Detailed information
Bioinformatically predicted
Overview
| Name | sepM | Type | Regulator |
| Locus tag | IBC04_RS07840 | Genome accession | NZ_CP061020 |
| Coordinates | 1515621..1516697 (-) | Length | 358 a.a. |
| NCBI ID | WP_011681549.1 | Uniprot ID | - |
| Organism | Streptococcus thermophilus strain 24740 | ||
| Function | processing of CSP (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 1500877..1573683 | 1515621..1516697 | within | 0 |
Gene organization within MGE regions
Location: 1500877..1573683
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IBC04_RS07760 (IBC04_07780) | - | 1501768..1502319 (-) | 552 | WP_002946999.1 | isochorismatase family cysteine hydrolase | - |
| IBC04_RS07765 (IBC04_07785) | codY | 1502382..1503167 (-) | 786 | WP_002951720.1 | GTP-sensing pleiotropic transcriptional regulator CodY | - |
| IBC04_RS07770 (IBC04_07790) | - | 1503427..1504641 (-) | 1215 | WP_002951721.1 | pyridoxal phosphate-dependent aminotransferase | - |
| IBC04_RS07775 (IBC04_07795) | - | 1504996..1505448 (+) | 453 | WP_002946987.1 | universal stress protein | - |
| IBC04_RS07780 (IBC04_07800) | - | 1505628..1506199 (+) | 572 | Protein_1501 | IS30 family transposase | - |
| IBC04_RS07785 (IBC04_07805) | - | 1506271..1506444 (-) | 174 | WP_011681546.1 | hypothetical protein | - |
| IBC04_RS07790 (IBC04_07810) | - | 1506505..1506879 (-) | 375 | WP_011681547.1 | membrane protein | - |
| IBC04_RS07795 (IBC04_07815) | pflA | 1507091..1507891 (-) | 801 | WP_071417327.1 | pyruvate formate-lyase-activating protein | - |
| IBC04_RS07800 (IBC04_07820) | - | 1508079..1508189 (-) | 111 | WP_014621906.1 | LPXTG cell wall anchor domain-containing protein | - |
| IBC04_RS07805 (IBC04_07825) | - | 1508887..1510218 (-) | 1332 | WP_024703987.1 | hemolysin family protein | - |
| IBC04_RS07810 (IBC04_07830) | - | 1510332..1511114 (+) | 783 | WP_024703988.1 | ABC transporter ATP-binding protein | - |
| IBC04_RS07820 (IBC04_07840) | - | 1511733..1513799 (-) | 2067 | WP_138496610.1 | sodium:proton antiporter | - |
| IBC04_RS07825 (IBC04_07845) | - | 1513808..1514050 (-) | 243 | WP_084830769.1 | hypothetical protein | - |
| IBC04_RS07830 (IBC04_07850) | - | 1514047..1514595 (-) | 549 | WP_011226462.1 | class I SAM-dependent methyltransferase | - |
| IBC04_RS07835 (IBC04_07855) | - | 1514592..1515536 (-) | 945 | WP_138496612.1 | TIGR01212 family radical SAM protein | - |
| IBC04_RS07840 (IBC04_07860) | sepM | 1515621..1516697 (-) | 1077 | WP_011681549.1 | SepM family pheromone-processing serine protease | Regulator |
