565192..1565494 (-)	303	WP_002884769.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
J7U34_RS08115 (J7U34_08055)	-	1565669..1565866 (-)	198	WP_242681688.1	glycosyltransferase	-
J7U34_RS08120	-	1565826..1565990 (-)	165	WP_242681665.1	glycosyltransferase	-
J7U34_RS08125 (J7U34_08065)	-	1566427..1567871 (-)	1445	Protein_1549	6-phospho-beta-glucosidase	-
J7U34_RS08130 (J7U34_08070)	msrA	1568024..1568533 (-)	510	WP_041827375.1	peptide-methionine (S)-S-oxide reductase MsrA	-
J7U34_RS08135 (J7U34_08075)	-	1568545..1569393 (-)	849	Protein_1551	MetQ/NlpA family ABC transporter substrate-binding protein	-
J7U34_RS08140 (J7U34_08080)	-	1569517..1570068 (-)	552	WP_002946999.1	cysteine hydrolase family protein	-
J7U34_RS08145 (J7U34_08085)	codY	1570131..1570916 (-)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
J7U34_RS08150 (J7U34_08090)	-	1571176..1572390 (-)	1215	WP_002951721.1	pyridoxal phosphate-dependent aminotransferase	-
J7U34_RS08155 (J7U34_08095)	-	1572745..1573197 (+)	453	WP_002946987.1	universal stress protein	-
J7U34_RS08160 (J7U34_08100)	-	1573377..1573948 (+)	572	Protein_1556	IS30 family transposase	-
J7U34_RS08165 (J7U34_08105)	-	1574020..1574193 (-)	174	WP_011681546.1	hypothetical protein	-
J7U34_RS08170 (J7U34_08110)	-	1574254..1574628 (-)	375	WP_011681547.1	membrane protein	-
J7U34_RS08175 (J7U34_08115)	pflA	1574840..1575640 (-)	801	WP_071417327.1	pyruvate formate-lyase-activating protein	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=484834 J7U34_RS08145 WP_002951720.1 1570131..1570916(-) (codY) [Streptococcus thermophilus strain S24748]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=484834 J7U34_RS08145 WP_002951720.1 1570131..1570916(-) (codY) [Streptococcus thermophilus strain S24748]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC
ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGCCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTGGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACAGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTGTCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATTACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGCACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502