Detailed information NTG0482146

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: J7U22_RS01265
• Genome accession: NZ_CP072428
• Coordinates: 243119..243904 (+)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus strain S24749
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 238119..248904

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
J7U22_RS01235 (J7U22_01235)	pflA	238395..239195 (+)	801	WP_071417327.1	pyruvate formate-lyase-activating protein	-
J7U22_RS01240 (J7U22_01240)	-	239407..239781 (+)	375	WP_232971393.1	hypothetical protein	-
J7U22_RS01245 (J7U22_01245)	-	239842..240015 (+)	174	WP_014621904.1	hypothetical protein	-
J7U22_RS01250 (J7U22_01250)	-	240087..240658 (-)	572	Protein_222	IS30 family transposase	-
J7U22_RS01255 (J7U22_01255)	-	240838..241290 (-)	453	WP_002946987.1	universal stress protein	-
J7U22_RS01260 (J7U22_01260)	-	241645..242859 (+)	1215	WP_002951721.1	pyridoxal phosphate-dependent aminotransferase	-
J7U22_RS01265 (J7U22_01265)	codY	243119..243904 (+)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
J7U22_RS01270 (J7U22_01270)	-	243967..244518 (+)	552	WP_002946999.1	cysteine hydrolase family protein	-
J7U22_RS01275 (J7U22_01275)	-	244642..245490 (+)	849	Protein_227	MetQ/NlpA family ABC transporter substrate-binding protein	-
J7U22_RS01280 (J7U22_01280)	msrA	245502..246011 (+)	510	WP_041827375.1	peptide-methionine (S)-S-oxide reductase MsrA	-
J7U22_RS01285 (J7U22_01285)	-	246164..247607 (+)	1444	Protein_229	6-phospho-beta-glucosidase	-
J7U22_RS01290 (J7U22_01290)	-	247971..248132 (+)	162	WP_224102937.1	glycosyltransferase	-
J7U22_RS01295 (J7U22_01295)	-	248145..248399 (+)	255	WP_024010053.1	glycosyl transferase	-
J7U22_RS01300 (J7U22_01300)	gatC	248539..248841 (+)	303	WP_002884769.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=482146 J7U22_RS01265 WP_002951720.1 243119..243904(+) (codY) [Streptococcus thermophilus strain S24749]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=482146 J7U22_RS01265 WP_002951720.1 243119..243904(+) (codY) [Streptococcus thermophilus strain S24749]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC
ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGCCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTGGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACAGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTGTCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATTACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGCACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502