| IBC04_RS07845 (IBC04_07865) | coaD | 1516675..1517172 (-) | 498 | WP_011681550.1 | pantetheine-phosphate adenylyltransferase | - |
| IBC04_RS07850 (IBC04_07870) | rsmD | 1517206..1517805 (-) | 600 | Protein_1514 | 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD | - |
| IBC04_RS07855 (IBC04_07875) | trxB | 1517896..1518849 (-) | 954 | WP_259699870.1 | thioredoxin-disulfide reductase | - |
| IBC04_RS07860 (IBC04_07880) | - | 1518882..1519106 (-) | 225 | WP_082309114.1 | DUF4059 family protein | - |
| IBC04_RS07865 (IBC04_07885) | - | 1519321..1520064 (-) | 744 | WP_011681551.1 | amino acid ABC transporter ATP-binding protein | - |
| IBC04_RS07870 (IBC04_07890) | - | 1520064..1520810 (-) | 747 | WP_095559509.1 | amino acid ABC transporter permease | - |
| IBC04_RS07875 (IBC04_07895) | - | 1521206..1522036 (-) | 831 | WP_014608653.1 | transporter substrate-binding domain-containing protein | - |
| IBC04_RS07880 (IBC04_07900) | - | 1522496..1522729 (-) | 234 | WP_002947030.1 | hypothetical protein | - |
| IBC04_RS07885 (IBC04_07905) | dinB | 1523027..1524130 (-) | 1104 | WP_014608654.1 | DNA polymerase IV | - |
| IBC04_RS07890 (IBC04_07910) | pflB | 1524409..1526718 (+) | 2310 | WP_011226473.1 | formate C-acetyltransferase | - |
| IBC04_RS07895 (IBC04_07915) | - | 1526985..1527767 (+) | 783 | WP_011681555.1 | carbonic anhydrase family protein | - |
| IBC04_RS07900 (IBC04_07920) | - | 1527818..1528270 (+) | 453 | WP_014608655.1 | GNAT family N-acetyltransferase | - |
| IBC04_RS07905 (IBC04_07925) | - | 1528621..1528926 (-) | 306 | WP_014621914.1 | restriction endonuclease subunit S | - |
| IBC04_RS10590 (IBC04_07930) | mobV | 1528951..1529459 (-) | 509 | Protein_1526 | MobV family relaxase | - |
| IBC04_RS07915 (IBC04_07935) | fetB | 1529904..1530659 (-) | 756 | WP_011681558.1 | iron export ABC transporter permease subunit FetB | - |
| IBC04_RS07920 (IBC04_07940) | - | 1530656..1531306 (-) | 651 | WP_011681559.1 | ATP-binding cassette domain-containing protein | - |
| IBC04_RS07925 (IBC04_07945) | - | 1531509..1532465 (-) | 957 | WP_002951776.1 | serine hydrolase domain-containing protein | - |
| IBC04_RS07930 (IBC04_07950) | - | 1532465..1533220 (-) | 756 | WP_011681560.1 | CppA family protein | - |
| IBC04_RS07935 (IBC04_07955) | - | 1533502..1533864 (+) | 363 | WP_014608659.1 | CPBP family intramembrane glutamic endopeptidase | - |
| IBC04_RS07940 (IBC04_07960) | gla | 1533951..1534814 (-) | 864 | WP_002951781.1 | aquaglyceroporin Gla | - |
| IBC04_RS07945 (IBC04_07965) | - | 1534935..1537202 (+) | 2268 | WP_011681561.1 | Xaa-Pro dipeptidyl-peptidase | - |
