Detailed information NTG0483219

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: J7T81_RS08145
• Genome accession: NZ_CP072439
• Coordinates: 1572257..1573042 (-)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus strain S24732
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1567257..1578042

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
J7T81_RS08110 (J7T81_08045)	gatC	1567318..1567620 (-)	303	WP_002884769.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
J7T81_RS08115 (J7T81_08050)	-	1567795..1568013 (-)	219	WP_242683841.1	glycosyltransferase	-
J7T81_RS08120	-	1567952..1568116 (-)	165	WP_242681665.1	glycosyltransferase	-
J7T81_RS08125 (J7T81_08060)	-	1568553..1569997 (-)	1445	Protein_1548	6-phospho-beta-glucosidase	-
J7T81_RS08130 (J7T81_08065)	msrA	1570150..1570659 (-)	510	WP_041827375.1	peptide-methionine (S)-S-oxide reductase MsrA	-
J7T81_RS08135 (J7T81_08070)	-	1570671..1571519 (-)	849	Protein_1550	MetQ/NlpA family ABC transporter substrate-binding protein	-
J7T81_RS08140 (J7T81_08075)	-	1571643..1572194 (-)	552	WP_002946999.1	cysteine hydrolase family protein	-
J7T81_RS08145 (J7T81_08080)	codY	1572257..1573042 (-)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
J7T81_RS08150 (J7T81_08085)	-	1573302..1574516 (-)	1215	WP_002951721.1	pyridoxal phosphate-dependent aminotransferase	-
J7T81_RS08155 (J7T81_08090)	-	1574871..1575323 (+)	453	WP_002946987.1	universal stress protein	-
J7T81_RS08160 (J7T81_08095)	-	1575503..1576074 (+)	572	Protein_1555	IS30 family transposase	-
J7T81_RS08165 (J7T81_08100)	-	1576146..1576319 (-)	174	WP_011681546.1	hypothetical protein	-
J7T81_RS08170 (J7T81_08105)	-	1576380..1576754 (-)	375	WP_011681547.1	membrane protein	-
J7T81_RS08175 (J7T81_08110)	pflA	1576966..1577766 (-)	801	WP_071417327.1	pyruvate formate-lyase-activating protein	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=483219 J7T81_RS08145 WP_002951720.1 1572257..1573042(-) (codY) [Streptococcus thermophilus strain S24732]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=483219 J7T81_RS08145 WP_002951720.1 1572257..1573042(-) (codY) [Streptococcus thermophilus strain S24732]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC
ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGCCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTGGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACAGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTGTCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATTACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGCACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502