| IBC04_RS07950 (IBC04_07970) | - | 1537282..1537662 (-) | 381 | WP_002951783.1 | hypothetical protein | - |
| IBC04_RS07955 (IBC04_07975) | - | 1537787..1538050 (-) | 264 | WP_002945924.1 | hypothetical protein | - |
| IBC04_RS07960 (IBC04_07980) | - | 1538372..1538668 (-) | 297 | WP_004197070.1 | bacteriocin immunity protein | - |
| IBC04_RS07965 (IBC04_07985) | - | 1538833..1539039 (-) | 207 | WP_011681562.1 | hypothetical protein | - |
| IBC04_RS07970 (IBC04_07990) | - | 1539070..1539759 (-) | 690 | WP_011681563.1 | thioredoxin family protein | - |
| IBC04_RS10480 | - | 1539953..1540639 (+) | 687 | WP_002947058.1 | helix-turn-helix domain-containing protein | - |
| IBC04_RS10485 | - | 1540643..1541524 (+) | 882 | WP_278249223.1 | IS3 family transposase | - |
| IBC04_RS07980 (IBC04_08000) | - | 1541670..1541924 (-) | 255 | WP_014608660.1 | Blp family class II bacteriocin | - |
| IBC04_RS10595 | - | 1542175..1542576 (-) | 402 | WP_024703992.1 | hypothetical protein | - |
| IBC04_RS07985 (IBC04_08005) | - | 1543581..1543811 (-) | 231 | WP_014608662.1 | bacteriocin class II family protein | - |
| IBC04_RS07990 (IBC04_08010) | - | 1544167..1544367 (-) | 201 | WP_011681569.1 | hypothetical protein | - |
| IBC04_RS07995 (IBC04_08015) | - | 1544386..1544562 (-) | 177 | WP_011681570.1 | Blp family class II bacteriocin | - |
| IBC04_RS08000 (IBC04_08020) | - | 1544813..1545550 (+) | 738 | WP_011681571.1 | response regulator transcription factor | - |
| IBC04_RS10295 | - | 1546081..1546884 (+) | 804 | WP_223899638.1 | ATP-binding protein | - |
| IBC04_RS08010 (IBC04_08030) | - | 1546902..1547063 (-) | 162 | WP_011681573.1 | ComC/BlpC family leader-containing pheromone/bacteriocin | - |
| IBC04_RS08015 (IBC04_08035) | - | 1547078..1548445 (-) | 1368 | WP_011681574.1 | bacteriocin secretion accessory protein | - |
| IBC04_RS08020 (IBC04_08040) | - | 1548461..1550613 (-) | 2153 | Protein_1550 | peptide cleavage/export ABC transporter | - |
| IBC04_RS08030 (IBC04_08050) | - | 1551627..1553372 (-) | 1746 | WP_024703994.1 | ABC transporter ATP-binding protein | - |
| IBC04_RS08035 (IBC04_08055) | - | 1553365..1555122 (-) | 1758 | WP_014608668.1 | ABC transporter transmembrane domain-containing protein | - |
| IBC04_RS10300 | - | 1555310..1555516 (-) | 207 | WP_002948879.1 | hypothetical protein | - |
| IBC04_RS08045 (IBC04_08065) | - | 1555721..1556248 (-) | 528 | WP_011226503.1 | VanZ family protein | - |
| IBC04_RS08050 (IBC04_08070) | rlmN | 1556250..1557419 (-) | 1170 | WP_011226504.1 | 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN | - |
| IBC04_RS08055 (IBC04_08075) | - | 1557423..1558145 (-) | 723 | WP_011226505.1 | YutD family protein | - |
| IBC04_RS08060 (IBC04_08080) | - | 1558200..1559555 (-) | 1356 | WP_002948886.1 | metallophosphatase | - |
| IBC04_RS08070 (IBC04_08085) | - | 1560403..1561746 (-) | 1344 | WP_014608670.1 | DEAD/DEAH box helicase | - |
| IBC04_RS08075 (IBC04_08090) | mraY | 1561821..1562843 (-) | 1023 | WP_011227524.1 | phospho-N-acetylmuramoyl-pentapeptide- transferase | - |
| IBC04_RS08080 (IBC04_08095) | pbp2X | 1562845..1565112 (-) | 2268 | WP_011226508.1 | penicillin-binding protein PBP2X | - |
| IBC04_RS08085 (IBC04_08100) | ftsL | 1565116..1565436 (-) | 321 | WP_014608671.1 | cell division protein FtsL | - |
| IBC04_RS08090 (IBC04_08105) | rsmH | 1565439..1566389 (-) | 951 | WP_002888254.1 | 16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH | - |
| IBC04_RS08095 (IBC04_08110) | - | 1566556..1567287 (-) | 732 | WP_224103288.1 | hypothetical protein | - |
| IBC04_RS08105 (IBC04_08120) | - | 1567616..1567879 (+) | 264 | WP_162877224.1 | hypothetical protein | - |
| IBC04_RS08110 (IBC04_08125) | - | 1568185..1568541 (-) | 357 | WP_023909925.1 | DUF805 domain-containing protein | - |
| IBC04_RS08115 (IBC04_08130) | - | 1568890..1569057 (-) | 168 | WP_153300736.1 | hypothetical protein | - |
| IBC04_RS08120 (IBC04_08135) | - | 1569390..1570640 (-) | 1251 | WP_207559893.1 | glutamate-5-semialdehyde dehydrogenase | - |
| IBC04_RS08125 (IBC04_08140) | proB | 1570642..1571445 (-) | 804 | WP_014608676.1 | glutamate 5-kinase | - |
| IBC04_RS08130 (IBC04_08145) | - | 1571566..1573155 (-) | 1590 | WP_014608677.1 | ABC transporter permease | - |
Sequence
Protein
Download Length: 358 a.a. Molecular weight: 39172.02 Da Isoelectric Point: 9.3888
>NTDB_id=479548 IBC04_RS07840 WP_011681549.1 1515621..1516697(-) (sepM) [Streptococcus thermophilus strain 24740]
MANKTKSKALLEKMWRIKWWLLSIFTVLFLLFALFFPLNNYYVELPGGAFDTKEVLTVNKKADDSKGSYNFVAVAQTKAT
LALMLYAQFNDFAKLQTAEEATGNYSDEDFMRINQFYMETSQNQAVYQGLTLAGKEVSLEYMGVYVLQVADDSSFKGVLN
IADTVTAVNGNTFDNSTDMIKYVQGLKLGSKVKVTYMRDGKEKTATGKIIKIANGKNGIGIGLTDHTEIKSPENVKFKLD
GVGGPSAGLMFTLAIYDQVSGQDLKAGRKIAGTGTIEKDGAVGDIGGAYLKVKSAADSGADIFFVPNNLVTKEMKKADPD
AKTNYQEAKEAAEKLGTKMKIVPVKTAQEAIDYLKKTK
MANKTKSKALLEKMWRIKWWLLSIFTVLFLLFALFFPLNNYYVELPGGAFDTKEVLTVNKKADDSKGSYNFVAVAQTKAT
LALMLYAQFNDFAKLQTAEEATGNYSDEDFMRINQFYMETSQNQAVYQGLTLAGKEVSLEYMGVYVLQVADDSSFKGVLN
IADTVTAVNGNTFDNSTDMIKYVQGLKLGSKVKVTYMRDGKEKTATGKIIKIANGKNGIGIGLTDHTEIKSPENVKFKLD
GVGGPSAGLMFTLAIYDQVSGQDLKAGRKIAGTGTIEKDGAVGDIGGAYLKVKSAADSGADIFFVPNNLVTKEMKKADPD
AKTNYQEAKEAAEKLGTKMKIVPVKTAQEAIDYLKKTK
Nucleotide
Download Length: 1077 bp
>NTDB_id=479548 IBC04_RS07840 WP_011681549.1 1515621..1516697(-) (sepM) [Streptococcus thermophilus strain 24740]
GTGGCAAACAAGACAAAATCTAAAGCGCTATTAGAGAAAATGTGGCGTATTAAGTGGTGGTTATTAAGTATTTTTACGGT
ACTTTTCCTCCTTTTTGCCCTCTTTTTCCCGCTCAATAATTACTATGTGGAGCTTCCGGGTGGTGCTTTTGATACCAAGG
AAGTCTTGACAGTGAATAAGAAAGCTGATGATTCTAAGGGCTCCTATAATTTTGTGGCGGTGGCTCAAACCAAGGCGACT
TTGGCCTTGATGCTCTATGCTCAGTTTAATGATTTTGCAAAGCTTCAAACGGCTGAAGAGGCAACTGGAAATTACTCTGA
TGAAGATTTCATGCGCATCAACCAATTTTACATGGAGACTTCTCAAAACCAAGCGGTTTATCAGGGCTTGACTCTGGCTG
GTAAGGAGGTTAGTTTGGAGTATATGGGTGTCTATGTGCTTCAGGTTGCTGATGATTCTAGCTTCAAGGGTGTCCTCAAT
ATTGCTGATACGGTGACGGCTGTTAATGGTAATACCTTTGATAATTCTACTGACATGATTAAATACGTTCAAGGACTTAA
GCTGGGTTCAAAGGTCAAGGTCACTTATATGAGAGATGGCAAAGAAAAGACTGCTACTGGTAAGATTATTAAGATTGCCA
ATGGCAAAAATGGTATTGGTATCGGCCTAACGGACCATACTGAGATCAAGAGTCCTGAGAATGTTAAGTTTAAACTGGAT
GGTGTCGGTGGGCCAAGTGCTGGTCTTATGTTTACCTTGGCTATTTACGATCAGGTGTCTGGTCAAGACCTCAAGGCTGG
CCGCAAGATTGCTGGTACAGGAACTATTGAAAAAGATGGGGCTGTCGGTGATATCGGTGGGGCCTATCTCAAGGTGAAAT
CTGCGGCTGATAGTGGCGCAGACATTTTCTTCGTGCCAAATAATCTAGTAACTAAGGAAATGAAAAAGGCTGATCCGGAT
GCCAAGACTAATTATCAAGAGGCCAAGGAAGCTGCCGAGAAACTGGGGACCAAGATGAAAATCGTCCCTGTTAAAACAGC
TCAAGAAGCCATTGATTATTTGAAAAAGACTAAATGA
GTGGCAAACAAGACAAAATCTAAAGCGCTATTAGAGAAAATGTGGCGTATTAAGTGGTGGTTATTAAGTATTTTTACGGT
ACTTTTCCTCCTTTTTGCCCTCTTTTTCCCGCTCAATAATTACTATGTGGAGCTTCCGGGTGGTGCTTTTGATACCAAGG
AAGTCTTGACAGTGAATAAGAAAGCTGATGATTCTAAGGGCTCCTATAATTTTGTGGCGGTGGCTCAAACCAAGGCGACT
TTGGCCTTGATGCTCTATGCTCAGTTTAATGATTTTGCAAAGCTTCAAACGGCTGAAGAGGCAACTGGAAATTACTCTGA
TGAAGATTTCATGCGCATCAACCAATTTTACATGGAGACTTCTCAAAACCAAGCGGTTTATCAGGGCTTGACTCTGGCTG
GTAAGGAGGTTAGTTTGGAGTATATGGGTGTCTATGTGCTTCAGGTTGCTGATGATTCTAGCTTCAAGGGTGTCCTCAAT
ATTGCTGATACGGTGACGGCTGTTAATGGTAATACCTTTGATAATTCTACTGACATGATTAAATACGTTCAAGGACTTAA
GCTGGGTTCAAAGGTCAAGGTCACTTATATGAGAGATGGCAAAGAAAAGACTGCTACTGGTAAGATTATTAAGATTGCCA
ATGGCAAAAATGGTATTGGTATCGGCCTAACGGACCATACTGAGATCAAGAGTCCTGAGAATGTTAAGTTTAAACTGGAT
GGTGTCGGTGGGCCAAGTGCTGGTCTTATGTTTACCTTGGCTATTTACGATCAGGTGTCTGGTCAAGACCTCAAGGCTGG
CCGCAAGATTGCTGGTACAGGAACTATTGAAAAAGATGGGGCTGTCGGTGATATCGGTGGGGCCTATCTCAAGGTGAAAT
CTGCGGCTGATAGTGGCGCAGACATTTTCTTCGTGCCAAATAATCTAGTAACTAAGGAAATGAAAAAGGCTGATCCGGAT
GCCAAGACTAATTATCAAGAGGCCAAGGAAGCTGCCGAGAAACTGGGGACCAAGATGAAAATCGTCCCTGTTAAAACAGC
TCAAGAAGCCATTGATTATTTGAAAAAGACTAAATGA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| sepM | Streptococcus mutans UA159 |
62.757 |
95.251 |
0.598 |